scholarly journals The Role of the Endocannabinoid Signaling System in the Pathophysiology of Asthma and Obesity

2019 ◽  
Vol 74 (3) ◽  
pp. 200-209 ◽  
Author(s):  
Oksana Y. Kytikovа ◽  
Tatyana P. Novgorodtseva ◽  
Yuliya K. Denisenko ◽  
Marina V. Antonyuk ◽  
Tatyana A. Gvozdenko
Keyword(s):  
Drug Exposure ◽  
Endocannabinoid System ◽  
Scientific Data ◽  
The Body ◽  
General Mechanism ◽  
Therapeutic Effects ◽  
Signaling System ◽  
Modern Problem ◽  
Peripheral Tissues

Bronchial asthma (BA) and obesity are one of the major modern problem, requiring the development of an effective therapeutic strategy. The frequent combination of these diseases in one patient indicates the general pathophysiological mechanisms and future study for targeted drug exposure are needed. The endocannabinoid system is involved in a variety of physiological and pathological processes and can be considered as a general mechanism and a potential therapeutic target in asthma and obesity, the receptors of the system are expressed in many central and peripheral tissues. This signal system modulates the functions of the autonomic nervous system, immune system and microcirculation, plays an important role in the regulation of energy balance, metabolism of carbohydrates and lipids. The main research aimed at studying the functioning of this system was focused on neurology and psychiatry, while numerous scientific data demonstrate the importance of the participation of this system in the pathogenesis of other diseases. In particular, this system is involved in the mechanisms of obesity. The role of the endocannabinoid system in the pathogenesis of asthma is actively studied. The wide prevalence of the endocannabinoid signaling system and its regulatory role in the body opens up prospects for therapeutic effects in the treatment of asthma and obesity, as well as the possible phenotype of asthma, combined with obesity. The review is devoted to modern ideas about endocannabinoids, their receptors, mechanisms of action and their role in the pathophysiology of asthma and obesity. The therapeutic prospects and difficulties associated with the use of endocannabinoids and phytocannabinoids in medicine are discussed.

scholarly journals Visual Acuity Charts: Analytical Review, Basic Terms

2019 ◽  
Vol 74 (3) ◽  
pp. 192-199
Author(s):  
Maria A. Gracheva ◽  
Anna A. Kazakova ◽  
Dmitry F. Pokrovskiy ◽  
Igor B. Medvedev
Keyword(s):  
Drug Exposure ◽  
Endocannabinoid System ◽  
Scientific Data ◽  
The Body ◽  
General Mechanism ◽  
Therapeutic Effects ◽  
Modern Problem ◽  
Peripheral Tissues ◽  
Main Research ◽  
Analytical Review

Bronchial asthma (BA) and obesity are one of the major modern problem, requiring the development of an effective therapeutic strategy. The frequent combination of these diseases in one patient indicates the general pathophysiological mechanisms and future study for targeted drug exposure are needed. The endocannabinoid system is involved in a variety of physiological and pathological processes and can be considered as a general mechanism and a potential therapeutic target in asthma and obesity, the receptors of the system are expressed in many central and peripheral tissues. This signal system modulates the functions of the autonomic nervous system, immune system and microcirculation, plays an important role in the regulation of energy balance, metabolism of carbohydrates and lipids. The main research aimed at studying the functioning of this system was focused on neurology and psychiatry, while numerous scientific data demonstrate the importance of the participation of this system in the pathogenesis of other diseases. In particular, this system is involved in the mechanisms of obesity. The role of the endocannabinoid system in the pathogenesis of asthma is actively studied. The wide prevalence of the endocannabinoid signaling system and its regulatory role in the body opens up prospects for therapeutic effects in the treatment of asthma and obesity, as well as the possible phenotype of asthma, combined with obesity. The review is devoted to modern ideas about endocannabinoids, their receptors, mechanisms of action and their role in the pathophysiology of asthma and obesity. The therapeutic prospects and difficulties associated with the use of endocannabinoids and phytocannabinoids in medicine are discussed.

Role of cannabinoids in various diseases: A review

2021 ◽  
Vol 23 ◽  
Author(s):  
Simran Kaur ◽  
Nikita Sharma ◽  
Arpita Roy
Keyword(s):  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Viral Infections ◽  
Cannabis Sativa ◽  
Endocannabinoid System ◽  
Psychological Disorders ◽  
Bioactive Compound ◽  
The Body ◽  
Therapeutic Aspect

Background: The plant, Cannabis sativa is heavily explored and researched with many industrial and pharmaceutical applications. The medicinal and therapeutic role of cannabis Sativa has been summarized in the paper, citing its mechanism of action and influence on the human body. Diseases like metabolic disorders, infectious diseases, and psychological disorders pose negative and long-term drastic effects on the body like neurodegeneration and other chronic system failures. Several existing literature has proved its effectiveness against such diseases. Objectives: This review aims to provide an overview of the role of cannabinoids in various diseases like metabolic disorders, infectious diseases, and psychological disorders. Method: Various e-resources like Pubmed, Science Direct, and Google Scholar were thoroughly searched and read to form a well-informed and information-heavy manuscript. Here we tried to summaries the therapeutic aspect of Cannabis sativa and its bioactive compound cannabinoids in various diseases. Result: This review highlights the various constituents which are present in Cannabis sativa, the Endocannabinoid system, and the role of cannabinoids in various diseases Conclusion: Recent research on Cannabis has suggested its role in neurodegenerative diseases, inflammation, sleep disorders, pediatric diseases, and their analgesic nature. Therefore, the authors majorly focus on the therapeutic aspect of Cannabis sativa in various diseases. The focus is also on the endocannabinoid system (ECS) and its role in fighting or preventing bacterial, parasitic, fungal, and viral infections.

The essential role of nesfatin-1 as a biological signal on the body systems

2021 ◽  
pp. 113-118
Keyword(s):  
Metabolic Disorders ◽  
Clinical Medicine ◽  
The Body ◽  
World Population ◽  
Peripheral Tissues ◽  
Future Studies ◽  
Body Organ ◽  
Regulate Food Intake ◽  
System Today

Nesfatin-1is first described in 2006 as an anorectic peptide and regulate food intake. In following years, the studies demonstrated the presence of nesfatin-1 in central and various peripheral tissues. Thus, nesfatin-1 popularity increasing widely in clinical medicine, especially in cardiology, neurology, reproduction, metabolic disorders, psychiatric disorders, gastrointestinal system. Today, the main point concerning nesfatin-1 action in body organ and systems is concentrate its biological signals effects. Thus the increasing knowledge in these area will be highlighted for future studies especially in serious health problem all over the world population.

scholarly journals Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Yanke Lin ◽  
Shuai Wang ◽  
Ziyue Zhou ◽  
Lianxia Guo ◽  
Fangjun Yu ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Drug Exposure ◽  
Defense Mechanism ◽  
Critical Role ◽  
The Body ◽  
Cellular Regulation ◽  
Circadian Expression ◽  
Distal Promoter ◽  
Daily Time

Abstract Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 deficiency decreases the mRNA, protein and microsomal activity of Cyp3a11, and blunts their circadian rhythms in mice. A screen for Cyp3a11 regulators identifies two circadian genes Dbp and Hnf4α as potential regulatory mediators. Cell-based experiments confirm that Dbp and Hnf4α activate Cyp3a11 transcription by their binding to a D-box and a DR1 element in the Cyp3a11 promoter, respectively. Bmal1 binds to the P1 distal promoter to regulate Hnf4α transcriptionally. Cellular regulation of Cyp3a11 by Bmal1 is Dbp- and Hnf4α-dependent. Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure. In summary, Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby impacting drug detoxification as a function of daily time.

scholarly journals The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2182 ◽  
Author(s):  
Oliver K Fuller ◽  
Martin Whitham ◽  
Suresh Mathivanan ◽  
Mark A Febbraio
Keyword(s):  
Physical Activity ◽  
Extracellular Vesicles ◽  
Potential Role ◽  
The Body ◽  
Therapeutic Effects ◽  
Health And Wellbeing ◽  
Systemic Factors ◽  
Diabetes And Obesity

Physical activity has systemic effects on the body, affecting almost every organ. It is important not only for general health and wellbeing, but also in the prevention of diseases. The mechanisms behind the therapeutic effects of physical activity are not completely understood; however, studies indicate these benefits are not confined to simply managing energy balance and body weight. They also include systemic factors which are released into the circulation during exercise and which appear to underlie the myriad of benefits exercise can elicit. It was shown that along with a number of classical cytokines, active tissues also engage in inter-tissue communication via extracellular vesicles (EVs), specifically exosomes and other small EVs, which are able to deliver biomolecules to cells and alter their metabolism. Thus, EVs may play a role in the acute and systemic adaptations that take place during and after physical activity, and may be therapeutically useful in the treatment of a range of diseases, including metabolic disorders such as type 2 diabetes and obesity; and the focus of this review, neurological disorders such as Alzheimer’s disease.

scholarly journals SILICON: ITS BIOLOGICAL IMPACT UNDER DIETARY INTAKE AND HYGIENIC STANDARDIZATION OF ITS CONTENT IN DRINKING WATER. A REVIEW

2019 ◽  
Vol 96 (5) ◽  
pp. 492-498
Author(s):  
Yu. A. Rakhmanin ◽  
N. A. Egorova ◽  
G. N. Krasovsky ◽  
R. I. Mikhailova ◽  
A. V. Alekseeva
Keyword(s):  
Drinking Water ◽  
Dietary Intake ◽  
Biological Effects ◽  
The Body ◽  
Water Soluble ◽  
Western World ◽  
Balkan Endemic Nephropathy ◽  
Human Organism ◽  
Therapeutic Effects

By the prevalence in the earth’s crust, silicon occupies the second place after oxygen. In different quantities silicon always presents in water and food products.The average daily dietary intake of silicon in Western world is about 20-50 mg/day. The biological role of silicon in human organism is still not clear, but it assumed to be necessary for processes of bone mineralization, collagen synthesis, it has a positive effect on the state of skin, hair, and nails, contributes to the prevention of atherosclerosis and Alzheimer disease. A number of scientific research is devoted to biological effects of silicon in animals and human subjects under intake with food and water, and substantiation of silicon (maximum admissible concentrations (MAC) in drinking water. In Chuvashia there was investigated the regional (geographical) pathology, which may be related with an increased silicon intake in association with the sharp imbalances of trace and macro elements in drinking water. Some measures were implemented to identify the possible role of silicon in etiology of Balkan endemic nephropathy. Organization for Economic Co-operation and Development (OECD) report summarized materials for the experimental evaluation of the toxicity and harmless levels of silicon intake with food and water in animals. A series of studies was executed to simulate the development of silicon urolithiasis and for the elucidation of the role of macro- and microelements accompanying the intake of silicon into the body in stone formation. There are studied potential therapeutic effects of water soluble silicon compounds on human health. The standards of silicon in drinking water are regulated only in Russia and Australia. At the same time in our country there were formed two opposing points of view in relation to the hygienic standardization of silicon. The first is one - MAC of silicon in drinking water needs to be cancelled, the second - MAC of silicon in the water needs to be tightened. To resolve the contradictions it is advisable to use both the experience of harmonization of standards with international requirements, and the principle of silicon regional standardization, taking into consideration the biogeochemical characteristics of geographic areas. When searching the literature databases PubMed and CyberLeninka were used.

scholarly journals Hyperammonemia in clinical practice: analysis of own clinical observations

2020 ◽  
Vol 4 (38) ◽  
pp. 23-26
Author(s):  
Z. M. Galeeva ◽  
O. F. Galiullin ◽  
E. G. Yeziukova ◽  
R. G. Tukhbatullina
Keyword(s):  
Clinical Practice ◽  
Drug Therapy ◽  
Human Body ◽  
Scientific Data ◽  
The Body ◽  
Mechanism Of Formation ◽  
Practice Analysis ◽  
Clinical Observations ◽  
The Brain

The article presents scientific data on the role of ammonia in the human body, examines in detail the mechanism of formation and utilization of ammonia in the body. The questions of etiology and separate forms of pathogenesis of hyperammonemia, and its influence on the processes of fibrosis in the liver and the role of stellate liver cells in it are highlighted separately. The data on the influence of hyperammonemia on cognitive functions of the brain with the development of encephalopathy are presented, which is of great importance in clinical practice, during medical examination. The data of own observations are given, the questions of drug therapy are highlighted.

scholarly journals Serotonergic regulation of energy metabolism in peripheral tissues

2020 ◽  
Vol 245 (1) ◽  
pp. R1-R10
Author(s):  
Wonsuk Choi ◽  
Joon Ho Moon ◽  
Hail Kim
Keyword(s):  
Energy Metabolism ◽  
Serotonin Receptors ◽  
Metabolic Diseases ◽  
The Body ◽  
Peripheral Tissues ◽  
Knock Out ◽  
Neuronal Tissues ◽  
Serotonin Signaling ◽  
Amino Acid Tryptophan

Serotonin is a biogenic amine synthesized from the essential amino acid tryptophan. Because serotonin cannot cross the blood-brain barrier, it functions differently in neuronal and non-neuronal tissues. In the CNS, serotonin regulates mood, behavior, appetite, and energy expenditure. Although most serotonin in the body is synthesized at the periphery, its biological roles have not been well elucidated. Older studies using chemical agonists and antagonists yielded conflicting results, because the complexity of serotonin receptors and the low selectivity of agonists and antagonists were not known. Several recent studies using specific knock-out of serotonin receptors have been performed to assess the role of peripheral serotonin in regulating energy metabolism. This review discusses (1) the tissue-specific roles of peripheral serotonin in regulating energy metabolism, (2) the mechanism by which dysfunctional peripheral serotonin signaling can progress to metabolic diseases, and (3) how peripheral serotonin signaling could be a therapeutic target for metabolic diseases.

scholarly journals Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Akhlaq A. Farooqui ◽  
Tahira Farooqui ◽  
Anil Madan ◽  
Jolin Hwee-Jing Ong ◽  
Wei-Yi Ong
Keyword(s):  
Signal Transduction ◽  
Medicinal Plants ◽  
Scientific Data ◽  
The Body ◽  
Ayurvedic Medicine ◽  
Acorus Calamus ◽  
Therapeutic Effects ◽  
Holistic View ◽  
Toxicological Studies ◽  
Sites Of Action

Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment which promotes and supports equilibrium in different aspects of human life: the body, mind, and soul. Popular Ayurvedic medicinal plants and formulations that are used to slow down brain aging and enhance memory include Ashwagandha (Withania somnifera), Turmeric (Curcuma longa), Brahmi (Bacopa monnieri), Shankhpushpi (Convolvulus pluricaulis, Evolvulus alsinoides, and other species), gotu kola (Centella asiatica), and guggulu (Commiphora mukul and related species) and a formulation known as Brāhmī Ghṛita, containing Brahmi, Vacā (Acorus calamus), Kuṣṭha (Saussurea lappa), Shankhpushpi, and Purāṇa Ghṛita (old clarified butter/old ghee). The rationale for the utilization of Ayurvedic medicinal plants has depended mostly on traditional usage, with little scientific data on signal transduction processes, efficacy, and safety. However, in recent years, pharmacological and toxicological studies have begun to be published and receive attention from scientists for verification of their claimed pharmacological and therapeutic effects. The purpose of this review is to outline the molecular mechanisms, signal transduction processes, and sites of action of some Ayurvedic medicinal plants. It is hoped that this description can be further explored with modern scientific methods, to reveal new therapeutic leads and jump-start more studies on the use of Ayurvedic medicine for prevention and treatment of dementia.

scholarly journals The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ivan Lobov ◽  
Natalia Mikhailova
Keyword(s):  
Blood Vessel ◽  
Transmembrane Protein ◽  
Mammalian Species ◽  
Vascular Development ◽  
Critical Role ◽  
Notch Pathway ◽  
The Body ◽  
Therapeutic Effects ◽  
Pathological Conditions

Background. Retina is the highest oxygen-demanding and vascularized tissue in the body. Retinal development and function require proper vascularization and blood vessel function and integrity. Dll4 is most prominently expressed in the endothelium of angiogenic blood vessels and in quiescent arteries and capillaries in all tissues and organs of the mammalian species, and it is the key regulator of blood vessel sprouting.Results. Dll4 is a transmembrane protein that acts as a ligand for Notch receptors 1 and 4. Genetic deletion of Dll4 causes severe abnormalities in embryonic and postnatal vascular development. Deletion of even a single Dll4 allele results in almost complete embryonic lethality due to severe vascular abnormalities, the phenomenon called haploinsufficiency indicating the critical role of Dll4/Notch in vascular development. Dll4/Notch pathway interplays at multiple levels with other signaling pathways including VEGF, Wnt/Fzd, and genes controlling vascular toning. Multiple studies of the effects of Dll4 inhibition were performed in the developing retina to elucidate the key functions of Dll4 in normal and pathological angiogenesis. Several genetic approaches and therapeutic molecules were tested to evaluate the biological and therapeutic effects of acute and prolonged Dll4 inhibition in the eye and oncology.Conclusions. All current studies demonstrated that Dll4 controls blood vessel sprouting, growth, and remodeling in normal and pathological conditions as well as arterial-venous differentiation. Genetic and therapeutic Dll4 modulation studies show that Dll4 inhibition can promote blood vessel sprouting and might be useful to stimulate vessel growth in the ischemic retina and Dll4 is the key modulator of the postangiogenic vascular remodeling that ultimately defines vascular patterning.

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