Enhancement of Osseointegration by Generating a Dynamic Implant Surface

10.1563/736.1 ◽  
2006 ◽  
Vol 32 (2) ◽  
pp. 72-76 ◽  
Author(s):  
Eduardo A. Anitua
Keyword(s):  
Environmental Scanning Electron Microscopy ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Environmental Scanning ◽  
Implant Surface ◽  
Autologous Plasma ◽  
Bone Implant ◽  
Rich Material ◽  
Protein Rich ◽  
Titanium Implant Surface

Abstract Preparations of autologous plasma rich in growth factors (PRGF) are used to promote healing and tissue regeneration. We seek to determine whether covering the titanium implant surface with this preparation could enhance osseointegration. The interaction of PRGF with the surface of titanium implants was examined by environmental scanning electron microscopy (ESEM). A total of 23 implants were placed in the tibiae and radii of 3 goats; 13 implants were inserted after covering the surface and filling the alveolus with PRGF, and 10 more implants were inserted following a conventional protocol and served as controls. Histomorphometric analysis of the bone-implant interface was performed after 8 weeks. Finally, 1391 implants were placed in 295 patients after bioactivating the surface with PRGF. Stability and implant survival were evaluated. The implant surface adsorbed the protein-rich material as shown by ESEM. In the animal study, osseointegration was enhanced when the surface was covered with PRGF as shown by histomorphometry (bone-implant contact: 51.28% ± 4.7% vs 21.89% ± 7.36%; P < .01). Finally, studies in patients showed that 99.6% of the implants treated with PRGF were well osseointegrated. Clinical use of this technique in oral implantology can improve the prognosis.

Does surface anodisation of titanium implants change osseointegration and make their extraction from bone any easier?

2008 ◽  
Vol 21 (03) ◽  
pp. 202-210 ◽  
Author(s):  
J. Langhoff ◽  
J. Mayer ◽  
L. Faber ◽  
S. Kaestner ◽  
G. Guibert ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
High Bone ◽  
Titanium Surfaces ◽  
Anodized Titanium ◽  
Titanium Implant Surface

Summary Objectives: Titanium implants have a tendency for high bone-implant bonding, and, in comparison to stainless steel implants are more difficult to remove. The current study was carried out to evaluate, i) the release strength of three selected anodized titanium surfaces with increased nanohardness and low roughness, and ii) bone-implant bonding in vivo. These modified surfaces were intended to give improved anchorage while facilitating easier removal of temporary implants. Material and methods: The new surfaces were referenced to a stainless steel implant and a standard titanium implant surface (TiMAX™). In a sheep limb model, healing period was 3 months. Bone-implant bonding was evaluated either biomechanically or histologically. Results: The new surface anodized screws demonstrated similar or slightly higher bone-implantcontact (BIC) and torque release forces than the titanium reference. The BIC of the stainless steel implants was significant lower than two of the anodized surfaces (p=0.04), but differences between stainless steel and all titanium implants in torque release forces were not significant (p=0.06). Conclusion: The new anodized titanium surfaces showed good bone-implant bonding despite a smooth surface and increased nanohardness. However, they failed to facilitate implant removal at 3 months.

Alkali-Modified Titanium Surface Stimulating Formation of Bone-Implant Interface

2007 ◽  
Vol 361-363 ◽  
pp. 749-752
Author(s):  
J. Strnad ◽  
Jan Macháček ◽  
Z. Strnad ◽  
C. Povýšil ◽  
Marie Strnadová
Keyword(s):  
Titanium Implant ◽  
Surface Characteristics ◽  
Healing Time ◽  
Machined Surface ◽  
Implant Surface ◽  
Bone Implant ◽  
Bone Response ◽  
Modified Surface ◽  
The Difference ◽  
Titanium Implant Surface

This study was carried out to assess the bone response to alkali-modified titanium implant surface (Bio surface), using histomorphometric investigation on an animal model. The mean net contribution of the Bio surface to the increase in bone implant contact (BIC) with reference to the turned, machined surface was evaluated at 7.94 % (BIC/week), within the first five weeks of healing. The contribution was expressed as the difference in the osseointegration rates ( BIC/'healing time) between the implants with alkali modified surface (Bio surface) and those with turned, machined surface. The surface characteristics that differed between the implant surfaces, i.e. surface morphology, specific surface area, contact angle, hydroxylation/hydration, may represent factors that influence the rate of osseointegration.

scholarly journals Torque Analysis of a Triple Acid-Etched Titanium Implant Surface

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ana Emília Farias Pontes ◽  
Cássio Torres de Toledo ◽  
Valdir Gouveia Garcia ◽  
Fernando Salimon Ribeiro ◽  
Celso Eduardo Sakakura
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Acid Etching ◽  
Subtraction Method ◽  
Implant Surface ◽  
Removal Torque ◽  
Torque Analysis ◽  
Preliminary Study ◽  
Torque Values ◽  
Titanium Implant Surface

The present study aimed to evaluate the removal torque of titanium implants treated with triple acid etching. Twenty-one rats were used in this study. For all animals, the tibia was prepared with a 2 mm drill, and a titanium implant (2 × 4 mm) was inserted after treatment using the subtraction method of triple acid etching. The flaps were sutured. Seven animals were killed 14, 28, and 63 days after implant installation, and the load necessary for removing the implant from the bone was evaluated by using a torque meter. The torque values were as follows: 3.3 ± 1.7 Ncm (14 days), 2.2 ± 1.3 Ncm (28 days), and 6.7 ± 1.4 Ncm (63 days). The torque value at the final healing period (63 days) was statistically significantly different from that at other time points tested (ANOVA,p=0.0002). This preliminary study revealed that treatment with triple acid etching can create a promising and efficient surface for the process of osseointegration.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

scholarly journals Erratum to: Biomechanical and histological evaluation of four different titanium implant surface modifications: an experimental study in the rabbit tibia

2015 ◽  
Vol 19 (7) ◽  
pp. 1699-1699 ◽  
Author(s):  
José Luis Calvo-Guirado ◽  
Marta Satorres ◽  
Bruno Negri ◽  
Piedad Ramirez-Fernandez ◽  
Jose Eduardo Maté-Sánchez de Val ◽  
...  
Keyword(s):  
Experimental Study ◽  
Titanium Implant ◽  
Surface Modifications ◽  
Histological Evaluation ◽  
Implant Surface ◽  
Rabbit Tibia ◽  
Titanium Implant Surface

State of Osseointegrated Titanium Implant Surfaces in Topographical Aspect

2018 ◽  
Vol 18 (12) ◽  
pp. 8016-8028 ◽  
Author(s):  
Xingying Qi† ◽  
Yuli Shang ◽  
Lei Sui
Keyword(s):  
Titanium Implant ◽  
World Market ◽  
Implant Surface ◽  
Preparation Methods ◽  
Clinical Investigations ◽  
Modify Surface ◽  
Metallic Biomaterial ◽  
Review State ◽  
Titanium Implant Surface ◽  
Selection Of

Titanium is a primary metallic biomaterial widely used in dental implants because of its favorable mechanical properties and osseointegration capability. Currently, increasing interests have been taken in the interaction between titanium implant surface and surrounding bone tissue, particularly in surface topographical aspect. There are currently several techniques developed to modify surface topographies in the world market of dental implant. In this review, state of titanium implant surfaces in topographical aspect is presented from relatively smooth surfaces to rougher ones with microtopographies and/or nanotopographies. Each surface is summarized with basic elaborations, preparation methods, mechanisms for cellular responses and current availabilities. It has been demonstrated that rough surfaces evolving from micro- to nano-scale, especially hierarchical micro-and nanotopographies, are favorable for faster and stronger osseointegration. Further experimental and clinical investigations will aid in the optimization of surface topography and clinical selection of suitable implants.

scholarly journals New titanium implant surface – An in vitro and in vivo evaluation

2019 ◽  
Vol 30 (S19) ◽  
pp. 213-213
Author(s):  
Sergio Gehrke ◽  
Leticia Pèrez‐DÌaz ◽  
Patricia Mazon ◽  
Piedad N. de Aza
Keyword(s):  
Titanium Implant ◽  
Implant Surface ◽  
In Vivo Evaluation ◽  
Titanium Implant Surface
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