FEATURES OF THE MORPHOLOGICAL LESIONS OF THE HUMAN BRAIN DURING TICK-BORNE ENCEPHALITIS CAUSED BY SIBERIAN SUBTYPE OF THE PATHOGEN

2016 ◽  
Vol 30 (2) ◽  
Author(s):  
V.Ya. Karmysheva ◽  
◽  
V.V. Pogodina ◽  
◽  
Keyword(s):  
Human Brain ◽  
Tick Borne Encephalitis ◽  
Siberian Subtype

scholarly journals Modern Problems of Tick-Borne Encephalitis Specific Prevention. Communication II: Peculiarity of Immunity in Area with Siberian Subtype Domination

2015 ◽  
Vol 14 (6) ◽  
pp. 65-73 ◽  
Author(s):  
V. V. Pogodina ◽  
M. S. Shcherbinina ◽  
L. S. Levina ◽  
S. G. Gerasimov ◽  
N. M. Kolyasnikova
Keyword(s):  
Far East ◽  
Inapparent Infection ◽  
The Far East ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Siberian Subtype

Siberian subtype of TBE virus dominates in the most part of Russia outside of the Far East. Peculiarity of immunity induced by Siberian subtype during disease or inapparent infection and change of immunity after vaccination are described in this article. Protective titre of antibodies and persistence of TBE virus (TBEV) in vaccinated organism are discussed.

Siberian subtype tick-borne encephalitis virus in Ixodes ricinus in a newly emerged focus, Finland

2016 ◽  
Vol 7 (1) ◽  
pp. 216-223 ◽  
Author(s):  
Anu Jääskeläinen ◽  
Elina Tonteri ◽  
Ilkka Pieninkeroinen ◽  
Tarja Sironen ◽  
Liina Voutilainen ◽  
...  
Keyword(s):  
Ixodes Ricinus ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

Genetic diversity and geographical distribution of the Siberian subtype of the tick-borne encephalitis virus

2020 ◽  
Vol 11 (2) ◽  
pp. 101327 ◽  
Author(s):  
S.E. Tkachev ◽  
I.V. Babkin ◽  
G.S. Chicherina ◽  
I.V. Kozlova ◽  
M.M. Verkhozina ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Geographical Distribution ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

scholarly journals Origin and distribution of tick-borne encephalitis virus strains of the Siberian subtype in the Middle Urals, the north-west of Russia and the Baltic countries

2009 ◽  
Vol 90 (12) ◽  
pp. 2884-2892 ◽  
Author(s):  
S. Yu. Kovalev ◽  
D. N. Chernykh ◽  
V. S. Kokorev ◽  
T. E. Snitkovskaya ◽  
V. V. Romanenko
Keyword(s):  
European Part ◽  
Middle Urals ◽  
Glycoprotein E ◽  
The Middle Urals ◽  
Baltic Countries ◽  
Tick Borne Encephalitis ◽  
European Part Of Russia ◽  
Tick Borne Encephalitis Virus ◽  
The Baltic ◽  
Siberian Subtype

Tick-borne encephalitis virus (TBEV) plays an important role in infectious human morbidity, particularly in Russia and the Middle Urals. The Siberian subtype of TBEV (S-TBEV) is dominant in the Middle Urals. Determining the origin of S-TBEV strains in this territory and also in the European part of Russia and the Baltic countries is very important for understanding the cause of its distribution. The surface glycoprotein E gene was partially sequenced in 165 S-TBEV isolates collected in the Middle Urals between 1966 and 2008. Nucleotide and amino acid sequence identity of the studied isolates is 94 and 97.4 %, respectively. Eighty per cent of them are represented by six clusters with identical amino acid sequences in the glycoprotein E fragment analysed. We have determined four types of isolate distribution in the explored territory: local, split, corridor and diffuse. The average rate of nucleotide substitutions per site year−1 is estimated to be 1.56×10−4. The age of the S-TBEV population was evaluated to be slightly less than 400 years. Phylogenetic analysis of the data and comparison with historical events indicate that the distribution of S-TBEV strains in the Middle Urals and the European part of Russia originated twice from different foci in western Siberia. This is related to the first land road into Siberia and the Trans-Siberian Way, which functioned at different times. The main reason for such rapid distribution of S-TBEV strains is the anthropogenic factor, i.e. human economic activity during the colonization of new territories in Siberia in the recent past.

Adaptation of tick-borne encephalitis virus from human brain to different cell cultures induces multiple genomic substitutions

2017 ◽  
Vol 162 (10) ◽  
pp. 3151-3156 ◽  
Author(s):  
Eugenia P. Ponomareva ◽  
Vladimir A. Ternovoi ◽  
Tamara P. Mikryukova ◽  
Elena V. Protopopova ◽  
Anastasia V. Gladysheva ◽  
...  
Keyword(s):  
Human Brain ◽  
Cell Cultures ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

New genetic lineage within the Siberian subtype of tick-borne encephalitis virus found in Western Siberia, Russia

2017 ◽  
Vol 56 ◽  
pp. 36-43 ◽  
Author(s):  
Sergey E. Tkachev ◽  
Galina S. Chicherina ◽  
Irina Golovljova ◽  
Polina S. Belokopytova ◽  
Artem Yu. Tikunov ◽  
...  
Keyword(s):  
Western Siberia ◽  
Encephalitis Virus ◽  
Genetic Lineage ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

Tick-borne encephalitis and its global importance

2018 ◽  
Vol 39 (4) ◽  
pp. 191 ◽  
Author(s):  
Gerhard Dobler
Keyword(s):  
Viral Disease ◽  
Oral Route ◽  
Ixodes Persulcatus ◽  
Tick Borne Encephalitis ◽  
Etiologic Agents ◽  
The Family ◽  
Viremic Phase ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Siberian Subtype

Tick-borne encephalitis (TBE) is the most important tick-transmitted human viral disease in Europe and Asia with up to 10000 human cases annually. The etiologic agents of TBE are the three subtypes of tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus in the family Flaviviridae. The Far-Eastern subtype and the Siberian subtype are both mainly transmitted by Ixodes persulcatus; the European subtype is mainly transmitted by Ixodes ricinus. Besides tick bite, TBEV can be transmitted by unpasteurised milk from goat, sheep and cattle during the viremic phase of infection by the oral route of infection (alimentary form of TBE). There is no treatment for TBE available, but there are effective and well tolerated vaccines against TBE, which are recommended for people living or travelling to endemic countries with a risk of infection.

scholarly journals The features of tick-borne encephalitis in the Yaroslavl region at the present stage. The problem of evolution of the infection

2014 ◽  
Vol 19 (4) ◽  
pp. 37-44
Author(s):  
S. G Gerasimov ◽  
T. A Druzhinina ◽  
L. S Karan ◽  
N. M Kolyasnikova ◽  
N. S Baranova ◽  
...  
Keyword(s):  
High Frequency ◽  
Federal District ◽  
Total Percentage ◽  
Cyclical Fluctuations ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Average Annual Incidence ◽  
Natural Foci ◽  
Siberian Subtype ◽  
Epidemiological Significance

In the Yaroslavl region (Central Federal District of Russia), endemic of tick-borne encephalitis (TBE), the features of epidemiology of this infection were studied during 1992-2012. Cyclical fluctuations in the incidence of TBE, the lack of the trend to decrease of the incidence were observed, the average annual incidence was 1,6 ± 0,32 per 100 thousand ofpopulation. The prevalence offebrile forms of disease was 62,2%, meningeal forms - 16,3%, the total percentage offocal forms was 13,9%. Manifestations of evolution of TBE were: the increase of the epidemiological significance of anthropogenically transformed natural foci, anthropurgical foci of TBE, until 81% of TBE cases were unvaccinated citizens, the high lethality of 4% and the high frequency of cases of alimentary infection of TBE of 7,8% with lethality of 10,8%. The aethiological agent of 10 lethal cases was Siberian subtype of TBE virus.

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