scholarly journals Eosinophilic granulomatosis with polyangiitis: modern view on pathogenesis and treatment (literature review)

2020 ◽  
pp. 49-62
Author(s):  
О.M. Okhotnikova ◽  
◽  
О.H. Kvacheniuk ◽  
K.V. Mellina ◽  
О.V. Ponochevna ◽  
...  
Keyword(s):  
Literature Review ◽  
Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Modern View ◽  
Eosinophilic Granulomatosis

scholarly journals Burden of illness associated with eosinophilic granulomatosis with polyangiitis: a systematic literature review and meta-analysis

2021 ◽  
Author(s):  
Rupert W. Jakes ◽  
Namhee Kwon ◽  
Beth Nordstrom ◽  
Rebecca Goulding ◽  
Kyle Fahrbach ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Disease Burden ◽  
Granulomatosis With Polyangiitis ◽  
Healthcare Resource ◽  
Meta Analysis ◽  
Emergency Department Visits ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis ◽  
Incidence Prevalence

Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease associated with vascular inflammation and multisystem organ damage. The literature reporting EGPA incidence or prevalence is limited. We performed a systematic literature review and meta-analysis to describe the incidence, prevalence, and disease burden associated with EGPA. Real-world, observational, English-language studies in MEDLINE, MEDLINE In-Process, and Embase up to 6 June, 2019, were included. A single investigator screened all identified titles/abstracts and extracted data; an additional, independent investigator repeated the screening and validated the extracted data. A random-effects meta-analysis was conducted to generate pooled estimates for EGPA incidence and prevalence. Data from 100 eligible publications were extracted (32 with incidence/prevalence data, 65 with morbidity/healthcare resource data; 3 with both types of data). Significant evidence of between-study heterogeneity for reported incidence (p = 0.0013–0.0016) and prevalence (p = 0.0001–0.0006) estimates was observed. Global and European pooled estimates (95% confidence interval) of EGPA incidence were 1.22 (0.93, 1.60) and 1.07 (0.94, 1.35) cases per million person-years, respectively; global and European pooled estimates (95% confidence interval) for EGPA prevalence were 15.27 (11.89, 19.61) and 12.13 (6.98, 21.06) cases per million individuals, respectively. The proportions of patients experiencing relapses, or who had nasal polyps or severe asthma, varied considerably across studies. EGPA healthcare resource use was high, with inpatient admissions and emergency department visits reported for 17–42% and 25–42% of patients, respectively. Our results indicate that although global and European EGPA incidence and prevalence is low, the associated disease burden is substantial. Key points• We performed a systematic literature review and meta-analysis of real-world, observational studies describing the incidence, prevalence, and disease burden associated with eosinophilic granulomatosis with polyangiitis (EGPA).• Based on meta-analysis data from 35 eligible studies reporting incidence and prevalence, the incidence and prevalence of EGPA were low (globally 1.22 cases per million person-years and 15.27 cases per million individuals, respectively).• Among the 49 studies with morbidity and/or healthcare resource data, most reported a large proportion of patients with EGPA relapses and comorbidities of nasal polyps and severe asthma.• Healthcare resource use was also high among patients with EGPA in these studies, with inpatient admissions and emergency department visits reported for 17–42% and 25–42% of patients, respectively. Taken together, these data indicate the substantial disease burden associated with EGPA.

Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report

2018 ◽  
Vol 37 (6) ◽  
pp. 1729-1735 ◽  
Author(s):  
Tatiana V. Beketova ◽  
Mikhail Y. Volkov ◽  
Evgeniy A. Naryshkin ◽  
Tatiana M. Novoselova ◽  
Evgeniy L. Nasonov
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Imatinib Mesylate ◽  
Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis

scholarly journals EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) WITH LUNG-KIDNEY SYNDROME: CASE REPORT WITH GOOD RESPONSE TO TREATMENT AND LITERATURE REVIEW

2021 ◽  
Author(s):  
Maikon Augusto Vogado Aranda Florenciano ◽  
Carolina Yume Arazawa ◽  
Marcos Antônio Marques ◽  
Taís Lie Tokikawa ◽  
Diogo Stradioto ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Granulomatosis With Polyangiitis ◽  
Response To Treatment ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Eosinophilic Granulomatosis

Eosinophilic granulomatosis with polyangiitis and laryngeal involvement: review of the literature and a cross-sectional prospective experience

2018 ◽  
Vol 132 (7) ◽  
pp. 619-623 ◽  
Author(s):  
V Seccia ◽  
L Cristofani-Mencacci ◽  
I Dallan ◽  
S Fortunato ◽  
M L Bartoli ◽  
...  
Keyword(s):  
Literature Review ◽  
Granulomatosis With Polyangiitis ◽  
Narrow Band Imaging ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Cross Sectional ◽  
Type Method ◽  
Health Related ◽  
Sectional Analysis ◽  
Eosinophilic Granulomatosis ◽  
Laryngeal Involvement

AbstractBackgroundEosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis show variable otorhinolaryngological involvement. Up to 14 per cent of granulomatosis with polyangiitis patients have subglottis involvement; little is known about the laryngeal involvement in eosinophilic granulomatosis with polyangiitis.MethodA literature review was conducted, together with a prospective cross-sectional analysis of 43 eosinophilic granulomatosis with polyangiitis patients. All patients underwent fibre-optic laryngoscopy with narrow-band imaging, and completed health-related questionnaires.ResultsThe literature review showed only two cases of laryngeal involvement in eosinophilic granulomatosis with polyangiitis; in our cohort, no cases of subglottis stenosis were found, but local signs of laryngeal inflammation were present in 72 per cent of cases. Of the patients, 16.2 per cent had a pathological Reflux Finding Score (of 7 or higher).ConclusionLaryngeal inflammation in eosinophilic granulomatosis with polyangiitis is frequent. It is possibly due more to local factors than to eosinophilic granulomatosis with polyangiitis itself. However, ENT evaluation is needed to rule out possible subglottis inflammation. These findings are in line with current literature and worthy of confirmation in larger cohorts.

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