Pharmacological and non-pharmacological treatment effects of an explosion-comminuted injury spine with spinal cord injury and dysfunction of pelvic organs

2015 ◽  
pp. 40-42
Author(s):  
S.K. Yevtushenko ◽  
◽  
S.P. Dubinа ◽  
O.S. Yevtushenko ◽  
N.V. Yanovskaya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pharmacological Treatment ◽  
Treatment Effects ◽  
Pelvic Organs ◽  
Cord Injury

Aberrant reflexes and function of the pelvic organs following spinal cord injury in man

2006 ◽  
Vol 126-127 ◽  
pp. 355-370 ◽  
Author(s):  
Michael D. Craggs ◽  
Amirthe Vernie Balasubramaniam ◽  
Eric A.L. Chung ◽  
Anton V. Emmanuel
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pelvic Organs ◽  
Cord Injury ◽  
And Function

The Effectiveness of Surgery on the Treatment of Acute Spinal Cord Injury and Its Relation to Pharmacological Treatment

Neurosurgery ◽  
1994 ◽  
Vol 35 (2) ◽  
pp. 240???249 ◽  
Author(s):  
Mei-Sheng Duh ◽  
Mary Jo Shepard ◽  
Jack E. Wilberger ◽  
Michael B. Bracken
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pharmacological Treatment ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

Decision tree analysis to better control treatment effects in spinal cord injury clinical research

2019 ◽  
Vol 31 (4) ◽  
pp. 464-472 ◽  
Author(s):  
Jin W. Tee ◽  
Carly S. Rivers ◽  
Nader Fallah ◽  
Vanessa K. Noonan ◽  
Brian K. Kwon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Decision Tree ◽  
Treatment Effects ◽  
Type A ◽  
Neurological Injury ◽  
Thoracic Injury ◽  
Cervical Injury ◽  
Cord Injury ◽  
Type C

OBJECTIVEThe aim of this study was to use decision tree modeling to identify optimal stratification groups considering both the neurological impairment and spinal column injury and to investigate the change in motor score as an example of a practical application. Inherent heterogeneity in spinal cord injury (SCI) introduces variation in natural recovery, compromising the ability to identify true treatment effects in clinical research. Optimized stratification factors to create homogeneous groups of participants would improve accurate identification of true treatment effects.METHODSThe analysis cohort consisted of patients with acute traumatic SCI registered in the Vancouver Rick Hansen Spinal Cord Injury Registry (RHSCIR) between 2004 and 2014. Severity of neurological injury (American Spinal Injury Association Impairment Scale [AIS grades A–D]), level of injury (cervical, thoracic), and total motor score (TMS) were assessed using the International Standards for Neurological Classification of Spinal Cord Injury examination; morphological injury to the spinal column assessed using the AOSpine classification (AOSC types A–C, C most severe) and age were also included. Decision trees were used to determine the most homogeneous groupings of participants based on TMS at admission and discharge from in-hospital care.RESULTSThe analysis cohort included 806 participants; 79.3% were male, and the mean age was 46.7 ± 19.9 years. Distribution of severity of neurological injury at admission was AIS grade A in 40.0% of patients, grade B in 11.3%, grade C in 18.9%, and grade D in 29.9%. The level of injury was cervical in 68.7% of patients and thoracolumbar in 31.3%. An AOSC type A injury was found in 33.1% of patients, type B in 25.6%, and type C in 37.8%. Decision tree analysis identified 6 optimal stratification groups for assessing TMS: 1) AOSC type A or B, cervical injury, and age ≤ 32 years; 2) AOSC type A or B, cervical injury, and age > 32–53 years; 3) AOSC type A or B, cervical injury, and age > 53 years; 4) AOSC type A or B and thoracic injury; 5) AOSC type C and cervical injury; and 6) AOSC type C and thoracic injury.CONCLUSIONSAppropriate stratification factors are fundamental to accurately identify treatment effects. Inclusion of AOSC type improves stratification, and use of the 6 stratification groups could minimize confounding effects of variable neurological recovery so that effective treatments can be identified.

The Effectiveness of Surgery on the Treatment of Acute Spinal Cord Injury and Its Relation to Pharmacological Treatment

Neurosurgery ◽  
1994 ◽  
Vol 35 (2) ◽  
pp. 240-249 ◽  
Author(s):  
Mei-Sheng Duh ◽  
Mary Jo Shepard ◽  
Jack E. Wilberger ◽  
Michael B. Bracken
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pharmacological Treatment ◽  
Acute Spinal Cord Injury ◽  
Cord Injury
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