MicroRNA as diagnostic biomarkers of liver damage at Epstein-Barr viral hepatitis in children

2015 ◽  
pp. 115-119
Author(s):  
V.O. Shadrin ◽  
◽  
V.E. Dosenko ◽  
Keyword(s):  
Viral Hepatitis ◽  
Liver Damage ◽  
Diagnostic Biomarkers ◽  
Epstein Barr

scholarly journals Analysis of common causes of liver damage among children 12 years and younger in Weifang

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110066
Author(s):  
Qinghong Meng ◽  
Na Li ◽  
Lianmei Yuan ◽  
Xiaona Gao
Keyword(s):  
Liver Damage ◽  
Epstein Barr Virus ◽  
Metabolic Diseases ◽  
Unknown Etiology ◽  
Severe Liver ◽  
Drug Induced ◽  
Barr Virus ◽  
Common Causes ◽  
Severe Liver Damage ◽  
Epstein Barr

Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most common causes of infectious liver damage were viral infection (1515 cases), Mycoplasma pneumoniae infection (343 cases), and bacterial infection (197 cases). The most common causes of viral liver damage were Epstein–Barr virus, cytomegalovirus, and enterovirus. The most common causes of non-infectious liver damage were drug-induced liver damage, Kawasaki disease, and genetic metabolic diseases. There were 31 cases of severe liver damage. Conclusion There were many causes of liver damage among children in Weifang. Infections, and especially viral infections such as Epstein–Barr virus, were the most common causes of liver damage. Severe liver damage was primarily caused by drugs or poisons.

scholarly journals Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Paulina Cybulska ◽  
Andy Ni ◽  
Carolina Jimenez-Rivera
Keyword(s):  
Viral Hepatitis ◽  
Epstein Barr Virus ◽  
Hepatitis A ◽  
Chart Review ◽  
Clinical Presentation ◽  
Retrospective Chart Review ◽  
Barr Virus ◽  
Mild Abdominal Pain ◽  
Epstein Barr ◽  
Acute And Chronic Hepatitis

Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4±4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.

scholarly journals About antiviral effects of vitamin D

2020 ◽  
pp. 152-158
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
D. E. Frolova ◽  
N. P. Lapochkina ◽  
O. A. Limanova
Keyword(s):  
Vitamin D ◽  
Human Papillomavirus ◽  
Viral Hepatitis ◽  
Vitamin D Deficiency ◽  
Clinical Studies ◽  
Respiratory Infections ◽  
Antiviral Immunity ◽  
Antiviral Action ◽  
Epstein Barr ◽  
Based Medicine

Preventing infectious diseases is very important in obstetric and gynaecological practice. Vitamin D is a complex regulator of innate and adaptive immunity. It is known that lack of vitamin D reduces antibacterial and antiviral immunity, stimulates the development of pathologies associated with chronic systemic inflammation. Evidence from evidence-based medicine indicates the importance of using vitamin D preparations to support immunity. The results of fundamental and clinical studies have shown that chronic inflammation and congenital immunity disorders resulting from vitamin D deficiency significantly reduce the body’s resistance not only to tuberculosis, but also to viral hepatitis, acute respiratory infections, papillomavirus and herpesvirus. In addition to a pronounced antibacterial effect, vitamin D is also characterized by its antiviral action. By increasing the expression of interferon-alpha, cathecidine, defensin and antiviral microRNA, vitamin D activates various mechanisms of congenital antiviral immunity. Studies show the need to compensate for vitamin D deficiency for successful therapy of viral hepatitis, respiratory infections, human papillomavirus (HPV) and herpesvirus. In the present article the molecular fundamentals of antiviral action of vitamin D are sequentially considered, as well as the results of fundamental and clinical studies indicating the action of vitamin D against the viruses of hepatitis, herpes, RSV, Epstein-Barr, human papillomavirus, the possibility of using vitamin D in the treatment of these and other viral pathologies is considered. The authors analyzed data on the effect of vitamin D on immunity functions and antiviral protection of the human body.

scholarly journals Viral hepatitis B, C and infectious mononucleosis: epidemiological similarities and differences

2020 ◽  
Vol 65 (1) ◽  
pp. 27-34
Author(s):  
T. V. Solomay ◽  
T. A. Semenenko
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Infectious Mononucleosis ◽  
Age Groups ◽  
Official Statistics ◽  
Epidemic Process ◽  
Barr Virus ◽  
Transmission Mechanisms ◽  
Viral Hepatitis B ◽  
Epstein Barr

Introduction. The presence of etiologically unencrypted diagnoses in the structure of viral hepatitis determines the relevance of searching for other pathogens involved in liver pathology formation. The role of Epstein-Barr virus in the development of hepatitis was described in the scientific literature, but official statistics do not allow to assess its contribution to liver damage along with hepatitis B and C viruses.The purpose – to identify common and distinctive epidemiological features of viral hepatitis B (HB), C (HC) and infectious mononucleosis (IM).Material and methods. A retrospective epidemiological analysis of these nosologies incidence was carried out according to official statistics in 2009-2018 in the Russian Federation.Results and discussion. The multidirectional trends in the long-term dynamics of the incidence of IM, acute and chronic HB and HC and the presence of strong direct correlation between the acute and chronic HB and HC incidence were established. Distinctive features include disparity in epidemic process intensity in different age groups (prevalence of morbidity in children aged 1–2 and 3–6 years with IM and persons older than 18 years – with viral hepatitis). It is common for IM and HB and HC to involve the majority of urban population in the epidemic process, as well as children under the age of 1 year. The described differences are due to the action of transmission mechanisms specific to each infection.Conclusion. The results obtained in this study may serve as a basis for further study of the interaction of EpsteinBarr virus with hepatitis B and C viruses.

Liver Assessment in Women Receiving Adjuvant CMF Chemotherapy

1981 ◽  
Vol 67 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Emilio Bajetta ◽  
Roberto Buzzoni ◽  
Roberto Giardini ◽  
Gianni Bonadonna
Keyword(s):  
Liver Function ◽  
Viral Hepatitis ◽  
Liver Damage ◽  
Medical Records ◽  
Chronic Liver ◽  
Osseous Metastases ◽  
Fatty Metamorphosis ◽  
Liver Biopsies ◽  
Liver Changes ◽  
Histologic Changes

The medical records of women taking part in the first 2 prospective adjuvant CMF (cyclophosphamide, methotrexate, fluorouracil) programs were reviewed to evaluate the incidence of liver damage which could be attributable to prolonged methotrexate administration. In 802 evaluable patients abnormal liver studies occurred in 7 of 170 controls (4.1 %) and 20 of 632 CMF-treated patients (3.2 %). In 22 of 27 patients they were reversible, while the persistence of enzyme abnormalities in 2 patients treated with 12 CMF cycles was followed by the occurrence of viral hepatitis and osseous metastases, respectively. Adjuvant CMF was never discontinued in the presence of liver function abnormalities. In 22 women liver biopsies through laparoscopy were performed for various diagnostic purposes. They yielded an incidence of aspecific histologic changes (fatty metamorphosis, subcapsular fibrosis) which was similar between controls and CMF-treated patients. Present analysis failed to demonstrate a higher incidence of acute and/or chronic liver changes in patients treated with cyclical CMF compared to controls treated with surgery alone.

scholarly journals Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Muhammad Farooq ◽  
Aveline Filliol ◽  
Mélanie Simoes Eugénio ◽  
Claire Piquet-Pellorce ◽  
Sarah Dion ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Liver Damage ◽  
Fulminant Viral Hepatitis

scholarly journals Nanomembrane-based Apheresis as Safe and Effective Therapy for Cytomegalovirus and Epstein-Barr Virus Reactivation

2021 ◽  
Vol 9 (C) ◽  
pp. 258-262
Author(s):  
Vjeroslava Slavic ◽  
Beti Djurdjic ◽  
Danijela Randjelovic ◽  
Gordana Rajovic ◽  
Marina Delic
Keyword(s):  
Case Report ◽  
Liver Damage ◽  
Epstein Barr Virus ◽  
Abdominal Ultrasound ◽  
Viral Reactivation ◽  
Marathon Running ◽  
Virus Reactivation ◽  
Barr Virus ◽  
Epstein Barr ◽  
Transient Elevation

BACKGROUND: Heavy training schedules or endurance competitions in marathon are forms of extreme physical stress and lead to immunodepression in runners which could be associated with increased susceptibility to viral reactivation by ubiquitous viral infection such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Lately, it was confirmed presence of elevated CMV and EBV loads and the lower antibody titers in competitive athletes. The most common clinical features are fatigue and adynamia accompanied with liver damage, varying from mild and transient elevation of aminotransferases to serious acute hepatitis and liver failure. CASE REPORT: Bearing in mind that a professional practice of marathon running is hazardous for the liver, therapeutic action is necessary as soon as possible to avoid serious complications and even cessation of professional competition. In our case report of professional female marathon runner, we need to treat CMV and EBV reactivation which caused liver damage, prevented regular trainings, and upcoming competitions. We opted for four sessions of nanomembrane based apheresis performed every other day for removal pathological products resulting from virus reactivation to break through the course of the disease and to prevent complications. After completing the whole procedure control laboratory tests and abdominal ultrasound were in physiological ranges. CONCLUSION: Hence, nanomembrane based apheresis can be effective and safe treatment of liver damages for elite marathon runners as well as for athletes.

scholarly journals Differential diagnosis of viral hepatitis (TT, Epstein-Barr) and systemic lupus erythematosus

2007 ◽  
Vol 0 (5) ◽  
pp. 88
Author(s):  
O N Egorova ◽  
R M Balabanova ◽  
O A Antelava ◽  
S K Solovjov ◽  
E L Nasonov ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Viral Hepatitis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Epstein Barr

scholarly journals Comparison of clinical and laboratory characteristics of viral hepatitis A and E in Montenegro

2010 ◽  
Vol 63 (3-4) ◽  
pp. 175-178
Author(s):  
Dragica Terzic ◽  
Gordana Mijovic ◽  
Brankica Dupanovic ◽  
Nenad Draskovic ◽  
Neda Svirtlih
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Liver Function Tests ◽  
Hepatitis E ◽  
Mean Value ◽  
Laboratory Parameters ◽  
Barr Virus ◽  
Route Of Transmission ◽  
Epstein Barr ◽  
Commercial Kits

Introduction Hepatitis E has many similarities in with hepatitis A concerning clinical picture, route of transmission and nonexistence of chronicity. Comparison of clinical and laboratory parameters of patients with hepatitis A and E to estimate characteristics of these diseases. Material and methods Total of 54 patients divided into two groups was investigated: 27 had hepatitis A, others had hepatitis E. Detailed history past, clinical examination, liver function tests and ultrasonography of the upper abdomen, were done in all patients. Etiology of viral hepatitis was investigated serologically by enzyme immunoassay (ELISA) using commercial kits for following viruses: Hepatitis A-E viruses, cytomegalovirus, and Epstein-Barr virus. Results Asymptomatic infections (29.6%) and clinical forms without jaundice (59.3%) were more frequent in patients with hepatitis E. Splenomegaly was found more frequent in patients with hepatitis A than in hepatitis E (66.7% vs. 33.3%). Patients with hepatitis E had significantly lower activity of aminotransferases than patients with hepatitis A. A significant increase of gamma-glutamyltranspeptidase was found in patients with hepatitis E (mean value: 120 IU/L). Discussion Our results are in concordance with other reports that hepatitis E virus infection is more common asymptomatic disease than hepatitis A. In addition, hepatocyte necrosis in hepatitis E is less extensive than in hepatitis A measured by the activity of aminotransferases. Contrary to that the value of gamma-glutamyltranspeptidase is more increased in hepatitis E than in hepatitis A without exact explanation uso far. Conclusion Viral hepatitis E and A have differences in some clinical features and laboratory parameters although both diseases principally have resolved without consequences after 6-8 weeks.

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