scholarly journals A modern view of medical accompaniment of the colic in neonate (literature review)

2020 ◽  
pp. 76-80
Author(s):  
M.M. Kiselova ◽  
◽  
O.S. Moshtuk ◽  
Keyword(s):  
High Frequency ◽  
The Body ◽  
Urgent Problem ◽  
Functional Disorders ◽  
Medical Support ◽  
Functional Bowel Disorder ◽  
Family Doctors ◽  
Bowel Diseases ◽  
Digestive Disorders ◽  
Functional Digestive Disorders

Many infants who represent one of the nosological units that refined functional digestive disorders remain an urgent problem of high frequency of parents' referrals to neonatologists, pediatricians, and general practice — family doctors. Existing studies of a number of hypotheses regarding the etiology, mechanisms of origin, and different approaches to the treatment of colic in infants indicate the relevance of this problem. The article presents current literature data, highlighting the main complaints of parents with suspected colic in a child, presents an analysis of the main causes of this functional bowel disorder, some knowledge about the etiopathogenetic mechanisms of colic, modern components of medical care in infants. Emphasis is placed on the existing ambiguous hypotheses that explain the pathogenetic processes in the body of infants with colic. The focus is on the fact that colic remains a diagnosis of exclusion from other functional bowel diseases. It is noted that the basis of medical support of colic are personalized measures aimed at reducing the severity of pain and choosing the optimal tactics for managing the baby in the period between attacks (background correction), taking into account the existing causes and mechanisms of colic. No conflict of interest was declared by the authors. Key words: functional disorders of digestion refinement, infants, colic in neonate, diagnosis, management.

scholarly journals Anti-PD-1-Induced Hidradenitis Suppurativa

2021 ◽  
Vol 8 (1) ◽  
pp. 37-39
Author(s):  
Alexia Maillard ◽  
Damien Pastor ◽  
Rastine Merat
Keyword(s):  
Adverse Events ◽  
Hidradenitis Suppurativa ◽  
Checkpoint Inhibitors ◽  
Latency Period ◽  
The Body ◽  
Skin Reactions ◽  
Zinc Gluconate ◽  
Severe Acne ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Mucocutaneous adverse events are commonly observed under immune checkpoint inhibitors (ICIs) therapy. Here, we report the case of a 43-year-old male patient with a stage IIIC melanoma disease who developed hidradenitis suppurativa (HS) three months after the beginning of an anti-PD-1 (nivolumab) adjuvant therapy. The patient had no comorbidities other than obesity and severe acne during adolescence. After an unsuccessful course of lymecycline while he was still treated with nivolumab, he gradually improved under zinc gluconate therapy and, more importantly, after nivolumab cessation. HS is a recurrent follicular inflammatory disease in the apocrine gland-bearing areas of the body often associated with obesity, metabolic syndrome, tobacco smoking, inflammatory bowel diseases, psoriasis, and arthritis. In our patient, the latency period between drug initiation and onset of HS symptoms and the improvement after immunotherapy discontinuation, argued strongly in favor of an anti-PD-1-induced HS. Anti-PD-1 therapies often trigger T cells-mediated adverse events that mimic Th17-mediated inflammatory and neutrophilic diseases. We suggest that HS, as other pustular skin reactions and ICIs-induced neutrophilic colitis, can be part of the anti-PD-1 mucocutaneous adverse event spectrum.

High Frequency Vibration Analysis of Automotive Body Panels with Damping Materials

2010 ◽  
Vol 36 ◽  
pp. 293-296
Author(s):  
Yoshio Kurosawa ◽  
Takao Yamaguchi
Keyword(s):  
High Frequency ◽  
Large Scale ◽  
The Body ◽  
Viscoelastic Damping ◽  
Fe Model ◽  
Test Results ◽  
Automotive Body ◽  
Modal Damping ◽  
Practical Tool ◽  
Damping Materials

We have developed a technique for estimating vibrations of an automotive body structures with viscoelastic damping materials using large-scale finite element (FE) model, which will enable us to grasp and to reduce high-frequency road noise（200～500Hz）. In the new technique, first order solutions for modal loss factors are derived applying asymptotic method. This method saves calculation time to estimate modal damping as a practical tool in the design stages of the body structures. Frequency responses were calculated using this technique and the results almost agreed with the test results. This technique can show the effect of the viscoelastic damping materials on the automotive body panels, and it enables the more efficient layout of the viscoelastic damping materials. Further, we clarified damping properties of the automotive body structures under coupled vibration between frames and panels with the viscoelastic damping materials.

scholarly journals Innate Immunity Modulation by the IL-33/ST2 System in Intestinal Mucosa

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Marina García-Miguel ◽  
M. Julieta González ◽  
Rodrigo Quera ◽  
Marcela A. Hermoso
Keyword(s):  
Ulcerative Colitis ◽  
Innate Immunity ◽  
Intestinal Mucosa ◽  
Inflammatory Bowel Diseases ◽  
The Body ◽  
Unknown Etiology ◽  
Adequate Food ◽  
Bowel Diseases ◽  
Surface Contact Area ◽  
Inflammatory Bowel

Innate immunity prevents pathogens from entering and spreading within the body. This function is especially important in the gastrointestinal tract and skin, as these organs have a large surface contact area with the outside environment. In the intestine, luminal commensal bacteria are necessary for adequate food digestion and play a crucial role in tolerance to benign antigens. Immune system damage can create an intestinal inflammatory response, leading to chronic disease including inflammatory bowel diseases (IBD). Ulcerative colitis (UC) is an IBD of unknown etiology with increasing worldwide prevalence. In the intestinal mucosa of UC patients, there is an imbalance in the IL-33/ST2 axis, an important modulator of the innate immune response. This paper reviews the role of the IL-33/ST2 system in innate immunity of the intestinal mucosa and its importance in inflammatory bowel diseases, especially ulcerative colitis.

A dynamic model for far-field acceleration

1982 ◽  
Vol 72 (4) ◽  
pp. 1049-1068
Author(s):  
John Boatwright
Keyword(s):  
Stress Drop ◽  
High Frequency ◽  
Dynamic Stress ◽  
The Body ◽  
Body Waves ◽  
Far Field ◽  
Rupture Velocity ◽  
Frequency Level ◽  
Average Change ◽  
Dynamic Stress Drop

abstract A model for the far-field acceleration radiated by an incoherent rupture is constructed by combining Madariaga's (1977) theory for the high-frequency radiation from crack models of faulting with a simple statistical source model. By extending Madariaga's results to acceleration pulses with finite durations, the peak acceleration of a pulse radiated by a single stop or start of a crack tip is shown to depend on the dynamic stress drop of the subevent, the total change in rupture velocity, and the ratio of the subevent radius to the acceleration pulse width. An incoherent rupture is approximated by a sample from a self-similar distribution of coherent subevents. Assuming the subevents fit together without overlapping, the high-frequency level of the acceleration spectra depends linearly on the rms dynamic stress drop, the average change in rupture velocity, and the square root of the overall rupture area. The high-frequency level is independent, to first order, of the rupture complexity. Following Hanks (1979), simple approximations are derived for the relation between the rms dynamic stress drop and the rms acceleration, averaged over the pulse duration. This relation necessarily depends on the shape of the body-wave spectra. The body waves radiated by 10 small earthquakes near Monticello Dam, South Carolina, are analyzed to test these results. The average change of rupture velocity of Δv = 0.8β associated with the radiation of the acceleration pulses is estimated by comparing the rms acceleration contained in the P waves to that in the S waves. The rms dynamic stress drops of the 10 events, estimated from the rms accelerations, range from 0.4 to 1.9 bars and are strongly correlated with estimates of the apparent stress.

The locust jump. I. The motor programme

1977 ◽  
Vol 66 (1) ◽  
pp. 203-219
Author(s):  
W. J. Heitler ◽  
M. Burrows
Keyword(s):  
High Frequency ◽  
Tactile Stimulation ◽  
The Body ◽  
Flexor Muscle ◽  
Tactile Stimuli ◽  
Extensor Muscles ◽  
Trigger Activity ◽  
Three Stages ◽  
Motor Programme ◽  
Made In

A motor programme is described for defensive kicking in the locust which is also probably the programme for jumping. The method of analysis has been to make intracellular recordings from the somata of identified motornuerones which control the metathoracic tibiae while defensive kicks are made in response to tactile stimuli. Three stages are recognized in the programme. (1) Initial flexion of the tibiae results from the low spike threshold of tibial flexor motorneurones to tactile stimulation of the body. (2) Co-contraction of flexor and extensor muscles followa in which flexor and extensor excitor motoneurones spike at high frequency for 300-600 ms. the tibia flexed while the extensor muscle develops tension isometrically to the level required for a kick or jump. (3) Trigger activity terminates the co-contraction by inhibiting the flexor excitor motorneurones and simultaneously exciting the flexor inhibitors. This causes relaxation of the flexor muscle and allows the tibiae to extend. If the trigger activity does not occur, the jump or kick is aborted, and the tibiae remain flexed.

High Frequency Vibration Analysis of Automotive Bodies With Panels That Have Attached Viscoelastic Layers

2003 ◽  
Author(s):  
Yoshio Kurosawa ◽  
Hideki Enomoto ◽  
Shuji Matsumura ◽  
Takao Yamaguchi
Keyword(s):  
High Frequency ◽  
Large Scale ◽  
The Body ◽  
Viscoelastic Damping ◽  
Fe Model ◽  
Automotive Body ◽  
Modal Damping ◽  
Practical Tool ◽  
Damping Materials ◽  
Viscoelastic Layers

A technique has been developed for estimating vibrations of an automotive body structures with viscoelastic damping materials using large-scale finite element (FE) model, which will enable us to grasp and to reduce high-frequency road noise (200∼500Hz). In the new technique, first order solutions for modal loss factors are derived applying asymptotic method. This method saves calculation time to estimate modal damping as a practical tool in the design stages of the body structures. Frequency responses were calculated using this technique and the results almost agreed with the test results. This technique can show the effect of the viscoelastic damping materials on the automotive body panels, and it enables the more efficient layout of the viscoelastic damping materials. Further, we clarified damping properties of the automotive body structures under coupled vibration between frames and panels with the viscoelastic damping materials.

scholarly journals Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage

2009 ◽  
Vol 3 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Yan-Ping Huang ◽  
Yong-Ping Zheng
Keyword(s):  
Articular Cartilage ◽  
Intravascular Ultrasound ◽  
High Frequency ◽  
Quantitative Assessment ◽  
The Body ◽  
High Frequency Ultrasound ◽  
Surface Reflection ◽  
Before And After ◽  
Highly Correlated

Conventional ultrasound examination of the articular cartilage performed externally on the body surface around the joint has limited accuracy due to the inadequacy in frequency used. In contrast to this, minimally invasive arthroscopy-based ultrasound with adequately high frequency may be a better alternative to assess the cartilage. Up to date, no special ultrasound transducer for imaging the cartilage in arthroscopic use has been designed. In this study, we introduced the intravascular ultrasound (IVUS) for this purpose. An IVUS system with a catheter-based probe (Ø ≈ 1mm) was used to measure the thickness and surface acoustical reflection of the bovine patellar articular cartilage in vitro before and after degeneration induced by enzyme treatments. Similar measurement was performed using another high frequency ultrasound system (Vevo) with a probe of much larger size and the results were compared between the two systems. The thickness measured using IVUS was highly correlated (r = 0.985, p < 0.001) with that obtained by Vevo. Thickness and surface reflection amplitude measured using IVUS on the enzymatically digested articular cartilage showed changes similar to those obtained by Vevo, which were expectedly consistent with previous investigations. IVUS can be potentially used for the quantitative assessment of articular cartilage, with its ready-to-use arthroscopic feature.

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