scholarly journals The concentration of pregnancy-associated plasma protein-a in the blood serum of tobacco smoking pregnant women in the first trimester of pregnancy

2017 ◽  
Vol 69 (1) ◽  
pp. 91-94
Author(s):  
M. Pasinska ◽  
◽  
A. Dabrowska ◽  
E. Lazarczyk ◽  
A. Repczynska ◽  
...  
Keyword(s):  
Blood Serum ◽  
Pregnant Women ◽  
Plasma Protein ◽  
Tobacco Smoking ◽  
Protein A ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Assessment of β-human-derived chorionic gonadotrophic hormone (βhCG) and pregnancy-associated plasma protein A (PAPP-A) levels as predictive factors of preeclampsia in the first trimester among Iranian women: a cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Honarjoo ◽  
Shahnaz Kohan ◽  
Elahe Zarean ◽  
Mohammad Javad Tarrahi
Keyword(s):  
Cohort Study ◽  
Plasma Protein ◽  
Predictive Factors ◽  
Protein A ◽  
First Trimester ◽  
Health Centers ◽  
Screening Tests ◽  
Iranian Women ◽  
First Trimester Of Pregnancy ◽  
Low Levels

Abstract Background Preeclampsia (PE) is a leading cause of maternal and perinatal mortality. There are controversial findings regarding the prediction of PE through the assessment of the Pregnancy-Associated Plasma Protein A (PAPP-A) and β-Human-Derived Chorionic Gonadotrophic hormone (βhCG) levels in the first trimester of pregnancy. Therefore, this cohort study was conducted to evaluate of PAPP-A and βhCG levels as predictive factors for PE development in the first trimester among Iranian women. Methods In this cohort study, a total of 4605 volunteer Primigravida and Multigravida women were selected by the census from 16 randomly selected Health Centers in Isfahan, Iran, from July 2016 to June 2018. Eligible pregnant women participated in the study had already undergone fetal anomalies screening tests between 11 + 0 and 13 + 6 weeks of pregnancy and their PAPP-A and βhCG biomarkers were adjusted to the Multiples of the Median (MOM). MOM PAPP-A <  0.4 and MOM βhCG > 3 were considered abnormal. The samples were followed up until delivery. The biomarkers’ levels were compared in the two groups of women with and without PE and Relative risk (RR) and odds ratio (OR) of PE calculated. Results In the PE group, the mean MOM PAPP-A was significantly lower (1 vs. 1.09 with P = 0.006) and MOM βhCG was significantly higher (1.51 vs. 1.14 with P = 0.001) than the group without PE. RR and OR for PE in subjects with MOM PAPP-A <  0.4 were reported as follows: RR = 2.49, (p = 0.001) and OR = 2.09, (p = 0.001). RR and OR for PE in subjects with MOM βhCG > 3 were also reported as follows: RR = 4.02, (p = 0.001) and OR = 5.65, (p = 0.001). Adjusted OR for MOM PAPP-A <  0.4 and MOM βhCG > 3 was obtained as follows: OR = 2.09 (P = 0.001) and OR = 5.65 (P = 0.001), respectively. Conclusion The results of the study showed that the high levels of βhCG would cause 5.65 times increase and the low levels of PAPP-A would cause 2.09 times increase in the chance of developing PE.

scholarly journals Does first‐trimester serum pregnancy‐associated plasma protein A differ in pregnant women with sickle cell disease?

2019 ◽  
Vol 39 (10) ◽  
pp. 921-924
Author(s):  
Gergana Peeva ◽  
Laura Oakley ◽  
Inez Rège ◽  
Kypros Nicolaides ◽  
Eugene Oteng‐Ntim
Keyword(s):  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Cell Disease

Can first trimester pregnancy-associated plasma protein-A predict the surfactant needs of preterm neonates?

2021 ◽  
pp. 1-6
Author(s):  
B. Yakiştiran ◽  
M.F. Karsli ◽  
F.E. Canpolat
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Preterm Neonates ◽  
Delivery Methods ◽  
Aneuploidy Screening ◽  
Birth Characteristics ◽  
Significant Independent Variable

BACKGROUND: Low values of pregnancy associated plasma protein A (PAPP-A), have been shown to be associated with some poor gestational outcomes, especially those related to placental deficiency such as pre-eclampsia and fetal growth restriction as well as preterm labor. The aim of this study was to compare first trimester PAPP-A MoM values with the surfactant needs of newborns of pregnant women who had a preterm delivery. METHODS: This study included 216 pregnant women who had a preterm delivery, who were found to be in the low-risk group based on their aneuploidy screening. The women were separated into two groups based on the surfactant receipts of their newborns. A record was made of the obstetric history, birth characteristics of the preterm infants, and whether or not there was a need for surfactant. RESULTS: A comparison of the PAPP-A values of the two groups revealed that the group that received surfactant had statistically significantly lower PAPP-A values (t(–3.97) = 0.203, p <  0.001). When the cut-off value of PAPP-A was taken as 1 MoM and the gestational age was analyzed together with the birth weight, PAPP-A alone was found to be a significant independent variable for the prediction of respiratory distress syndrome (RDS) (p = 0.031; OR:8.2 (1.2–55.6)). CONCLUSIONS: The result of this study demonstrated that PAPP-A MoM values may be significant in predicting the need for surfactant in RDS, which is a frequently seen condition in the neonatal period.

scholarly journals Effect of first trimester maternal serum pregnancy associated plasma protein: a level on fetomaternal outcome

2019 ◽  
Vol 9 (1) ◽  
pp. 87
Author(s):  
Shilpi Singh ◽  
Pushpa Singh
Keyword(s):  
Pregnant Women ◽  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Fetal Outcome ◽  
Maternal Serum ◽  
Maternal Outcome ◽  
Adverse Outcomes ◽  
High Risk Factors ◽  
Study Population

Background: Serum pregnancy-associated plasma protein-A (PAPP-A) levels fluctuate in continuation with the pregnancy and thus become an important standalone marker in monitoring the adverse outcomes that may occur in pregnancy.Methods: A prospective observational study was conducted in the department of obstetrics and gynaecology. A total of 240 pregnant women in their first trimester were included in the study. Serum PAPP-A levels were measured at 11-13+6week of gestation and were evaluated with respect to the feto-maternal outcome. The data was entered in MS excel spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0.Results: The mean age of the study population was 27 years. Among the maternal pregnancy parameters, PIH, pre-term labor and Emergency LSCS were significantly associated with low (<0.5 MoM) Serum PAPP-A levels, P<0.05. All the fetal outcome measures: IUGR, IUD, low birth weight, SGA babies, prematurity and NICU admissions, were significantly associated with low (<0.5 MoM) Serum PAPP-A levels, p <0.05.Conclusions: Serum PAPP-A in the early pregnancy showed significant correlation with feto-maternal outcome. Thus, it has the potential to be used as a prognostic factor and in the management of adverse outcomes by increasing surveillance for pregnant women with high-risk factors.

Low maternal pregnancy-associated plasma protein A during the first trimester of pregnancy and pregnancy outcomes

2016 ◽  
Vol 136 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Marja Kaijomaa ◽  
Leena Rahkonen ◽  
Veli-Matti Ulander ◽  
Esa Hämäläinen ◽  
Henrik Alfthan ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Pregnancy Outcomes ◽  
Protein A ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Development of a Radioimmunoassay for Pregnancy-Associated Plasma Protein A and Establishment of Normal Levels in the First Trimester of Pregnancy

1983 ◽  
Vol 20 (1) ◽  
pp. 26-30 ◽  
Author(s):  
F Anthony ◽  
G M Masson ◽  
P J Wood
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Serum Samples ◽  
Double Antibody ◽  
Normal Ranges ◽  
Antibody Method ◽  
First Trimester Of Pregnancy

An accelerated double antibody method has been developed for the radioimmunoassay of pregnancy-associated plasma protein A (PAPP-A) in serum. The workable range for the assay was 0·04–1·8 mg/l of serum. PAPP-A levels were determined in single serum samples from 110 women with prospective normal pregnancies of between 7 and 14 weeks' gestation. The level of pregnancy specific β1 glycoprotein (SP1) was also measured in these samples and normal ranges for PAPP-A and SP1 were constructed from the results obtained.

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