Biomimetic Synthesis of Water Soluble Conductive Polypyrrole and Poly (3,4 ethylenedioxythiophene).

2002 ◽  
Vol 736 ◽  
Author(s):  
Ferdinando F. Bruno ◽  
Jacqueline M. Fortier ◽  
Ramaswamy Nagarajan ◽  
Sucharita Roy ◽  
Jayant Kumar ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Water Solubility ◽  
Water Soluble ◽  
Biomimetic Synthesis ◽  
Polystyrene Sulfonate ◽  
Unique Combination ◽  
Poly Ethylene Glycol ◽  
Electrically Conductive ◽  
Biomimetic Method ◽  
Poly Ethylene

ABSTRACTA novel biomimetic method for the synthesis of a conducting molecular complex of polypyrrole and of Poly(3,4 ethylenedioxythiophene) (PEDOT) in the presence of a polyelectrolyte, such as polystyrene sulfonate (SPS) is presented. A poly(ethylene glycol) modified hematin (PEG-Hematin) was used to catalyze the polymerization of pyrrole and of 3,4 ethylenedioxythiophene in the presence of SPS to form a Polypyrrole/SPS and PEDOT/SPS complex. UV-vis, FTIR, electrical conductivity and TGA studies for all complexes indicate the presence of a thermally stable and electrically conductive form of these polymers. Furthermore the presence of SPS in this complex provides a unique combination of properties such as processability and water-solubility. Water-soluble polypyrrole opens new avenues for the fabrication of novel biosensors.

scholarly journals Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin

Bioimpacts ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Ashkan Hassankhani Rad ◽  
Farshid Asiaee ◽  
Sevda Jafari ◽  
Ali Shayanfar ◽  
Afsaneh Lavasanifar ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Targeted Delivery ◽  
Water Solubility ◽  
Polymeric Micelles ◽  
Inhibitory Effect ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
The One ◽  
Dialysis Bag

Introduction: Silibinin is a naturally occurring compound with known positive impacts on prevention and treatment of many types of human illnesses in general and cancer in particular. Silibinin is poorly water soluble which results in its insufficient bioavailability and lack of therapeutic efficacy in cancer. Here, we proposed to examine the potential of micelles composed of poly(ethylene glycol) (PEG) as the hydrophilic block and poly(ε-caprolactone) (PCL), poly(α-benzylcarboxylate-ε-caprolactone) (PBCL), or poly(lactide)-(PBCL) (PLA-PBCL) as hydrophobic blocks for enhancing the water solubility of silibinin and its targeted delivery to tumor. Methods: Co-solvent evaporation method was used to incorporate silibinin into PEG-PCL based micelles. Drug release profiles were assessed using dialysis bag method. MTT assay also was used to analyze functional activity of drug delivery in B16 melanoma cells. Results: Silibinin encapsulated micelles were shown to be less than 60 nm in size. Among different structures under study, the one with PEG-PBCL could incorporate silibinin with the highest encapsulation efficiency being 95.5%, on average. PEG-PBCL micelles could solubilize 1 mg silibinin in 1 mL water while the soluble amount of silibinin was found to be 0.092 mg/mL in the absence of polymeric micelles. PEG-PBCL micelles provided the sustained release of silibinin indicated with less than 30% release of silibinin within 24 hours. Silibinin encapsulated in PEG-PBCL micelles resulted in growth inhibitory effect in B16 cancer cells which was significantly higher than what observed with free drug. Conclusion: Our findings showed that PEG-PBCL micellar nanocarriers can be a useful vehicle for solubilization and targeted delivery of silibinin.

Water-soluble polyesters from long chain alkylesters of citric acid and poly(ethylene glycol)

2007 ◽  
Vol 43 (4) ◽  
pp. 1288-1301 ◽  
Author(s):  
Fabienne Barroso-Bujans ◽  
Ricardo Martínez ◽  
Mehrdad Yazdani-Pedram ◽  
Pedro Ortiz ◽  
Holger Frey
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Chain

Tracing the transport of organic colloids in porous media using tailored poly(ethylene glycol)

2021 ◽  
Author(s):  
Thomas Ritschel ◽  
Katharina Lehmann ◽  
Michaela Brunzel ◽  
Jürgen Vitz ◽  
Ivo Nischang ◽  
...  
Keyword(s):  
Porous Media ◽  
Ethylene Glycol ◽  
Water Solubility ◽  
Size Range ◽  
Large Fraction ◽  
Colloid Interface ◽  
Poly Ethylene Glycol ◽  
Polymer Backbone ◽  
Colloidal Transport ◽  
Poly Ethylene

<p>A large fraction of organic matter in natural aqueous soil solutions is given by molecules in sizes above one nanometer, which classifies them as colloids according to the IUPAC definition. Such colloids feature discernable mobility in soils and their transport is decisive for the cycling of carbon as well as the migration of nutrients or contaminants. Yet, their size-dependent hydrodynamics and functional diversity result in transport phenomena that are specific to colloids and, thus, largely differ from those observed for smaller substances. Still, tracers that appropriately represent small organic colloids are not available and the investigation of their transport in laboratory column experiments, in dependence of size and chemistry, remains difficult. To overcome this limitation, we tested if well-defined synthetic polymers in the colloidal size range are suitable as non-conventional tracers of colloidal transport. As polymer backbone, we selected poly(ethylene glycol) (PEG) due to its high water-solubility and established pathway of synthesis that permits tailoring of functional moieties to the fullest extent. An easy and sensitive detection in the aqueous phase became possible by using a fluorophore as starting group. After full characterization, we studied PEG adsorption to quartz, illite, goethite, and their mixtures in batch and column transport experiments. In numerical simulations, we successfully reconstructed and predicted PEG transport based on its physicochemical as well as hydrodynamic properties and, thus, show that PEG transport can be comprehensively and quantitatively studied. Considering also its low adverse effect on the environment, functional PEG therefore presents as promising candidate to be used as organic tracer, designable in the size range of natural organic (macro-)molecules (Ritschel et al., 2021).</p><p>References</p><p>Ritschel, T., Lehmann, K., Brunzel, M., Vitz, J., Nischang, I., Schubert, U., Totsche, K. U. (2021) <strong>Well-defined poly(ethylene glycol) polymers as non-conventional reactive tracers of colloidal transport in porous media</strong>.<em> J. Colloid Interface Sci.</em> 548, 592-601, doi: 10.1016/j.jcis.2020.09.056.</p>

A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier

2007 ◽  
Vol 342-343 ◽  
pp. 425-428 ◽  
Author(s):  
Dhananjay Jere ◽  
Tae Hee Kim ◽  
Rohidas B. Arote ◽  
Hu Lin Jiang ◽  
Myung Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Water Soluble ◽  
Gene Carrier ◽  
Gene Delivery System ◽  
Poly Ethylene Glycol ◽  
Wide Range ◽  
Poly Ethylene

Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.

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