α-BSM™: A Calcium Phosphate Delivery Vehicle

1998 ◽  
Vol 550 ◽  
Author(s):  
D. Knaack ◽  
D.D. Lee
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
The United States ◽  
Biologically Active ◽  
Delivery Vehicle ◽  
Critical Size Defects ◽  
Ectopic Bone ◽  
Biomechanical Strength

Abstractα-BSM™ is an injectable endothermically setting calcium phosphate bone substitute. α-BSM™ has been shown to be effective in promoting the healing of surgically created critical size defects and restoring bone biomechanical strength in several animal models. It has received regulatory clearance for orthopedic indications in both Canada and Europe and for dental and craniofacial indications in the United States.α-BSM™ is distinguished as a bone substitute by its prolonged working time at room temperature, and rapid hardening at body temperature. These properties, as well as its compatibility with a variety of aqueous hydrating agents, make α-BSM™ an attractive vehicle for the in situ delivery of therapeutic agents. In vitro studies have shown that antibiotics, such as gentamicin, can be stably incorporated into α-BSM™ prior to and during hardening, and that delivery kinetics can be controlled with the appropriate formulation and preparative procedures. The setting reaction is also compatible with biologically active proteins. rhBMP-2 has been incorporated into α-BSM™ and was demonstrated to be effective in stimulating ectopic bone formation in soft tissue and accelerating the restoration of a differentiated phenotype in a rabbit osteotomy model.

scholarly journals In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations

2020 ◽  
Vol 5 (3) ◽  
pp. 644-658 ◽  
Author(s):  
M.A. Goldberg ◽  
P.A. Krohicheva ◽  
A.S. Fomin ◽  
D.R. Khairutdinova ◽  
O.S. Antonova ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
One Pot ◽  
Calcium Phosphate Cements

Microwave assisted-in situ synthesis of porous titanium/calcium phosphate composites and their in vitro apatite-forming capability

2015 ◽  
Vol 83 ◽  
pp. 50-57 ◽  
Author(s):  
Man-Tik Choy ◽  
Chak-Yin Tang ◽  
Ling Chen ◽  
Wing-Cheung Law ◽  
Chi-Pong Tsui ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Porous Titanium ◽  
In Situ Synthesis ◽  
Microwave Assisted

Composite Calcium Phosphate Coatings on Mg Alloy for Medicine

2015 ◽  
Vol 245 ◽  
pp. 159-165 ◽  
Author(s):  
Sergey V. Gnedenkov ◽  
Sergey L. Sinebryukhov ◽  
Artyom М. Puz' ◽  
Dmitry V. Mashtalyar ◽  
Natalya G. Plekhova
Keyword(s):  
Calcium Phosphate ◽  
Biologically Active ◽  
Mg Alloy ◽  
High Tech ◽  
Calcium Phosphate Coating ◽  
Phosphate Coatings ◽  
Calcium Phosphate Layer ◽  
Plasma Electrolytic ◽  
Calcium Phosphate Coatings

The high-tech method of creating anticorrosion calcium phosphate coating on the magnesium alloy MA8 (MgMnCe) has been developed. As was demonstrated by the volumetry method the sealing of the layer formed on the surface of Mg alloy using plasma electrolytic oxidation by superdispersed polytetrafluoroethylene substantially reduced the rate of the corrosion process. Here, the surface of the calcium phosphate layer containing hydroxyapatite (Ca/P = 1.61) remains biologically active. Studies of architectonics of the surface of innate immune cells have been performed in vitro.

In situ synthesis of magnesium-substituted biphasic calcium phosphate and in vitro biodegradation

2012 ◽  
Vol 47 (9) ◽  
pp. 2506-2512 ◽  
Author(s):  
Tae-Wan Kim ◽  
Hyeong-Shin Lee ◽  
Dong-Hyun Kim ◽  
Hyeong-Ho Jin ◽  
Kyu-Hong Hwang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
In Situ Synthesis

Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo

2014 ◽  
Vol 614 ◽  
pp. 31-34 ◽  
Author(s):  
Christine Knabe ◽  
Marco Lopez Heredia ◽  
Dirk Barnemitz ◽  
Antje Genzel ◽  
Fabian Peters ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Substitute ◽  
Bone Repair ◽  
Critical Size ◽  
Potassium Phosphate ◽  
Critical Size Defects ◽  
Bone Substitute Materials ◽  
Silicon Doped ◽  
Substitute Materials

This study evaluates the effect of two novel particulate silicon-doped calcium phosphate graft materials as compared to the currently clinically used material β-TCP on osteogenesis and bone formation after implantation in critical-size defects the sheep scapula. These materials were developed in order to create biodegradable bone substitute materials that degrade rapidly, but still stimulate osteogenesis at the same time, thereby resulting in bone repair and regeneration with fully functional bone tissue. All bone substitute materials studied facilitated excellent bony regeneration of critical-size defects in the sheep scapula. Of the three grafting materials studied, the calcium alkali orthophosphate material with the crystalline phase Ca2KNa (PO4)2, with a small amorphous portion containing magnesium potassium phosphate and a small addition of sodium magnesium silicate had the greatest stimulatory effect on bone formation and expression of osteogenic markers, while exhibiting the highest biodegradability.

scholarly journals Assessment of temozolomide action encapsulated in chitosan and polymer nanostructures on glioblastoma cell lines

2014 ◽  
Vol 21 (1) ◽  
pp. 19-30
Author(s):  
C. Abrudan ◽  
I.S. Florian ◽  
A. Baritchii ◽  
O. Soritau ◽  
S. Dreve ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Lines ◽  
Malignant Gliomas ◽  
Tumor Biology ◽  
The United States ◽  
Biologically Active ◽  
Polypropylene Glycol ◽  
Polymer Nanostructures

Abstract Purpose : Glioblastoma multiforme (GBM) remains one of the most devastating diseases known to mankind and affects more than 17,000 patients in the United States alone every year. This malignancy infiltrates the brain early in its course and makes complete neurosurgical resection almost impossible. Recent years have brought significant advances in tumor biology. Many cancers, including gliomas, appear to be supported by cells with stemlike properties. Nanoparticles are excellent candidates to serve as delivery vectors of drugs or biologically active molecules because of their unique chemical and physical properties that result in specific transportation and deposition of such agents in specific organs and tissues.. In the current study we have investigated the in vitro action of nanostructural systems (temozolomide encapsulated in chitosan and polymer nanostructures) on high-grade gliomaderived cancer stem cells (CSCs), with the intention of developing a new therapy to treat specific brain tumors with increased efficacy and minimal toxicity. In vitro cytotoxicity and apoptosis measurements indicated that the drug/vector combination facilitated the ability of the alkylating drug TMZ to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy even for patients diagnosed with inoperable or recurrent malignant gliomas Methods : At the National Institute for R & D of Isotopic and Molecular Technologies form Cluj Napoca were synthesized three types of nanostructures chitosan-TMZ, TMZ-chitosan-PEG (polyethylene glycol), TMZ-chitosan-PPG (polypropylene glycol). Three type of cell lines (Glioma-derived stem, HFL and HUVEC) were treated with the 3 types of nanostructures and the survival rate of the cells was compare to standard therapy (TMZ). Results : The results showed a reduction in the rate of survival of the tumor cells. Cell proliferation assays clearly demonstrate the differences betweenconventional chemotherapy (TMZ) and temozolomide encapsulated in chitosan and polymer nanostructures. Conclusion: Nanostructures like chitosan, PEG, PPG are useful as vectors for drugs transport. Despite combined therapy (surgery, radiotherapy, chemotherapy), currently median patient survival is reduced. The key to improving life expectancy could be an effective therapy targeted, customized for each case. An increasingly important role will be new methods of treatment such as immunotherapy, gene therapy or nanotherapy.

In Vitro and In Vivo Evaluation of Non-Crystalline Calcium Phosphate Glass as a Bone Substitute

2003 ◽  
Vol 254-256 ◽  
pp. 185-188 ◽  
Author(s):  
Yong Keun Lee ◽  
J. Song ◽  
Hyun Ju Moon ◽  
Sang Bae Lee ◽  
Kwang Mahn Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Phosphate Glass ◽  
Bone Substitute ◽  
In Vivo Evaluation
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