Concentiration Dependence of the Translational Diffusion of Monoclonal Antibodies Specifically Bound to Phospholipid Langmmuir-Blodgett Films

The concentration dependence of protein diffusion in solution and in two-dimensional biological membranes is of current theoretical and experimental interest [1]. Langmuir-Blodgett films can be employed to measure protein diffusion coefficients in or on fluid phospholipid bilayers, as a function of protein concentration. Substrate-supported phospholipid monolayers and bilayers have been used extensively as models of immunological cell membranes, and are also of interest in fields other than membrane biophysics, including protein crystallography, medical technology, bioelectronics, optics, and surface science [2,3].