Fabrication and Characterization of Macroporous Chitosan/PVA Composite Sponges for Wound Dressing

2014 ◽  
Vol 1626 ◽  
Author(s):  
Changfeng Chen ◽  
Li Liu ◽  
Qiong Wang ◽  
Tao Huang ◽  
Yue`e Fang
Keyword(s):  
Wound Dressing ◽  
Freeze Drying ◽  
Transmission Rate ◽  
High Water ◽  
Poly Vinyl Alcohol ◽  
Drying Method ◽  
Moisture Permeability ◽  
Liquid Absorption ◽  
Fabrication And Characterization

ABSTRACTThe present investigation involves the synthesis of chitosan based composite sponges in view of their applications in wound dressing, antibacterial and haemostatic. A facile CO2 bubbles template freeze-drying method was developed for the fabrication of macroporous chitosan- poly(vinyl alcohol) (PVA) composite sponges with a typical porosity of 50% and pore size of 100-300 µm. The composite sponges show a high water absorption rate up to 60 times of its weight and a water vapor transmission rate of 30 ∼ 70g/m2 • h. Effects of the content of cross-linking agent and PVA on mechanical properties and moisture permeability were examined. Improved strength and flexibility of the chitosan sponges were observed with the presence of PVA. Further, the antibacterial and haemostatic activities have been demonstrated. The Chitosan/PVA sponges of high liquid absorption, appropriate moisture permeability, excellent antimicrobial and haemostatic activities have a great potential for wound dressing applications.

Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing

Biomaterials ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Fwu-Long Mi ◽  
Shin-Shing Shyu ◽  
Yu-Bey Wu ◽  
Sung-Tao Lee ◽  
Jen-Yeu Shyong ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Chitosan Membrane ◽  
Fabrication And Characterization

Electrospinning fabrication and characterization of poly(vinyl alcohol)/montmorillonite/silver hybrid nanofibers for antibacterial applications

2009 ◽  
Vol 288 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Jae Hyeung Park ◽  
Mohammad Rezaul Karim ◽  
In Kyo Kim ◽  
In Woo Cheong ◽  
Jong Won Kim ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Hybrid Nanofibers ◽  
Fabrication And Characterization

Fabrication and Characterization of Fibrous Polycaprolactone Blended with Natural Green Tea Extracts Using Dual Solvent Systems

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ainatul Aqilah Binti Mohd Rashid ◽  
Saravana Kumar Jaganathan ◽  
Ahmad Zahran Mohd Khudzari ◽  
Ahmad Fauzi Ismail
Keyword(s):  
Electron Microscopy ◽  
Green Tea ◽  
Water Uptake ◽  
Wound Dressing ◽  
Electrospun Fibers ◽  
Fibrous Morphology ◽  
Solvent Systems ◽  
Fabrication And Characterization ◽  
Scanning Electron

AbstractNanofibrous dressings serve as an impeccable candidate in the management of wounds. Nanofibrous composites composed of polycaprolactone (PCL) and green tea using dual solvent systems at different ratios were fabricated through electrospinning. Pure PCL electrospun fibers along with composites were characterized by using scanning electron microscopy (SEM), wettability, water uptake analysis, and Fourier transform infrared spectroscopy (FTIR). SEM indicated that fibrous morphology and the diameter of PCL/green tea were smaller for chloroform/dimethylformamide (DMF) (601 nm) and acetone/DMF (896 nm) than the pure PCL (673 nm and 1,104 nm for chloroform/DMF and acetone/DMF, respectively). Wettability of the fabricated composites was increased, and pure PCL fibers were slightly more hydrophobic (100°) than PCL/green tea (94°). Water uptake of the composites was enhanced compared with PCL significantly in acetone/DMF. The PCL/green tea nanofibrous wound dressing with enhanced physicochemical properties serves as an indispensable candidate for wound healing applications.

scholarly journals Evaluation of PVA/dextran/chitosan hydrogel for wound dressing

2019 ◽  
Vol 38 (1-2) ◽  
pp. 15-30 ◽  
Author(s):  
Shin-Ping Lin ◽  
Kai-Yin Lo ◽  
Tien-Ni Tseng ◽  
Jui-Ming Liu ◽  
Ting-Yu Shih ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wound Dressing ◽  
Antimicrobial Property ◽  
High Water ◽  
Poly Vinyl Alcohol ◽  
High Water Content ◽  
Chitosan Hydrogel ◽  
Proliferation Ability ◽  
Pva Hydrogel

Developing a multiple functional wound dressing suitable for different stages of wound healing is important for patients with special wound such as burn or decubital ulcers. In this study, poly (vinyl alcohol) (PVA), dextran, and chitosan are integrated to produce ideal wound dressing where glutaraldehyde (GA) is used as the cross-linker. The result demonstrated that 6% PVA hydrogel with 0.25% chitosan was found to provide antimicrobial ability. The PVA/chitosan hydrogel combined with 4% dextran utilizing GA cross-linking also presents the high cell proliferation ability, which suggests that the hydrogel is potential as a wound dressing. In the following physical analyses, the addition of chitosan and dextran appeared to promote the thermostability, mechanical properties, water retention, and moisturizing ability in the PVA hydrogel. In conclusion, the PVA/chitosan/dextran hydrogel has promising potential such as high water content, antimicrobial property, and well cell proliferation, which can be applied to wound healing application.

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