High throughput synthesis of ceramic nanofibers

2014 ◽  
Vol 1659 ◽  
pp. 175-180 ◽  
Author(s):  
S. Sood ◽  
G. Zheng ◽  
P. Gouma
Keyword(s):  
High Throughput ◽  
Electrostatic Field ◽  
Electrospinning Process ◽  
High Yield ◽  
Flow Rates ◽  
Functional Applications ◽  
Single Jet ◽  
High Yields ◽  
Ceramic Nanofibers ◽  
Novel Design

AbstractHigh yield nanomanufacturing is important to turning nanotechnology advances into industrial products. Electrospinning is a nanomanufacturing process that has been used to process advanced ceramic nanofibers suitable for functional applications in sensing and catalysis, yet it has been limited in its scalability thus far. In this study a novel design of the electrospinning process and related equipment that could produce large qualities of ceramic nanofibers is described. This scaled-up approach to traditional needle electrospinning allows the formation of 24 jets operating under the same conditions as those set in the single jet lab-based process. Due to a thin metallic disc design, with tiny (0.5mm) holes drilled at the bottom corner of the disc, all jets experience a uniform impact of the electrostatic field. Continuous replenishment of the source disk at higher flow rates allows for high yields of nanofibers.

Evaluation of germ plasm for resistant to Soybean mosaic virus (SMV)

2020 ◽  
Vol 21 (1) ◽  
pp. 6-9
Author(s):  
Wuye Ria Andayanie
Keyword(s):  
Abiotic Stress ◽  
Environmental Factors ◽  
Mosaic Virus ◽  
Polyclonal Antibody ◽  
Symptom Severity ◽  
Germ Plasm ◽  
Polyclonal Antibodies ◽  
Soybean Mosaic Virus ◽  
High Yield ◽  
High Yields

Soybean superior varieties with high yields and are resistant to abiotic stress have been largely released, although some varieties grown in the field are not resistant to SMV. In addition, the opportunity to obtain lines of hope as prospective varieties with high yield and resistance to SMV is very small. The method for evaluating soybean germplasm is based on serological observations of 98 accessions of leaf samples from SMV inoculation with T isolate. The evaluation results of 98 accessions based on visual observations showed 31 genotypes reacting very resistant or healthy to mild resistant category to SMV T isolate  with a percentage of symptom severity of 0 −30 %. Among 31 genotypes there are 2 genotypes (PI 200485; M8Grb 44; Mlg 3288) with the category of visually very resistant and resistant, respectively and  Mlg 3288  with the category of mild resistant.  They have a good agronomic appearance with a weight of 100 seeds (˃10 g) and react negatively with polyclonal antibodies to SMV, except Mlg 3288 reaction is not consistent, despite the weight of 100 seeds (˃ 10 g). Leaf samples from 98 accessions revealed various symptoms of SMV infection in the field. This diversity of symptoms is caused by susceptibility to accession, when infection occurs, and environmental factors. Keywords—: soybean; genotipe; Soybean mosaic virus (SMV); disease severity; polyclonal  antibody

scholarly journals Design of Low-Cost and High-Strength Titanium Alloys Using Pseudo-Spinodal Mechanism through Diffusion Couple Technology and CALPHAD

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2910
Author(s):  
Chaoyi Ding ◽  
Chun Liu ◽  
Ligang Zhang ◽  
Di Wu ◽  
Libin Liu
Keyword(s):  
Diffusion Couple ◽  
Titanium Alloys ◽  
High Throughput ◽  
Volume Fraction ◽  
Raw Materials ◽  
Low Cost ◽  
High Strength ◽  
High Yield ◽  
Α Phase ◽  
Cr System

The high cost of development and raw materials have been obstacles to the widespread use of titanium alloys. In the present study, the high-throughput experimental method of diffusion couple combined with CALPHAD calculation was used to design and prepare the low-cost and high-strength Ti-Al-Cr system titanium alloy. The results showed that ultra-fine α phase was obtained in Ti-6Al-10.9Cr alloy designed through the pseudo-spinodal mechanism, and it has a high yield strength of 1437 ± 7 MPa. Furthermore, application of the 3D strength model of Ti-6Al-xCr alloy showed that the strength of the alloy depended on the volume fraction and thickness of the α phase. The large number of α/β interfaces produced by ultra-fine α phase greatly improved the strength of the alloy but limited its ductility. Thus, we have demonstrated that the pseudo-spinodal mechanism combined with high-throughput diffusion couple technology and CALPHAD was an efficient method to design low-cost and high-strength titanium alloys.

scholarly journals Performance of Strawberry Varieties Developed for Perennial Matted-Row Production in Annual Plasticulture in a Cold Climate Region

Agronomy ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1407
Author(s):  
Courtney A. Weber
Keyword(s):  
Large Scale ◽  
Fruit Size ◽  
Weather Conditions ◽  
Cold Climate ◽  
Annual Production ◽  
High Yield ◽  
Production Cycle ◽  
Late Season ◽  
Berry Weight ◽  
High Yields

Annual plasticulture production of strawberries promises superior weed control, fruit quality and yields. However, strawberry varieties adapted for perennial, matted-row production and local markets in cold climate regions have not been widely tested for adaptation to an annual production cycle. Productivity of seven short-day varieties developed for matted-row and/or annual production was examined in an annual plasticulture system in two consecutive trials in central NY (lat. 42.87° N, long. 76.99° W) harvested in 2013 and 2014. ‘Flavorfest’ demonstrated good performance in Trial 1 with high yield (390 g/plant) and large fruit size (13.9 g mean berry weight). ‘Jewel’ was shown to be well adapted to the annual plasticulture system with consistently high yields (330 and 390 g/plant) that equaled or surpassed other varieties and had moderate fruit size. ‘Chandler’ performed similarly to previous trials conducted in warmer regions with yield (340 g/plant) and fruit size (9.8 g mean berry weight) similar to ‘Jewel’. ‘Clancy’ yielded less but was consistent from year to year. The late season varieties Seneca and Ovation showed marked variability between years, possibly due to drastically different temperatures during flowering and fruit development in Trial 1 compared to Trial 2. High temperatures in Trial 1 likely caused higher early fruit yield, a compressed season and a precipitous decline in fruit size in the later season, thus reducing yield in the late season. Survival after a second dormant period was poor resulting in a small second harvest and reduced fruit size. Overall, the system demonstrated many of the expected benefits but may be more sensitive to weather conditions in the region. While many varieties developed for matted-row production may work well in an annual plasticulture system, not all varieties are equally adapted. Performance of each variety should be determined independently before large scale adoption by growers.

Direct conversion of cellulose to high-yield methyl lactate over Ga-doped Zn/H-nanozeolite Y catalysts in supercritical methanol

2017 ◽  
Vol 19 (8) ◽  
pp. 1969-1982 ◽  
Author(s):  
Deepak Verma ◽  
Rizki Insyani ◽  
Young-Woong Suh ◽  
Seung Min Kim ◽  
Seok Ki Kim ◽  
...  
Keyword(s):  
Lignocellulosic Biomass ◽  
Value Added ◽  
Direct Conversion ◽  
High Yield ◽  
Supercritical Methanol ◽  
Methyl Lactate ◽  
High Yields

For realizing sustainable bio-based refineries, it is crucial to obtain high yields of value-added chemicalsviadirect conversion of cellulose and lignocellulosic biomass.

Continuous detection of trace level concentration of oil droplets in water using microfluidic AC electroosmosis (ACEO)

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 70197-70203 ◽  
Author(s):  
D. Das ◽  
Z. Yan ◽  
N. V. Menon ◽  
Y. Kang ◽  
V. Chan ◽  
...  
Keyword(s):  
Oil Spill ◽  
High Throughput ◽  
Ac Electroosmosis ◽  
Oil Droplets ◽  
Trace Level ◽  
High Throughput Detection ◽  
Novel Design

A novel design for high throughput detection of oil micro-droplets in water which is important to environmental oil spill monitoring agencies.

scholarly journals Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Helge Thisgaard ◽  
Joel Kumlin ◽  
Niels Langkjær ◽  
Jansen Chua ◽  
Brian Hook ◽  
...  
Keyword(s):  
Radiochemical Purity ◽  
High Yield ◽  
Clinical Use ◽  
Automated Production ◽  
Automated Method ◽  
Gallium 68 ◽  
High Yields ◽  
High Level ◽  
Mev Protons ◽  
Very High

Abstract Background With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([68Ge]Ge/[68Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, we demonstrate a high-yield, automated method for producing multi-Curie levels of [68Ga]GaCl3 from solid zinc-68 targets and subsequent labelling to produce clinical-grade [68Ga]Ga-PSMA-11 and [68Ga]Ga-DOTATATE. Results Enriched zinc-68 targets were irradiated at up to 80 µA with 13 MeV protons for 120 min; repeatedly producing up to 194 GBq (5.24 Ci) of purified gallium-68 in the form of [68Ga]GaCl3 at the end of purification (EOP) from an expected > 370 GBq (> 10 Ci) at end of bombardment. A fully automated dissolution/separation process was completed in 35 min. Isolated product was analysed according to the Ph. Eur. monograph for accelerator produced [68Ga]GaCl3 and found to comply with all specifications. In every instance, the radiochemical purity exceeded 99.9% and importantly, the radionuclidic purity was sufficient to allow for a shelf-life of up to 7 h based on this metric alone. Fully automated production of up to 72.2 GBq [68Ga]Ga-PSMA-11 was performed, providing a product with high radiochemical purity (> 98.2%) and very high apparent molar activities of up to 722 MBq/nmol. Further, manual radiolabelling of up to 3.2 GBq DOTATATE was performed in high yields (> 95%) and with apparent molar activities (9–25 MBq/nmol) sufficient for clinical use. Conclusions We have developed a high-yielding, automated method for the production of very high amounts of [68Ga]GaCl3, sufficient to supply proximal radiopharmacies. The reported method led to record-high purified gallium-68 activities (194 GBq at end of purification) and subsequent labelling of PSMA-11 and DOTATATE. The process was highly automated from irradiation through to formulation of the product, and as such comprised a high level of radiation protection. The quality control results obtained for both [68Ga]GaCl3 for radiolabelling and [68Ga]Ga-PSMA-11 are promising for clinical use.

High yield and greener C–H difluoromethylation reactions using copper iodide nanoparticles/boron nitride nanosheets as a versatile and recyclable heterogeneous catalyst

2021 ◽  
Author(s):  
Udayakumar Veerabagu ◽  
Gowsika Jaikumar ◽  
Fushen Lu ◽  
Franck Quero
Keyword(s):  
Boron Nitride ◽  
Heterogeneous Catalyst ◽  
High Efficiency ◽  
High Yield ◽  
Copper Iodide ◽  
Boron Nitride Nanosheets ◽  
Greener Synthesis ◽  
High Yields ◽  
Recyclable Heterogeneous Catalyst

The 3 wt% CuI/BNNS catalyst exhibited high efficiency for C–H difluoromethylation reactions and enabled greener synthesis at high yields using cyrene as a solvent. Furthermore, the catalyst could be easily recovered and recycled for at least five cycles.

scholarly journals Metrological performance of single-jet water meters over time

2018 ◽  
Vol 13 (5) ◽  
pp. 1
Author(s):  
Carmen Virginia Palau ◽  
Juan Manzano ◽  
Iban Balbastre Peralta ◽  
Benito Moreira de Azevedo ◽  
Guilherme Vieira do Bomfim
Keyword(s):  
Measurement Error ◽  
Water Consumption ◽  
Operating Conditions ◽  
Economic Losses ◽  
Flow Rates ◽  
Metrological Operation ◽  
Operation Period ◽  
Single Jet ◽  
Water Meters ◽  
Over Time

To maintain quality measurement of water consumption, it is necessary to know the metrology of single-jet water meters over time. Knowing the accuracy of these instruments over time allows establishing a metrological operation period for different flow rates. This will aid water companies to optimize management and reduce economic losses due to unaccounted water consumption. This study analyzed the influence of time on the measurement error of single-jet water meters to evaluate the deterioration of the equipment and, with that, launch the metrological operation period. According to standards 8316 and 4064 of the International Organization for Standardization (ISO), 808 meters of metrological Class B were evaluated in six water supplies, with age ranges of 3.7 to 16.4 years of use. The measurement error was estimated by comparing the volume measured in a calibrated tank with the volume registered by the meters at flow rates of 30, 120, 750 and 1,500 L h-1. The metrological operation period of the meters was obtained for each flow rate by the relation between error of measurement and time of use (simple linear regression). According to the results, the majority of the equipment presents increasing under-registration errors over time, more pronounced at low flow rates and with less favorable operating conditions. The metrological operation period for flow rates of 30, 120, 750 and 1,500 L h-1 is estimated at approximately 3, 8, 14 and 13 years. This operation period combined with consumption patterns of users will establish the best time to replace the meters.

scholarly journals A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields

2021 ◽  
Author(s):  
Yoichiro Fujioka ◽  
Sayaka Kashiwagi ◽  
Aiko Yoshida ◽  
Aya O. Satoh ◽  
Mari Fujioka ◽  
...  
Keyword(s):  
Global Economy ◽  
Expression System ◽  
Antiviral Agents ◽  
Production Method ◽  
Spike Protein ◽  
High Yield ◽  
Pseudotyped Virus ◽  
Efficient Production ◽  
Live Virus ◽  
High Yields

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be conducted with biosafety level 3 confinement. Pseudotyped viruses have been widely adopted for studies of virus entry and pharmaceutical development to overcome this restriction. Here we describe a modified protocol to generate vesicular stomatitis virus (VSV) pseudotyped with SARS-CoV or SARS-CoV-2 Spike protein in high yield. We found that pseudovirions produced with the conventional transient expression system lacked coronavirus Spike protein at their surface as a result of inhibition of parental VSV infection by overexpression of this protein. Establishment of stable cell lines with an optimal expression level of coronavirus Spike protein allowed the efficient production of progeny pseudoviruses decorated with Spike protein. This improved VSV pseudovirus production method should facilitate studies of coronavirus entry and development of antiviral agents.

scholarly journals Epimerization-free C-term Activation of Peptide Fragments by Ball-Milling

2020 ◽  
Author(s):  
Yves Yeboue ◽  
Marion Jean ◽  
Gilles Subra ◽  
Jean Martinez ◽  
Frédéric Lamaty ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ball Milling ◽  
High Yield ◽  
Coupling Agents ◽  
Peptide Fragment ◽  
Peptide Fragments ◽  
Solution Synthesis ◽  
High Yields ◽  
Synthesis Approach ◽  
Yield And Purity

Ball-milling enabled to perform [2+1], [2+2], and [2+3] peptide couplings with high yields and, if any, very low epimerization. Very good results were obtained with peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term such as phenylglycine, cysteine and valine. Ball-milling was clearly identified as the key element to obtain both high yield and purity along with low epimerization. Indeed, the ball-milling conditions proved to be superior to the classical solution synthesis approach on a various array of widely used coupling agents. These results open avenues for the development of highly efficient, convergent and flexible peptide synthesis strategies based on peptide fragment couplings mediated by ball-milling.

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