Development of hydroxyapatite-mediated synthesis of collagen-based copolymers for application as bio scaffolds in bone regeneration

2014 ◽  
Vol 1621 ◽  
pp. 53-58
Author(s):  
Didarul Bhuiyan ◽  
John Middleton ◽  
Rina Tannenbaum
Keyword(s):  
Mechanical Properties ◽  
Bone Graft ◽  
In Situ Polymerization ◽  
Bone Graft Substitute ◽  
The Body ◽  
Graft Material ◽  
Novel Approach ◽  
Absorbable Polymers ◽  
Biocomposite Material

ABSTRACTHydroxyapatite (HAP) is a biocompatible bio-ceramic whose structure and composition is similar to bone. However, its lack of strength and toughness have seriously hampered its applications as a bone graft substitute material. Attempts have been made to overcome these mechanical properties deficiencies by combining HAP bioceramic material with absorbable polymers in order to improve its mechanical properties. However, poor interfacial bonding between the HAP and the polymers has limited the benefits of such biocomposite structures. At the other end of the biomaterials spectrum is collagen, which constitutes the most abundant proteins in the body and exhibits properties such as biodegradability, bioadsorbability with low antigenicity, high affinity to water, and the ability to interact with cells through integrin recognition. These favorable properties renders collagen as a natural candidate for the modification and compatibilization of the polymer-HAP biocomposite. In this study, we developed a novel approach to the synthesis of a potential bone graft material, where the HAP moiety acts not only as a bioceramic filler, but also constitutes the initiator surface that promotes the in-situ polymerization of the adsorbable polymer of choice. The synthesis of poly(D,L-lactide-co-glycolide) (PLGA) polymer was catalyzed by nano-hydroxyapatite (nHAP) particles and upon reaction completion, the biocomposite material was tethered with collagen. The synthesis was monitored by 1H NMR and FTIR spectroscopies and the products after each step were characterized by thermal analysis to probe both thermal stability, morphological integrity and mechanical properties.

scholarly journals Immediate Implant Placement in Infected Sockets: A Consecutive Cohort Study

2020 ◽  
Vol 11 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Ashish Kakar ◽  
Kanupriya Kakar ◽  
Minas D. Leventis ◽  
Gaurav Jain
Keyword(s):  
Bone Graft ◽  
Clinical Results ◽  
Bone Graft Substitute ◽  
Graft Material ◽  
Success Rates ◽  
Implant Surface ◽  
Implant Placement ◽  
Immediate Placement ◽  
Immediate Implant

Introduction: Immediate placement of implants in a fresh post-extraction socket is an increasingly popular and established treatment option. However, active infection in the extraction site may adversely affect the outcome of this procedure. This study was designed to assess the clinical results of immediate placement of dental implants in infected extraction sockets using a standardized protocol, which included (a) the use of an Er,Cr:YSGG laser for the decontamination of the infected socket prior to implant insertion, and (b) the utilization of an in situ hardening alloplastic bone graft substitute to augment the gap between the implant surface and the labial plate of bone. Patients and Methods: A retrospective record review was used to identify 68 patients who had implants placed as per the described protocol. A total of 126 implants were placed in 68 patients (65 implants in the maxilla, 61 implants in the mandible). The implants were loaded 136 ± 73 days (mean ± standard deviation; range: 37–400 days) after implant placement. Eight patients (16 implants) were subsequently lost to follow up. Results: 105 of the 110 implants (95.45%) placed immediately in the infected sites using the described protocol survived after prosthetic loading. Conclusion: Immediate implant placement in previously infected sites using the protocols mentioned in our study with laser decontamination of the socket, grafting with an in situ hardening alloplastic bone graft material and non-submerged healing shows a similar survival rate to the published success rates for immediate implants placed in non-infected sites.

Synthesis and Characterizations of Poly(Butylene Succinate) Copolyester

2014 ◽  
Vol 1015 ◽  
pp. 381-384
Author(s):  
Li Liu ◽  
Li Hai Cai ◽  
Dan Liu ◽  
Jun Xu ◽  
Bao Hua Guo
Keyword(s):  
Mechanical Properties ◽  
Polymer Matrix ◽  
Crystallization Temperature ◽  
In Situ Polymerization ◽  
Nucleating Agent ◽  
Single Fiber ◽  
Butylene Succinate ◽  
Crystallization Behaviors ◽  
Polymerization Method

The poly (butylene succinate) (PBS) and 3 wt% attapulgite (ATP) reinforced PBS/ATP nanocomposites with 1,6-hexanediol were fabricated using an in situ polymerization method. The crystallization behaviors indicated that ATP had effectively acted as nucleating agent, resulting in the enhancement on the crystallization temperature. The SEM results showed a superior interfacial linkage between ATP and PBS. Also, ATP could disperse as a single fiber and embed in the polymer matrix, which resulted in the improved mechanical properties.

Mechanical Properties of Thermoplastic Composites via In Situ Polymerization from Cyclic Oligomers

2013 ◽  
Vol 750-752 ◽  
pp. 7-10
Author(s):  
Kou An Hao ◽  
Zhen Qing Wang ◽  
Li Min Zhou
Keyword(s):  
Mechanical Properties ◽  
In Situ Polymerization ◽  
High Viscosity ◽  
Thermoplastic Composites ◽  
Thermoplastic Matrix ◽  
Polymerization Catalyst ◽  
Short Beam ◽  
Beam Shear ◽  
Cyclic Oligomers

Fiber impregnation has been the main obstacle for thermoplastic matrix with high viscosity. This problem could be surmounted by adapting low viscous polymeric precursors Woven basalt fabric reinforced poly (butylenes terephthalate) composites were produced via in-situ polymerization at T=210°C. Before polymerization, catalyst was introduced to the reinforcement surface with different concentration. DSC is used to determine the polymerization and crystallization. SEM is used to detect whether the catalyst existed on surface. Both flexural and short-beam shear test are employed to study the corresponding mechanical properties.

A Novel Approach to Restore a Decayed Mandibular Posterior Tooth by Immediate Implant Placement Using Autogenous Tooth Graft Material Mixed with Platelet-Rich Fibrin: A Case Report

2021 ◽  
Author(s):  
Amit Khunger
Keyword(s):  
Case Report ◽  
Bone Graft ◽  
Graft Material ◽  
Present Case Report ◽  
Platelet Rich Fibrin ◽  
Implant Placement ◽  
Novel Approach ◽  
Decayed Tooth ◽  
Immediate Implant ◽  
Missing Tooth

A dental implant is the most accepted treatment option to replace the badly decayed tooth or missing tooth. The jumping gap left after the placement of the implant in the socket will require augmentation of bone graft material. In this case report, the extracted root stumps are used as an autogenous tooth graft material after its preparation. And PRF is mixed with graft material for additive advantage. So, the present case report discusses the feasibility of the use of autogenous tooth graft material along with PRF for the better osseointegration of the implant.

scholarly journals The Effect of the Parameters of T-RTM on the Properties of Polyamide 6 Prepared by in Situ Polymerization

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 4 ◽  
Author(s):  
Orsolya Viktória Semperger ◽  
András Suplicz
Keyword(s):  
Mechanical Properties ◽  
Automotive Industry ◽  
Cycle Time ◽  
In Situ Polymerization ◽  
Rapid Development ◽  
Polyamide 6 ◽  
Raw Material ◽  
Short Cycle ◽  
Short Cycle Time

With the rapid development of the automotive industry, there is also a significant need to improve the raw materials used. Therefore, the demand is increasing for polymer composites with a focus on mass reduction and recyclability. Thermoplastic polymers are preferred because of their recyclability. As the automotive industry requires mass production, they require a thermoplastic raw material that can impregnate the reinforcement in a short cycle time. The most suitable monomer for this purpose is caprolactam. It can be most efficiently processed with T-RTM (thermoplastic resin transfer molding) technology, during which polyamide 6 is produced from the low-viscosity monomer by anionic ring-opening (in situ) polymerization in a tempered mold with a sufficiently short cycle time. Manufacturing parameters, such as polymerization time and mold temperature, highly influence the morphological and mechanical properties of the product. In this paper, the properties of polyamide 6 produced by T-RTM are analyzed as a function of the production parameters. We determine the crystallinity and the residual monomer content of the samples and their effect on mechanical properties.

scholarly journals Fabrication, Crystalline Behavior, Mechanical Property and In-Vivo Degradation of Poly(l–lactide) (PLLA)–Magnesium Oxide Whiskers (MgO) Nano Composites Prepared by In-Situ Polymerization

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1123 ◽  
Author(s):  
Hui Liang ◽  
Yun Zhao ◽  
Jinjun Yang ◽  
Xiao Li ◽  
Xiaoxian Yang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnesium Oxide ◽  
Bone Repair ◽  
In Situ Polymerization ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
Biomedical Material ◽  
In Vivo Degradation

The present work focuses on the preparation of poly(l–lactide)–magnesium oxide whiskers (PLLA–MgO) composites by the in-situ polymerization method for bone repair and implant. PLLA–MgO composites were evaluated using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and solid-state 13C and 1H nuclear magnetic resonance spectroscopy (NMR). It was found that the whiskers were uniformly dispersed in the PLLA matrix through the interfacial interaction bonding between PLLA and MgO; thereby, the MgO whisker was found to be well-distributed in the PLLA matrix, and biocomposites with excellent interface bonding were produced. Notably, the MgO whisker has an effect on the crystallization behavior and mechanical properties; moreover, the in vivo degradation of PLLA–MgO composites could also be adjusted by MgO. These results show that the whisker content of 0.5 wt % and 1.0 wt % exhibited a prominent nucleation effect for the PLLA matrix, and specifically 1.0 wt % MgO was found to benefit the enhanced mechanical properties greatly. In addition, the improvement of the degrading process of the composite illustrated that the MgO whisker can effectively regulate the degradation of the PLLA matrix as well as raise its bioactivity. Hence, these results demonstrated the promising application of PLLA–MgO composite to serve as a biomedical material for bone-related repair.

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