Theranostic Anticancer Agents Based on Internally Functionalized ORMOSIL Nanoparticles

2014 ◽  
Vol 1625 ◽  
Author(s):  
Nathan I. Walton ◽  
Zhe Gao ◽  
Ilya Zharov
Keyword(s):  
Functional Groups ◽  
Anticancer Agents ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Mri Imaging ◽  
Modified Silica ◽  
Metal Chelating ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Ormosil Nanoparticles

ABSTRACTWe prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging

2013 ◽  
Vol 43 (9) ◽  
pp. 1214-1214
Author(s):  
GuangDi CHEN ◽  
Wei QIN ◽  
ZhengPing XU ◽  
Jun QIAN ◽  
ZhenFeng ZHU ◽  
...  
Keyword(s):  
Cellular Imaging ◽  
Modified Silica ◽  
Two Photon ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Ormosil Nanoparticles

Preparation of ORMOSIL nanoparticles conjugated with vitamin D3analogues and their biological evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (38) ◽  
pp. 31840-31849 ◽  
Author(s):  
Tania González-García ◽  
Susana Fernández ◽  
Elisa Lubian ◽  
Fabrizio Mancin ◽  
Miguel Ferrero
Keyword(s):  
Vitamin D ◽  
Biological Evaluation ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Ormosil Nanoparticles

Dye-doped multifunctional organically modified silica (ORMOSIL) nanoparticles were prepared within surfactant stabilized microemulsions and conjugated with several vitamin D3derivatives.

Gold Nanoparticle-Enhanced Photodynamic Therapy from Photosensitiser-Entrapped Ormosil Nanoparticles

2019 ◽  
Vol 19 (11) ◽  
pp. 6942-6948 ◽  
Author(s):  
Parul ◽  
Indrajit Roy
Keyword(s):  
Pancreatic Cancer ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Modified Silica ◽  
Surface Attachment ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Different Diameters ◽  
Ormosil Nanoparticles

Herein, we investigate the effect of the surface attachment of gold nanoparticles (AuNPs) on photosensitiser-entrapped organically modified silica (ormosil) nanoparticles for enhanced photodynamic therapy (PDT). Photosensitiser methylene blue (MB)-entrapped ormosil nanoparticles of three different diameters (30/55/80 nm) were synthesised, and AuNPs were attached to their surface. Subsequent light irradiation with a 630 nm laser resulted in the production of singlet oxygen (1O2), with different amounts depending on the diameter of the ormosil nanoparticle. Enhancement in 1O2 production was observed upon the AuNP attachment on the ormosil surface. In vitro studies in pancreatic cancer (Panc-1) cells have demonstrated that cellular uptake and photodynamic cytotoxicity are also dependent on the size of ormosil nanoparticles and AuNP attachment. These studies pave the way for designing ormosil nanoparticles with suitable size and surface attachment for PDT applications.

scholarly journals Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis

RSC Advances ◽  
2019 ◽  
Vol 9 (24) ◽  
pp. 13855-13862 ◽  
Author(s):  
Changyue Wu ◽  
Yifan Wu ◽  
Yang Jin ◽  
Piaoyu Zhu ◽  
Weiwei Shi ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles ◽  
Ormosil Nanoparticles

Organically modified silica (ORMOSIL) nanoparticles (NPs) are widely used in biomedicine.

Development of organically modified silica nanoparticles for monitoring the intracellular level of oxygen using a frequency-domain FLIM platform

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36938-36947 ◽  
Author(s):  
Barbara Korzeniowska ◽  
Marcel Raspe ◽  
Dorota Wencel ◽  
Robert Woolley ◽  
Kees Jalink ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Frequency Domain ◽  
Oxygen Concentration ◽  
Dynamic Quenching ◽  
Intracellular Level ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles ◽  
Ormosil Nanoparticles

The dynamic quenching of luminescence derived from Ru(dpp3)2+-doped ORMOSIL nanoparticles is used for monitoring of the intracellular oxygen concentration.

Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging

2013 ◽  
Vol 56 (9) ◽  
pp. 1247-1252 ◽  
Author(s):  
ZhenFeng Zhu ◽  
XinYuan Zhao ◽  
Wei Qin ◽  
GuangDi Chen ◽  
Jun Qian ◽  
...  
Keyword(s):  
Cellular Imaging ◽  
Modified Silica ◽  
Two Photon ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Ormosil Nanoparticles
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