Dextran Based Polyampholyte Having Cryoprotective Properties

2013 ◽  
Vol 1498 ◽  
pp. 33-38
Author(s):  
Minkle Jain ◽  
Kazuaki Matsumura
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Dimethyl Sulfoxide ◽  
High Molecular Weight ◽  
Carboxyl Groups ◽  
Engineering Applications ◽  
L929 Cells ◽  
Cryoprotective Agent

ABSTRACTDimethyl sulfoxide (DMSO) has been used for several decades as the most efficient cryoprotective agent (CPA) for many types of cells in spite of its cytotoxicity and its effect on differentiation. Recently we showed that carboxylated poly-L-lysine, which is classified as a polyampholyte, has a cryoprotective effect on cells in solution without any other cryoprotectant. Here we developed high molecular weight polyampholytes with an appropriate ratio of amino and carboxyl groups and evaluated their cryopreservation efficiency. A novel polyampholyte based on naturally available polymer dextran, in which we introduced both amino and carboxyl groups shows an excellent post thaw-survival efficiency of more than 90% of murine L929 cells. It can serve as the sole high molecular weight CPA for tissue engineering applications without animal derived materials.

A metal-free method for ultra-high molecular weight polyacrylonitrile under dimethyl sulfoxide

Polymer ◽  
2020 ◽  
pp. 123245
Author(s):  
Guanchun Rui ◽  
Qiang Lv ◽  
Jianmin Lu ◽  
Tianyu Wu ◽  
Shuai Zhao ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Dimethyl Sulfoxide ◽  
High Molecular Weight ◽  
Metal Free ◽  
Ultra High Molecular Weight

scholarly journals Carbopol 71G-NF polymer –The next pillar of oral solid dosage form

2020 ◽  
Vol 1 (1) ◽  
pp. 010-017
Author(s):  
R. Priyanka ◽  
R. Senthil Prabhu
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Acrylic Acid ◽  
High Molecular Weight ◽  
Dosage Form ◽  
Carboxyl Groups ◽  
Dry Powders ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Pharmaceutical Application

For pharmaceutical Oral Solid Dosage Form (OSDF) there are lots of excipients used and these excipients influence the drug release. In the recent decades there has been considerable interest in using carbopol polymers as excipients in a distinctive range of pharmaceutical application. Carbopol polymers are high molecular weight, cross linked, acrylic, acid-based polymers. Carbopol homopolymers are polymers of acrylic acid cross linked with ally sucrose or allylPentaerythritol. These polymers are offered as fluffy, white, dry powders. The carboxyl groups provided by the acrylic acid backbone of the polymer are responsible for many of the product benefits. This review work aims at guesstimate the characteristic of Carbopol 71G-NF polymer to be used as excipients in oral solid dosage form (OSDF).

scholarly journals Fabrication of Stable Nanofiber Matrices for Tissue Engineering via Electrospinning of Bare Laser-Synthesized Au Nanoparticles in Solutions of High Molecular Weight Chitosan

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1058 ◽  
Author(s):  
Viraj P. Nirwan ◽  
Ahmed Al-Kattan ◽  
Amir Fahmi ◽  
Andrei V. Kabashin
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Au Nanoparticles ◽  
Hybrid Nanofibers ◽  
Prolonged Contact ◽  
Ligand Free ◽  
The Mean ◽  
Biological Environment ◽  
Phosphate Buffered Saline

We report a methodology for the fabrication of neutralized chitosan-based nanofiber matrices decorated with bare Au nanoparticles, which demonstrate stable characteristics even after prolonged contact with a biological environment. The methodology consists of electrospinning of a mixture of bare (ligand-free) laser-synthesized Au nanoparticles (AuNPs) and solutions of chitosan/polyethylene oxide (ratio 1/3) containing chitosan of a relatively high molecular weight (200 kDa) and concentration of 3% (w/v). Our studies reveal a continuous morphology of hybrid nanofibers with the mean fiber diameter of 189 nm ± 86 nm, which demonstrate a high thermal stability. Finally, we describe a protocol for the neutralization of nanofibers, which enabled us to achieve their structural stability in phosphate-buffered saline (PBS) for more than six months, as confirmed by microscopy and FTIR measurements. The formed hybrid nanofibers exhibit unique physicochemical properties essential for the development of future tissue engineering platforms.

In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering

2010 ◽  
Vol 95A (3) ◽  
pp. 673-681 ◽  
Author(s):  
Jungju Kim ◽  
In Sook Kim ◽  
Tae Hyung Cho ◽  
Ho Chul Kim ◽  
So Jeong Yoon ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Molecular Weight ◽  
In Vivo Evaluation

Rheological properties of concentrated solutions of high-molecular-weight polyacrylonitrile in dimethyl sulfoxide

2011 ◽  
Vol 43 (1) ◽  
pp. 104-107 ◽  
Author(s):  
N. I. Kuz’min ◽  
A. V. Makarov ◽  
T. I. Podol’skaya ◽  
E. A. Rogova
Keyword(s):  
Molecular Weight ◽  
Dimethyl Sulfoxide ◽  
Rheological Properties ◽  
High Molecular Weight ◽  
Concentrated Solutions
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