Improvement of solubility and biocompatibility of MnO based nanoparticles in aqueous solutions

2011 ◽  
Vol 1346 ◽  
Author(s):  
Kerstin Koll ◽  
Thomas D. Schladt ◽  
Stefan Weber ◽  
Florian D. Jochum ◽  
Patrick Theato ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Term Stability ◽  
Long Term Stability ◽  
Sterile Filtration ◽  
Surface Modified ◽  
Multifunctional Polymers

ABSTRACTMnO nanoparticles were surface modified using two different multifunctional polymers. By introducing a PEG group, the long term stability, MRI applicability and sterile filtration could be greatly improved. Furthermore, PEGylated MnO NPs were less toxic compared to non-PEGylated NPs. The results suggest that these nanoparticles are suitable for in vivo applications.

Long-term stability of heparin-surface-modified intraocular lenses in vivo

1992 ◽  
Vol 18 (3) ◽  
pp. 247-251 ◽  
Author(s):  
Rolf Larsson ◽  
Göran Selén ◽  
Birgitta Formgren ◽  
Annsofi Holst
Keyword(s):  
Intraocular Lenses ◽  
Term Stability ◽  
Long Term Stability ◽  
Surface Modified

Robust oil-core nanocapsules with hyaluronate-based shells as promising nanovehicles for lipophilic compounds

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18867-18880 ◽  
Author(s):  
Joanna Szafraniec ◽  
Agnieszka Błażejczyk ◽  
Edyta Kus ◽  
Małgorzata Janik ◽  
Gabriela Zając ◽  
...  
Keyword(s):  
Lipophilic Compounds ◽  
Term Stability ◽  
Long Term Stability ◽  
Free Process

Biocompatible hyaluronate-based nanocapsules with liquid oil cores exhibiting long-term stability and tunable size were obtained in a versatile surfactant-free process and their biodistribution was studied in vivo and in vitro.

scholarly journals Comparison of the Efficacy of Two Novel Antitubercular Agents in Free and Liposome-Encapsulated Formulations

2021 ◽  
Vol 22 (5) ◽  
pp. 2457
Author(s):  
Nikoletta Kósa ◽  
Ádám Zolcsák ◽  
István Voszka ◽  
Gabriella Csík ◽  
Kata Horváti ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Drug Carrier ◽  
Antimycobacterial Activity ◽  
Size Exclusion ◽  
In Silico Docking ◽  
Term Stability ◽  
Long Term Stability

Tuberculosis is one of the top ten causes of death worldwide, and due to the appearance of drug-resistant strains, the development of new antituberculotic agents is a pressing challenge. Employing an in silico docking method, two coumaran (2,3-dihydrobenzofuran) derivatives—TB501 and TB515—were determined, with promising in vitro antimycobacterial activity. To enhance their effectiveness and reduce their cytotoxicity, we used liposomal drug carrier systems. Two types of small unilamellar vesicles (SUV) were prepared: multicomponent pH-sensitive stealth liposome (SUVmixed) and monocomponent conventional liposome. The long-term stability of our vesicles was obtained by the examination of particle size distribution with dynamic light scattering. Encapsulation efficiency (EE) of the two drugs was determined from absorption spectra before and after size exclusion chromatography. Cellular uptake and cytotoxicity were determined on human MonoMac-6 cells by flow cytometry. The antitubercular effect was characterized by the enumeration of colony-forming units on Mycobacterium tuberculosis H37Rv infected MonoMac-6 cultures. We found that SUVmixed + TB515 has the best long-term stability. TB515 has much higher EE in both types of SUVs. Cellular uptake for native TB501 is extremely low, but if it is encapsulated in SUVmixed it appreciably increases; in the case of TB515, quasi total uptake is accessible. It is concluded that SUVmixed + TB501 seems to be the most efficacious antitubercular formulation given the presented experiments; to find the most promising antituberculotic formulation for therapy further in vivo investigations are needed.

Long-Term Stability of Optical Properties of Colloidal CdSe Nanocrystals in Polymer Matrices

2019 ◽  
Vol 18 (03n04) ◽  
pp. 1940052
Author(s):  
Yu. M. Azhniuk ◽  
V. V. Lopushansky ◽  
A. V. Gomonnai ◽  
B. V. Lopushanska ◽  
A. E. Raevskaya ◽  
...  
Keyword(s):  
Optical Properties ◽  
Optical Absorption ◽  
Polyvinyl Alcohol ◽  
Aqueous Solutions ◽  
Polymer Matrices ◽  
Cdse Nanocrystals ◽  
Term Stability ◽  
Long Term Stability ◽  
Mild Conditions

Properties of CdSe nanocrystals (NCs) fabricated in aqueous solutions at relatively mild conditions in the presence of gelatine and stabilized in polymer (gelatine, gelatine + polyvinylpyrrolidone, polyvinyl alcohol) matrices are characterized by Raman, optical absorption and photoluminescence spectroscopies. The effect of heating of the reaction mixture on the average NC size is discussed.

Polydopamine nanoparticles' activity and long-term stability should be fully studied for gene therapy applications

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Structural Control ◽  
Thrombus Formation ◽  
Contact Process ◽  
Protein Corona ◽  
Structure Property ◽  
Term Stability ◽  
Long Term Stability

Many substantial hurdles must be solved for in vivo or in vitro clinical translation of the Polydopamine (PDA)-based nanomaterials. Excessive accumulation of residual unreacted DA and specific metabolites (DA or other small molecules) of PDA in vivo may trigger a possible syndrome of dopamine dysregulation characterized by addictive behaviour, as DA may act as an endogenous neurotoxin when its vesicular sequestration is dysregulated. PDA nanoparticles' activity and long-term stability should be fully studied for in vivo applications aside from probable toxicity. According to the findings, PDA's strong reactivity with numerous functional groups (catechol, quinone, and amine) is comparatively favorable, but in mild circumstances it may have negative effects on the organism owing to direct alcohol interactions. More crucially, the charged, moist adhesive PDA has a high affinity for protein attachment, which might be a major defect in the blood contact process. Direct blood contact with these PDA-based nanomaterials with high specific surface area would result in fast protein adsorption, the establishment of a "protein corona" within minutes, and increased thrombus formation risk. In vitro applications, on the other hand, can prevent the threat of detrimental cell or tissue effects. New rules, theories and processes on structure property performance relationships may be developed by researching the in vivo bioapplications of the above-mentioned PDA nanoarchitectures, possibly leading to fundamental and useful insights into in-vitro material translations. Despite the fact that major impediments to structural control persist, it is predicted that in the future, electron coupling will bring new answers to challenges of improved illness diagnosis and therapy.

Long term stability of organic selenium species in aqueous solutions

1998 ◽  
Vol 360 (5) ◽  
pp. 512-519 ◽  
Author(s):  
R. Muñoz Olivas ◽  
Philippe Quevauviller ◽  
O. F. X. Donard
Keyword(s):  
Aqueous Solutions ◽  
Selenium Species ◽  
Term Stability ◽  
Organic Selenium ◽  
Long Term Stability

The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent

Biomaterials ◽  
2012 ◽  
Vol 33 (31) ◽  
pp. 7794-7802 ◽  
Author(s):  
V. Vaijayanthimala ◽  
Po-Yun Cheng ◽  
Shih-Hua Yeh ◽  
Kuang-Kai Liu ◽  
Cheng-Hsiang Hsiao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Term Stability ◽  
Long Term Stability

A surface-modified sperm sorting device with long-term stability

2006 ◽  
Vol 8 (2) ◽  
pp. 99-107 ◽  
Author(s):  
Jason M. Wu ◽  
Yaokuang Chung ◽  
Kimberly J. Belford ◽  
Gary D. Smith ◽  
Shuichi Takayama ◽  
...  
Keyword(s):  
Term Stability ◽  
Long Term Stability ◽  
Sperm Sorting ◽  
Surface Modified
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