The Synthesis and Self-Assembly Studies of Two Bioactive BMP-7 Short Peptides Modified Rosette Nanotubes for Bone Tissue Engineering

2011 ◽  
Vol 1316 ◽  
Author(s):  
Alaaeddin Alsbaiee ◽  
Mounir El Bakkari ◽  
Hicham Fenniri
Keyword(s):  
Self Assembly ◽  
Organic Materials ◽  
Cell Function ◽  
Bone Fractures ◽  
Bone Cell ◽  
Titanium Implants ◽  
Implant Loosening ◽  
Bone Fixation ◽  
Rosette Nanotubes ◽  
Bone Complications

ABSTRACTBone fractures are one of the most common bone complications. In more severe cases, bone fixation is accomplished using titanium (Ti) implant materials. Unfortunately, the need for revision surgery often arises due to implant loosening and/or deterioration of the implant/bone interface. Rosette nanotubes (RNTs) are a class of self-assembled organic materials obtained through the self-assembly of a guanine-cytosine hybrid base (G∧C motif). These organic materials have been found to increase osteoblast (bone forming cells) adhesion and hydroxyapatite deposition (bone regeneration) on titanium implants as well as on engineered hydrogels. In order to increase the bioactivity of RNTs to enhance bone cell function on Ti implants, two RNT motifs functionalized with different bioactive deca-peptides (A, B) chosen from the knuckle region of bone morphogenic proteins-7 (BMP-7) were synthesized. Their self-assembly process was investigated in water using UV-Vis and SEM techniques.

Cadmium toxicity: A role in bone cell function and teeth development

2021 ◽  
Vol 769 ◽  
pp. 144646
Author(s):  
Yonggang Ma ◽  
Di Ran ◽  
Xueni Shi ◽  
Hongyan Zhao ◽  
Zongping Liu
Keyword(s):  
Cell Function ◽  
Cadmium Toxicity ◽  
Bone Cell ◽  
Teeth Development

Cells of the Immune System Orchestrate Changes in Bone Cell Function

2013 ◽  
Vol 94 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Sarah E. Wythe ◽  
Vicky Nicolaidou ◽  
Nicole J. Horwood
Keyword(s):  
Immune System ◽  
Cell Function ◽  
Bone Cell

Hierarchical Self-Assembly of Organic Prolate Nanospheroids from Hydrophobic Rosette Nanotubes

Langmuir ◽  
2008 ◽  
Vol 24 (9) ◽  
pp. 4447-4450 ◽  
Author(s):  
Grigory Tikhomirov ◽  
Takeshi Yamazaki ◽  
Andriy Kovalenko ◽  
Hicham Fenniri
Keyword(s):  
Self Assembly ◽  
Rosette Nanotubes

Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis

2021 ◽  
Author(s):  
Wenqing Liang ◽  
Xudong Wu ◽  
Yongqiang Dong ◽  
Xuerong Chen ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Cell Function ◽  
Bone Cell ◽  
Mechanical Stimuli

scholarly journals Redox-promoted associative assembly of metal–organic materials

2016 ◽  
Vol 7 (1) ◽  
pp. 707-712 ◽  
Author(s):  
Martin Glavinović ◽  
Feng Qi ◽  
Athanassios D. Katsenis ◽  
Tomislav Friščić ◽  
Jean-Philip Lumb
Keyword(s):  
Solid State ◽  
Self Assembly ◽  
Organic Materials ◽  
Metal Oxidation ◽  
Metal Organic ◽  
One Step

We develop an associative synthesis of metal–organic materials that combines solid-state metal oxidation and coordination-driven self-assembly into a one-step, waste-free transformation.

Role of calcium in bone maturation arrest after thyroparathyroidectomy in the rat

1977 ◽  
Vol 232 (1) ◽  
pp. F33-F41
Author(s):  
J. M. Burnell ◽  
E. Teubner ◽  
D. Korn ◽  
A. Miller
Keyword(s):  
Cell Function ◽  
Bone Cell ◽  
X Ray Diffraction ◽  
Mineral Density ◽  
Bone Maturation ◽  
Bone Changes ◽  
Chemical Studies ◽  
Normal Increase ◽  
Bone Abnormalities

Thyroparathyroidectomy in the rat results in decreased plasma calcium and magnesium and increased phosphorus. The associated bone changes are decreased calcium, hydroxyproline, carbonate, and wholebone density. Bone magnesium, sodium, mineral density, and percent crystallinity are increased. The delayed matrix formation and mineralization previously identified by histologic techniques are herein characterized by direct measurement as arrest of the normal increase of hydroxyproline/matrix and percent mineral. The bone mineral present is of high density and x-ray-diffraction crystallinity, suggesting a decrease in the mineralization front high in the amorphous phase and/or small nondiffracting crystalloids. The chemical studies reveal that in the absence of available Ca, Mg and Na are substituted, and CO3 is decreased. The restoration of these plasma and bone abnormalities to normal by a diet high in CaCO3 adds further emphasis to the essential role of Ca in bone cell function.

Clopidogrel (plavix), a P2Y12 receptor antagonist, inhibits bone cell function in vitro and decreases trabecular bone in vivo

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S45
Author(s):  
S. Syberg ◽  
A. Brandao-Burch ◽  
J.J. Patel ◽  
M.O. Hajjawi ◽  
T.R. Arnett ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Trabecular Bone ◽  
Cell Function ◽  
Bone Cell ◽  
P2y12 Receptor ◽  
P2y12 Receptor Antagonist

scholarly journals Clopidogrel (Plavix), a P2Y12receptor antagonist, inhibits bone cell function in vitro and decreases trabecular bone in vivo

2012 ◽  
Vol 27 (11) ◽  
pp. 2373-2386 ◽  
Author(s):  
Susanne Syberg ◽  
Andrea Brandao-Burch ◽  
Jessal J Patel ◽  
Mark Hajjawi ◽  
Timothy R Arnett ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Cell Function ◽  
Bone Cell
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