Electrostatic and Steric Effect of Peptides Functionalized on Self-Assembled Rosette Nanotubes

2011 ◽  
Vol 1316 ◽  
Author(s):  
Mounir El-Bakkari ◽  
Rachel L. Beingessner ◽  
Aws Alshamsan ◽  
Jae-Young Cho ◽  
Hicham Fenniri
Keyword(s):  
Self Assembly ◽  
Photonic Devices ◽  
Net Charge ◽  
Rosette Nanotubes ◽  
Self Assembling ◽  
Dna Base ◽  
Artificial Channel ◽  
Group Density ◽  
The Stability

ABSTRACTDiscrete nanoscale tubular architectures have received significant attention during the past decade because of their potential role in electronic and photonic devices, sensors, liquid crystals, artificial channel systems and biomedical engineering [1-2]. Our research group has reported the synthesis and characterization of the bicyclic G∧C motif, a self complementary DNA base analogue, which undergoes hierarchical self-assembly to form Rosette Nanotubes (RNTs) [3]. The stability of this system depends however, on functional group density (sterics) and net charge (electrostatics) on the RNT surface [5c]. To this end, we have synthesized several G∧C modules bearing oligopeptides with different lengths and net charge and investigated their self-assembling properties.

scholarly journals On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 91 ◽  
Author(s):  
Marta Gozzi ◽  
Benedikt Schwarze ◽  
Peter Coburger ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Assembly Behavior ◽  
Biological Performance ◽  
Type 3

3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

Novel Self-Complimentary Tricyclic Heterocycles: Expanding the Chemistry of Self-Assembled Rosette Nanotubes

2007 ◽  
Vol 1057 ◽  
Author(s):  
Gabor Borzsonyi ◽  
Andrew J. Myles ◽  
Ross Johnson ◽  
Jae-Young Cho ◽  
Takeshi Yamazaki ◽  
...  
Keyword(s):  
Self Assembly ◽  
External Diameter ◽  
Rosette Nanotubes ◽  
Self Assembled

ABSTRACTIn an effort to increase the internal and external diameter of the RNT's, tricyclic GΛC base derivatives (XGΛC) have been synthesized and characterized. Hierchichal self-assembly results in formation of RNT's with an increased diameter, as evidenced by AFM and TEM measurements. Progress on the derivitization and characterization of the XGΛC RNT's will be presented.

Labeling of Nanofiber-Forming Peptides by Site-Directed Bioconjugation: Effect of Spacer Length on Self-Assembly

2019 ◽  
Vol 16 (2) ◽  
pp. 319-325
Author(s):  
Alessandra Scelsi ◽  
Brigida Bochicchio ◽  
Antonietta Pepe
Keyword(s):  
Self Assembly ◽  
Organic Molecules ◽  
Periodate Oxidation ◽  
Photonic Devices ◽  
Serine Residue ◽  
Spacer Length ◽  
Small Organic Molecules ◽  
Self Assembling ◽  
Versatile Tool

Background: The conjugation of small organic molecules to self-assembling peptides is a versatile tool to decorate nanostructures with original functionalities. Labeling with chromophores or fluorophores, for example, creates optically active fibers with potential interest in photonic devices. Aim and Objective: In this work, we present a rapid and effective labeling procedure for a self-assembling peptide able to form nanofibers. Rapid periodate oxidation of the N-terminal serine residue of the peptide and subsequent conjugation with dansyl moiety generated fluorophore-decorated peptides. Results: Three dansyl-conjugated self-assembling peptides with variable spacer-length were synthesized and characterized and the role of the size of the linker between fluorophore and peptide in self-assembling was investigated. Our results show that a short linker can alter the self-assembly in nanofibers of the peptide. Conclusions: Herein we report on an alternative strategy for creating functionalized nanofibrils, able to expand the toolkit of chemoselective bioconjugation strategies to be used in site-specific decoration of self-assembling peptides.

Spectroscopic characterization of water soluble phosphonato corrole: The effect of H-bounds on the self-assembled species

2016 ◽  
Vol 20 (08n11) ◽  
pp. 1272-1276 ◽  
Author(s):  
Rosalba Randazzo ◽  
Andrea Savoldelli ◽  
D. Andrea Cristaldi ◽  
Alessandra Cunsolo ◽  
Massimiliano Gaeta ◽  
...  
Keyword(s):  
Self Assembly ◽  
Hierarchical Control ◽  
Functional Materials ◽  
Spectroscopic Characterization ◽  
Research Field ◽  
Water Soluble ◽  
Self Assembling ◽  
Hierarchical Aggregation ◽  
Porphyrin Derivatives

Hierarchical self-assembly of porphyrins is an intrigue research field, which can lead to the design of functional materials. Porphyrin derivatives self-assembling under hierarchical control allows to understand the principles governing molecular recognition processes, as demonstrated for meso-tetrakis(4-phosphonatophenyl)porphyne (H2TPPP) whose polyprotic nature is responsible for a pH-dependent hierarchical aggregation. Herein, self-assembly of meso-tris(4-phosphonatophenyl)corrole (TPPC) in aqueous solution has been spectroscopically studied and compared to that of TPPP. The corrole aggregation does not follow the hierarchical rules that govern the porphyrin counterpart due to the accessibility of the core of the macrocycle to protons, promoted by the reduced number of involved intermolecular H-bonds.

Preparation of Self-Assembly Monolayer by Scratching Si(100) Surface in the Presence of Aryl Diazonium Salts

2009 ◽  
Vol 60-61 ◽  
pp. 406-409
Author(s):  
Li Qiu Shi ◽  
Tao Sun ◽  
Feng Yu ◽  
Shen Dong ◽  
Fu Long Yuan
Keyword(s):  
Self Assembly ◽  
Density Functional ◽  
Active Species ◽  
First Principles Calculation ◽  
Silicon Sample ◽  
Covalent Bonds ◽  
Self Assembling ◽  
Aryldiazonium Salt ◽  
Before And After ◽  
The Stability

Mechanical scratching and chemical self-assembling can be combined to fabricate nano- or micro-scale functional structures on the oxide-coated silicon. The chemo-active species, such as NO2C6H4 groups, can be produce from aryldiazonium salt due to the breaking of chemical bond of silicon substrate when the diamond tool scratches the silicon sample in the presence of 4-benzoic nitryl diazonium tetrafluoroborate (NO2C6H4N2BF4). They may then induce grafting of an organic monolayer on the substrate via Si-C connection. The surface morphologies before and after chemomechanical reaction are characterized with Atomic Force Microscopy (AFM). We propose that chemomechanical reaction, which occurred during scratching the silicon surface, produce NO2C6H4 groups from aryldiazonium salt. The NO2C6H4 groups further bond with surface Si atoms via Si-C covalent bonds as confirmed from Infrared Spectroscopy (IR) results. To better understand the framework of the self-assembly monolayers (SAMs) on Si (100) surface, the first principles calculation at density functional theory levels has been employed to investigate the binding energy, bonds length and bonds angle. The reduced energy of system illuminates that the SAMs can be fabricated easily between aryldiazonium salt and Si (100) surface. The stability of system can be improved and SAMs can firmly stay on Si (100) surface.

Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

2011 ◽  
Vol 1301 ◽  
Author(s):  
Min Dai ◽  
Jennifer S. Haghpanah ◽  
Carlo Yuvienco ◽  
Jin Kim Montclare
Keyword(s):  
Self Assembly ◽  
Matrix Protein ◽  
Coiled Coil ◽  
Supramolecular Assembly ◽  
Stimuli Responsive ◽  
Block Polymers ◽  
Self Assembling ◽  
Assembly Behavior ◽  
Protein Block

ABSTRACTWe describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

Combinatorial Approach to Materials Fabrication from Higher Hierarchies of Rosette Nanotubes

2007 ◽  
Vol 1057 ◽  
Author(s):  
Grigory Tikhomirov ◽  
Hicham Fenniri
Keyword(s):  
Electron Microscopy ◽  
Self Assembly ◽  
The Self ◽  
Combinatorial Approach ◽  
X Ray ◽  
Force Microscopy ◽  
Rosette Nanotubes ◽  
Self Assembling ◽  
Atomic Force ◽  
Transmission Electron

ABSTRACTThe self-assembly of six self-complimentary Guanine – Cytosine hybrid heterocycles bearing hydrophobic substituents has been studied using combinatorial approach in eight solvents under different conditions. The parameters that were varied include: the structure of the self-assembling module, its concentration, the solvent, temperature, and time of self-assembly. scanning electron microscopy (SEM) was used as a screening tool. A wide variety of interesting morphologies was found. The most interesting structures were studied by atomic force microscopy (AFM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray powder diffraction (XRD).

scholarly journals Polyaniline–nanodiamond fibers resulting from the self-assembly of nano-fibrils: a nanomechanical study

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14358-14367 ◽  
Author(s):  
Daniele Passeri ◽  
Emanuela Tamburri ◽  
Maria Letizia Terranova ◽  
Marco Rossi
Keyword(s):  
Atomic Force Microscopy ◽  
Self Assembly ◽  
The Self ◽  
Force Microscopy ◽  
Self Assembling ◽  
Atomic Force

Nanomechanical characterization of micrometric fibers of polyaniline (PANI) doped with nanodiamond (ND) particles resulting from the self-assembling of PANI/ND nano-fibrils has been performed using torsional harmonics atomic force microscopy.

Preparation and Characterization of Poly-γ-Glutamic Acid-Based Nanoparticles Biomacromolecules

2014 ◽  
Vol 915-916 ◽  
pp. 891-894
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Glutamic Acid ◽  
Surface Charge ◽  
Size Distribution ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Low Ph ◽  
Biodegradable Nanoparticles ◽  
Self Assembling ◽  
Ph Conditions

The present paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-γ-glutamic acid (γ-PGA). The nanosystems were stable inaqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. Surface charge and mobility were measured electrophoretically. It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA solutions and their ratio as well as on the pH of the mixture and the order of addition. The average hydrodynamic diameters were between 150 and 330 nm. These biodegradable,self-assembling stable nanocomplexes might be useful for several biomedical applications.

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