Guided assembly of nanowires and their integration in microfluidic devices

2011 ◽  
Vol 1346 ◽  
Author(s):  
Josep Puigmarti-Luis ◽  
Phillip Kuhn ◽  
Benjamin Z. Cvetković ◽  
Daniel Schaffhauser ◽  
Marta Rubio-Martínez ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Coordination Polymers ◽  
Microfluidic Devices ◽  
Hybrid Structures ◽  
Effective Strategy ◽  
Microfluidic Platforms ◽  
Guided Assembly

ABSTRACTIn this contribution, we present an effective strategy for assembling and integrating functional, in situ formed micro- and nanosized structures. Microfluidic platforms are employed to form anisotropic hybrid structures and coordination polymers at the interface of two precursor streams. Microstamps, embedded in the microfluidic device and actuated by pressure, provide a facile and reliable technology for structure trapping, localization and integration.

scholarly journals Design and application of a microfluidic device for protein crystallization using an evaporation-based crystallization technique

2011 ◽  
Vol 45 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Yong Yu ◽  
Xuan Wang ◽  
Dominik Oberthür ◽  
Arne Meyer ◽  
Markus Perbandt ◽  
...  
Keyword(s):  
Relative Humidity ◽  
Microfluidic Device ◽  
Gas Permeability ◽  
Protein Crystallization ◽  
Microfluidic Devices ◽  
Protein Crystals ◽  
Air Bubbles ◽  
Crystallization System ◽  
Relationship Of

A new crystallization system is described, which makes it possible to use an evaporation-based microfluidic crystallization technique for protein crystallization. The gas and water permeability of the used polydimethylsiloxane (PDMS) material enables evaporation of the protein solution in the microfluidic device. The rates of evaporation are controlled by the relative humidity conditions, which are adjusted in a precise and stable way by using saturated solutions of different reagents. The protein crystals could nucleate and grow under different relative humidity conditions. Using this method, crystal growth could be improved so that approximately 1 mm-sized lysozyme crystals were obtained more successfully than using standard methods. The largest lysozyme crystal obtained reached 1.57 mm in size. The disadvantage of the good gas permeability in PDMS microfluidic devices becomes an advantage for protein crystallization. The radius distributions of aggregrates in the solutions inside the described microfluidic devices were derived fromin situdynamic light scattering measurements. The experiments showed that the environment inside of the microfluidic device is more stable than that of conventional crystallization techniques. However, the morphological results showed that the protein crystals grown in the microfluidic device could lose their morphological stability. Air bubbles in microfluidic devices play an important role in the evaporation progress. A model was constructed to analyze the relationship of the rates of evaporation and the growth of air bubbles to the relative humidity.

A Thread/Fabric-Based Band as A Flexible and Wearable Microfluidic Device for Sweat Sensing and Monitoring

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Zhiqi Zhao ◽  
Qiujin Li ◽  
Linna Chen ◽  
Yu Zhao ◽  
Jixian Gong ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Point Of Care ◽  
Monitoring Systems ◽  
Biological Analytes

Flexible biosensors for monitoring systems have emerged as a promising portable diagnostics platform due to their potential for in situ point-of-care (POC) analytic devices. Assessment of biological analytes in sweat...

scholarly journals Adenosine Triphosphate Measurement in Deep Sea Using a Microfluidic Device

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 370 ◽  
Author(s):  
Tatsuhiro Fukuba ◽  
Takuroh Noguchi ◽  
Kei Okamura ◽  
Teruo Fujii
Keyword(s):  
Adenosine Triphosphate ◽  
Microfluidic Device ◽  
Deep Sea ◽  
Temperature Sensor ◽  
Biochemical Parameter ◽  
Underwater Vehicle ◽  
Luciferase Assay ◽  
Bioluminescence Intensity

Total ATP (adenosine triphosphate) concentration is a useful biochemical parameter for detecting microbial biomass or biogeochemical activity anomalies in the natural environment. In this study, we describe the development and evaluation of a new version of in situ ATP analyzer improved for the continuous and quantitative determination of ATP in submarine environments. We integrated a transparent microfluidic device containing a microchannel for cell lysis and a channel for the bioluminescence L–L (luciferin–luciferase) assay with a miniature pumping unit and a photometry module for the measurement of the bioluminescence intensity. A heater and a temperature sensor were also included in the system to maintain an optimal temperature for the L–L reaction. In this study, the analyzer was evaluated in deep sea environments, reaching a depth of 200 m using a remotely operated underwater vehicle. We show that the ATP analyzer successfully operated in the deep-sea environment and accurately quantified total ATP within the concentration lower than 5 × 10−11 M.

scholarly journals Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4124 ◽  
Author(s):  
Fabiana Felix ◽  
Alexandre Baccaro ◽  
Lúcio Angnes
Keyword(s):  
Quality Management ◽  
Signal Amplification ◽  
Screen Printing ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Strong Interactions ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Broad Variety ◽  
Interesting Alternative

Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.

Four unexpected lanthanide coordination polymers involving in situ reaction of solvent N, N-Dimethylformamide

2015 ◽  
Vol 225 ◽  
pp. 216-221 ◽  
Author(s):  
Jun-Cheng Jin ◽  
Wen-Quan Tong ◽  
Ai-Yun Fu ◽  
Cheng-Gen Xie ◽  
Wen-Gui Chang ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
In Situ Reaction ◽  
Lanthanide Coordination Polymers

The construction of Cu(i)/Cu(ii) coordination polymers based on pyrazine–carboxylate: Structural diversity tuned by in situ hydrolysis reaction

CrystEngComm ◽  
2013 ◽  
Vol 15 (26) ◽  
pp. 5359 ◽  
Author(s):  
Zhen-Zhen Wen ◽  
Xi-Ling Wen ◽  
Song-Liang Cai ◽  
Sheng-Run Zheng ◽  
Jun Fan ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Structural Diversity ◽  
Hydrolysis Reaction

scholarly journals Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 387
Author(s):  
Carlos Toshiyuki Matsumi ◽  
Wilson José da Silva ◽  
Fábio Kurt Schneider ◽  
Joaquim Miguel Maia ◽  
Rigoberto E. M. Morales ◽  
...  
Keyword(s):  
Electric Fields ◽  
Microfluidic Device ◽  
Soft Lithography ◽  
Low Cost ◽  
Characteristic Curve ◽  
Microfluidic Devices ◽  
Average Diameter ◽  
Internal Diameter ◽  
Medical Diagnostic ◽  
Average Size

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e.g., CEHDA) or soft lithography equipment for the production of microfluidic devices. This study presents a hybrid manufacturing process using micropipettes and 3D printing for the construction of a T-Junction microfluidic device resulting in simple and low cost generation of monodisperse microbubbles. In this work, microbubbles with an average size of 16.6 to 57.7 μm and a polydispersity index (PDI) between 0.47% and 1.06% were generated. When the device is used at higher bubble production rate, the average diameter was 42.8 μm with increased PDI of 3.13%. In addition, a second-order polynomial characteristic curve useful to estimate micropipette internal diameter necessary to generate a desired microbubble size is presented and a linear relationship between the ratio of gaseous and liquid phases flows and the ratio of microbubble and micropipette diameters (i.e., Qg/Ql and Db/Dp) was found.

In situ fabrication of a microfluidic device for immobilised metal affinity sensing

2012 ◽  
Vol 29 (4) ◽  
pp. 494-501 ◽  
Author(s):  
Abhishek G. Deshpande ◽  
Nicholas J. Darton ◽  
Kamran Yunus ◽  
Adrian C. Fisher ◽  
Nigel K.H. Slater
Keyword(s):  
Microfluidic Device ◽  
Metal Affinity ◽  
In Situ Fabrication
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