Material considerations for optical interfacing to the nervous system

MRS Bulletin ◽  
2012 ◽  
Vol 37 (6) ◽  
pp. 599-605 ◽  
Author(s):  
Mykyta M. Chernov ◽  
Austin R. Duke ◽  
Jonathan M. Cayce ◽  
Spencer W. Crowder ◽  
Hak-Joon Sung ◽  
...  
Keyword(s):  
Optical Sensors ◽  
Materials Science ◽  
Neural Interfaces ◽  
Neuronal Populations ◽  
Science Community ◽  
New Generation ◽  
Voltage Sensitive Dyes ◽  
Electrophysiological Methods ◽  
Implanted Devices

Optical neural interfaces offer several advantages over electrophysiological methods in both clinical and experimental applications. Optical stimulation techniques exhibit high spatial selectivity, do not create electrical artifacts, and allow for stimulation of specific neuronal populations. Calcium- and voltage-sensitive dyes can probe neuronal and astrocytic signaling at both single cell and network scales, and miniature optical sensors can measure a variety of physiological signals in situ. However, optical neural interfaces must be robust, safe, and effective over long periods of time in order to be acceptable for use in human patients. In this article, we draw the attention of the materials science community to the need for a new generation of materials that have the necessary optical performance and, at the same time, conform to the constraints placed on implanted devices in terms of size, relevant mechanical properties, and biocompatibility, providing some examples of recent advancements in the field.

scholarly journals Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1173 ◽  
Author(s):  
Alberto Rico-Yuste ◽  
Sergio Carrasco
Keyword(s):  
Hybrid Materials ◽  
Optical Sensors ◽  
Materials Science ◽  
Synergetic Effect ◽  
Optical Signal ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Recognition Ability ◽  
Recognition Elements ◽  
New Generation

We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

Electron holography of interfaces in electroceramics

1993 ◽  
Vol 51 ◽  
pp. 1088-1089
Author(s):  
Vinayak P. Dravid ◽  
V. Ravikumar ◽  
Richard Plass
Keyword(s):  
Space Charge ◽  
Direct Evidence ◽  
Materials Science ◽  
Theoretical Work ◽  
Electron Holography ◽  
Resolution Limit ◽  
Interference Phenomenon ◽  
X Ray ◽  
Electron Sources ◽  
Science Community

With the advent of coherent electron sources with cold field emission guns (cFEGs), it has become possible to utilize the coherent interference phenomenon and perform “practical” electron holography. Historically, holography was envisioned to extent the resolution limit by compensating coherent aberrations. Indeed such work has been done with reasonable success in a few laboratories around the world. However, it is the ability of electron holography to map electrical and magnetic fields which has caught considerable attention of materials science community.There has been considerable theoretical work on formation of space charge on surfaces and internal interfaces. In particular, formation and nature of space charge have important implications for the performance of numerous electroceramics which derive their useful properties from electrically active grain boundaries. Bonnell and coworkers, in their elegant STM experiments provided the direct evidence for GB space charge and its sign, while Chiang et al. used the indirect but powerful technique of x-ray microchemical profiling across GBs to infer the nature of space charge.

Remote On-Line Control of a High-Voltage in situ Transmission Electron Microscope with A Rational User Interface

1996 ◽  
Vol 54 ◽  
pp. 384-385
Author(s):  
M.A. O’Keefe ◽  
J. Taylor ◽  
D. Owen ◽  
B. Crowley ◽  
K.H. Westmacott ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
User Interface ◽  
Transmission Electron Microscope ◽  
High Voltage ◽  
Materials Science ◽  
Transmission Electron ◽  
On Line ◽  
Electron Microscopes

Remote on-line electron microscopy is rapidly becoming more available as improvements continue to be developed in the software and hardware of interfaces and networks. Scanning electron microscopes have been driven remotely across both wide and local area networks. Initial implementations with transmission electron microscopes have targeted unique facilities like an advanced analytical electron microscope, a biological 3-D IVEM and a HVEM capable of in situ materials science applications. As implementations of on-line transmission electron microscopy become more widespread, it is essential that suitable standards be developed and followed. Two such standards have been proposed for a high-level protocol language for on-line access, and we have proposed a rational graphical user interface. The user interface we present here is based on experience gained with a full-function materials science application providing users of the National Center for Electron Microscopy with remote on-line access to a 1.5MeV Kratos EM-1500 in situ high-voltage transmission electron microscope via existing wide area networks. We have developed and implemented, and are continuing to refine, a set of tools, protocols, and interfaces to run the Kratos EM-1500 on-line for collaborative research. Computer tools for capturing and manipulating real-time video signals are integrated into a standardized user interface that may be used for remote access to any transmission electron microscope equipped with a suitable control computer.

The Contribution of Intermediate-Voltage, High-Resolution Electron Microscopy In Materials Science: An Appraisal

1990 ◽  
Vol 48 (1) ◽  
pp. 478-479
Author(s):  
John L. Hutchison
Keyword(s):  
High Resolution ◽  
Materials Science ◽  
High Resolution Electron Microscopy ◽  
Optical Diffraction ◽  
The Past ◽  
Resolution Electron ◽  
Extreme Sensitivity ◽  
Electron Microscopes ◽  
New Generation ◽  
Small Metal Particles

Over the past five years or so the development of a new generation of high resolution electron microscopes operating routinely in the 300-400 kilovolt range has produced a dramatic increase in resolution, to around 1.6 Å for “structure resolution” and approaching 1.2 Å for information limits. With a large number of such instruments now in operation it is timely to assess their impact in the various areas of materials science where they are now being used. Are they falling short of the early expectations? Generally, the manufacturers’ claims regarding resolution are being met, but one unexpected factor which has emerged is the extreme sensitivity of these instruments to both floor-borne and acoustic vibrations. Successful measures to counteract these disturbances may require the use of special anti-vibration blocks, or even simple oil-filled dampers together with springs, with heavy curtaining around the microscope room to reduce noise levels. In assessing performance levels, optical diffraction analysis is becoming the accepted method, with rotational averaging useful for obtaining a good measure of information limits. It is worth noting here that microscope alignment becomes very critical for the highest resolution.In attempting an appraisal of the contributions of intermediate voltage HREMs to materials science we will outline a few of the areas where they are most widely used. These include semiconductors, oxides, and small metal particles, in addition to metals and minerals.

scholarly journals Review on advances in microcrystalline, nanocrystalline and ultrananocrystalline diamond films-based micro/nano-electromechanical systems technologies

2021 ◽  
Vol 56 (12) ◽  
pp. 7171-7230
Author(s):  
Orlando Auciello ◽  
Dean M. Aslam
Keyword(s):  
Materials Science ◽  
Positive Impact ◽  
Diamond Films ◽  
Energy Generation ◽  
Nanoelectromechanical Systems ◽  
Environmental Sensors ◽  
Implantable Biosensors ◽  
Ultrananocrystalline Diamond ◽  
Film Synthesis ◽  
New Generation

AbstractA comprehensive review is presented on the advances achieved in past years on fundamental and applied materials science of diamond films and engineering to integrate them into new generations of microelectromechanical system (MEMS) and nanoelectromechanical systems (NEMS). Specifically, the review focuses on describing the fundamental science performed to develop thin film synthesis processes and the characterization of chemical, mechanical, tribological and electronic properties of microcrystalline diamond, nanocrystalline diamond and ultrananocrystalline diamond films technologies, and the research and development focused on the integration of the diamond films with other film-based materials. The review includes both theoretical and experimental work focused on optimizing the films synthesis and the resulting properties to achieve the best possible MEMS/NEMS devices performance to produce new generation of MEMS/NEMS external environmental sensors and energy generation devices, human body implantable biosensors and energy generation devices, electron field emission devices and many more MEMS/NEMS devices, to produce transformational positive impact on the way and quality of life of people worldwide.

Engaging with the science and politics of biodiversity futures: a literature review

2021 ◽  
pp. 1-8
Author(s):  
Carina Wyborn ◽  
Elena Louder ◽  
Mike Harfoot ◽  
Samantha Hill
Keyword(s):  
Human Life ◽  
Global Environmental Change ◽  
Life Forms ◽  
Trade Offs ◽  
Global Environmental ◽  
Science And Politics ◽  
Science Community ◽  
Impact On Biodiversity ◽  
Made In

Summary Future global environmental change will have a significant impact on biodiversity through the intersecting forces of climate change, urbanization, human population growth, overexploitation, and pollution. This presents a fundamental challenge to conservation approaches, which seek to conserve past or current assemblages of species or ecosystems in situ. This review canvases diverse approaches to biodiversity futures, including social science scholarship on the Anthropocene and futures thinking alongside models and scenarios from the biophysical science community. It argues that charting biodiversity futures requires processes that must include broad sections of academia and the conservation community to ask what desirable futures look like, and for whom. These efforts confront political and philosophical questions about levels of acceptable loss, and how trade-offs can be made in ways that address the injustices in the distribution of costs and benefits across and within human and non-human life forms. As such, this review proposes that charting biodiversity futures is inherently normative and political. Drawing on diverse scholarship united under a banner of ‘futures thinking’ this review presents an array of methods, approaches and concepts that provide a foundation from which to consider research and decision-making that enables action in the context of contested and uncertain biodiversity futures.

Application of In-Situ Mechanics Approach in Materials Science Problems

2020 ◽  
pp. 141-203
Author(s):  
Pranjal Nautiyal ◽  
Benjamin Boesl ◽  
Arvind Agarwal
Keyword(s):  
Materials Science

scholarly journals In situ tether formation from amines and alcohols enabling highly selective Tsuji–Trost allylation and olefin functionalization

2017 ◽  
Vol 8 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Ugo Orcel ◽  
Jérôme Waser
Keyword(s):  
New Generation

A new generation of methods based on in situ tether formation greatly enhances the efficiency and selectivity of olefin functionalization.

Dynamic Formation Evaluation to Reduce Uncertainty and Confirm Completed Intervals in Brown Fields

2021 ◽  
Author(s):  
Muhamad Aizat Kamaruddin ◽  
Ayham Ashqar ◽  
Muhammad Haniff Suhaimi ◽  
Fairus Azwardy Salleh
Keyword(s):  
Real Time ◽  
Optical Sensors ◽  
Sensor Technology ◽  
Innovative Technology ◽  
Fluid Type ◽  
Formation Evaluation ◽  
Reservoir Fluid ◽  
Logging While Drilling ◽  
Dynamic Formation

Abstract Uncertainties in fluid typing and contacts within Sarawak Offshore brown field required a real time decision. To enhance reservoir fluid characterisation and confirm reservoir connectivity prior to well final total depth (TD). Fluid typing while drilling was selected to assure the completion strategy and ascertain the fluvial reservoir petrophysical interpretation. Benefiting from low invasion, Logging While Drilling (LWD) sampling fitted with state of ART advanced spectroscopy sensors were deployed. Pressures and samples were collected. The well was drilled using synthetic base mud. Conventional logging while drilling tool string in addition to sampling tool that is equipped with advanced sensor technology were deployed. While drilling real time formation evaluation allowed selecting the zones of interest, while fluid typing was confirmed using continually monitored fluids pump out via multiple advanced sensors, contamination, and reservoir fluid properties were assessed while pumping. Pressure and sampling were performed in drilling mode to minimise reservoir damage, and optimise rig time, additionally sampling while drilling was performed under circulation conditions. Pressures were collected first followed by sampling. High success in collecting pressure points with a reliable fluid gradient that indicated a virgin reservoir allowed the selection of best completion strategy without jeopardising reserves, and reduced rig time. Total of seven samples from 3 different reservoirs, four oil, and three formation water. High quality samples were collected. The dynamic formation evaluation supported by while drilling sampling confirmed the reservoir fluid type and successfully discovered 39ft of oil net pay. Reservoir was completed as an oil producer. The Optical spectroscopy measurements allowed in situ fluid typing for the quick decision making. The use of advanced optical sensors allowed the sample collection and gave initial assessment on reservoir fluids properties, as a result cost saving due to eliminating the need for additional Drill Stem Test (DST) run to confirm the fluid type. Sample and formation pressures has confirmed reservoir lateral continuity in the vicinity of the field. The reservoir developed as thick and blocky sandstone. Collected sample confirmed the low contamination levels. Continuous circulation mitigated sticking and potential well-control risks. This is the first time in surrounding area, advanced optical sensors are used to aid LWD sampling and to finalize the fluid identification. The innovative technology allowed the collection of low contamination. The real-time in-situ fluid analysis measurement allowed critical decisions to be made real time, consequently reducing rig downtime. Reliable analysis of fluid type identification removed the need for additional run/service like DST etc.

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