scholarly journals 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

2018 ◽  
Vol 9 (01) ◽  
pp. 37-52 ◽  
Author(s):  
Annamarija Raic ◽  
Toufik Naolou ◽  
Anna Mohra ◽  
Chandralekha Chatterjee ◽  
Cornelia Lee-Thedieck
Keyword(s):  
Bone Marrow ◽  
3D Models ◽  
Health And Disease ◽  
Image Position

Abstract

scholarly journals A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 480
Author(s):  
Caitlyn A. Moore ◽  
Zain Siddiqui ◽  
Griffin J. Carney ◽  
Yahaira Naaldijk ◽  
Khadidiatou Guiro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Translational Medicine ◽  
Drug Response ◽  
Drug Approval ◽  
3D Models ◽  
3D Bioprinting ◽  
Effective Evaluation ◽  
Experimental Systems ◽  
Cancer Models

Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

scholarly journals Quantification of plasma cell dynamics using mathematical modelling

2018 ◽  
Vol 5 (1) ◽  
pp. 170759 ◽  
Author(s):  
Marcel Mohr ◽  
Dirk Hose ◽  
Anja Seckinger ◽  
Anna Marciniak-Czochra
Keyword(s):  
Mathematical Model ◽  
Bone Marrow ◽  
Mathematical Modelling ◽  
Plasma Cells ◽  
Cell Dynamics ◽  
Growth And Survival ◽  
Specific Antibodies ◽  
Health And Disease ◽  
Potential Basis ◽  
The Impact

Plasma cells (PCs) are the main antibody-producing cells in humans. They are long-lived so that specific antibodies against either pathogens or vaccines are produced for decades. PC longevity is attributed to specific areas within the bone marrow micro-environment, the so-called ‘niche’, providing the cells with required growth and survival factors. With antigen encounters, e.g. infection or vaccination, new PCs are generated and home to the bone marrow where they compete with resident PCs for the niche. We propose a parametrized mathematical model describing healthy PC dynamics in the bone marrow. The model accounts for competition for the niche between newly produced PCs owing to vaccination and resident PCs. Mathematical analysis and numerical simulations of the model allow explanation of the recovery of PC homoeostasis after a vaccine-induced perturbation, and the fraction of vaccine-specific PCs inside the niche. The model enables quantification of the niche-related dynamics of PCs, i.e. the duration of PC transition into the niche and the impact of different rates for PC transitions into and out of the niche on the observed cell dynamics. Ultimately, it provides a potential basis for further investigations in health and disease.

scholarly journals Quantification and three-dimensional microanatomical organization of the bone marrow

2017 ◽  
Vol 1 (6) ◽  
pp. 407-416 ◽  
Author(s):  
Cesar Nombela-Arrieta ◽  
Markus G. Manz
Keyword(s):  
Bone Marrow ◽  
Blood Cells ◽  
Structural Organization ◽  
Imaging Techniques ◽  
White Blood Cells ◽  
Three Dimensional ◽  
The Body ◽  
Cellular Composition ◽  
Spatial Logic ◽  
Health And Disease

Abstract Bone marrow (BM) constitutes one of the largest organs in mice and humans, continuously generating, in a highly regulated manner, red blood cells, platelets, and white blood cells that together form the majority of cells of the body. In this review, we provide a quantitative overview of BM cellular composition, we summarize emerging knowledge on its structural organization and cellular niches, and we argue for the need of multidimensional approaches such as recently developed imaging techniques to uncover the complex spatial logic that underlies BM function in health and disease.

scholarly journals Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Arjen van der Horst ◽  
Frits L. Boogaard ◽  
Marcel van't Veer ◽  
Marcel C. M. Rutten ◽  
Nico H. J. Pijls ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
3D Models ◽  
Left Ventricular ◽  
Propagation Model ◽  
Patient Specific ◽  
Health And Disease ◽  
Heart Contraction ◽  
Patient Specific Modeling ◽  
Diseased State ◽  
Specific Modeling

A model describing the primary relations between the cardiac muscle and coronary circulation might be useful for interpreting coronary hemodynamics in case multiple types of coronary circulatory disease are present. The main contribution of the present study is the coupling of a microstructure-based heart contraction model with a 1D wave propagation model. The 1D representation of the vessels enables patient-specific modeling of the arteries and/or can serve as boundary conditions for detailed 3D models, while the heart model enables the simulation of cardiac disease, with physiology-based parameter changes. Here, the different components of the model are explained and the ability of the model to describe coronary hemodynamics in health and disease is evaluated. Two disease types are modeled: coronary epicardial stenoses and left ventricular hypertrophy with an aortic valve stenosis. In all simulations (healthy and diseased), the dynamics of pressure and flow qualitatively agreed with observations described in literature. We conclude that the model adequately can predict coronary hemodynamics in both normal and diseased state based on patient-specific clinical data.

scholarly journals Osteoimmunology: Interactions of the Bone and Immune System

2008 ◽  
Vol 29 (4) ◽  
pp. 403-440 ◽  
Author(s):  
Joseph Lorenzo ◽  
Mark Horowitz ◽  
Yongwon Choi
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Immune Cells ◽  
Bone Cells ◽  
The Other ◽  
Organ Systems ◽  
Health And Disease ◽  
The Many ◽  
And Function ◽  
Broad Overview

Abstract Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body’s response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines developed independently, investigators in each don’t always fully appreciate the significance that the other system has on the function of the tissue they are studying. This review is meant to provide a broad overview of the many ways that bone and immune cells interact so that a better understanding of the role that each plays in the development and function of the other can develop. It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both.

The bone marrow microenvironment in health and disease at a glance

2018 ◽  
Vol 131 (4) ◽  
pp. jcs201707 ◽  
Author(s):  
Rahul Kumar ◽  
P. Sonika Godavarthy ◽  
Daniela S. Krause
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Microenvironment ◽  
Health And Disease

scholarly journals What a Clinical Hematologist Should Know about T Cells?

2020 ◽  
pp. 20-32
Author(s):  
Sanjeev Kumar Sharma
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Short Review ◽  
Cell Precursor ◽  
Peripheral Tissues ◽  
Memory T Cell ◽  
Basic Understanding ◽  
Health And Disease ◽  
Secondary Lymphoid Organs

T cell’s journey begins from the bone marrow and ends in the peripheral tissues by either fighting the infections or residing in the secondary lymphoid organs as memory T cell. Thymus plays most important role in transforming a docile T cell precursor into a warrior. T cell is one of the most important cells in health and disease. Various diseases originate from qualitative or quantitative defects in T cells leading to various inherited and acquired diseases. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of T cells.

scholarly journals Analysis of dux4 expression in bone marrow and re-discussion of dux4 function in the health and disease

2021 ◽  
Author(s):  
Ceren Hangul ◽  
Oznur Tokta ◽  
Sibel Berker Karauzum ◽  
Bahar Akkaya ◽  
Hulya Yildirim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Health And Disease

scholarly journals Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

2020 ◽  
Vol 35 (11) ◽  
pp. 2103-2120 ◽  
Author(s):  
Junyu Chen ◽  
Michelle Hendriks ◽  
Alexandros Chatzis ◽  
Saravana K Ramasamy ◽  
Anjali P Kusumbe
Keyword(s):  
Bone Marrow ◽  
Health And Disease ◽  
Bone Vasculature
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