Effects of QDs@Gd3+-NGR on targeted fluorescence-magnetic resonance imaging and inhibition of pancreatic cancer cells

2020 ◽  
Vol 35 (6) ◽  
pp. 591-599
Author(s):  
Qinqin Yan ◽  
Lin Wang ◽  
Fengxiang Song ◽  
Yijun Zhang ◽  
Lu Gao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pancreatic Cancer ◽  
Magnetic Resonance ◽  
Cancer Cells ◽  
Resonance Imaging ◽  
Pancreatic Cancer Cells ◽  
Image Position

Abstract

scholarly journals Targeting Pancreatic Cancer Cells with Peptide-Functionalized Polymeric Magnetic Nanoparticles

2019 ◽  
Vol 20 (12) ◽  
pp. 2988
Author(s):  
Xiuliang Zhu ◽  
Nan Lu ◽  
Ying Zhou ◽  
Shaoyan Xuan ◽  
Jiaojiao Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pancreatic Cancer ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Cancer Cells ◽  
Mri Contrast Agents ◽  
Membrane Receptors ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Pancreatic Cancer Cells

Pancreatic cancer is a concealed and highly malignant tumor, and its early diagnosis plays an increasingly weighty role during the course of cancer treatment. In this study, we developed a polymeric magnetic resonance imaging (MRI) nanoplatform for MRI contrast agents. To improve tumor-targeting delivery of MRI contrast agents, we employed a pancreatic cancer targeting CKAAKN peptide to prepare a peptide-functionalized amphiphilic hyaluronic acid–vitamin E succinate polymer (CKAAKN–HA–VES) for delivering ultra-small superparamagnetic iron oxide (USPIO), namely, CKAAKN–HA–VES@USPIO. With the modification of the CKAAKN peptide, CKAAKN–HA–VES@USPIO could specifically internalize into CKAAKN-positive BxPC-3 cells. The CKAAKN–HA–VES@USPIO nanoparticles presented a more specific accumulation into pancreatic cancer cells than normal pancreatic cells, and an obvious decrease in signal intensity was observed in CKAAKN-positive BxPC-3 cells, compared with CKAAKN-negative HPDE6-C7 cells and non-targeting HA–VES@USPIO nanoparticles. The results demonstrated that our polymeric MRI nanoplatform could selectively internalize into CKAAKN-positive pancreatic cancer cells by the specific binding of CKAAKN peptide with pancreatic cancer cell membrane receptors, which provided a novel polymeric MRI contrast agent with high specificity for pancreatic cancer diagnosis, and makes it a very promising candidate for magnetic resonance imaging contrast enhancement.

Aptamer modified nanoprobe for multimodal fluorescence/magnetic resonance imaging of human ovarian cancer cells

2021 ◽  
Vol 127 (1) ◽  
Author(s):  
Mahdi Asgari ◽  
Hossein Khanahmad ◽  
Hasan Motaghi ◽  
Amin Farzadniya ◽  
Masoud A. Mehrgardi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ovarian Cancer ◽  
Magnetic Resonance ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Resonance Imaging

scholarly journals Qualitative skeletal muscle analysis predicts survival in patients with pancreatic cancer undergoing surgery: A novel method using magnetic resonance imaging

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e152-e153
Author(s):  
D.P.J. van Dijk ◽  
S. Sanduleanu ◽  
F.C.H. Bakers ◽  
S.S. Rensen ◽  
C.H.C. Dejong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Skeletal Muscle ◽  
Pancreatic Cancer ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Novel Method
Sign in / Sign up

Export Citation Format

Share Document