Analysis of in vitro corrosion behavior and hemocompatibility of electrophoretically deposited bioglass–chitosan–iron oxide coating for biomedical applications

2020 ◽  
Vol 35 (13) ◽  
pp. 1749-1761
Author(s):  
Sandeep Singh ◽  
Gurpreet Singh ◽  
Niraj Bala

Abstract

Author(s):  
Venkat S. Kalambur ◽  
Ellen Longmire ◽  
John C. Bischof

Magnetic iron oxide nanoparticles (NPs) have intrinsic advantages over other NPs for various biomedical applications. These advantages include visualization under Magnetic Resonance Imaging (MRI), heating with Radiofrequency (RF), and movement in a magnetic field. There are now numerous efforts to expand the applications of these particles for non-invasive drug and adjuvant delivery, cellular imaging and in vitro cell sorting and purification. In the present study, we describe methods to (i) assess and quantify NP cell association (ii) facilitate NP heat destruction of cells after association with RF and laser. First, we show that (i) the cell association of iron oxide NPs is dependent on the surface coating (surfactant greater than dextran), time, cell-type and extracellular NP concentrations (saturation with concentration and time). Furthermore, the association fits a simple enzyme Michealis-Menten model. Second, (ii) improved heat destruction of cells can be achieved after laser irradiation compared to traditional RF treatment for similar NP associations. These results and assays show promise for cell sorting and purification applications.


2020 ◽  
Vol 1 (2) ◽  
pp. 219-248
Author(s):  
Moataz Abdalla ◽  
Alexander Joplin ◽  
Mohammad Elahinia ◽  
Hamdy Ibrahim

Biodegradable metals have been under significant research as promising alternatives to the currently in-use nonbiodegradable materials in the field of supportive medical implants. In this scope, magnesium and its alloys were widely investigated due to their superior biocompatibility over other metals. Most of the research effort in the literature has been focused on assuring the biocompatibility, improving mechanical properties, and tailoring the corrosion rate of magnesium-based implants. Furthermore, considerable research was done to develop numerical models towards an inexpensive and fast designing tools capable of simulating the degradation/corrosion behavior of magnesium-based implants. Due to the complexity of the degradation process and the various factors that can be involved, several hypotheses were introduced to provide a realistic simulation of the corrosion behavior in vitro and in vivo. A review of the current literature hypothesis and different modeling constitutive equations for modeling the corrosion of magnesium alloys along with a summary of the supplementary experimental methods is provided in this paper.


2016 ◽  
Vol 5 (1) ◽  
pp. 235-247 ◽  
Author(s):  
Gözde Kiliç ◽  
Carla Costa ◽  
Natalia Fernández-Bertólez ◽  
Eduardo Pásaro ◽  
João Paulo Teixeira ◽  
...  

Iron oxide nanoparticles (ION) have been widely used in biomedical applications, for both diagnosis and therapy, due to their unique magnetic properties.


2020 ◽  
Vol 56 (3) ◽  
pp. 628-637
Author(s):  
Mohammadreza Daroonparvar ◽  
Muhamad Azizi Mat Yajid ◽  
Hamid Reza Bakhsheshi-Rad ◽  
Rajeev Kumar Gupta ◽  
A. F. Ismail

2018 ◽  
Vol 8 (02) ◽  
pp. 604-609 ◽  
Author(s):  
Thangavel Shanmugasundaram ◽  
Manikkam Radhakrishnan ◽  
Arasu Poongodi ◽  
Krishna Kadirvelu ◽  
Ramasamy Balagurunathan

Abstract


2019 ◽  
Vol 5 (1) ◽  
pp. 573-576
Author(s):  
Claudia Matschegewski ◽  
Anja Kowalski ◽  
Knut Müller ◽  
Henrik Teller ◽  
Niels Grabow ◽  
...  

AbstractMagnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their suitability as theranostics.


2003 ◽  
Vol 789 ◽  
Author(s):  
M. Chastellain ◽  
A. Petri ◽  
H. Hofmann

ABSTRACTNanoscaled particles showing a superparamagnetic behavior have been intensively studied these past years for biomedical applications and water-based ferrofluids turned out to be promising candidates for various in vivo as well as in vitro applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large-scale synthesis of particles with a narrow size distribution. In this work iron oxide nanoparticles are obtained by classical co-precipitation in a water-based medium and are subsequently coated with polyvinyl alcohol. The thus obtained ferrofluids are studied and a focus is made on their colloidal stability.


2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Carmen Burtea ◽  
Sophie Laurent ◽  
Isabelle Mahieu ◽  
Lionel Larbanoix ◽  
Alain Roch ◽  
...  

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