G-protein-coupled receptors function as logic gates for nanoparticle binding using systems and synthetic biology approach

2019 ◽  
Vol 34 (11) ◽  
pp. 1854-1867 ◽  
Author(s):  
Aman Chandra Kaushik ◽  
Xueying Mao ◽  
Cheng-Dong Li ◽  
Yan Li ◽  
Dong-Qing Wei ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
G Protein ◽  
Logic Gates ◽  
G Protein Coupled Receptors ◽  
Image Position ◽  
G Protein Coupled ◽  
Synthetic Biology Approach

Abstract

Synthetic GPCRs and signal transduction cascades

2019 ◽  
Vol 3 (5) ◽  
pp. 609-614 ◽  
Author(s):  
Colleen Mulvihill ◽  
Andrew Ellington
Keyword(s):  
Signal Transduction ◽  
Synthetic Biology ◽  
Membrane Proteins ◽  
G Protein ◽  
Drug Targets ◽  
G Protein Coupled Receptors ◽  
Complex Signal ◽  
Diverse Group ◽  
Orthogonal Components ◽  
G Protein Coupled

G protein-coupled receptors (GPCRs) are a large and diverse group of membrane proteins that constitute over 30% of FDA approved drug targets. Despite their importance, much remains unknown about GPCR signaling at a system's level. Efforts to engineer receptors with orthogonal components have attempted to provide tools to parse signaling and resultant phenotypes. Recent advances in synthetic biology provide opportunities to engineer receptors at scale and with additional properties that could further inform GPCR biology at a system's level, and enhance the ability to engineer complex signal transduction.

scholarly journals G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake

2010 ◽  
Vol 107 (23) ◽  
pp. 10667-10672 ◽  
Author(s):  
W. Hild ◽  
K. Pollinger ◽  
A. Caporale ◽  
C. Cabrele ◽  
M. Keller ◽  
...  
Keyword(s):  
G Protein ◽  
Logic Gates ◽  
G Protein Coupled Receptors ◽  
Cell Uptake ◽  
G Protein Coupled
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