scholarly journals 3D-printed β-TCP bone tissue engineering scaffolds: Effects of chemistry on in vivo biological properties in a rabbit tibia model

2018 ◽  
Vol 33 (14) ◽  
pp. 1939-1947 ◽  
Author(s):  
Samit Kumar Nandi ◽  
Gary Fielding ◽  
Dishary Banerjee ◽  
Amit Bandyopadhyay ◽  
Susmita Bose
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Properties ◽  
Tissue Engineering Scaffolds ◽  
Rabbit Tibia ◽  
3D Printed ◽  
Image Position

Abstract

scholarly journals Systematic characterization of 3D-printed PCL/β-TCP scaffolds for biomedical devices and bone tissue engineering: Influence of composition and porosity

2018 ◽  
Vol 33 (14) ◽  
pp. 1948-1959 ◽  
Author(s):  
Arnaud Bruyas ◽  
Frank Lou ◽  
Alexander M. Stahl ◽  
Michael Gardner ◽  
William Maloney ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Devices ◽  
3D Printed ◽  
Image Position

Abstract

scholarly journals Enhancing X-ray Attenuation of 3D Printed Gelatin Methacrylate (GelMA) Hydrogels Utilizing Gold Nanoparticles for Bone Tissue Engineering Applications

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 367 ◽  
Author(s):  
Nehar Celikkin ◽  
Simone Mastrogiacomo ◽  
X. Walboomers ◽  
Wojciech Swieszkowski
Keyword(s):  
Tissue Engineering ◽  
Gold Nanoparticles ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Properties ◽  
Proof Of Concept ◽  
New Bone Formation ◽  
X Ray ◽  
3D Printed ◽  
Low Toxicity

Bone tissue engineering is a rapidly growing field which is currently progressing toward clinical applications. Effective imaging methods for longitudinal studies are critical to evaluating the new bone formation and the fate of the scaffolds. Computed tomography (CT) is a prevailing technique employed to investigate hard tissue scaffolds; however, the CT signal becomes weak in mainly-water containing materials, which hinders the use of CT for hydrogels-based materials. Nevertheless, hydrogels such as gelatin methacrylate (GelMA) are widely used for tissue regeneration due to their optimal biological properties and their ability to induce extracellular matrix formation. To date, gold nanoparticles (AuNPs) have been suggested as promising contrast agents, due to their high X-ray attenuation, biocompatibility, and low toxicity. In this study, the effects of different sizes and concentrations of AuNPs on the mechanical properties and the cytocompatibility of the bulk GelMA-AuNPs scaffolds were evaluated. Furthermore, the enhancement of CT contrast with the cytocompatible size and concentration of AuNPs were investigated. 3D printed GelMA and GelMA-AuNPs scaffolds were obtained and assessed for the osteogenic differentiation of mesenchymal stem cells (MSC). Lastly, 3D printed GelMA and GelMA-AuNPs scaffolds were scanned in a bone defect utilizing µCT as the proof of concept that the GelMA-AuNPs are good candidates for bone tissue engineering with enhanced visibility for µCT imaging.

scholarly journals Feasibility of Spatially Offset Raman Spectroscopy for in Vitro and in Vivo Monitoring Mineralization of Bone Tissue Engineering Scaffolds

2016 ◽  
Vol 89 (1) ◽  
pp. 847-853 ◽  
Author(s):  
Zhiyu Liao ◽  
Faris Sinjab ◽  
Amy Nommeots-Nomm ◽  
Julian Jones ◽  
Laura Ruiz-Cantu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Raman Spectroscopy ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffolds ◽  
In Vivo Monitoring

scholarly journals Fabrication and Application of a 3D-Printed Poly-ε-Caprolactone Cage Scaffold for Bone Tissue Engineering

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Siyi Wang ◽  
Rong Li ◽  
Yongxiang Xu ◽  
Dandan Xia ◽  
Yuan Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Synthetic Material ◽  
Hybrid Scaffold ◽  
Natural Bone Mineral ◽  
Application Potential ◽  
3D Printed

Poly-ε-caprolactone (PCL) is a promising synthetic material in bone tissue engineering (BTE). Particularly, the introduction of rapid prototyping (RP) represents the possibility of manufacturing PCL scaffolds with customized appearances and structures. Bio-Oss is a natural bone mineral matrix with significant osteogenic effects; however, it has limitations in being constructed and maintained into specific shapes and sites. In this study, we used RP and fabricated a hollow-structured cage-shaped PCL scaffold loaded with Bio-Oss to form a hybrid scaffold for BTE. Moreover, we adopted NaOH surface treatment to improve PCL hydrophilicity and enhance cell adhesion. The results showed that the NaOH-treated hybrid scaffold could enhance the osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMMSCs) both in vitro and in vivo. Altogether, we reveal a novel hybrid scaffold that not only possesses osteoinductive function to promote bone formation but can also be fabricated into specific forms. This scaffold design may have great application potential in bone tissue engineering.

scholarly journals Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

2017 ◽  
Vol 76 ◽  
pp. 701-714 ◽  
Author(s):  
Fateme Fayyazbakhsh ◽  
Mehran Solati-Hashjin ◽  
Abbas Keshtkar ◽  
Mohammad Ali Shokrgozar ◽  
Mohammad Mehdi Dehghan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Layered Double Hydroxides ◽  
In Vivo Study ◽  
Tissue Engineering Scaffolds ◽  
Double Hydroxides
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