Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system

2018 ◽  
Vol 33 (11) ◽  
pp. 1602-1611 ◽  
Author(s):  
Hamed Nosrati ◽  
Elham Javani ◽  
Marziyeh Salehiabar ◽  
Hamidreza Kheiri Manjili ◽  
Soodabeh Davaran ◽  
...  

Abstract

2019 ◽  
Vol 34 (23) ◽  
pp. 3976-3976
Author(s):  
Hamed Nosrati ◽  
Elham Javani ◽  
Marziyeh Salehiabar ◽  
Hamidreza Kheiri Manjili ◽  
Soodabeh Davaran ◽  
...  

Drug Research ◽  
2018 ◽  
Vol 69 (05) ◽  
pp. 277-283 ◽  
Author(s):  
Hamed Nosrati ◽  
Hossein Hamzehei ◽  
Saeed Afroogh ◽  
Seyedeh Ashabi ◽  
Elahe Attari ◽  
...  

AbstractIn this study we reported the synthesis of L-phenyl alanine (Phe) & L-tyrosine (Tyr) Natural Amino acids coated iron oxide magnetic nanoparticles under one-pot and in situ reaction. Functionalized iron oxide magnetic nanoparticles were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Vibrating Sample Magnetometer (VSM), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of amino acids coated iron oxide magnetic nanoparticles was also investigated on HEK-293 cell lines. Additionally, a hemolysis test of as prepared magnetic nanoparticles were performed. It was found that the synthesized Phe and Tyr coated magnetic nanoparticles (F@Phe NPs and F@Tyr NPs) were spherical in shape with an average size less than 25 nm, also the saturation magnetization (Ms) of the F@Phe NPs and F@Tyr NPs were about 30.02 and 58.23 emu/g, respectively, which was lower than those of bare Fe3O4. The TGA results show that apart from this weight loss, the coated sample shows a weight loss of 5.48, and 6.88% respectively corresponding to loss of Tyr, and Phe which is coated on the Fe3O4 nanoparticles. At a high concentration, less than 2.92 and 3.13% hemolytic activity were observed for F@Phe NPs and F@Tyr NPs, respectively. The F@Phe NPs and F@Tyr NPs show the possibility of using this nanoparticles in the development of in vitro and in vivo pharmaceutical and biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.


2015 ◽  
Vol 24 (10) ◽  
pp. 815-828 ◽  
Author(s):  
Chinmayee Saikia ◽  
Anowar Hussain ◽  
Anand Ramteke ◽  
Hemanta K. Sharma ◽  
Pritam Deb ◽  
...  

2021 ◽  
pp. 089270572098557
Author(s):  
M Abu-Abdeen ◽  
O Saber ◽  
E Mousa

A solvent thermal method which depends on a thermal process under critical temperature and pressure was used to prepare cobalt iron oxide magnetic nanoparticles with a molar ratio 2. The prepared particles were in the form of nanoparticles with diameter ranging from 5 to 10 nm and with amorphous structure. Magnetic hysteresis behavior with saturation magnetization 36.31 emu/g and coercivity 4 Oe were observed for the nanoparticles. Polyvinyl alcohol was loaded with different concentrations of cobalt iron oxide nanoparticles using casting technique. Hysteresis loops for the polymer films were observed and both the saturation magnetization and coercivity were increased from 0.36 to 16.03 emu/g and 115 to 293 Oe for samples containing 5 and 20 wt% of nanoparticles, respectively. The elastic modulus of films was increased from 2.7 to 4.9 GPa for unloaded and loaded samples with 20 wt%, respectively. The storage modulus of the polymer films was found to obey the percolation behavior.


Author(s):  
Chang-Mao Hung ◽  
Chiu-Wen Chen ◽  
Yu-Zhe Jhuang ◽  
Cheng-Di Dong

AbstractIn this study, the oxidation of methylene blue (MB) over iron oxide magnetic nanoparticles (Fe


2013 ◽  
Vol 779-780 ◽  
pp. 1674-1677 ◽  
Author(s):  
Dan Lian Huang ◽  
Guang Ming Zeng ◽  
Piao Xu ◽  
Cui Lai ◽  
Mei Hua Zhao ◽  
...  

Immobilized microbe technologies are expected to be effectively used in wastewater treatment. Removal of heavy-metals from wastewater by immobilized Phanerochaete chrysosporium (Pc) with Ca-alginate and iron oxide magnetic nanoparticles (MNPs) was studied. The results showed that a biosorbent as Pc immobilized by Ca-alginate and iron oxide magnetic nanoparticles was successfully developed. And the iron oxide magnetic nanoparticles played an important role in the increase of biosorption capacity of Pc. Energy dispersive spectrometer (EDS) analysis confirmed that metal ions adsorbed to the surface of the biosorbents were partly transmitted to the interior of biosorbents, mainly embedded with iron oxide nanoparticles and Ca-alginate. Moreover, it was found that MNPs-Ca-alginate immobilized Pc showed a good affinity to various heavy metals, such as Pb(II), Zn(II), Cd(II) or Mg(II) and so on. The results proved the high efficiency of the biosorbents for heavy-metal removal and its potential application in the treatment of metal-containing wastewater.


Nanomedicine ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. 375-386 ◽  
Author(s):  
Brian Wan-Chi Tse ◽  
Gary J Cowin ◽  
Carolina Soekmadji ◽  
Lidija Jovanovic ◽  
Raja S Vasireddy ◽  
...  

2019 ◽  
Vol 174 ◽  
pp. 224-231 ◽  
Author(s):  
Ana Paula Miranda Vieira ◽  
Laís Salomão Arias ◽  
Francisco Nunes de Souza Neto ◽  
Andressa Mayumi Kubo ◽  
Bruno Henrique Ramos Lima ◽  
...  

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