Self-assembly of P22 protein cages with polyamidoamine dendrimer and inorganic nanoparticles

2016 ◽  
Vol 32 (2) ◽  
pp. 465-472 ◽  
Author(s):  
Soubantika Palchoudhury ◽  
Ziyou Zhou ◽  
Karthik Ramasamy ◽  
Franklin Okirie ◽  
Peter E. Prevelige ◽  
...  
Keyword(s):  
Self Assembly ◽  
Inorganic Nanoparticles ◽  
Polyamidoamine Dendrimer ◽  
Protein Cages ◽  
Image Position

Abstract

Programmable in vitro Co-Encapsidation of Guest Proteins Inside Protein Nanocages

2018 ◽  
Author(s):  
Noor H. Dashti ◽  
Rufika S. Abidin ◽  
Frank Sainsbury
Keyword(s):  
Self Assembly ◽  
Mammalian Cells ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Super Resolution ◽  
Cell Engineering ◽  
Particle Analysis ◽  
Protein Cages

Bioinspired self-sorting and self-assembling systems using engineered versions of natural protein cages have been developed for biocatalysis and therapeutic delivery. The packaging and intracellular delivery of guest proteins is of particular interest for both <i>in vitro</i> and <i>in vivo</i> cell engineering. However, there is a lack of platforms in bionanotechnology that combine programmable guest protein encapsidation with efficient intracellular uptake. We report a minimal peptide anchor for <i>in vivo</i> self-sorting of cargo-linked capsomeres of the Murine polyomavirus (MPyV) major coat protein that enables controlled encapsidation of guest proteins by <i>in vitro</i> self-assembly. Using Förster resonance energy transfer (FRET) we demonstrate the flexibility in this system to support co-encapsidation of multiple proteins. Complementing these ensemble measurements with single particle analysis by super-resolution microscopy shows that the stochastic nature of co-encapsidation is an overriding principle. This has implications for the design and deployment of both native and engineered self-sorting encapsulation systems and for the assembly of infectious virions. Taking advantage of the encoded affinity for sialic acids ubiquitously displayed on the surface of mammalian cells, we demonstrate the ability of self-assembled MPyV virus-like particles to mediate efficient delivery of guest proteins to the cytosol of primary human cells. This platform for programmable co-encapsidation and efficient cytosolic delivery of complementary biomolecules therefore has enormous potential in cell engineering.

Self-assembly of nanostructures with multiferroic components using nucleic acid linkers

2016 ◽  
Vol 7 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Ferman A. Chavez ◽  
Gopalan Srinivasan
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Image Position

Abstract

Routes to self-assembly of nanorods

2013 ◽  
Vol 28 (13) ◽  
pp. 1761-1776 ◽  
Author(s):  
Karthik Ramasamy ◽  
Arunava Gupta
Keyword(s):  
Self Assembly ◽  
Image Position

Abstract

Self-assembly of plasmonic/excitonic silicon nanocrystals into photonic crystals

2015 ◽  
Vol 5 (4) ◽  
pp. 573-577
Author(s):  
Jihua Yang ◽  
Nicolaas J. Kramer ◽  
Christopher J. Hogan ◽  
Uwe R. Kortshagen
Keyword(s):  
Photonic Crystals ◽  
Self Assembly ◽  
Silicon Nanocrystals ◽  
Image Position

Abstract

Hydrophobic Cargo Encapsulation into Virus Protein Cages by Self-Assembly in an Aprotic Organic Solvent

2021 ◽  
Author(s):  
Amberly Xie ◽  
Irina Tsvetkova ◽  
Yang Liu ◽  
Xingchen Ye ◽  
Priyadarshine Hewavitharanage ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Self Assembly ◽  
Virus Protein ◽  
Protein Cages

Bioinspired synthesis of silica nanocups - Polymer-mediated self-assembly of inorganic nanoparticles

Impact ◽  
2020 ◽  
Vol 2020 (1) ◽  
pp. 38-40
Author(s):  
Ayae Sugawara-Narutaki
Keyword(s):  
Liquid Phase ◽  
Self Assembly ◽  
Associate Professor ◽  
Inorganic Nanoparticles ◽  
Materials Chemistry ◽  
Vast Array ◽  
Bioinspired Synthesis ◽  
The World ◽  
Health Related

Nature oversees a vast array of amazing shapes formed by organisms such as plants, fungi and animals. Some of these manifest as intricate patterns in structures like coral and the nests of insects and birds. Associate Professor Ayae Sugawara-Narutaki, from the Department of Materials Chemistry at Nagoya University, Japan has a particular interest in these patterns. Sugawara-Narutaki's team focuses on research inspired by these self-organised nanostructures to develop nanomaterials for a variety of health-related applications. The ability of these nanomaterials to self-assemble and self-organise in a liquid phase has attracted a great deal of interest from materials scientists the world over.

Metal-ions directed self-assembly of hybrid diblock copolymers

2014 ◽  
Vol 29 (22) ◽  
pp. 2694-2706 ◽  
Author(s):  
Birong Zeng ◽  
Yueguang Wu ◽  
Qilong Kang ◽  
Ying Chang ◽  
Conghui Yuan ◽  
...  
Keyword(s):  
Metal Ions ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Image Position

Abstract

scholarly journals Directed self-assembly of inorganic nanoparticles at air/liquid interfaces

Nanoscale ◽  
2016 ◽  
Vol 8 (37) ◽  
pp. 16589-16595 ◽  
Author(s):  
Juan J. Giner-Casares ◽  
Javier Reguera
Keyword(s):  
Self Assembly ◽  
Inorganic Nanoparticles ◽  
Liquid Interfaces
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