Reversible fluorescence modulation based on photochromic diarylethene and fluorescent coumarin

2007 ◽  
Vol 22 (6) ◽  
pp. 1558-1563 ◽  
Author(s):  
Xiaohai Sheng ◽  
Aidong Peng ◽  
Hongbing Fu ◽  
Jiannian Yao ◽  
Yuanyuan Liu ◽  
...  
Keyword(s):  
Luminescence Intensity ◽  
High Sensitivity ◽  
Optical Data ◽  
High Contrast ◽  
Photochromic Compound ◽  
Image Storage ◽  
Fluorescence Switch ◽  
Fluorescence Modulation ◽  
Fluorescence Quencher

A fluorescence switch by the photoisomerization of a photochromic compound in CH3CN and in a polymer film using a bistable photochromic (1,2-bis(2-methylbenzo[b]thiophen-3-yl) hexafluorocyclopentene) (BTF6) and a fluorescent 3-(2-benzothiazolyl)-7-(diethylamino) coumarin (coumarin6) was demonstrated. Because only the closed form of BTF6 serves as a fluorescence quencher of coumarin6, and the read (406 nm), write (254 nm), and erase (>500 nm) wavelengths are well-separated, a reversible modulation of the fluorescence of coumarin6 with high contrast and high sensitivity is expected to be realized. This system may represent an alternative to the fluorescence switches that are based on covalent systems in the potentially long-term optical data or image storage schemes utilizing luminescence intensity readout.

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

scholarly journals Patients With a History of Idiopathic Deep Venous Thrombosis Have Long-Term Increased Levels of Inflammatory Markers and Markers of Endothelial Damage

2016 ◽  
Vol 23 (2) ◽  
pp. 124-131 ◽  
Author(s):  
Mateja Kaja Jezovnik ◽  
Jawed Fareed ◽  
Pavel Poredos
Keyword(s):  
Inflammatory Markers ◽  
High Sensitivity ◽  
Endothelial Damage ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
History Of ◽  
Hemostatic Markers

Introduction: Although the role of inflammation in DVT has been investigated in different studies, there is no definite answer as to whether increased systemic inflammation is the cause or the consequence of DVT. Aim: To follow inflammatory parameters in a cohort of patients with idiopathic DVT. Methods: Out of 49 patients with an acute idiopathic DVT, which were investigated four months after an acute episode (DEVTA 1), 43 patients were included in the follow-up study investigating inflammatory markers and hemostatic markers of endothelial damage five years after an acute DVT (DEVTA 2). A control group consisted of 43 sex and age matched healthy subjects (CONTROLS). Results: The levels of inflammatory markers were significantly higher in DEVTA 2 in comparison to CONTROLS: tumor necrosis factor alpha 2.0 pg/mL (1.1-2.3) vs 1.3 pg/mL (0.8-1.9), p < .001, high sensitivity C-reactive protein 3.2 mg/L (1.5-5.2) vs 1.7 mg/L (0.9-3.0), p = .008, interleukin-6 (IL-6) 2.7 pg/mL (2.0-3.5) vs 2.1 pg/mL (1.5-2.6), p = .025, IL-8 5.0 pg/mL (3.6-7.3) vs 2.4 pg/mL (1.8-2.8), p < .001. IL-10 was significantly decreased (0.9 pg/mL (0.7-1.8) vs 1.8 (1.5-2.2), p < .001. Most of the proinflammatory markers remained elevated in the DEVTA 2 in comparison to DEVTA 1. Markers of endothelial damage were higher in DEVTA 2 in comparison to CONTROLS and higher than in DEVTA 1. Conclusion: Patients with idiopathic DVT have long-term increased inflammatory markers and markers of endothelial damage. These findings favor the hypothesis that inflammation is a cause and not merely a consequence of acute DVT.

scholarly journals Short- and Long-term Biologic Variability of Galectin-3 and Other Cardiac Biomarkers in Patients with Stable Heart Failure and Healthy Adults

2016 ◽  
Vol 62 (2) ◽  
pp. 360-366 ◽  
Author(s):  
Emily I Schindler ◽  
Jeffrey J Szymanski ◽  
Karl G Hock ◽  
Edward M Geltman ◽  
Mitchell G Scott
Keyword(s):  
Heart Failure ◽  
Troponin I ◽  
Prognostic Biomarker ◽  
High Sensitivity ◽  
Cardiac Biomarkers ◽  
Healthy Individuals ◽  
Short Term ◽  
Galectin 3 ◽  
Short And Long Term

Abstract BACKGROUND Galectin-3 (Gal-3) has been suggested as a prognostic biomarker in heart failure (HF) patients that may better reflect disease progression than traditional markers, including B-type natriuretic peptide (BNP) and cardiac troponins. To fully establish the utility of any biomarker in HF, its biologic variability must be characterized. METHODS To assess biologic variability, 59 patients were prospectively recruited, including 23 male and 16 female patients with stable HF and 10 male and 10 female healthy individuals. Gal-3, BNP, and high-sensitivity cardiac troponin I (hs-cTnI) were assayed at 5 time points within a 3-week period to assess short-term biologic variability. Long-term (3-month) biologic variability was assessed with samples collected at enrollment and after 4, 8, and 12 weeks. RESULTS Among healthy individuals, mean short-term biologic variability, expressed as intraindividual CV (CVI), was 4.5% for Gal-3, 29.0% for BNP, and 14.5% for hs-cTnI; long-term biologic variability was 5.5% for Gal-3, 34.7% for BNP, and 14.7% for hs-cTnI. In stable HF patients, mean short-term biologic variability was 7.1% for Gal-3, 22.5% for BNP, and 8.5% for hs-cTnI, and mean long-term biologic variability was 7.7% for Gal-3, 27.6% for BNP, and 9.6% for hs-cTnI. CONCLUSIONS The finding that Gal-3 has minimal intraindividual biological variability adds to its potential as a useful biomarker in HF patients.

High-performance humidity sensors from Ni(SO4)0.3(OH)1.4 nanobelts

Nanoscale ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 6521-6525 ◽  
Author(s):  
Ming Zhuo ◽  
Yuejiao Chen ◽  
Tao Fu ◽  
Haonan Zhang ◽  
Zhi Xu ◽  
...  
Keyword(s):  
High Performance ◽  
Humidity Sensor ◽  
High Sensitivity ◽  
Fast Response ◽  
Humidity Sensors ◽  
Term Stability ◽  
Long Term Stability

Ni(SO4)0.3(OH)1.4 nanobelts are utilized in a humidity sensor by a facile method. The nanobelt based sensor shows a high sensitivity, fast response and long-term stability in the sensing process.

scholarly journals Crédito consignado: segmentos e efeitos econômicos

2018 ◽  
Vol 17 (2) ◽  
pp. 783-810
Author(s):  
Angélica Pott de Medeiros ◽  
Giulia Xisto de Oliveira ◽  
Reisoli Bender Filho
Keyword(s):  
Economic Recession ◽  
High Sensitivity ◽  
Variance Decomposition ◽  
Economic Effects ◽  
Short Term ◽  
Macroeconomic Variables ◽  
The Public ◽  
Short And Long Term ◽  
Vector Estimation

Resumo: O cenário de instabilidade política, a recessão econômica e as mudanças nas regras de concessão de crédito pautaram o objetivo de examinar o relacionamento do crédito consignado, por segmento de concessão, com variáveis macroeconômicas, caso do consumo, da produção industrial e do produto agregado, na última década (2007-2017). Os resultados foram obtidos por meio da estimação do vetor de correção de erros, funções de impulso-resposta e decomposição da variância, possibilitando a análise das relações de curto e de longo prazo entre as séries temporais e indicaram que as diferentes modalidades do crédito consignado implicam efeitos distintos sobre as variáveis econômicas em curto prazo. O segmento de aposentados e pensionistas impacta positivamente ambas as variáveis analisadas, com destaque para os bens de consumo das famílias. Já a concessão ao setor privado, embora represente a menor parcela do crédito consignado concedido, mostrou elevada sensibilidade a alterações na oferta dessa modalidade de crédito, enquanto que o crédito ao setor público, de maior participação, apresentou efeitos reduzidos e de curta duração.Palavras-chave: Crédito consignado. Segmentos. Economia brasileira. Payroll loans: segments and economic effects Abstract: The environment of political instability, economic recession and changes in the rules of granting credit were guiders to aim to examine the payroll loans relationship, by concession segment, with macroeconomic variables, case of consumption, industrial production and aggregate product, in the last decade (2007-2017). The results obtained by error correction vector estimation, and functions of impulse-response and variance decomposition, making it possible to analyze the short- and long-term relationships between the time series and indicated that the different modalities of payroll loans imply different effects on economic short-term variables. With retirees and pensioners segment positively impact on both analyzed variables, highlighting the household consumption goods. The concession to the private sector, although it represents the smallest portion of payroll loans granted, it showed high sensitivity to the changes of this modality. About credit to the public sector, which has the biggest portion, it showed reduced and short-term effects.Keywords: Payroll loans. Segments. Brazilian economy.

scholarly journals Effects of temperature variations in high-sensitivity Sagnac gyroscope

2021 ◽  
Vol 136 (5) ◽  
Author(s):  
Andrea Basti ◽  
Nicolò Beverini ◽  
Filippo Bosi ◽  
Giorgio Carelli ◽  
Donatella Ciampini ◽  
...  
Keyword(s):  
Earth Rotation ◽  
Mechanical Design ◽  
Low Frequency ◽  
Environmental Parameters ◽  
High Sensitivity ◽  
Rotation Axes ◽  
The Earth ◽  
Sagnac Gyroscope ◽  
Laser Gyroscopes

AbstractGINGERINO is one of the most sensitive Sagnac laser-gyroscopes based on an heterolithic mechanical structure. It is a prototype for GINGER, the laser gyroscopes array proposed to reconstruct the Earth rotation vector and in this way to measure General Relativity effects. Many factors affect the final sensitivity of laser gyroscopes, in particular, when they are used in long-term measurements, slow varying environmental parameters come into play. To understand the role of different terms allows to design more effective mechanical as well as optical layouts, while a proper model of the dynamics affecting long-term (low frequency) signals would increase the effectiveness of the data analysis for improving the overall sensitivity. In this contribution, we focus our concerns on the effects of room temperature and pressure aiming at further improving mechanical design and long-term stability of the apparatus. Our data are compatible with a local orientation changes of the Gran Sasso site below $$\mu $$ μ rad as predicted by geodetic models. This value is consistent with the requirements for GINGER and the installation of an high-sensitivity Sagnac gyroscope oriented at the maximum signal, i.e. along the Earth rotation axes.

Non-invasive fluorescence switch in polymer films based on spiropyran-photoacid modified TPE

2018 ◽  
Vol 6 (8) ◽  
pp. 2113-2122 ◽  
Author(s):  
Qi Yu ◽  
Xing Su ◽  
Ting Zhang ◽  
Yu-Mo Zhang ◽  
Minjie Li ◽  
...  
Keyword(s):  
Polymer Films ◽  
High Contrast ◽  
Non Invasive ◽  
Fluorescence Switch ◽  
Fluorescence Switching

High-contrast fluorescence switching has been achieved in polymer films or fibers with non-invasive stimuli.

Development and Assembly of a MEMS Based High-Sensitivity Relative Gravimeter for Multi-Pixel Imaging Applications 

2021 ◽  
Author(s):  
Karl Toland ◽  
Abhinav Prasad ◽  
Andreas Noack ◽  
Kristian Anastasiou ◽  
Richard Middlemiss ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Cost Effective ◽  
Mount Etna ◽  
Earth Tides ◽  
Gravity Measurements ◽  
Stepper Motors ◽  
Long Term Monitoring ◽  
The Stability ◽  
Term Monitoring

&lt;p&gt;The manufacture and production of a&amp;#160;high-sensitivity&amp;#160;cost-effective gravimeter has the potential to change the&amp;#160;methodology&amp;#160;and efficiency&amp;#160;of gravity measurements. Currently,&amp;#160;the&amp;#160;most common&amp;#160;method&amp;#160;to conduct a survey is&amp;#160;by using&amp;#160;a single gravimeter, usually costing tens of thousands of Dollars,&amp;#160;with measurements taken at multiple locations to&amp;#160;obtain the required data.&amp;#160;The availability of a cost-effective gravimeter&amp;#160;however would allow the user to install multiple gravimeters, at the same cost of a single gravimeter,&amp;#160;to increase the efficiency of&amp;#160;surveys and long-term monitoring.&amp;#160;&amp;#160;&lt;/p&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;p&gt;Since the previous reporting on a low-drift relative MEMS gravimeter for multi-pixel imaging applications (Prasad, A. et al,&amp;#160;EGU2020-18528), significant&amp;#160;progress&amp;#160;has&amp;#160;been made in the&amp;#160;development and assembly of the previously reported system. Field prototypes have been manufactured and undergone significant testing&amp;#160;to investigate the stability and robustness of the system&amp;#160;in preparation for&amp;#160;the&amp;#160;deployment&amp;#160;of multiple devices&amp;#160;as part of the gravity imager on Mount Etna. The device, known as Wee-g, has several key features which makes it an attractive prospect in the field of gravimetry. Examples of these features are that the Wee-g is small and portable with the ability to connect to the device remotely, can be powered through a mains connected power supply, or through portable batteries, weighs under 4kg, has a low power consumption during normal use of 5W, correct for tilt through manual adjustments or remotely through integrated stepper motors with a total tilt correction range of 5 degrees, the ability to read out tilt of the device through an inclinometer for either alignment or long term monitoring and numerous temperature sensors and heater servos to control the temperature of the MEMS to &lt;1mK.&lt;/p&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;p&gt;This presentation aims to report on the progress that has been achieved&amp;#160;in the&amp;#160;development and&amp;#160;manufacturing of the prototype devices, various testing of the devices under various laboratory conditions (such as the measurements of the Earth tides, and a relative measurement of gravity at various floor levels), as well as additional&amp;#160;applications that are to be explored in 2021.&amp;#160;&lt;/p&gt;

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