Development of a facile one-pot synthesis method for an ingestible pH sensitive actuator

MRS Advances ◽  
2019 ◽  
Vol 5 (17) ◽  
pp. 881-889
Author(s):  
Alex Keller ◽  
Holly Warren ◽  
Marc in het Panhuis
Keyword(s):  
Acrylic Acid ◽  
Calcium Hydroxide ◽  
Sodium Citrate ◽  
Synthesis Method ◽  
Gastric Fluid ◽  
Ph Sensitive ◽  
One Pot ◽  
Acidic Environments ◽  
Printed Materials ◽  
Poly Acrylic Acid

ABSTRACTEdible devices are an emergent technology and in this paper the simplicity and efficacy that poly(acrylic acid)/calcium hydroxide possess in creating a pH sensitive ingestible actuator which responds to acidic environments such as gastric fluid is demonstrated. It was found that poly(acrylic acid)/calcium hydroxide hydrogels exhibit reversible actuation upon submerging in 0.1 M sodium citrate for 2 hours. Our results show that these hydrogels can restore their compressive stress to 0.19 ± 0.06 MPa, swelling ratio to 26 ± 2 and volume to 56% ± 3% of its original volume. This work offers new possibilities for developments in a variety of fields such as drug delivery, 4D printed materials, soft robotics and edible devices.

One-Pot Synthetic Strategy to Core Cross-Linked Micelles with pH-Sensitive Cross-Linked Cores and Temperature-Sensitive Shells through RAFT Polymerization

2006 ◽  
Vol 59 (10) ◽  
pp. 733 ◽  
Author(s):  
Li-Ping Yang ◽  
Cai-Yuan Pan
Keyword(s):  
Acrylic Acid ◽  
Ethylene Glycol ◽  
Raft Polymerization ◽  
Ph Sensitive ◽  
Temperature Sensitive ◽  
One Pot ◽  
Glycol Diacrylate ◽  
Synthetic Strategy ◽  
Raft Agent ◽  
Poly Acrylic Acid

Functional micelles with a poly(N-isopropylacrylamide) (PNIPAM) shell and a cross-linked poly((acrylic acid)-co-(ethylene glycol diacrylate)) core have been successfully prepared in one pot by the reversible addition–fragmentation chain transfer (RAFT) copolymerization of acrylic acid and ethylene glycol diacrylate in selective solvent using PNIPAM-SC(S)Ph as a RAFT agent. Since PNIPAM and poly(acrylic acid) are temperature- and pH-sensitive polymers, respectively, the micelles obtained should display double environmental sensitivity to temperature and pH in water.

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

2015 ◽  
Vol 3 (13) ◽  
pp. 2685-2697 ◽  
Author(s):  
Xinyu Hu ◽  
Wei Wei ◽  
Xiaoliang Qi ◽  
Hao Yu ◽  
Liandong Feng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Ph Sensitive ◽  
Swelling Behaviour ◽  
Poly Acrylic Acid

The pH-sensitive swelling behaviour and DOX release of Salecan-g-PAA hydrogels are discussed.

Sign in / Sign up

Export Citation Format

Share Document