Magnesium-based Biodegradable Materials for Biomedical Applications

MRS Advances ◽  
2018 ◽  
Vol 3 (40) ◽  
pp. 2359-2364 ◽  
Author(s):  
Chaoxing Zhang ◽  
Jiajia Lin ◽  
Huinan Liu
Keyword(s):  
Mechanical Properties ◽  
Surface Treatment ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Clinical Applications ◽  
Research Progress ◽  
Biodegradable Materials ◽  
Future Directions ◽  
Rapid Degradation ◽  
Device Applications

ABSTRACTMagnesium (Mg)-based biomaterials have attracted increasing attention in biomedical applications, such as orthopaedic, cardiovascular, urological, and neural applications because of the biocompatibility, biodegradability, antibacterial properties, and excellent mechanical properties. However, rapid degradation of Mg is the major concern for many clinical applications. Alloying Mg with other elements and engineering proper surfaces are the two approaches to control the degradation of Mg-based biomaterials. Our lab has investigated several classes of Mg-based biodegradable alloys and various surface treatment methods for medical implant and device applications. This mini-review highlights key research progress on Mg-based biomaterials and suggests future directions for Mg-based biomaterials.

scholarly journals Advances and Challenges of Fluorescent Nanomaterials for Synthesis and Biomedical Applications

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Deli Xiao ◽  
Haixiang Qi ◽  
Yan Teng ◽  
Dramou Pierre ◽  
Perpetua Takunda Kutoka ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Rapid Development ◽  
Critical Role ◽  
Clinical Applications ◽  
Noble Metal Nanoparticles ◽  
Nanometer Scale ◽  
Fluorescent Nanoparticles ◽  
Future Directions ◽  
The Past ◽  
Fluorescent Nanomaterials

AbstractWith the rapid development of nanotechnology, new types of fluorescent nanomaterials (FNMs) have been springing up in the past two decades. The nanometer scale endows FNMs with unique optical properties which play a critical role in their applications in bioimaging and fluorescence-dependent detections. However, since low selectivity as well as low photoluminescence efficiency of fluorescent nanomaterials hinders their applications in imaging and detection to some extent, scientists are still in search of synthesizing new FNMs with better properties. In this review, a variety of fluorescent nanoparticles are summarized including semiconductor quantum dots, carbon dots, carbon nanoparticles, carbon nanotubes, graphene-based nanomaterials, noble metal nanoparticles, silica nanoparticles, phosphors and organic frameworks. We highlight the recent advances of the latest developments in the synthesis of FNMs and their applications in the biomedical field in recent years. Furthermore, the main theories, methods, and limitations of the synthesis and applications of FNMs have been reviewed and discussed. In addition, challenges in synthesis and biomedical applications are systematically summarized as well. The future directions and perspectives of FNMs in clinical applications are also presented.

Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties

2018 ◽  
Vol 90 (5) ◽  
pp. 901-911 ◽  
Author(s):  
Sandra L. Orellana ◽  
Annesi Giacaman ◽  
Alejandra Vidal ◽  
Carlos Morales ◽  
Felipe Oyarzun-Ampuero ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Chondroitin Sulfate ◽  
Colloidal Suspensions ◽  
Clinical Applications ◽  
Biodegradable Materials ◽  
Solid Materials ◽  
Freeze Dried ◽  
Low Stiffness ◽  
Oppositely Charged ◽  
Highly Porous

Abstract The formation of ultralight, highly porous solid materials (porosity higher than 99%) containing equivalent molar amounts of chitosan (CS) and chondroitin sulfate (ChS) is presented. First, we show protocols to produce colloidal suspensions of assembled polymer nanocomplexes by simultaneously mixing equimolar amounts of the oppositely charged polysaccharides, preventing macroprecipitation. The colloidal suspensions were then freeze-dried to form the active aerogels. Apparent density in the order of 100–101 mg/cm3 was achieved. The materials show low stiffness (Young’s modulus of about 2 kPa), which make them easy to handle for clinical applications, and easy to compress, pack, store and transport. These characteristics promote them as cheap, safe and biodegradable materials able to be used for several therapeutic purposes, such as wound healing.

scholarly journals Advances on biodegradable zinc-silver-based alloys for biomedical applications

2021 ◽  
Vol 19 ◽  
pp. 228080002110624
Author(s):  
Ximei Xiao ◽  
Enyang Liu ◽  
Jinlong Shao ◽  
Shaohua Ge
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Human Body ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Research Field ◽  
Medical Applications ◽  
Secondary Surgery ◽  
Biodegradable Metals ◽  
Potential Applications

The biodegradable metals have great potential for the biomedical applications, which could be gradually degraded, absorbed, or excreted in the human body, avoiding the removal though secondary surgery. Zinc-based alloys are novel series of degradable metals for medical applications, and they are gaining lots of attention in the research field of absorbable metals. Zinc-silver (Zn-Ag) alloys show superior mechanical strength, good biodegradability, biocompatibility, and antibacterial properties, which render them to be potential candidates for biomedical applications. In this paper, we reviewed the development of Zn-Ag alloys in terms of mechanical properties, degradabilities, biocompatibilities, antibacterial properties, and potential applications in dentistry.

A novel biocompatible polymeric blend for applications requiring high toughness and tailored degradation rate

2021 ◽  
Vol 9 (10) ◽  
pp. 2532-2546 ◽  
Author(s):  
Behzad Shiroud Heidari ◽  
Peilin Chen ◽  
Rui Ruan ◽  
Seyed Mohammad Davachi ◽  
Hani Al-Salami ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Applications ◽  
Degradation Rate ◽  
Biodegradable Materials ◽  
High Toughness ◽  
The Right ◽  
Polymeric Blend

Finding the right balance in mechanical properties and degradation rate of biodegradable materials for biomedical applications is challenging, not only at the time of implantation but also during biodegradation.

Mechanical Properties and Bio-Corrosion Properties of CaO added ZM21 alloys as Biodegradable Materials

2014 ◽  
Vol 52 (11) ◽  
pp. 949-956
Author(s):  
Hyunkyu Lim ◽  
Wonseok Yang ◽  
Young-Gil Jung ◽  
Shae K. Kim ◽  
Do-Hyang Kim
Keyword(s):  
Mechanical Properties ◽  
Biodegradable Materials ◽  
Corrosion Properties

KAISER ALUMINUM ALLOY 7049

Alloy Digest ◽  
1999 ◽  
Vol 48 (12) ◽  
Keyword(s):  
Mechanical Properties ◽  
Shear Strength ◽  
Aluminum Alloy ◽  
Physical Properties ◽  
Surface Treatment ◽  
Stress Corrosion Cracking ◽  
Heat Treating ◽  
Kaiser Aluminum ◽  
Resistance To Stress ◽  
Structural Parts

Abstract Kaiser Aluminum Alloy 7049 has high mechanical properties and good machinability. The alloy offers a resistance to stress-corrosion cracking and is typically used in aircraft structural parts. This datasheet provides information on composition, physical properties, hardness, tensile properties, and shear strength as well as fatigue. It also includes information on forming, heat treating, machining, and surface treatment. Filing Code: AL-365. Producer or source: Tennalum, A Division of Kaiser Aluminum.

KAISER ALUMINUM ALLOY KA62

Alloy Digest ◽  
1999 ◽  
Vol 48 (10) ◽  
Keyword(s):  
Mechanical Properties ◽  
Corrosion Resistance ◽  
Shear Strength ◽  
Aluminum Alloy ◽  
Physical Properties ◽  
Surface Treatment ◽  
Physical And Mechanical Properties ◽  
Heat Treating ◽  
Lead Free ◽  
Kaiser Aluminum

Abstract Kaiser Aluminum alloy KA62 (Tennalum alloy KA62) is a lead-free alternative to 6262. It offers good machinability and corrosion resistance and displays good acceptance of coatings (anodize response). It can be used in place of 6262 because its physical and mechanical properties are equivalent to those of 6262 (see Alloy Digest Al-361, September 1999). This datasheet provides information on composition, physical properties, hardness, tensile properties, and shear strength. It also includes information on corrosion resistance as well as forming, heat treating, machining, and surface treatment. Filing Code: AL-362. Producer or source: Tennalum, A Division of Kaiser Aluminum.

WC-3015 Alloy

Alloy Digest ◽  
1974 ◽  
Vol 23 (5) ◽  
Keyword(s):  
Mechanical Properties ◽  
High Temperature ◽  
Physical Properties ◽  
Surface Treatment ◽  
Base Alloy ◽  
Heat Treating ◽  
Rolled Sheet ◽  
Good Oxidation Resistance ◽  
Structural Applications ◽  
Cold Rolled

Abstract WC-3015 is a columbium-base alloy developed for structural applications in high-temperature oxidizing environments. It is characterized by good oxidation resistance, good mechanical properties and compatibility with silicide coatings. Cold-rolled sheet can be joined and welded without cracking. This datasheet provides information on composition, physical properties, elasticity, and tensile properties as well as creep. It also includes information on forming, heat treating, machining, joining, and surface treatment. Filing Code: Cb-21. Producer or source: Wah Chang, a Teledyne Corporation.

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

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