Diatoms Biosilica as Efficient Drug-Delivery System

MRS Advances ◽  
2015 ◽  
Vol 1 (57) ◽  
pp. 3825-3830 ◽  
Author(s):  
Danilo Vona ◽  
Gabriella Leone ◽  
Roberta Ragni ◽  
Fabio Palumbo ◽  
Antonio Evidente ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Amorphous Silica ◽  
Model System ◽  
Silica Shell ◽  
Diatom Species ◽  
Size And Morphology ◽  
Fossil Diatoms

ABSTRACTDiatoms are the most abundant resource of biosilica on Earth. These microalgae are encased in a 3-D amorphous silica “shell” called frustule whose size and morphology is strictly dependent on the diatom species. Naturally nanostructured biosilica from diatoms exhibit unique adsorption and confinement properties useful for delivery of molecules of pharmacological interest.In this work fossil biosilica was used as a carrier for Ophiobolin A (a fungal macrolide with anticancer and antiparasitic properties), with the aim to develop a model system of Ophiobolin A loading / delivery. Ophiobolin A delivery properties of fossil diatoms were investigated by spectophotometric analyses.

Gold Nanorods Coated with Mesoporous Silica Shell as Drug Delivery System for Remote Near Infrared Light-Activated Release and Potential Phototherapy

Small ◽  
2015 ◽  
Vol 11 (19) ◽  
pp. 2323-2332 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Christine Jérôme ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Silica Shell ◽  
Infrared Light ◽  
Near Infrared Light

scholarly journals First step towards a model system of the drug delivery network based on amide-POSS nanocarriers

RSC Advances ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 8394-8401 ◽  
Author(s):  
Łukasz John ◽  
Mariola Malik ◽  
Mateusz Janeta ◽  
Sławomir Szafert
Keyword(s):  
Drug Delivery ◽  
Carboxylic Acid ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Model System ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Delivery Network ◽  
Acid Salts

We present the synthetic and release aspects of a novel drug delivery system (DDS) based on amido-functionalized POSS. DDS after drug release hydrolyses at pH = 7.40 to non-toxic products such as carboxylic acid salts and aminopropyl-POSS.

scholarly journals Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

2021 ◽  
Vol 22 (9) ◽  
pp. 4708
Author(s):  
Adrian Szewczyk ◽  
Adrianna Skwira ◽  
Agnieszka Konopacka ◽  
Rafał Sądej ◽  
Magdalena Prokopowicz
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Amorphous Silica ◽  
Prolonged Release ◽  
Human Osteoblasts ◽  
Mcm 41

For decades, local bone drug delivery systems have been investigated in terms of their application in regenerative medicine. Among them, inorganic polymers based on amorphous silica have been widely explored. In this work, we combined two types of amorphous silica: bioglass and doxycycline-loaded mesoporous silica MCM-41 into the form of spherical granules (pellets) as a bifunctional bone drug delivery system. Both types of silica were obtained in a sol-gel method. The drug adsorption onto the MCM-41 was performed via adsorption from concentrated doxycycline hydrochloride solution. Pellets were obtained on a laboratory scale using the wet granulation-extrusion-spheronization method and investigated in terms of physical properties, drug release, antimicrobial activity against Staphylococcus aureus, mineralization properties in simulated body fluid, and cytotoxicity towards human osteoblasts. The obtained pellets were characterized by satisfactory mechanical properties which eliminated the risk of pellets cracking during further investigations. The biphasic drug release from pellets was observed: burst stage (44% of adsorbed drug released within the first day) followed by prolonged release with zero-order kinetics (estimated time of complete drug release was 19 days) with maintained antimicrobial activity. The progressive biomimetic apatite formation on the surface of the pellets was observed. No cytotoxic effect of pellets towards human osteoblasts was noticed.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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