Overexpression of Chemokine Receptors on Neural Stem Cells Pretreated with Valproic acid: Towards Improved Homing

2016 ◽  
Vol 1 (3) ◽  
pp. 98
Author(s):  
Fahime Karimi ◽  
Mohammad Reza Hashemzadeh ◽  
Muhammad Irfan-Maqsood ◽  
Mohammad Amin Edalatmanesh ◽  
Hojjat Naderi-Meshkin
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Neural Stem Cells ◽  
Chemokine Receptors

scholarly journals Overexpression of Chemokine Receptors on Neural Stem Cells Pretreated with Valproic acid: Towards Improved Homing

2018 ◽  
Vol 4 ◽  
pp. 33
Author(s):  
Fahime Karimi ◽  
Mohammad Reza Hashemzadeh ◽  
Mohammad Amin Edalatmanesh ◽  
Hojjat Naderi-Meshkin
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Neural Stem Cells ◽  
Chemokine Receptors ◽  
Mammalian Brain ◽  
Isolated Cells ◽  
Migration Ability ◽  
Neuronal Markers ◽  
Cord Injury ◽  
Lateral Sclerosis

Neural stem cells (NSCs) have considerable capacity for self-renewing and also ability for generating neurons in the mammalian brain. However, one of the big challenges is the migration and targeted homing of transplanted NSCs into the injured site to treat neurodegenerative diseases including Alzheimer´s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), brain ischemia (BI) and spinal cord injury (SCI). To improve homing capacity, pretreatment of NSCs with Valproic acid (VPA), which is supposed to cause diverse effects on migration ability of NSCs, is a strategy. More recently, hind brain and olfactory bulbs have been introduced as a good source of NSCs. So, NSCs were isolated from these two sources of postnatal day 1 (PND1) rats. These isolated cells were characterized by expressing neuronal markers such as Nestin and Sox2. The expression of four selected chemokine receptors (CXCR4, CXCR6, CCR1 and CCR7), which are important effectors in homing of stem cells, was investigated. It is concluded that VPA treatment enhances NSCs migration and homing showing its potential to be applied for cell-based therapies.

Induction of Neurotrophic and Differentiation Factors in Neural Stem Cells by Valproic Acid

2014 ◽  
Vol 115 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Walaa Almutawaa ◽  
Na Hyea Kang ◽  
Yi Pan ◽  
Lennard P. Niles
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Neural Stem Cells ◽  
Differentiation Factors

scholarly journals PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

2017 ◽  
Vol 8 (5) ◽  
pp. 1256-1269 ◽  
Author(s):  
Xi Zhang ◽  
Xiaosong He ◽  
Qingqing Li ◽  
Xuejian Kong ◽  
Zhenri Ou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Epigenetic Modifications ◽  
Mtor Signaling

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro

2007 ◽  
Vol 184 (1-2) ◽  
pp. 198-208 ◽  
Author(s):  
J BEECH ◽  
D WHEELER ◽  
J RECKLESS ◽  
A GRANT ◽  
J PRICE ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Chemokine Receptors
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