scholarly journals Pathophysiological changes of umbilical vessels in intrauterine growth restriction

2014 ◽  
Vol 155 (50) ◽  
pp. 1989-1995
Author(s):  
Mária Jakó ◽  
Andrea Surányi ◽  
László Kaiser ◽  
Dóra Domokos ◽  
Róbert Gáspár ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Perinatal Morbidity ◽  
Control Groups ◽  
Umbilical Vessels ◽  
Intrauterine Growth ◽  
Basal Tone ◽  
Vasopressin Receptors ◽  
And Control

Introduction: The prevalence of intrauterine growth restriction is 4–5000/100,000 births, and they give the majority of perinatal morbidity. Aim: The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies. Method: Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists’ protocol. Results: After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups. Conclusions: The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight. Orv. Hetil., 2014, 155(50), 1989–1995.

scholarly journals Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Anindita Dutta ◽  
Donee Alexander ◽  
Theodore Karrison ◽  
Oludare Morhasson-Bello ◽  
Nathaniel Wilson ◽  
...  
Keyword(s):  
Air Pollution ◽  
Fetal Growth ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Growth Trajectories ◽  
Second Trimester ◽  
Control Groups ◽  
Intrauterine Growth ◽  
Biometric Parameters ◽  
And Control

Abstract Background Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are rare. We investigated the effect of a cookstove intervention on FBP and IUGR in a randomized controlled trial (RCT) cohort of HAP-exposed pregnant Nigerian women. Methods We recruited 324 women early in the second trimester of pregnancy. Between 16 and 18 weeks, we randomized them to either continue cooking with firewood/kerosene (control group) or receive a CleanCook stove and ethanol fuel (intervention group). We measured fetal biparietal diameter (BPD), head circumference (HC), femur length (FL), abdominal circumference (AC) and ultrasound-estimated fetal weight (U-EFW) in the second and third trimesters. The women were clinically followed up at six regular time points during their pregnancies. Once during the women’s second trimester and once during the third, we made 72-h continuous measurements of their personal exposures to particulate matter having aerodynamic diameter < 2.5 μm (PM2.5). We adopted a modified intent-to-treat approach for the analysis. Differences between the intervention and control groups on impact of HAP on fetal growth trajectories were analyzed using mixed effects regression models. Results There were no significant differences in fetal growth trajectories between the intervention and control groups. Conclusions Larger studies in a setting of low ambient air pollution are required to further investigate the effect of transitioning to a cleaner fuel such as ethanol on intrauterine growth. Trial registration ClinicalTrials.gov NCT02394574; September 2012

scholarly journals Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction

2006 ◽  
Vol 163 (11) ◽  
pp. 1035-1041 ◽  
Author(s):  
Laura M. Grosso ◽  
Elizabeth W. Triche ◽  
Kathleen Belanger ◽  
Neal L. Benowitz ◽  
Theodore R. Holford ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Cytochrome P 450

scholarly journals Carboxyhemoglobin Levels in Umbilical Cord Blood of Women With Preeclampsia and Intrauterine Growth Restriction

2010 ◽  
Vol 15 (suppl_A) ◽  
pp. 33A-33A
Author(s):  
K Yusuf ◽  
M Kamaluddeen ◽  
E Al-awad ◽  
RA Finch ◽  
B Caron ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta

2016 ◽  
Vol 55 (4) ◽  
pp. 616-617 ◽  
Author(s):  
André Campos da Cunha ◽  
Rosilene da Silveira Betat ◽  
Thaís Kappel Vieira Dal Pai ◽  
Camila Pauluci Arcolini ◽  
Amanda Muriela Gobatto ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Placenta Accreta ◽  
Growth Restriction ◽  
Intrauterine Growth

OC-81 Umbilical cord ghrelin levels in newborns with intrauterine growth restriction

2017 ◽  
Author(s):  
L&acaron;cr&acaron;mioara Bucur-Grosu ◽  
Andreea Avasiloaiei ◽  
Cristina Dimitriu ◽  
Mihaela Moscalu ◽  
Maria Stamatin
Keyword(s):  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

Experimental aspects of nutrition and fetal growth

1998 ◽  
Vol 10 (2) ◽  
pp. 91-107 ◽  
Author(s):  
FH Bloomfield ◽  
JE Harding
Keyword(s):  
Effective Treatment ◽  
Fetal Growth ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Perinatal Morbidity ◽  
Intrauterine Growth ◽  
Fetal Nutrition ◽  
Determining Factor ◽  
Ultrasound Evidence ◽  
Made In

Intrauterine growth restriction (IUGR) remains a major cause of perinatal morbidity and mortality and, as yet, there is no effective treatment. Most fetuses with ultrasound evidence of moderate to severe IUGR do not grow better out of the womb than in, despite early enteral feeds and subsequent calorie supplementation. Research into possible therapies for growth restricted babies has thus also been directed towards the fetus. Major advances have been made in recent years in the understanding of the physiology of fetal growth, and it has become clear that fetal nutrition is the determining factor.

scholarly journals A Review of Biomechanics Analysis of the Umbilical–Placenta System With Regards to Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Shier Nee Saw ◽  
Yichen Dai ◽  
Choon Hwai Yap
Keyword(s):  
Maternal Health ◽  
Medical Care ◽  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Ultrasound Elastography ◽  
Biomechanical Analysis ◽  
Intrauterine Growth ◽  
Clinical Detection ◽  
Future Work

Placenta is an important organ that is crucial for both fetal and maternal health. Abnormalities of the placenta, such as during intrauterine growth restriction (IUGR) and pre-eclampsia (PE) are common, and an improved understanding of these diseases is needed to improve medical care. Biomechanics analysis of the placenta is an under-explored area of investigation, which has demonstrated usefulness in contributing to our understanding of the placenta physiology. In this review, we introduce fundamental biomechanics concepts and discuss the findings of biomechanical analysis of the placenta and umbilical cord, including both tissue biomechanics and biofluid mechanics. The biomechanics of placenta ultrasound elastography and its potential in improving clinical detection of placenta diseases are also discussed. Finally, potential future work is listed.

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