scholarly journals Psychological and biological background of the interaction between psoriasis and stress

2014 ◽  
Vol 155 (24) ◽  
pp. 939-948 ◽  
Author(s):  
L. János Kálmán ◽  
Xénia Gonda ◽  
Lajos Kemény ◽  
Zoltán Rihmer ◽  
Zoltán Janka
Keyword(s):  
Neurogenic Inflammation ◽  
Significant Proportion ◽  
Stress Perception ◽  
Exact Role ◽  
New Techniques ◽  
The Past ◽  
Psychotherapeutic Interventions ◽  
Objective Evidence ◽  
Long Time

Stress is considered as a major contributor to the development and exacerbation of psoriasis by a significant proportion of patients and dermatologists. As both stressor and its effects are subject-dependent, thus extremely difficult to measure, our understanding of the exact role of stress in disease development was limited for a long time. In the past decade several new studies were carried out which expanded our knowledge on the pathophysiologic processes linking stress to psoriasis via with their objective measurements and the applied new techniques. The authors review the current literature of both psychological (alexithymia, personality, affect) and biological (cortisol, epinephrine, neurogenic inflammation) factors influencing stress perception and response in psoriasis. Results of recent investigations support previous reports about the interaction between stress and psoriasis with objective evidence. Knowing how effective stress-reducing psychopharmacologic and psychotherapeutic interventions are in the treatment of psoriasis the authors hope that this review contributes to a wider acceptance of the psychosomatic attitude in everyday dermatologic practice. Orv. Hetil., 2014, 155(24), 939–948.

scholarly journals Calcium Signaling in Plant Programmed Cell Death

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1089
Author(s):  
Huimin Ren ◽  
Xiaohong Zhao ◽  
Wenjie Li ◽  
Jamshaid Hussain ◽  
Guoning Qi ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Abiotic Stresses ◽  
Animal Studies ◽  
Future Research ◽  
Significant Progress ◽  
Biotic And Abiotic Stresses ◽  
Stress Perception ◽  
The Past

Programmed cell death (PCD) is a process intended for the maintenance of cellular homeostasis by eliminating old, damaged, or unwanted cells. In plants, PCD takes place during developmental processes and in response to biotic and abiotic stresses. In contrast to the field of animal studies, PCD is not well understood in plants. Calcium (Ca2+) is a universal cell signaling entity and regulates numerous physiological activities across all the kingdoms of life. The cytosolic increase in Ca2+ is a prerequisite for the induction of PCD in plants. Although over the past years, we have witnessed significant progress in understanding the role of Ca2+ in the regulation of PCD, it is still unclear how the upstream stress perception leads to the Ca2+ elevation and how the signal is further propagated to result in the onset of PCD. In this review article, we discuss recent advancements in the field, and compare the role of Ca2+ signaling in PCD in biotic and abiotic stresses. Moreover, we discuss the upstream and downstream components of Ca2+ signaling and its crosstalk with other signaling pathways in PCD. The review is expected to provide new insights into the role of Ca2+ signaling in PCD and to identify gaps for future research efforts.

12.—The National Physical Laboratory—Aspects of work on the primary standards of measurement

1972 ◽  
Vol 70 ◽  
pp. 125-141
Author(s):  
J. V. Dunworth ◽  
P. Dean
Keyword(s):  
National Physical Laboratory ◽  
New Techniques ◽  
The Past ◽  
Velocity Of Light ◽  
Physical Laboratory ◽  
The Future ◽  
Primary Standards ◽  
Infrared Frequencies ◽  
Very High

One of the traditional activities of the National Physical Laboratory is its work on the maintenance and improvement of the primary standards of measurement. Although one may possibly visualise such work, because of its long history and its association with calibration services, as of a largely routine character, this is certainly far from the case at the present time. The present is a period of considerable activity and change in fundamental metrology, with the classical material standards of measurement being superseded by atomic or quantum standards. The past decade has seen a change to atomic standards for the units of length and time, and there seems little doubt that the future will see an extension of atomic-based standards to other areas, notably that of the electrical quantities. Some of the changes which may come about as a consequence of adopting the most accurate and convenient quantum methods have interesting implications. For example, a possible outcome of the new techniques being developed for the accurate measurement of very high (infrared) frequencies is that the standards of length and time may become unified, with the velocity of light taking the role of an agreed defined constant rather than an experimentally determinable quantity.

De (on) Verklaarbaarheid Van Fossilisatie

1998 ◽  
Vol 58 ◽  
pp. 101-109
Author(s):  
Elisabeth van der Linden
Keyword(s):  
Learning Process ◽  
Past Tense ◽  
Advanced Learners ◽  
Syntactic Structures ◽  
The Past ◽  
Knowledge Based ◽  
Long Time ◽  
Past Tenses ◽  
Different Levels

In the literature about fossilization, several definitions have been given and several explanations have been suggested for this phenomenon. I see fossilization as a long-time stagnation in the T2 learning process, leading to errors based on transfer. Fossilization is caused by sociolinguistic, pyscholinguistic and purely linguistic factors. In this paper I concentrate on the acquisition of syntactic structures and on the role of input and instruction in that process. I argue that, although in the acquisition of some syntactic structures, UG plays an important role, this does not account for the whole learning process: learners have not only to reset parameters when acquiring T2 but have to proceduralize knowledge based on the surface structure of sentences. In the case of the use of past tenses in French, many of the Dutch advanced learners of three different levels of proficiency do not acquire native-like intuitions about the use of these tenses, although input as well as instruction are thorough on this point. I suggest that the past tense system is not UG-dependent and that the instruction does not allow proceduralization of the knowledge.

scholarly journals Neural Control of Immunity in Hypertension: Council on Hypertension Mid Career Award for Research Excellence, 2019

Hypertension ◽  
2020 ◽  
Vol 76 (3) ◽  
pp. 622-628
Author(s):  
Daniela Carnevale
Keyword(s):  
Immune Response ◽  
Nervous System ◽  
Neural Control ◽  
Neural Signals ◽  
The Past ◽  
Target Organs ◽  
Long Time ◽  
The Common ◽  
The Brain

The nervous system and the immune system share the common ability to exert gatekeeper roles at the interfaces between internal and external environment. Although interaction between these 2 evolutionarily highly conserved systems has been recognized for long time, the investigation into the pathophysiological mechanisms underlying their crosstalk has been tackled only in recent decades. Recent work of the past years elucidated how the autonomic nervous system controls the splenic immunity recruited by hypertensive challenges. This review will focus on the neural mechanisms regulating the immune response and the role of this neuroimmune crosstalk in hypertension. In this context, the review highlights the components of the brain-spleen axis with a focus on the neuroimmune interface established in the spleen, where neural signals shape the immune response recruited to target organs of high blood pressure.

Oxidants and antioxidative defense

2002 ◽  
Vol 21 (2) ◽  
pp. 61-62 ◽  
Author(s):  
T Grune
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Expression Patterns ◽  
Signal Transduction Pathways ◽  
Low Doses ◽  
The Past ◽  
Small Doses ◽  
Long Time ◽  
High Doses

The role of oxygen free radicals and other oxidants in several diseases has been well established over the past decade. Whereas it was long known that high doses of oxidants may damage or kill cells, the effect of low doses or long-time exposure to small flux rates of oxidants have been the focus of the free radical research until now. Here one has to take into account that most physiological and pathophysiological actions of oxidants and free radicals are based on the permanent action of small doses and flux rates. This includes effects of oxidants on signal transduction pathways and gene expression patterns. Therefore, only a few answers can be given today on the relevance of the effects of low doses of oxidants.

Role of the maternal microbiome in the pathogenesis of preeclampsia

2020 ◽  
Vol 18 (6) ◽  
pp. 8-12
Author(s):  
M. E. ZHELEZOVA ◽  
◽  
B. K. BEKTUR ◽  
R. I. SHARIPOVA ◽  
◽  
...  
Keyword(s):  
Bacterial Communities ◽  
Preterm Labor ◽  
Diagnostic Methods ◽  
Systematic Analysis ◽  
The Past ◽  
Long Time ◽  
Severe Manifestation ◽  
Pathological Pregnancy ◽  
Modern Russian

The purpose — to conduct a systematic analysis of the modern Russian and foreign publications on the role of microbiome in preeclampsia pathogenesis. Material and methods. Analysis of the modern Russian and foreign publications over the past eight years on the PubMed platform, systematic reviews of Cochrane, MEDLINE, and Google Scholar was conducted. Results. Preeclampsia is a severe manifestation of placental dysfunction resulting from angiogenic imbalance and inflammation. For a long time, the «sterile uterus» paradigm rejected the possible role of bacteria in the pathogenesis of preeclampsia and other complications of pregnancy. The introduction of new molecular genetics diagnostic methods made it possible to confirm the presence of bacterial communities in the uterus, placenta and amniotic fluid. The physiological microbiome maintains gravidar homeostasis, but dysbiosis in various niches is a potential cause of inflammation and can lead to pathological pregnancy outcomes such as preterm labor and preeclampsia. Conclusion. The microbiome of the oral cavity, intestines, vagina, uterus and placenta may play a certain role in the preeclampsia pathogenesis.

scholarly journals LIMITED STAGE FOLLICULAR LYMPHOMA: THE ROLE OF RADIATION THERAPY.

2016 ◽  
Vol 8 ◽  
pp. 2016041 ◽  
Author(s):  
Andrea Riccardo Filippi
Keyword(s):  
Radiation Therapy ◽  
Systemic Therapy ◽  
Historical Data ◽  
Early Stage ◽  
Therapeutic Option ◽  
Significant Proportion ◽  
Limited Stage ◽  
Long Time ◽  
Local Disease Control

Radiation therapy (RT) alone has been considered for a long time as the standard therapeutic option for limited stage FL, due to its high efficacy in terms of local disease control with a quite significant proportion of “cured” patients (without further relapses at 10-15 years). Multiple therapeutic choices are now accepted for the management of early stage FL at diagnosis, and better staging procedures as well as better systemic therapy partially modified the role of RT in this setting. RT has also changed in terms of prescribed dose as well as treatment volumes. In this review, we present and discuss the current role of RT for limited stage FL in light of the historical data, the modern RT approach and the best combination with systemic therapy.

Cutting Edge Techniques in Intramural Sports Officials' Development

2002 ◽  
Vol 26 (1) ◽  
pp. 54-64 ◽  
Author(s):  
David A. Gaskins ◽  
Bradley C. Petty ◽  
Stephen V. Rey
Keyword(s):  
Group Instruction ◽  
Practical Application ◽  
New Techniques ◽  
Mentor Programs ◽  
Intramural Sports ◽  
The Past ◽  
Training Motivation ◽  
Sports Officials ◽  
Critical Aspects

Many professionals have identified the crucial role of officiating in determining the success of an intramural sports program. Topics such as recruiting, retention, training, motivation, and evaluation have endured over time as critical aspects in managing these personnel. However, the landscape of sports officials' development itself has changed dramatically over the past decade. New approaches that are more effective have replaced the old traditional methods in many cases. These changes reflect a transition that encompasses philosophical, practical, and implementation elements. New recruiting methods include increased pay, specialized brochures, webpages, online applications, and promotional videos. Extramural assignments, “memorable moments” championship game experiences, assuming booking duties for outside recreational leagues, and mentor programs are among the new techniques implemented for retention/recognition. There is greater computer use to schedule officials, as well as establishing “crews” for the season. The area of training has undergone a significant transformation. Locating outstanding clinicians, access to NIRSA-sponsored educational workshops, the development of “approved” clinicians certification, greater usage of practical application teaching stations, emphasis on small-group instruction, and technological innovations are changing the way sports officials are trained. Sports officials' performance assessment is now done in a variety of ways. Audiotape, webpage forms, and videotaping, just some of the more effective techniques to study and critique the official's skills and abilities, are replacing old observation and evaluation forms.

Exploring exploration: the role of affective states as forces that hinder change

2019 ◽  
Vol 29 (1) ◽  
pp. 207-223
Author(s):  
Stefano Brusoni ◽  
Daniella Laureiro-Martínez ◽  
Nicola Canessa ◽  
Maurizio Zollo
Keyword(s):  
Environmental Change ◽  
The Other ◽  
Affective States ◽  
Cognitive Sciences ◽  
The Past ◽  
Other Hand ◽  
Long Time ◽  
Tentative Evidence ◽  
Negative Affective States

Abstract In this article we argue that in order to understand failure or success in adapting to environmental change, we should better understand why people hesitate to pursue novel choices. This article asks: what forces hinder individuals’ exploration choices of different alternatives, and hence their ability to learn from them? To answer this question, this article looks to the cognitive sciences to identify a set of plausible mechanisms that hinder people’s tendency to explore. So far, “exploration” has been studied as a relatively monolithic behavior. Instead, we propose that exploration can be characterized in terms of some distinctive forces behind it. On one hand, agents experience “attachment” to choices that proved successful in the past, and hence comfort when sticking with them. On the other hand, they also experience concerns about less familiar options, as they lack knowledge about “distant” choices that have not been tried for a long time, or ever. We propose that high attachment is related to anxiety, and high distance to fear. Both these negative affective states hinder exploration. We find and discuss preliminary and tentative evidence of this effect.

scholarly journals Miejsce i rola kobiety w rodzinie na przestrzeni wieków. Od Antyku po I wojnę światową. Zarys problematyki

2018 ◽  
pp. 33-41
Author(s):  
Rafał Kamprowski
Keyword(s):  
Twentieth Century ◽  
Time History ◽  
Women's Issues ◽  
The Past ◽  
The Status ◽  
Long Time ◽  
History Of ◽  
Role Of Women ◽  
The One

For a long time, history of women was not in the mainstream of interest. The interest for this topic was not shown untill the twentieth century. The aim of this paper is to present a long and difficult struggle to gain the status similar to the one women have nowadays. It is difficult to understand the present reality without going back to the past. The role of women is undergoing a lot of changes all the time. This subject is a huge field for research. The article attempts to give a summary of publications which deal with women’s issues.

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