scholarly journals Effect of Pintes white wine on metabolic parameters in patients with metabolic syndrome

2012 ◽  
Vol 153 (22) ◽  
pp. 861-865 ◽  
Author(s):  
Tatjána Ábel ◽  
Anna Blázovics ◽  
Alexandra Wimmer ◽  
Gabriella Bekő ◽  
Balázs Gaál ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Ldl Cholesterol ◽  
White Wine ◽  
Metabolic Parameters ◽  
Moderate Alcohol Consumption ◽  
Wine Consumption ◽  
Glucose Levels ◽  
Before And After ◽  
The Impact

Moderate alcohol consumption has been associated with decreased cardiovascular mortality in the general population. Relatively few studies have been conducted to evaluate the effect of white wine on insulin sensitivity. Aims: The authors studied the impact of moderate Pintes white wine consumption on insulin sensitivity and other metabolic parameters. Methods: The prospective study involved 18 patients with metabolic syndrome. The patients consumed Pintes white wine for 4 weeks, and parameters were measured before and after consumption. Results: The HOMA-IR decreased significantly after white wine consumption (2.28±2.04 vs 1.08±0.6; p = 0.002). There were no changes in serum cholesterol, LDL-cholesterol, triglyceride and fasting plasma glucose levels. Conclusion: White wine consumption improved insulin sensitivity in patients with metabolic syndrome. Orv. Hetil., 2012, 153, 861–865.

Beneficial effect of moderate white wine consumption on insulin sensitivity in patients with metabolic syndrome

2013 ◽  
Vol 42 (4) ◽  
pp. 631-639 ◽  
Author(s):  
T. Ábel ◽  
A. Blázovics ◽  
A. Wimmer ◽  
G. Bekő ◽  
B. Gaál ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Beneficial Effect ◽  
White Wine ◽  
Wine Consumption

scholarly journals Dietary fibre, lente carbohydrates and the insulin-resistant diseases

2000 ◽  
Vol 83 (S1) ◽  
pp. S157-S163 ◽  
Author(s):  
David J. A. Jenkins ◽  
Mette Axelsen ◽  
Cyril W. C. Kendall ◽  
Livia S. A. Augustin ◽  
Vladimir Vuksan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Major Type ◽  
Clotting Factors ◽  
Soluble Fibre ◽  
Cholesterol Levels ◽  
The Metabolic Syndrome

Several epidemiological studies link consumption of fibre-rich foods to a reduced risk of type 2 diabetes and CHD. The ‘fibre hypothesis’ suggested that this was a direct effect of fibre. However, fibre-rich foods contain different types of fibre as well as other potentially beneficial compounds, and many foods naturally high in fibre have low glycaemic and insulinaemic indices, possibly due to food form. The question therefore emerges as to the effect of isolated fibre per se on insulin sensitivity, lipids and other risk factors associated with the metabolic syndrome. Many beneficial effects are seen with pharmacological doses of isolated viscous soluble fibre, including improved insulin sensitivity, decreased LDL-cholesterol levels and decreased clotting factors. Similar effects are seen with low glycaemic-index foods. In contrast, insoluble non-viscous cereal fibre is not seen to act directly on risk factors when taken in refined foods such as in milled flour. Since cereal fibre, the major type of fibre in western diets, does not directly act on the risk factors for the metabolic syndrome, the question remains as to possible mechanisms. Until now, fibre and the nature and processing of the starch and particle size have been seen as the main determinants of the metabolic response to starchy foods. However, fibre-rich foods also have an increased protein-to-carbohydrate ratio. Hence we suggest that the protective effect of fibre may also be due to increased vegetable protein content, which may act directly to reduce clotting factors and oxidized LDL-cholesterol levels.

scholarly journals A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Yaqiong Chen ◽  
Jiang Wang ◽  
Yibing Wang ◽  
Pengfei Wang ◽  
Zan Zhou ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Fasting Blood Glucose ◽  
Obese Mice ◽  
Glucose Levels ◽  
Diet Induced Obesity ◽  
Blood Glucose Levels ◽  
Suitable Target ◽  
Artepillin C ◽  
Transcriptional Complex

AbstractThe molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not fully understood. Here, we report that Brazilian green propolis reduces fasting blood glucose levels in obese mice by disrupting the formation of CREB/CRTC2 transcriptional complex, a key regulator of hepatic gluconeogenesis. Using a mammalian two-hybrid system based on CREB-CRTC2, we identify artepillin C (APC) from propolis as an inhibitor of CREB-CRTC2 interaction. Without apparent toxicity, APC protects mice from high fat diet-induced obesity, decreases fasting glucose levels, enhances insulin sensitivity and reduces lipid levels in the serum and liver by suppressing CREB/CRTC2-mediated both gluconeogenic and SREBP transcriptions. To develop more potential drugs from APC, we designed and found a novel compound, A57 that exhibits higher inhibitory activity on CREB-CRTC2 association and better capability of improving insulin sensitivity in obese animals, as compared with APC. In this work, our results indicate that CREB/CRTC2 is a suitable target for developing anti-metabolic syndrome drugs.

scholarly journals AMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism

2019 ◽  
Author(s):  
Elko Randrianarisoa ◽  
Angela Lehn-Stefan ◽  
Johannes Krier ◽  
Anja Böhm ◽  
Martin Heni ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Hdl Cholesterol ◽  
Oral Glucose ◽  
Genetic Determinants ◽  
The Impact

Abstract Context AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all seven subunit genes on adiposity, glucose- and lipid metabolism has not been systematically studied yet. Objective To analyze the associations of common SNPs in all AMPK genes, and of different scores thereof, with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-, LDL- and HDL-cholesterol and triglycerides. Study Design and Methods A cohort of 2789 non-diabetic subjects from the Tübingen Family study of type-2 diabetes, metabolically characterized by oral glucose tolerance test and genotyped by genome-wide SNP array was analyzed. Results We identified largely non-overlapping SNP sets across four AMPK genes (PRKAA1, PRKAA2, PRKAG2, PRKAG3) associated with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-/LDL-cholesterol or HDL-cholesterol, respectively. A genetic score of body-fat-increasing alleles revealed per-allele effect sizes on BMI of +0.22 kg/m² (p=2.3·10-7), insulin sensitivity of -0.12·1019 L²/mol² (p=9.9·10-6) and 2-h blood glucose of +0.02 mmol/L (p=0.0048). Similar effects on blood glucose were observed with scores of insulin-sensitivity-reducing, insulin-secretion-reducing and glucose-raising alleles, respectively. A genetic cholesterol score increased total- and LDL-cholesterol by 1.17 mg/dL per allele (p=0.0002 and p=3.2·10-5, respectively), and a genetic HDL score decreased HDL-cholesterol by 0.32 mg/dL per allele (p=9.1·10-6). Conclusions We describe largely non-overlapping genetic determinants in AMPK genes for diabetes-/atherosclerosis-related traits which reflect the metabolic pathways controlled by the enzyme. Formation of trait-specific genetic scores revealed additivity of allele effects, with body-fat-raising alleles reaching a marked effect size.

Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome

2017 ◽  
Vol 163 (2) ◽  
pp. 184-189 ◽  
Author(s):  
K. V. Derkach ◽  
A. O. Ivantsov ◽  
O. V. Chistyakova ◽  
I. B. Sukhov ◽  
D. M. Buzanakov ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Metabolic Parameters ◽  
Intranasal Insulin

Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: effect of a 3-day, high-fat diet

2014 ◽  
Vol 307 (9) ◽  
pp. R1136-R1145 ◽  
Author(s):  
Andreas B. Jordy ◽  
Annette K. Serup ◽  
Kristian Karstoft ◽  
Henriette Pilegaard ◽  
Bente Kiens ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Protein Trafficking ◽  
High Fat Diet ◽  
Human Skeletal Muscle ◽  
Lipid Binding ◽  
High Fat ◽  
Before And After ◽  
The Impact ◽  
Sarcolemmal Vesicles

The aim of the present study was to investigate lipid-induced regulation of lipid binding proteins in human skeletal muscle and the impact hereof on insulin sensitivity. Eleven healthy male subjects underwent a 3-day hypercaloric and high-fat diet regime. Muscle biopsies were taken before and after the diet intervention, and giant sarcolemmal vesicles were prepared. The high-fat diet induced decreased insulin sensitivity, but this was not associated with a relocation of FAT/CD36 or FABPpm protein to the sarcolemma. However, FAT/CD36 and FABPpm mRNA, but not the proteins, were upregulated by increased fatty acid availability. This suggests a time dependency in the upregulation of FAT/CD36 and FABPpm protein during high availability of plasma fatty acids. Furthermore, we did not detect FATP1 and FATP4 protein in giant sarcolemmal vesicles obtained from human skeletal muscle. In conclusion, this study shows that a short-term lipid-load increases mRNA content of key lipid handling proteins in human muscle. However, decreased insulin sensitivity after a high-fat diet is not accompanied with relocation of FAT/CD36 or FABPpm protein to the sarcolemma. Finally, FATP1 and FATP4 protein was located intracellularly but not at the sarcolemma in humans.

scholarly journals Postoperative Glycaemia in Patients Following the CABG Surgery

2008 ◽  
Vol 8 (1) ◽  
pp. 48-51
Author(s):  
Mirsad Kacila ◽  
Elnur Tahirović ◽  
Zina Lazović
Keyword(s):  
Artery Bypass ◽  
Medical Documentation ◽  
Control Group ◽  
Entire Study ◽  
Antidiabetic Therapy ◽  
Glucose Levels ◽  
Study Results ◽  
Before And After ◽  
Glycaemia Control ◽  
The Impact

In this study we analyzed patients glucose levels taken before and after coronary artery bypass surgery. The data are taken from University of Sarajevo Clinics Centre-medical documentation of Heart Center from January 1st, 2007 to October 31st, 2007. Therefore, the entire study is done retrospectively. The patients considered in this analysis were divided into three groups. The patients in the first group were treated with peroral antidiabetics. The second group included patients treated with insulin while the third group consisted of patients without diabetes and acted as control group. All the patients had increased BMI. In the first two groups glucose levels were elevated before the surgery. Data analysis showed that three patients from the first group changed from peroral antidiabetics to insulin during postoperative period, and they were dismissed from hospital with this therapy. In the control group, peroral antidiabetis were introduced in four patients. The study results show that all the three groups have had high glycaemia on the first postoperative day. This may be caused by a number of reasons: inadequate pre-operative antidiabetic therapy, the impact of stress during surgery, inadequate pre-operative treatment of glycaemia or avoidance of the proscribed therapy by patients themselves. Stress during operation and administration of several medications after operation may also cause increased insulin resistance and distort glycaemia control.

scholarly journals Some Aspects of Nutrition and Moderate Body Weight Reduction in Lithuanian Olympic Sport Centre Female Basketball Players

2018 ◽  
Vol 2 (81) ◽  
Author(s):  
Marius Baranauskas ◽  
Linas Tubelis ◽  
Rimantas Stukas ◽  
Edmundas Švedas ◽  
Laimutė Samsonienė ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Weight Reduction ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Basketball Players ◽  
Body Weight Reduction ◽  
Glucose Levels ◽  
Before And After ◽  
Amino Acid Methionine ◽  
Olympic Sport

Research background and hypothesis. Many athletes know the benefi ts of low carbohydrate diets these days, but recently healthcare specialists have paid much attention to high carbohydrate diets and safer methods of losing weight. Research aim was to investigate Lithuanian Olympic Sport Centre female basketball players’ (n = 10) actual and special nutrition and their physical condition. Research methods. Athletes’ food records were analyzed and assessed. We determined plasma triacylglycerol, total cholesterol, LDL cholesterol, HDL cholesterol, glucose. Physical Working Capacity (PWC 170 ) test was conducted to determine aerobic fi tness before and after moderate weight reduction. Research results showed that the basketball players received too little carbohydrates, linoleic acid, amino acid methionine and too much fat. Vitamins D, PP, B 1  and folic acid intakes were insuffi cient. During moderate bodyweight reduction basketball players signifi cantly decreased in their BW (–2.2 ± 0.3 kg, p < 0.05), BF (–1.6 ± 0.3 kg, p < 0.05) and minerals (–0.1 ± 0.4 kg, p < 0.05), but they non-signifi cantly decreased in BP (p > 0.05). Furthermore, lipid panels markers (triacylglycerol, total cholesterol, LDL cholesterol, HDL cholesterol) experienced non-signifi cant improvements while glucose levels (p < 0.05) and PWC 170  (p < 0.05) resulted in signifi cant decrease following a 12-day hipocaloric diet. Discussion and conclusions. The results indicate that hipoenergetic moderate weight loss at < 30 kcal· kg –1  · day –1 , < 5 g · kg –1  · day  –1  carbohydrate is not recommended for athletes as it can affect aerobic fi tness.Keywords: nutrition, female basketball, bodyweight reduction.

scholarly journals Verification of the Impact of Blood Glucose Level on Liver Carcinogenesis and the Efficacy of a Dietary Intervention in a Spontaneous Metabolic Syndrome Model

2021 ◽  
Vol 22 (23) ◽  
pp. 12844
Author(s):  
Mayuko Ichimura-Shimizu ◽  
Takeshi Kageyama ◽  
Takeshi Oya ◽  
Hirohisa Ogawa ◽  
Minoru Matsumoto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Liver Tumors ◽  
Liver Carcinogenesis ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Urinary Glucose ◽  
The Impact

Metabolic syndrome (MS) is a risk factor for type 2 diabetes mellitus, vascular inflammation, atherosclerosis, and renal, liver, and heart diseases. Non-alcoholic steatohepatitis (NASH) is a progressive representative liver disease and may lead to the irreversible calamities of cirrhosis and hepatocellular carcinoma. Metabolic disorders such as hyperglycemia have been broadly reported to be related to hepatocarcinogenesis in NASH; however, direct evidence of a link between hyperglycemia and carcinogenesis is still lacking. Tsumura Suzuki Obese Diabetic (TSOD) mice spontaneously develop metabolic syndrome, including obesity, insulin resistance, and NASH-like liver phenotype, and eventually develop hepatocellular carcinomas. TSOD mice provide a spontaneous human MS-like model, even with significant individual variations. In this study, we monitored mice in terms of their changes in blood glucose levels, body weights, and pancreatic and liver lesions over time. As a result, liver carcinogenesis was delayed in non-hyperglycemic TSOD mice compared to hyperglycemic mice. Moreover, at the termination point of 40 weeks, liver tumors appeared in 18 of 24 (75%) hyperglycemic TSOD mice; in contrast, they only appeared in 5 of 24 (20.8%) non-hyperglycemic mice. Next, we investigated three kinds of oligosaccharide that could lower blood glucose levels in hyperglycemic TSOD mice. We monitored the levels of blood and urinary glucose and assessed pancreatic lesions among the experimental groups. As expected, significantly lower levels of blood and urinary glucose and smaller deletions of Langerhans cells were found in TSOD mice fed with milk-derived oligosaccharides (galactooligosaccharides and lactosucrose). At the age of 24 weeks, mild steatohepatitis was found in the liver but there was no evidence of liver carcinogenesis. Steatosis in the liver was alleviated in the milk-derived oligosaccharide-administered group. Taken together, suppressing the increase in blood glucose level from a young age prevented susceptible individuals from diabetes and the onset of NAFLD/NASH, as well as carcinogenesis. Milk-derived oligosaccharides showed a lowering effect on blood glucose levels, which may be expected to prevent liver carcinogenesis.

Sign in / Sign up

Export Citation Format

Share Document