scholarly journals Spontaneous aortic rupture during pregnancy

2011 ◽  
Vol 152 (23) ◽  
pp. 929-933 ◽  
Author(s):  
Zita Pánczél ◽  
Levente Sára ◽  
Péter Tóth ◽  
Márta Hubay ◽  
Éva Keller ◽  
...  
Keyword(s):  
Sudden Death ◽  
Aortic Dissection ◽  
Genetic Basis ◽  
Aortic Rupture ◽  
Relevant Literature ◽  
Ascending Aorta ◽  
Multiparous Woman ◽  
Rare Entity ◽  
Third Trimester ◽  
The Third

Aortic dissection is a rare entity. Half of the aortic dissection cases occur during pregnancy in women under the age of 40. The authors report a case of a multiparous woman at the third trimester of her sixth pregnancy, who died from a sudden and intractable cardiovascular shock. Autopsy revealed the dissection of the ascending aorta. The case is interesting, especially because in the pregnant woman’s family it was not the first sudden death during pregnancy. Authors review the relevant literature regarding the symptoms and the genetic basis of this rare but potentially lethal complication of pregnancy. Orv. Hetil., 2011, 152, 929–933.

Sudden death due to aortic dissection in early pregnancy – a case report

2017 ◽  
Vol 85 (3) ◽  
pp. 162-164 ◽  
Author(s):  
Akshith RS Shetty ◽  
YP Girish Chandra ◽  
S Praveen ◽  
Somusekhar Gajula
Keyword(s):  
Case Report ◽  
Chest Pain ◽  
Sudden Death ◽  
Aortic Dissection ◽  
Early Pregnancy ◽  
First Trimester ◽  
Ascending Aorta ◽  
Severe Chest Pain ◽  
Rule Out

Forensic pathologists come across many deaths due to natural causes which are sudden. Sudden natural deaths in females who are pregnant warrant thorough investigation and a medico-legal autopsy to rule out any foul play. Here, we report a case of 21-year-old primigravida in her first trimester who suddenly complained of severe chest pain and was brought dead to the hospital with no history suggestive of prior natural disease. At autopsy, the death was attributed to dissection of ascending aorta.

scholarly journals Lethal acute aortic dissection complicated with ischemic bowels in the third trimester of pregnancy: A case report

2020 ◽  
Vol 59 (5) ◽  
pp. 740-743
Author(s):  
Kun-Long Huang ◽  
Leo Leung-Chit Tsang ◽  
Hsu-Ting Yen ◽  
Yu-Lun Chou ◽  
Ching-Chang Tsai ◽  
...  
Keyword(s):  
Case Report ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Third Trimester ◽  
The Third

scholarly journals Aortic dissection in the third trimester pregnancy without risk factors

2019 ◽  
Vol 58 (5) ◽  
pp. 723-724 ◽  
Author(s):  
Hsu-Dong Sun ◽  
Sheng-Mou Hsiao ◽  
Szu-Ting Yang ◽  
Nai-Ming Cheng ◽  
Peng-Hui Wang
Keyword(s):  
Risk Factors ◽  
Aortic Dissection ◽  
Third Trimester ◽  
The Third ◽  
Trimester Pregnancy

Successful management of spontaneous aortic dissection type B in the third trimester of pregnancy : case report - online article

2012 ◽  
Vol 23 (10) ◽  
pp. e7-e9 ◽  
Author(s):  
Yavuz Simsek ◽  
Cengiz Colak ◽  
Ercan Yilmaz ◽  
Ebru Celik ◽  
Nevzat Erdil ◽  
...  
Keyword(s):  
Case Report ◽  
Aortic Dissection ◽  
Type B ◽  
Third Trimester ◽  
Successful Management ◽  
The Third

Abstract 2137: Bicuspid Aortic Valve, Aortic Dissection And Sudden Death In The Young: Just A Matter Of Ascending Aorta Diameters?

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Cristina Basso ◽  
Stefano Nistri ◽  
Stefania Rizzo ◽  
Aierkeen Abudureheman ◽  
Gaetano Thiene
Keyword(s):  
Aortic Valve ◽  
Sudden Death ◽  
Aortic Dissection ◽  
Bicuspid Aortic Valve ◽  
Aortic Root ◽  
Ascending Aorta ◽  
Type I ◽  
Tunica Media ◽  
Structural Abnormalities ◽  
Medial Necrosis

Background. Although bicuspid aortic valve (BAV) may remain silent during life, it can announce dramatically with aortic dissection and sudden death. The aim of the study was to determine the aortic diameters and histopathologic background in young people with BAV and aortic dissection. Design. Among 449 cardiovascular sudden deaths in the young (<35 years), 15 (3.3%), mean age 27±6.6, 14 M/1F, had a mechanical cardiac arrest due to aortic dissection (type I: 7, type II: 6, type III: 2): 6 had isolated BAV, 2 BAV associated with coarctation, 2 Marfan syndrome, 1 coarctation, 1 pregnancy, 1 hypertension and 2 were idiopathic. Ten young BAV patients who died suddenly without aortic dissection and 10 sex and age-matched controls were considered for comparison. Aortic root was measured at 4 levels (A1, annulus; A2, sinuses of Valsalva, A3, supraaortic ridge and A4, proximal ascending aorta). Histopathologic evaluation of the aortic tunica media was performed to assess elastic fragmentation, disarray, medial necrosis, proteoglycans deposits and fibrosis. Results. Aortic diameter values in dissected BAV vs normal BAV vs controls were: A1, 30.7±2.0 vs 27.4±2.3 (p=0.05) vs 26.3±1.6 (p<0.001); A2, 35.0±5.2 vs 28.9±1.8 (p=0.01) vs 27.3±1.5 (p=0.003); A3, 32.5±5.8 vs 26.7±2.5 (p=0.03) vs 24.5±1.5 (p=0.003); and A4, 38.7±7.0 vs 26.6±3.4 (p=0.002) vs 23.9±1.8 (p<0.001). Aortic diameters were significantly higher in Marfan patients (A1, 34.4±2.7; A2, 44.9±4.0; A3, 45.8±5.4; A4, 46.4±1.9). When comparing BAVs with and without dissection, higher scores of medial necrosis (1.2±0.4 vs 0.2±0.5, p=0.01), elastic fragmentation (2.4±0.5 vs 0.7±0.5, p=0.001) and fibrosis (1.6±0.5 vs 0.2±0.5, p=0.004) were found. Moreover, when comparing dissected BAVs and Marfan patients, similar structural abnormalities were found except lower medial necrosis (1.2±0.4 vs 2±0.0, p=0.002). Conclusions. Aortic root diameters are lower in dissected BAV than Marfan patients. However, structural abnormalities of the tunica media in terms of elastic fragmentation and fibrosis are similar. Imaging techniques able to assess not only a progressive increase of aortic diameters, but also abnormal aortic elasticity and stiffness are warranted to indentify patients at risk of aortic dissection.

The role of B cells and IgG in aortic dissection

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Nishida ◽  
A Furusho ◽  
H Aoki ◽  
S Ohno-Urabe ◽  
M Nishihara ◽  
...  
Keyword(s):  
B Cells ◽  
Sudden Death ◽  
Inflammatory Response ◽  
Aortic Dissection ◽  
Aortic Rupture ◽  
Funding Source ◽  
Wild Type ◽  
Tissue Destruction ◽  
Conceptual Foundation

Abstract Background Aortic dissection (AD) is one of the destructive and fatal aortic diseases, for which molecular pathogenesis is largely unknown. Recent studies have highlighted the importance of inflammatory response in AD. We and others reported that B cells and immunoglobulins participate in pathogenesis of abdominal aortic aneurysm, another form of aortic destructive disease, by promoting inflammatory response. It is not known whether and how B cells participate in AD pathogenesis. Methods and results Immunohistochemical staining of human AD tissue revealed that B cells were clustered together with T cells, macrophages and neutrophils at the entry site of AD with medial disruption. B cell cluster was also observed at the site of medial disruption in mouse model of AD that was induced by continuous infusion of beta-aminopropionitrile and angiotensin II (BAPN+AngII). In muMT mouse, which is deficient for B cells and immunoglobulins due to genetic deletion of immunoglobulin heavy chain, BAPN+AngII induced significantly less severe AD compared to that in wild type. Depositions of IgG and fibrinogen, one of the endogenous antigen for natural IgG, were observed after BAPN+AngII infusion before and after AD development in wild type mice. Deposition of fibrinogen was also observed in mMT mice after BAPN+AngII infusion. The rate of aortic rupture and sudden death was approximately 42% in wild type mice, while that in muMT mouse was 12% (P&lt;0.05). Administration of mouse normal polyclonal IgG to muMT mice resulted in dramatic increase in aortic rupture and sudden death, starting at day 7 of BAPN+AngII infusion, and reaching 69% of rupture rate, indicating the critical role of IgG in AD. Conclusion These findings demonstrated B cells and IgG are critically involved in the destructive inflammation of AD pathogenesis. Further, the deposition of fibrinogen, one of the targets of natural IgG, precedes the development of AD. Our findings may provide the conceptual foundation of the diagnostic strategy for on-going tissue destruction and for the therapeutic opportunities to intervene the progressive tissue destruction in AD. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): The Japan Society for the Promotion of Science

Cannulating a Dissecting Aorta Using Ultrasound-Epiaortic and Transesophageal Guidance

2011 ◽  
Vol 14 (6) ◽  
pp. 373 ◽  
Author(s):  
Saina Attaran ◽  
Maria Safar ◽  
Hesham Zayed Saleh ◽  
Mark Field ◽  
Manoj Kuduvalli ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
False Lumen ◽  
Type A ◽  
Ascending Aorta ◽  
Type A Aortic Dissection ◽  
Complete Rupture

<p>Management of acute Stanford type A aortic dissection remains a major surgical challenge. Directly cannulating the ascending aorta provides a rapid establishment of cardiopulmonary bypass but consists of risks such as complete rupture of the aorta, false lumen cannulation, subsequent malperfusion and propagation of the dissection.</p><p>We describe a technique of cannulating the ascending aorta in patients with acute aortic dissection that can be performed rapidly in hemodynamically unstable patients under ultrasound-epiaortic and transesophageal (TEE) guidance.</p>

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