Quantitative structure-retention relationship modeling of the retention behavior of guanidine and imidazoline derivatives in reversed-phase thin-layer chromatography

2015 ◽  
Vol 28 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Slavica Filipic ◽  
Milica Elek ◽  
Katarina Nikolic ◽  
Danica Agbaba
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Reversed Phase ◽  
Quantitative Structure ◽  
Retention Behavior ◽  
Imidazoline Derivatives ◽  
Structure Retention ◽  
Layer Chromatography ◽  
Quantitative Structure Retention Relationship

scholarly journals Normal and reversed phase thin-layer chromatography of new 16, 17-secoestrone derivatives

2003 ◽  
Vol 68 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Marijana Acanski ◽  
Suzana Jovanovic-Santa ◽  
Lidija Jevric
Keyword(s):  
Thin Layer ◽  
Stationary Phase ◽  
Thin Layer Chromatography ◽  
Silica Gel ◽  
Reversed Phase ◽  
Retention Behavior ◽  
Mobile Phases ◽  
Layer Chromatography

The retention behavior and separation ability of a series of new 16,17-secoestrone derivatives has been studied on silica gel, alumina and C-18 silica gel layers with non-aqueous and aqueous-organic mobile phases. The retention behavior and separation ability are discussed in terms of the nature of the solute, eluent and stationary phase.

scholarly journals Reversed-Phase Thin-Layer Chromatography with Different Stationary Phases in Studies of Quantitative Structure–Biological Activity Relationship of New Antimycotic Compounds

1999 ◽  
Vol 82 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Jan K Rózylo ◽  
Anna Zabiñska ◽  
Joanna Matysiak ◽  
Andrzej Niewiadomy
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Stationary Phases ◽  
Quantitative Structure Activity Relationship ◽  
Reversed Phase ◽  
Activity Relationship ◽  
Quantitative Structure ◽  
Acetone Concentration ◽  
Qsar Studies ◽  
Layer Chromatography

Abstract Reversed-phase thin-layer chromatography with RP-8, RP-18, and RP-18W stationary phases was used in quantitative structure–activity relationship (QSAR) studies of new antimycotic compounds. The retention behavior of 10 dihydroxythioben-zanilides was examined for acquisition of log k data. With water–acetone mixtures as the mobile phases, the concentration range for which the correlation between log k′ and acetone concentration is linear was established for each stationary phase and used to determine hydrophobicity parameters log k′w by linear extrapolation. The effect of substituents on retention constants was quantitated by using the group contribution parameters τw. On the basis of QSAR equations obtained from these studies, log k′w, data can be used to predict antifungal activities of dihydroxythiobenzanilides with satisfactory accuracy.

scholarly journals Estimation of the correlation between the retention of s-triazine derivatives and some molecular descriptors

2011 ◽  
pp. 231-239 ◽  
Author(s):  
Lidija Jevric ◽  
Gordana Koprivica ◽  
Nevena Misljenovic ◽  
Aleksandra Tepic ◽  
Tatjana Kuljanin ◽  
...  
Keyword(s):  
Linear Regression ◽  
Molecular Descriptors ◽  
Reversed Phase ◽  
Quantitative Structure ◽  
Mobile Phases ◽  
Physico Chemical ◽  
Triazine Derivatives ◽  
Structure Retention ◽  
Layer Chromatography ◽  
Quantitative Structure Retention Relationship

In this study, 14 newly synthesized s-triazine derivatives were investigated by means of reversed-phase thin-layer chromatography (TLC) on C-18 stationary and two different mobile phases: acetonitrile-water and methanol-water. Quantitative structure-retention relationship (QSRR) was developed for a series of s-triazine compounds by the multiple linear regression (MLR) analysis. An MLR procedure was used to model the relationships between molecular descriptors and retention of s-triazine derivatives. Physico-chemical molecular descriptors were calculated from the optimized structures. Statistically significant and physically meaningful QSRRs were obtained.

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