Enantiomeric resolution of chiral aromatic sulfoxides on non-commercial cellulose tribenzoate plates

2012 ◽  
Vol 25 (3) ◽  
pp. 214-219 ◽  
Author(s):  
Massimo Bubba ◽  
Leonardo Checchini ◽  
Alessandra Cincinelli ◽  
Luciano Lepri
Keyword(s):  
Enantiomeric Resolution

Synthesis and Enantiomeric Resolution of Medetomidine

2015 ◽  
Vol 47 (2) ◽  
pp. 141-148 ◽  
Author(s):  
H. Fakhraian ◽  
H. Toulabi ◽  
E. Choobdari ◽  
M. H. Peyrovi ◽  
H. Hadj Ghanbary
Keyword(s):  
Enantiomeric Resolution

scholarly journals Enantiomeric Resolution and Absolute Configuration of a Chiral δ-Lactam, Useful Intermediate for the Synthesis of Bioactive Compounds

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6023
Author(s):  
Roberta Listro ◽  
Giacomo Rossino ◽  
Serena Della Volpe ◽  
Rita Stabile ◽  
Massimo Boiocchi ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Bioactive Compounds ◽  
Absolute Configuration ◽  
Chiral Center ◽  
Reference Compound ◽  
Enantiomeric Resolution ◽  
Enantiomerically Pure ◽  
X Ray ◽  
The Past ◽  
Configuration Assignment

During the past several years, the frequency of discovery of new molecular entities based on γ- or δ-lactam scaffolds has increased continuously. Most of them are characterized by the presence of at least one chiral center. Herein, we present the preparation, isolation and the absolute configuration assignment of enantiomeric 2-(4-bromophenyl)-1-isobutyl-6-oxopiperidin-3-carboxylic acid (trans-1). For the preparation of racemic trans-1, the Castagnoli-Cushman reaction was employed. (Semi)-preparative enantioselective HPLC allowed to obtain enantiomerically pure trans-1 whose absolute configuration was assigned by X-ray diffractometry. Compound (+)-(2R,3R)-1 represents a reference compound for the configurational study of structurally related lactams.

Enantiomeric resolution, stereochemical assignment and toxicity evaluation of TPA enantiomers

2017 ◽  
Vol 31 (8) ◽  
pp. e3924 ◽  
Author(s):  
Yulang Chi ◽  
Zhijun Wu ◽  
Yi Zhong ◽  
Sijun Dong
Keyword(s):  
Toxicity Evaluation ◽  
Enantiomeric Resolution ◽  
Stereochemical Assignment
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