Use of a deslorelin implant for influencing sex hormones and male behaviour in a stallion — Case report

2012 ◽  
Vol 60 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Susanne Schönert ◽  
Martina Reher ◽  
Achim Gruber ◽  
Bianca Carstanjen
Keyword(s):  
Case Report ◽  
Sex Hormones ◽  
Serum Testosterone ◽  
Testicular Volume ◽  
Histopathological Analysis ◽  
Sperm Analysis ◽  
Promising Tool ◽  
Oestrone Sulphate ◽  
Serum Lh

This case report describes the use of a subcutaneously applied 4.7-mg deslorelin acetate implant in a three-year-old Arabian crossbred stallion showing unwanted strong male behaviour. Following deslorelin acetate implantation the stallion showed a short transitional increase in male behaviour. A ‘gelding-like’ behaviour was noted 15 days (D15) after treatment. The horse was surgically castrated at the owners request at D52 after treatment. Serum testosterone, oestradiol-17β and oestrone sulphate values decreased after deslorelin acetate implantation, but serum LH and FSH levels remained unchanged. Histopathological analysis of both testes and sperm analysis revealed a reduced spermatogenesis at D52. The testicular volume decreased after treatment. The use of a subcutaneously applied deslorelin acetate implant might be a promising tool to change the behaviour of aggressive stallions.

scholarly journals Primary pancreatic glomus tumor invading into the superior mesenteric vein: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Ichiro Tamaki ◽  
Yohei Hosoda ◽  
Hironobu Sasano ◽  
Yu Sasaki ◽  
Hidenori Kiyochi ◽  
...  
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Solid Tumor ◽  
Superior Mesenteric Vein ◽  
Glomus Tumor ◽  
Small Cells ◽  
Histopathological Analysis ◽  
Glomus Tumors ◽  
Mesenteric Vein ◽  
Direct Invasion

Abstract Background Glomus tumors are subcutaneous tumors arising from glomus bodies, thermoregulatory components of the skin. These tumors could occur in visceral organs where glomus bodies are not normally present. Herein, we report a case of primary pancreatic glomus tumor with aggressive direct invasion into the superior mesenteric vein (SMV). To the best of our knowledge, this is the second case report of a glomus tumor arising in the pancreas. Case presentation A 46-year-old woman was referred to our hospital due to vomiting with epigastric and back pain. Dynamic-CT revealed a well-circumscribed hypervascular mass, measuring 37 mm in its maximal diameter involving the pancreatic head. Both CT and endoscopic ultrasonography (EUS) revealed direct invasion into the SMV and radiologically suspected tumor thrombus. Biopsy sample obtained by EUS-guided fine needle aspiration revealed proliferation of small cells, round-to-oval tumor cells with round nuclei and scant cytoplasm. A histological diagnosis of pancreatic neuroendocrine tumor, G1 was initially considered. Therefore, subtotal stomach-preserving pancreatoduodenectomy using Child-II reconstruction was subsequently performed. Her SMV was resected and reconstructed due to extensive tumor involvement. Subsequent histopathological analysis revealed solid tumor cells proliferation that comprised oval-shaped nuclei and scant cytoplasm around disorganized or slit-shaped vessels in hematoxylin–eosin-stained slides. Immunohistochemical analysis then demonstrated positive immunoreactivity for smooth muscle actin, vimentin, and CD34, but negative for chromogranin A, synaptophysin, CD56, and signal transducer and activator of transcription 6. Based on these histological findings of resected specimens, the lesion was subsequently diagnosed as a primary pancreatic glomus tumor harboring direct invasion into the SMV. Her postoperative course was uneventful and annual surveys for the following 4 years post-op detected no clinical signs of recurrence. Conclusions We report a very rare case of glomus tumor of the pancreas accompanied by venous invasion. Curative surgical resection is the best treatment option for pancreatic glomus tumors. Although pancreatic glomus tumor is rare, it should be taken into consideration in the differential diagnosis of a pancreatic solid tumor with hypervascularity.

scholarly journals Large intraperitoneal lipoleiomyoma in a pre-menopausal woman: a case report

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sara L. Schaefer ◽  
Amy L. Strong ◽  
Sheena Bahroloomi ◽  
Jichang Han ◽  
Michella K. Whisman ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Histopathological Analysis ◽  
Menopausal Woman ◽  
En Bloc ◽  
Cross Sectional

Abstract Background Lipoleiomyoma is a rare, benign variant of the commonplace uterine leiomyoma. Unlike leiomyoma, these tumors are composed of smooth muscle cells admixed with mature adipose tissue. While rare, they are most frequently identified in the uterus, but even more infrequently have been described in extrauterine locations. Case presentation We describe a case report of a 45-year-old woman with a history of in vitro fertilization pregnancy presenting 6 years later with abdominal distention and weight loss found to have a 30-cm intra-abdominal lipoleiomyoma. While cross-sectional imaging can narrow the differential diagnosis, histopathological analysis with stains positive for smooth muscle actin, desmin, and estrogen receptor, but negative for HMB-45 confirms the diagnosis of lipoleiomyoma. The large encapsulated tumor was resected en bloc. The patients post-operative course was uneventful and her symptoms resolved. Conclusions Lipoleiomyoma should be considered on the differential diagnosis in a woman with a large intra-abdominal mass. While considered benign, resection should be considered if the mass is symptomatic, and the diagnosis is unclear or there is a concern for malignancy.

EFFECTS OF GENERAL ANAESTHESIA AND SEVERITY OF SURGICAL STRESS ON SERUM LH AND TESTOSTERONE IN MALES

1975 ◽  
Vol 78 (2) ◽  
pp. 258-269 ◽  
Author(s):  
A. Nakashima ◽  
K. Koshiyama ◽  
T. Uozumi ◽  
Y. Monden ◽  
Y. Hamanaka ◽  
...  
Keyword(s):  
General Anaesthesia ◽  
Surgical Stress ◽  
Fiberoptic Bronchoscopy ◽  
Serum Testosterone ◽  
Major Surgery ◽  
Succinylcholine Chloride ◽  
Serum Luteinizing Hormone ◽  
Serum Lh ◽  
Rate Of Increase ◽  
Male Patients

ABSTRACT Significantly decreased levels of serum testosterone from the pre-anaesthesia level were found during and up to 7 days following major surgery under general anaesthesia (nitrous oxide, oxygen and halothane following induction with thiopental and succinylcholine chloride) in 18 male patients. On the other hand, in the same patients, the serum luteinizing hormone (LH) increased significantly from the pre-anaesthesia level 30 min and 1 h after the beginning of anaesthesia. A slight increase in LH level was also noted on the 7th post-operative day. The determinations of serum testosterone and LH in fiberoptic bronchoscopy under the same general anaesthesia as that used in surgery or local anaesthesia in 26 male patients, revealed that the change in the serum LH during and following surgery seemed to be mainly induced by the general anaesthesia and that the rate of decrease in the serum testosterone may be related to the severity of surgical stress including the anaesthesia. The rate of increase in serum testosterone following the injection of gonadotrophin in 20 males on the 6th post-operative day was similar to that in 10 pre-operative males. The effects of pulmonary lobectomy on serum testosterone and urinary steroids were also studied in 6 males under adrenal suppression with dexamethasone. On the 6th post-operative day, the urinary aetiocholanolone plus androsterone and serum testosterone were found to be half the level of those on the pre-operative day, while the urinary 5β-pregnane-3α,17α,20α-triol remained unchanged. These observations in human are not inconsistent with the report of Tcholakian & Eik-Nes (1971) in dogs namely that a shift in androgen biosynthetic pathway is present in the testis under surgical stress.

ENDOCRINE STUDIES AND SUCCESSFUL TREATMENT IN A PATIENT WITH TRUE HERMAPHRODITISM

1979 ◽  
Vol 91 (1) ◽  
pp. 184-192
Author(s):  
Evangelina Valdés ◽  
Carlos Fernández del Castillo ◽  
Raul Gutiérrez ◽  
Fernando Larrea ◽  
Martha Medina ◽  
...  
Keyword(s):  
Chromosome Complement ◽  
Reproductive Function ◽  
External Genitalia ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Normal Children ◽  
Serum Lh ◽  
Genital Ambiguity ◽  
And Gender ◽  
Lh Rh

ABSTRACT A 12-year old, 46 XX true hermaphrodite born with genital ambiguity was studied and successfully treated. The serum LH and FSH profile resembled that of a pubertal normal individual, and LH-RH administration induced a normal LH response. Baseline testosterone serum levels were within the range for normal children. Exogenous HCG stimulation induced a significant serum testosterone increase up to values similar to those observed in normal post-pubertal males. Surgical examination disclosed the presence of bilateral ovotestis, normal Mullerian derivatives, epididymis, and vas deferens. A complete ovotestis with testicular predominance and the testicular portion of the contralateral ovotestis as well as the Wolffian derivatives, were removed. A further HCG stimulation 3 months after surgery, failed to induce serum testosterone increase. Spontaneous menarche was observed 6 months after surgery and ovulation was well documented. At present the patient has several characteristics of female sex including those of chromosome complement, gonad, internal and external genitalia, hormone levels and gender identity, thus demonstrating that treatment was successful and that reproductive function could be obtained. The finding of spontaneous ovulation following removal of the testicular portion suggests normal cyclic gonadotrophic release implying a difference between animal models and man in regard to hypothalamic virilization.

scholarly journals Length of efficacy and effect of implant location in adult tom cats treated with a 9.4 mg deslorelin subcutaneous implant

2018 ◽  
Vol 21 (6) ◽  
pp. 507-519 ◽  
Author(s):  
Stefano Romagnoli ◽  
Anna Baldan ◽  
Silvia Ferro ◽  
Camilla Righetti ◽  
Ludovico Scenna ◽  
...  
Keyword(s):  
Side Effects ◽  
Semen Quality ◽  
Serum Testosterone ◽  
Post Treatment ◽  
Testicular Volume ◽  
Duration Of Action ◽  
Testosterone Production ◽  
Duration Of Effect ◽  
Duration Of Efficacy ◽  
Testicular Histology

Objectives The objective of this study was to assess duration of efficacy, side effects and return to fertility following use of the 9.4 mg deslorelin implant (Suprelorin 12; Virbac) in cats, and test whether efficacy and duration of action are influenced by implantation site (interscapular vs periumbilical). Methods Sixteen healthy adult tom cats were checked with (1) reproductive examination, (2) gonadotropin-releasing hormone stimulation test and (3) semen collection until achievement of sterility, then with (1) and (2) only at 2, 4, 6 and 12 months, and every 6 months thereafter until treatment effect disappeared. Results Serum testosterone reached basal levels by 7 days post-treatment. Semen quality improved initially then started to worsen by 1 month post-treatment and after 70 days post-treatment all cats were sterile. Early in the third month post-treatment there was a significant decrease in testicular volume and penile spikes. Testicular histology was normal upon neutering performed after resumption of fertility. No injection site lesions or treatment-related side effects were observed. There was no difference between periumbilical and interscapular placement for all criteria, but there was a trend for the decrease in testicular volume to last longer and for the regression of penile spikes to start sooner after interscapular administration. One of 16 cats did not respond to treatment. Six cats were lost at variable times during the study while fully responding to treatment. In the cats that completed the study, normal fertility was regained after 805 days, on average, but with a variable duration of effect from 750–850 days. Conclusions and relevance Treatment with a 9.4 mg deslorelin implant in male cats was effective for a period of 750–850 days, which is 1.5–2 times longer than the effect of the 4.7 mg deslorelin implant. Fertility (based on serum testosterone production and the presence of penile spikes) was regained at the end of the study. Placing implants in the intrascapular vs periumbilical location did not affect duration of suppression of testosterone production. The interscapular location may be characterised by a better efficacy, although further studies are needed to clarify this issue.

scholarly journals Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst and anomalous pancreaticobiliary junction: case report

2019 ◽  
Vol 5 (2) ◽  
pp. 20180079
Author(s):  
Marta Reis de Sousa ◽  
Inês Santiago ◽  
Maria J Barata ◽  
Mireia Castillo ◽  
Celso Matos
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Gastric Adenocarcinoma ◽  
Choledochal Cyst ◽  
Histopathological Analysis ◽  
Gallbladder Neoplasms ◽  
Choledochal Cysts ◽  
Bile Duct Dilatation ◽  
Duct Dilatation ◽  
Anomalous Pancreaticobiliary Junction

A 75-year-old female incidentally presented with an enhancing intraluminal gallbladder mass, main bile duct dilatation and anomalous pancreaticobiliary junction (APBJ) during the staging of gastric adenocarcinoma. Histopathological analysis confirmed the diagnosis of intracholecystic papillary-tubular neoplasm. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder are rare gallbladder neoplasms, defined as intramucosal, preinvasive, exophytic, mass forming lesions. An association between choledochal cysts and anomalous pancreaticobiliary junction with gallbladder neoplasms is well known, and this case potentially illustrates gallbladder carcinogenesis related to these biliary anomalies.

scholarly journals Clinical features, histopathological analysis and surgical treatment of a free floating vitreous cyst: a case report

2006 ◽  
Vol 69 (5) ◽  
pp. 753-755 ◽  
Author(s):  
Rodrigo Pessoa Cavalcanti Lira ◽  
Patrícia Jungmann ◽  
Luis Felipe Lynch de Moraes ◽  
Ana Paula Teles Silveira
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Clinical Features ◽  
Histopathological Analysis ◽  
Vitreous Cyst

scholarly journals Varikocelės gydymas naudojant mikrochirurginį metodą

2012 ◽  
Vol 10 (1-2) ◽  
pp. 0-0
Author(s):  
Tigran Zotov ◽  
Deimantas Šukys
Keyword(s):  
Surgical Treatment ◽  
Sperm Quality ◽  
Testicular Volume ◽  
University Hospital ◽  
Adult Males ◽  
Sperm Analysis ◽  
Postoperative Control ◽  
Vilnius University ◽  
The Republic ◽  
E Mail

Tigran Zotov, Deimantas Šukys Respublikinės Vilniaus universitetinės ligoninės Urologijos skyrius, Šiltnamių g. 29, LT-04130 Vilnius El. paštas: [email protected] Įvadas Varikocelė yra gan dažna liga, nustatoma 10 proc. suaugusių vyrų, ir net 25 proc. tų vyrų, kurie tiriami dėl nevaisingumo. Varikocelė mažina sėklidžių apimtį, blogina spermos kokybę ir Leidigo ląstelių funkciją. Po varikocelės gydymo sėklidė padidėja, pagerėja spermos kokybė. Respublikinėje Vilniaus universitetinėje ligoninėje buvo pradėta naudoti mikrochirurginė varikocelės gydymo metodika. Metodai Nuo 2009 m. balandžio iki 2011 m. gegužės buvo atliktos septynios varikocelektomijos operacijos naudojant mikrochirurginę techniką. Rezultatai Intraoperacinių ar ankstyvųjų pooperacinių komplikacijų nebuvo. Iškvietus pakartotinio patikrinimo operuotus pacientus nerasta nė vieno varikocelės recidyvo. Išvados Varikocelė yra gan dažna liga, galinti lemti nevaisingumą. Dėl nevaisingumo besikreipiantiems vyrams, kuriems yra klinikinė varikocelės raiška ir nenormalius spermos tyrimas, indikuojamas operacinis gydymas. Jei yra galimybė pasinaudoti operaciniu mikroskopu, tikslinga atlikti mikrochirurginę varikocelektomiją, o jei tokios galimybės nėra, pirmučiausia alternatyva yra laparoskopinė varikocelektomija. Reikšminiai žodžiai: varikocelė, chirurginis gydymas. Varicocele treatment by the microsurgical method Tigran Zotov, Deimantas Šukys Republican Vilnius University Hospital, Department of Urology, Šiltnamių Str. 29, LT-04130 Vilnius, Lithuania E-mail: [email protected] Background Varicocele is a rather frequent disease found in 10% of adult males and in 25% of infertile men. Varicocele reduces the testicular volume, declines sperm quality and the function of the Leydig cells. After varicocele treatment, the testicular volume increases and sperm quality improves. Varicocele treatment by the microsurgical method was started at the Republic Vilnius University Hospital. Methods Seven varicocelectomies by the microsurgical way were performed from April 2009 till May 2011. Results No intraoperative or early postoperative complications were observed. There was no varicocele recurrences found on postoperative control visits. Conclusions Varicocele is a rather frequent disease which can cause infertility. Its surgical treatment is indicated in cases of a clinically apparent varicocele and abnormal sperm analysis. If possible (where a surgical microscope is accessible), microsurgical varicocelectomy is the preferred way of treatment. Laparoscopic varicocelectomy is the method of choice if there is no possibility to perform a microsurgical procedure. Key words: varicocele, surgical treatment

scholarly journals Platynosomum fastosum (Digenea: Dicrocoeliidae) infection in a domestic cat in northeastern Brazil: high fluke burden and associated lesions Infecção por Platynosomum fastosum (Digenea: Dicrocoeliidae) em gato doméstico no nordeste do Brasil: alta carga parasitária e lesões associadasdoi:10.12662/2317-3076jhbs.v4i3.775.p198-202.2016

2016 ◽  
Vol 4 (3) ◽  
pp. 198
Author(s):  
Roberta Da Rocha Braga ◽  
Djan Zanchi ◽  
John Allyson Andrade Oliveira ◽  
André Costa Teixeira ◽  
Luciano Pamplona de Góes Cavalcanti
Keyword(s):  
Case Report ◽  
Cystic Duct ◽  
Domestic Cat ◽  
Northeastern Brazil ◽  
Histopathological Analysis ◽  
Precursor Lesions ◽  
Domestic Cats ◽  
Prevalence Survey ◽  
Associated Lesions ◽  
Biliary Ducts

Introduction: Platynosomum fastosum is a dicrocoeliid fluke that infects birds and mammals, especially wild and domestic cats. Case report: A middle-aged male domestic cat was euthanized and examined. Its clinical features had included apathy, emaciation, hepatomegaly and mild jaundice on the mucosae. At necropsy, we noticed enlarged liver and dilated gallbladder. After opening the gallbladder lengthwise, multiple whitish flattened ellipsoidal structures were observed and identified as P. fastosum. The larger parasites were found in gallbladder, with significant different size from cystic duct and intrahepatic biliary ducts (p<0.05). Histopathological analysis revealed fluke-induced suppurative cholecystitis and chronic cholangitis. Precursor lesions of cholangiocarcinoma were reported. Conclusion: This report was part of the first prevalence survey of P.fastosum in municipality of Maracanaú, state of Ceará, northeastern Brazil.

scholarly journals Pleural effusion caused by polyostotic fibrous dysplasia involving the ribs, the sternum and the thoracic spine associated with multiple cystic degenerations – a case report

2019 ◽  
Vol 72 (1-2) ◽  
pp. 39-42
Author(s):  
Ivan Ergelasev ◽  
Ivan Kuhajda ◽  
Dejan Djuric ◽  
Danijela Kuhajda ◽  
Sinisa Maksimovic
Keyword(s):  
Case Report ◽  
Pleural Effusion ◽  
Fibrous Dysplasia ◽  
The Body ◽  
Bone Involvement ◽  
Cystic Degeneration ◽  
Histopathological Analysis ◽  
Daily Routine ◽  
Polyostotic Fibrous Dysplasia ◽  
Chest Wall Injury

Introduction. Fibrous dysplasia is a noninherited benign skeletal disorder associated with abnormal bone development. Single bone involvement, the monostotic form, accounts for 70 ? 80% of cases, while the polyostotic form, with multiple bone involvement, accounts for 20 ? 30% of cases. Cystic degeneration and occasional aneurysmal bone cyst formation may be found in fibrous dysplasia lesions, particularly in the costal lesions. Case Report. A 51-year-old man presented with acute shortness of breath after sustaining simple chest wall injury. Chest computed tomography showed multiple massive osteolytic rib lesions, as well as a massive left-sided pleural effusion with compression atelectasis of the lung parenchyma. Osteolytic lesions of the anterior 2nd and 7th thoracic vertebral body were found, along with a well defined osteolytic lesion in the body of the sternum. Video-assisted thoracoscopy of the left pleural space was performed and frozen sections, collected using endoscopic biopsy forceps of the cystic wall and solid parts of the tumors, were sent for ex tempore histopathological analysis. Results showed fibrous dysplasia with suspected malignancy. Talc pleurodesis was performed based on the obtained results. At present, the patient is asymptomatic with his daily routine uninterrupted by his medical condition. Conclusion. Treatment of pleural effusion caused by a cyst rupture of unresectable degenerated polyostotic fibrous dysplasia of the ribs represents a surgical challenge. Surgical drainage of the cysts followed by chemical pleurodesis seems to be a reasonable solution in cases where pulmonary functions are impacted by combined effects of pleural effusion and cystic compression.

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