scholarly journals A gluténérzékenység extraintestinalis spektruma

2019 ◽  
Vol 160 (34) ◽  
pp. 1327-1334
Author(s):  
István Fedor ◽  
Éva Zöld ◽  
Zsolt Barta
Keyword(s):  
Gastrointestinal Disease ◽  
Wide Spectrum ◽  
Gastrointestinal Symptoms ◽  
Autoimmune Disorder ◽  
Gluten Sensitivity ◽  
Age Group ◽  
Extraintestinal Manifestations ◽  
Gluten Sensitive Enteropathy ◽  
Paediatric Age ◽  
Delayed Recognition

Abstract: Although celiac disease (gluten-sensitive enteropathy) is a relatively well known malady, yet is surrounded by several misconceptions. It is in fact, a multi-systemic autoimmune disorder with a wide spectrum of possible presentations, though most clinicians regard it as a solely gastrointestinal disease. Another misconception that it is a disease of paediatric age group. Thus, the diagnosis of adult or elderly patients is often delayed. Recognition of the disease in the adults can be challenging, as there are less pronounced gastrointestinal symptoms, and patients present with other manifestations (i.e., neurologic, cardiovascular, hepatobiliary, or hematologic involvement are common). As these extraintestinal manifestations are less well known among practicing physicians, here we propose a brief overview of these. We aimed to summarize the available literature on the extraintestinal manifestations associated with gluten sensitivity. Orv Hetil. 2019; 160(34): 1327–1334.

scholarly journals Movement Disorders Related to Gluten Sensitivity: A Systematic Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1034 ◽  
Author(s):  
Ana Vinagre-Aragón ◽  
Panagiotis Zis ◽  
Richard Grunewald ◽  
Marios Hadjivassiliou
Keyword(s):  
Movement Disorders ◽  
Medical Literature ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Pubmed Database ◽  
Gluten Sensitive Enteropathy ◽  
The Subject

Gluten related disorders (GRD) represent a wide spectrum of clinical manifestations that are triggered by the ingestion of gluten. Coeliac disease (CD) or gluten sensitive enteropathy is the most widely recognised, but extra-intestinal manifestations have also been increasingly identified and reported. Such manifestations may exist in the absence of enteropathy. Gluten sensitivity (GS) is another term that has been used to include all GRD, including those where there is serological positivity for GS related antibodies in the absence of an enteropathy. Gluten ataxia (GA) is the commonest extraintestinal neurological manifestation and it has been the subject of many publications. Other movement disorders (MDs) have also been reported in the context of GS. The aim of this review was to assess the current available medical literature concerning MDs and GS with and without enteropathy. A systematic search was performed while using PubMed database. A total of 48 articles met the inclusion criteria and were included in the present review. This review highlights that the phenomenology of gluten related MDs is broader than GA and demonstrates that gluten-free diet (GFD) is beneficial in a great percentage of such cases.

scholarly journals Risk factors for sporadicYersinia enterocoliticainfections, Germany 2009–2010

2011 ◽  
Vol 140 (10) ◽  
pp. 1738-1747 ◽  
Author(s):  
B. M. ROSNER ◽  
K. STARK ◽  
M. HÖHLE ◽  
D. WERBER
Keyword(s):  
Risk Factors ◽  
Young Children ◽  
Yersinia Enterocolitica ◽  
Gastrointestinal Disease ◽  
Gastrointestinal Symptoms ◽  
Population Based ◽  
Local Health ◽  
Age Group ◽  
The European Union ◽  
Federal States

SUMMARYYersinia enterocoliticais an important cause of acute gastrointestinal disease and post-infectious complications. In Germany, incidence of reported yersiniosis is relatively high compared with other countries of the European Union. Children aged <5 years are most frequently affected. The aim of our study was to identify risk factors for sporadic yersiniosis in Germany. A population-based case-control study was conducted in five federal states of Germany from April 2009 to June 2010. Cases exhibiting gastrointestinal symptoms were notified to the local health department with aYersinia enterocoliticainfection culture-confirmed from stool. Controls were selected from population registries and frequency-matched on age group and state of residency. Cases and controls received a questionnaire on possible risk factors by mail. Multivariable logistic regression modelling was used to identify risk factors and to calculate adjusted odds ratios (aORs). Population attributable fractions (PAFs) were estimated for exposures associated with yersiniosis. We analysed data on 571 case patients and 1798 controls. Consumption of raw minced pork, a dish frequently consumed even by young children in Germany, was the main risk factor for disease (aOR 4·7, 95% confidence interval (CI) 3·5–6·3, PAF 30%). This association varied by age group and, unexpectedly, was strongest for children aged <2 years (aOR 17·5, 95% CI 6·0–51·2). Other independent risk factors included recent preparation of minced pork in the household (aOR 1·4, 95% CI 1·1–1·9, PAF 21%), playing in a sandbox (aOR 1·7, 95% CI 1·3–2·4, PAF 17%), and contact with birds (aOR 1·7, 95% CI 1·1–2·6, PAF 4%). Prevention efforts should specifically target parents and caregivers of young children and focus on the high infection risk associated with consumption of raw minced pork.

Eosinophilic disorders

2011 ◽  
Author(s):  
R. Mark Beattie ◽  
Anil Dhawan ◽  
John W.L. Puntis
Keyword(s):  
Dietary Protein ◽  
Gastrointestinal Disease ◽  
Wide Spectrum ◽  
Gastrointestinal Symptoms ◽  
Eosinophilic Oesophagitis ◽  
Full Spectrum ◽  
Ige Mediated ◽  
Eosinophilic Disorders ◽  
Allergic Disorders ◽  
Symptoms And Signs

Eosinophilic proctocolitis of infancy (dietary protein-induced proctocolitis of infancy) 320Eosinophilic enterocolitis of infancy (dietary protein-induced enterocolitis of infancy) 321Eosinophilic gastroenteropathies in the older child 322Eosinophilic oesophagitis 323Features suggestive of food allergy as a cause of gastrointestinal disease 323This chapter discusses the wide spectrum of eosinophilic (allergic) disorders of the gut. They are generally not IgE mediated. Presentation is with the full spectrum of gastrointestinal symptoms and signs. Outside infancy the disorders may only become apparent on investigation of chronic gut symptoms by endoscopy to exclude oesophagitis, peptic ulceration, enteropathy, or colitis. Important disorders to consider are: ...

Clinico-pathological study of acute pain abdomen in paediatric age group

2019 ◽  
Vol 13 (2) ◽  
pp. 108-111
Author(s):  
Vidya M Saravagol ◽  
◽  
Deepak Shanbhag ◽  
Ashraf Ahamed ◽  
Kartik Sadananda ◽  
...  
Keyword(s):  
Acute Pain ◽  
Age Group ◽  
Pathological Study ◽  
Pain Abdomen ◽  
Paediatric Age

scholarly journals Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols

2021 ◽  
Vol 22 (2) ◽  
pp. 595
Author(s):  
Charlene B. Van Buiten ◽  
Ryan J. Elias
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Gastrointestinal Symptoms ◽  
Autoimmune Disorder ◽  
Treatment Method ◽  
Mucosal Damage ◽  
Protective Effects ◽  
Novel Therapy ◽  
Gluten Proteins ◽  
Prospective Application

Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method.

scholarly journals Management of colonic diverticulitis

BMJ ◽  
2021 ◽  
pp. n72
Author(s):  
Anne F Peery
Keyword(s):  
Gastrointestinal Disease ◽  
Acute Diverticulitis ◽  
Anaerobic Bacteria ◽  
Gastrointestinal Symptoms ◽  
Colon Resection ◽  
Acute Onset ◽  
Colonic Diverticulitis ◽  
Uncomplicated Diverticulitis ◽  
Recurrent Diverticulitis ◽  
Primary Resection And Anastomosis

ABSTRACT Left sided colonic diverticulitis is a common and costly gastrointestinal disease in Western countries, characterized by acute onset of often severe abdominal pain. Imaging is necessary to make an initial diagnosis and determine disease severity. Colonoscopy should be done six to eight weeks after diagnosis to rule out a missed colon malignancy. Antibiotic treatment is used selectively in immunocompetent patients with mild acute uncomplicated diverticulitis. The clinical course of diverticulitis commonly includes unpredictable recurrences and chronic gastrointestinal symptoms, which are a detriment to quality of life. A better understanding of prognosis has prompted a shift toward non-operative approaches. The decision to undergo prophylactic colon resection should be individualized to consider the severity of diverticulitis, the patient’s health and immune status, and the patient’s preferences and values, as well as benefits and risks. Because only a section of colon is removed, recurrent diverticulitis remains a risk. Acute diverticulitis with an abscess is treated with antibiotics that cover Gram negative and anaerobic bacteria, with or without percutaneous drainage. Acute diverticulitis with purulent or feculent contamination of the peritoneal cavity is managed with surgery; primary resection and anastomosis is the procedure of choice in stable patients.

Profile and outcomes of critically ill children in a lower middle-income country

2017 ◽  
Vol 35 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Muhammad Irfan Habib ◽  
Khalid Mehmood A Khan
Keyword(s):  
Critically Ill ◽  
Respiratory Symptoms ◽  
Gastrointestinal Symptoms ◽  
Middle Income Country ◽  
Income Country ◽  
Critically Ill Children ◽  
Age Group ◽  
Middle Income ◽  
Lower Middle Income Country ◽  
Level 1

ObjectiveTo determine the clinical profile and outcome of critically ill children presenting to a paediatric ED in a lower middle-income country.MethodsWe performed a retrospective analysis of children (<14 years) presenting to the ED of the National Institute of Child Health, Karachi, between January and December 2014 who were assigned to acuity 1 (requiring immediate life-saving interventions) according to the Emergency Severity Index. Data included demographic variables, presenting complaints, interventions and outcomes in the ED.ResultsThere were 172 162 visits during the year. Of these, 13 551 (8%) were level 1. 64% of level 1 patients were transported to the ED without ambulance service. Neonates (0–28 days) constituted 48% of level 1 children; their most frequent presenting complaints were respiratory symptoms, followed by fever and reluctance to feed. Above the neonatal age group, the most common presenting complaints were gastrointestinal symptoms (with signs of hypoperfusion), followed by seizures, reluctance to feed and respiratory symptoms. 64% of children of >28 days presenting were malnourished. Interventions included cardiopulmonary resuscitation, application of bubble continuous positive airway pressure and endotracheal intubation. Overall mortality was 13%; 63% of all deaths were in the neonatal age group.ConclusionChildren with the highest triage acuity represent 8% of all visits to a paediatric ED. In this group, neonates account for nearly half of all the children, and more than half of all the deaths among critically ill children came in ED. A large proportion of high-acuity children are malnourished.

scholarly journals Pattern of Ear Diseases among Paediatric ENT Patient: An Experience from Tertiary Care Centre, Pokhara, Nepal

2012 ◽  
Vol 32 (2) ◽  
pp. 142-145 ◽  
Author(s):  
B Sigdel ◽  
R Nepali
Keyword(s):  
Tertiary Care ◽  
Age Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Suppurative Otitis Media ◽  
Ear Diseases ◽  
Paediatric Age ◽  
One Year ◽  
A Prospective Study ◽  
Nose And Throat

Introduction: Ear diseases are common in children mainly due to altered anatomy of Eustachian tube which is straighter in children as compared to that in adults. However, the cause of hearing loss in children is more varied, including the etiologies. This study was done to find out the pattern of ear diseases in paediatric age group attending ear, nose and throat OPD in a tertiary care centre in Pokhara, Nepal. Materials and Methods: This is a prospective study done in paediatric patients attending ENT OPD over a period of one year from January 2010 to January 2011. The diagnoses were made on the basis of history and clinical examination. Results were expressed in numbers and percentages. Results: Out of 1632 Pediatric ENT patients, 944 had ear diseases, 59.2% were males and 40.8% females. Wax (33.4%) was the commonest diagnosis followed by Chronic suppurative otitis media (24.3%) and Acute ottitis media (13%). Conclusion: Ear diseases are most common condition in ENT OPD among paediatric age group. Wax, CSOM and ASOM were the three most common ear diseases. J. Nepal Paediatr. Soc. 32(2) 2012 142-145 doi: http://dx.doi.org/10.3126/jnps.v32i2.5673

Should pulmonary radiographs be taken routinely following paediatric tracheostomy?

2021 ◽  
pp. 021849232110063
Author(s):  
Nazik Yener ◽  
Muhammed Üdürgücü ◽  
Fatma Alaçam ◽  
Muhammed Şükrü Paksu ◽  
İrem Sarı ◽  
...  
Keyword(s):  
High Risk ◽  
Tracheostomy Tube ◽  
Risk Groups ◽  
Age Group ◽  
Paediatric Radiology ◽  
Surgical Tracheostomy ◽  
Emergency Tracheostomy ◽  
New Findings ◽  
Paediatric Age ◽  
Study Support

Aim As the rates of complications related to tracheostomy procedures have fallen in recent years, the routine taking of pulmonary radiographs following tracheostomy has become a matter of debate. The aim of this study was to compare the incidence of complications developing in 120 children who had pulmonary radiographs taken following surgical tracheostomy and to thereby evaluate the necessity of routine pulmonary radiographs after tracheostomy. Methods The data were retrospectively reviewed of 120 children who had pulmonary radiographs taken following surgical tracheostomy between January 2012 and January 2018. The pulmonary radiographs taken before and immediately after tracheostomy were evaluated independently by two paediatric radiology specialists and the results were recorded. Results The incidence of complications after tracheostomy was determined as 23.3%, and no pneumothorax was determined in any patient. An increase was not seen in the complication incidence in those who had undergone emergency tracheostomy and patients aged < 2 years, which are accepted as high-risk groups. In the evaluation of the pre- and post-tracheostomy radiographs, new findings were determined on the post-tracheostomy radiograph that had not been there previously in eight patients (6.6%). These findings were newly formed infiltration in seven patients (5.8%), and malposition of the tracheostomy tube in one patient (0.8%). No pathology requiring intervention was determined on the radiographs of any patient. Conclusion The results of this study support the view that it is not necessary to take pulmonary radiographs routinely following tracheostomy in the paediatric age group, including those at higher risk.

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