scholarly journals A preoperatív antibiotikus és antiszeptikus kezelés hatása a műtéti úton eltávolított alsó bölcsességfogak sebgyógyulására – prospektív randomizált vizsgálat

2017 ◽  
Vol 158 (1) ◽  
pp. 13-19 ◽  
Author(s):  
István Kaposvári ◽  
Kinga Körmöczi ◽  
Zsuzsa Beáta László ◽  
Ferenc Oberna ◽  
Ferenc Horváth ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Third Molar ◽  
Control Group ◽  
Surgical Removal ◽  
Group Iii ◽  
Prophylactic Dose ◽  
Group I ◽  
Mandibular Third Molar ◽  
Amoxicillin Clavulanate ◽  
Group 2

Abstract: Introduction and aim: The study compares the antibiotic prophylaxis combined with postoperative antibiotic therapy to preoperative chlorhexidine rinse combined with postoperative antibiotic therapy in preventing complications after surgical removal of a mandibular third molar. Method: 71 healthy patients in four groups were enrolled in the study: I. prophylactic dose of 2000 mg of amoxicillin clavulanate, continued with amoxicillin clavulanate postoperatively; II. prophylactic dose of 600 mg of clindamycin, continued with clindamycin postoperatively; III. prophylactic chlorhexidin rinsing, continued randomized amoxicillin clavulanate or clindamycin postoperatively; IV. control, with clindamycin postoperatively. Results: The pain was smaller in the prophylaxis groups. Alveolitis occurred only in the control group: 2 patients. Wound opening occurred in 22,2 % in group IV., 14,2 % in group II, 10 % in group I., 5 % in group III. Conclusion: We consider completing the indicated postoperative antibiotic prescription with antibiotic or antiseptic prophylaxis. Chlorhexidin prophylaxis could have the same positive effect. Orv. Hetil., 2017, 158(1), 13–19.

scholarly journals Clinical Evaluation of Corticosteroid on Post Operative Morbidity in Impacted Lower Third Molar Surgery

2020 ◽  
Vol 32 (1) ◽  
pp. 5-9
Author(s):  
Mohammad Iqbal Kabir ◽  
Muhammad Mizanur Rahaman ◽  
Md Atiqul Islam Rabby ◽  
Samira Taufique Reshma ◽  
Md Abdur Rab ◽  
...  
Keyword(s):  
Maxillofacial Surgery ◽  
Third Molar ◽  
Study Groups ◽  
Military Hospital ◽  
Third Molar Surgery ◽  
Control Group ◽  
Surgical Removal ◽  
Early Recovery ◽  
Operative Morbidity ◽  
Mandibular Third Molar

Introduction: Mandibular third molar is most commonly dental impacted and it’s removal is not without morbidity. Post operative pain, swelling and trismus are universal. This study was carried out to compare the effect of co-administered corticosteroid and diclofenac Na+/K+ with diclofenac Na+/K+ alone on the post operative morbidity like pain, swelling and trismus after surgical removal of impacted lower third molars. Materials and Methods: The study was a prospective study done over a period of 01.01.13 to 30.06.14 in Department of Oral & Maxillofacial Surgery (OMS), Military Dental Center, Combined Military Hospital, Dhaka and the department of OMS Dhaka Dental College and Hospital, Dhaka. Sixty patients were included in the study and were randomly divided into two study groups: Control group received only diclofenac Na+/K+, Experimental group received corticosteroid and diclofenac Na+/K+. Pain, swelling and trismus were evaluated before, 1st, 2nd and 7th POD after surgery. Results: Among the 60 cases common type of impaction was horizontal and vertical type (30%) followed by Mesioangular (23%) and Distoangular (17%). All corticosteroid groups showed statistically significant (p < 0.01) improvement in pain and trismus at 1st and 2nd pod, but statistically significant (p < 0.01) improvement of swelling occur only on 2nd pod as compared to control group. Conclusion: Corticosteroid and diclofenac Na+/K+ combination was found effective for early recovery and the patients who used this combination suffered less pain, swelling and trismus after impacted mandibular third molar surgery. Medicine Today 2020 Vol.32(1): 5-9

scholarly journals ISONIAZID (INH)

2018 ◽  
Vol 25 (10) ◽  
pp. 1587-1595
Author(s):  
Umer Aleem ◽  
Rahman Shah ◽  
Noor Khan ◽  
M. Suliman
Keyword(s):  
Serum Bilirubin ◽  
Statistical Significance ◽  
Negative Control Group ◽  
Protective Role ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group 2

Objectives: Hepatotoxicity is the most complicated side effect of isoniazid (inh)in the patient treated for tuberculosis. In causes 8–30% hepatotoxicity in the developing world.Metabolism of INH produces a metabolite, called acetyl isoniazid. In this study hepatoprotectiveeffect of honey, in isoniazid induced animal model was assessed. Study Design: Randomizedcontrol trial. Setting: Saidu Medical College, Saidu Sharif Swat, KP. Period: October ToDecember 2017. Material and Methods: 40 healthy male rabbits were assigned randomly tothe group i, ii, iii and iv by using lottery method. Ten animals were grouped each row. Theisoniazid-induced hepatotoxic model was created by giving 50 mg inh/kg orally on daily basisfor eleven days. Group i was taken as negative control group ii as a positive control. Group iii andiv were experimental groups treated with 50 mg /kg/day and 100 mg /kg/day buckwheat honeyrespectively for eleven days. SPSS Version 16 software was used, mean, s.d. were determinedin all the groups. Values of serum bilirubin, sgpt, and alkaline phosphatase were comparedwith each other using pairt-test. Results: SGPT, Serum bilirubin, and alkaline phosphatasewere obtained in all the animals. Comparing group 1 negative control with group 2, 3 and 4shows statistical significance, (p=0.00). Comparing group 2 positive control with 3 and 4 showsstatistical significance, (p=0.00). Further comparing group 3 with group 4 also shows statisticalsignificance (p=0.00). Conclusion: From the above finding, it has been revealed that honeyhas got a protective effect in regressing hepatitis that has been induced in rabbit’s model byhigh doses of isoniazid. Related studies performed in which different chemicals and drugs havebeen tried for their protective role in isoniazid induced hepatitis also shows a similar type ofresults.

scholarly journals Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings

2020 ◽  
Vol 12 (3) ◽  
pp. 234-240
Author(s):  
I. Valchev ◽  
К. Stojanchev ◽  
N. Nicolov ◽  
R. Binev
Keyword(s):  
Aflatoxin B1 ◽  
Total Protein ◽  
Blood Chemistry ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Group Iii ◽  
Group I ◽  
Hepatotoxic Effect ◽  
Group 2 ◽  
Glutamyl Transferase

Abstarct. The aim of the present investigation was to evaluate the effects of aflatoxin B1 and Mycotox NG applied either independently or together, on blood total protein, albumin, blood glucose, total bilirubin, triglycerides, cholesterol, enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), gamma-glutamyl transferase (γ GT), lactate dehydrogenase (LDH) and changes in liver morphology. At the same time, the potential of supplementation of feed with a mycosorbent (Mycotox NG) was evaluated. Experiments were carried out with 40 1-day-old Toulouse geese from mixed sexes divided into one control and three treatment groups (n=10). Groups were as followed: Group I – control (0 mg/kg AFB1 not supplemented with Mycotox NG); Group II (0.5 g/kg Mycotox NG), Group III (0.5 mg/kg AFB1) and Group IV (0.5 mg/kg AFB1 and 0.5 g/kg Mycotox NG). In this study, commercially available geese of Toulouse strain were reared from day one to forty two days in the deep litter system of management and the birds were divided into four groups. Normal feed tested free of aflatoxin (AFB1), was given to the control (Group – 1). 0.5 g/kg Mycotox was supplemented with the feed to Group 2, Aflatoxin (0.5 mg/kg feed) was supplemented with the feed to Group 3 and Mycotox Ng (0.5 g/kg feed) + 0.5 mg/kg feed AFB1 was supplemented with the feed to Group 4. The duration of the experiments was 42 days. The monitored blood chemical parameters were analysed on post treatment days 21 and 42. In birds treated only with AFB1, (group III) increased blood activities of studied enzymes. At the same time, blood total protein, albumin, cholesterol, glucose and triglycerides were reduced as compared to controls. The observed histopathological changes in the liver consisted in various extent of dystrophy (congestion, vacuolar and granular dystrophy, round cell proliferation, necrobiotic changes, hyperplasia of gallbladder epithelium). The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions. The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions.

scholarly journals Efficacy of Intraoperative Administration of Topical Tranexamic Acid Solution on Blood Loss During Surgical Removal of Impacted Mandibular Third Molar

2021 ◽  
Vol 10 (35) ◽  
pp. 2989-2993
Author(s):  
Subhashini Ramasubbu ◽  
Shivangi Gaur ◽  
Abdul Wahab PU ◽  
Madhulaxmi Marimuthu
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Third Molar ◽  
Surgical Removal ◽  
Impacted Mandibular Third Molar ◽  
Mandibular Third Molar ◽  
Male Patients ◽  
The Mean ◽  
Group 2 ◽  
Group 1

BACKGROUND Perioperative haemorrhage is an important concern during any surgical procedure. The purpose of this study was to assess the effect of tranexamic acid (TXA) irrigation on perioperative haemorrhage during the surgical removal of impacted mandibular third molar. METHODS In this double-blind, randomized controlled clinical trial, 120 participants who underwent surgical removal of horizontally impacted mandibular third molar were divided into 2 groups. The patients in the Group 1 received 0.9 % normal saline for irrigation during the procedure and the patients in the Group 2 received TXA irrigation with normal saline (1 mg / mL), age, gender, operation duration, amount of blood loss and visual assessment of surgical field were the variables that were studied. The use of TXA solution for irrigation was the predictive factor of the study. RESULTS Each group consisted of 60 patients. Group 1 consisted of 31 male patients (51.7 %) and 29 female patients (48.3 %) and group 2 consisted of 30 male patients (50 %) and 30 female patients (50 %). There was no difference in the distribution of the variables between the 2 groups, except for the duration of the operation. The mean operative time was 20.94 ± 0.61 minutes in group 1 and 26.17 ± 0.98 minutes in group 2 (P > .05) which was not statistically significant. The mean intraoperative blood loss was 44.47 ± 6.416 mL in group 1 and 84.73 ± 7.861 in group 2 (P < .05). The mean volume of irrigation was 100.08 ± 7.658 mL in group 1 and 140.33 ± 12.332 mL in group 2 (P < .05). CONCLUSIONS TXA is effective in reducing the risk of intraoperative blood loss in patients for whom substantial blood loss is anticipated. KEY WORDS Tranexamic Acid, TXA, Blood Loss, Third Molar Surgery, Impacted Tooth Removal.

scholarly journals Preemptive Oral Etoricoxib on Health-Related Quality of Life after Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Long Xie ◽  
Zhi Li ◽  
Zheng-Jun Shang
Keyword(s):  
Quality Of Life ◽  
Postoperative Pain ◽  
Third Molar ◽  
Control Group ◽  
Surgical Removal ◽  
Health Related Quality ◽  
Mandibular Third Molar ◽  
Related Quality ◽  
Health Related

This study was aimed at evaluating the use of oral etoricoxib for preemptive analgesia on the health-related quality of life (QoL) outcome after the extraction of mandibular third molar. The study population consisted of 60 participants that required extraction of a single partial bony impacted mandibular third molar under local anesthesia and met the inclusion criteria. The participants were randomized into two groups. The etoricoxib group orally received 60 mg etoricoxib 30 min before surgery, whereas the control group was given a placebo. The patients were assessed postoperatively after 1, 2, 3, 4, 5, 6, and 7 days using the United Kingdom oral health-related QoL questionnaire and visual analog scale for maximum postoperative pain. The total dose of ibuprofen rescue intake and total number of days the drug was taken were recorded. Surgical removal of impacted teeth had a negative influence on the patient’s QoL across various physical, social, and psychological aspects. The scores for postoperative pain in the etoricoxib group were significantly lower than those in the control group on each postoperative observation day. The number of patients without analgesic rescue medication, the average amount, and total number of days emergency analgesics were taken were significantly lower in the etoricoxib group than in the control group. The etoricoxib group showed better QoL score than the control group. Preemptive oral etoricoxib is an effective therapeutic strategy for improving the QoL after surgical removal of the impacted lower third molar.

scholarly journals Comparing the Efficacy of Triclosan Coated Sutures versus Chlorhexidine Coated Sutures in Preventing Surgical Site Infection after Removal of Impacted Mandibular Third Molar

2020 ◽  
pp. 138-148
Author(s):  
Sneha Krishnan ◽  
Senthilnathan Periasamy ◽  
Arun Murugaiyan
Keyword(s):  
Surgical Site Infection ◽  
Maxillofacial Surgery ◽  
Third Molar ◽  
P Value ◽  
Surgical Removal ◽  
Site Infection ◽  
Impacted Mandibular Third Molar ◽  
Mandibular Third Molar ◽  
Significant Difference ◽  
Group 2

The aim of this present clinical trial study is evaluate the efficacy of triclosan coated sutures versus chlorhexidine coated sutures in preventing surgical site infection after removal of an impacted mandibular third molar. This prospective, single blind study included 30 patients divided into two groups with 15 patients each who had been referred to the Oral Surgery Clinic at Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Chennai for surgical removal of impacted mandibular third molar under local anaesthesia. The patients were randomly assigned to two groups: Group 1 were treated with (3-0) antimicrobial triclosan impregnated polyglactin sutures for closure and in group 2 with (3–0) antimicrobial chlorhexidine diacetate-impregnated polyglactin sutures. Evaluation in regard to infection rate, abnormal erythema, pain and trismus between two groups was done on the 7th day postoperatively. In this study we observed that no significant difference in rates of infection between the groups. Abnormal erythema and trismus showed better results in group 2(chlorhexidine group) on 7th day postoperatively whereas incidence of pain was higher in patients treated with chlorhexidine coated sutures on the 7th day postoperatively as compared to patients treated with triclosan coated sutures. However, P value was >0.05 which was considered statistically insignificant. Within the limitations of the present study, chlorhexidine diacetate-impregnated polyglactin sutures showed reduced infection rates,erythema and trismus  as compared to triclosan impregnated polyglactin sutures in healthy patients undergoing surgical removal of third molar under local anesthesia.

scholarly journals The Effectiveness of the Cold Therapy (cryotherapy) in the Management of Inflammatory Parameters after Removal of Mandibular Third Molars: A Meta-Analysis

2019 ◽  
Vol 23 (02) ◽  
pp. 221-228 ◽  
Author(s):  
Ighor Andrade Fernandes ◽  
Anna Catharina Vieira Armond ◽  
Saulo Gabriel Moreira Falci
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Third Molar ◽  
Cochrane Library ◽  
Control Group ◽  
Surgical Removal ◽  
Third Molars ◽  
Cold Therapy ◽  
Mandibular Third Molar

Introduction Cold therapy (cryotherapy) is a common procedure recommended by dental surgeons after surgical removal of third molars, which is an invasive intervention that often deals with an expressive inflammatory response. Objective To investigate whether cryotherapy interferes with clinical outcomes such as pain, edema, and trismus in the postoperative period of mandibular third molar surgeries. Data Synthesis An electronic search was conducted in the OVID, PubMed, VHL, Science Direct, Cochrane Library, and Web of Science databases, through March 2018. The eligibility criteria included clinical trials that evaluated the effect of cryotherapy in at least one of the following variables: pain, swelling, and trismus.Two independent reviewers assessed the studies. The methodological quality of each article was analyzed. The search strategy resulted in 1,088 articles. Following the selection process, 11 studies were included in the systematic review and 4 of them in the meta-analysis. High risk of bias was found in most of the studies according to the Cochrane Handbook assessment. Patients receiving cryotherapy had less edema than patients in the control group at second day follow-up (mean difference [MD]: -0.94; 95%CI [-1.49; -0.39]). There were no statistically significant results when comparing trismus between experimental and control group (MD: 0.43; 95%CI [-0.34;1.20]). There were insufficient available data to support influences in postoperative pain. Conclusions Cryotherapy applied on the first day after mandibular third molar removal can manage edema in the patients. Well-designed randomized clinical trials to test the efficacy of cryotherapy after surgical removal of third molars are needed to justify its indication.

scholarly journals Early removal of asymptomatic mandibular third molar-is it safe?

2017 ◽  
Vol 2 (3) ◽  
pp. 172
Author(s):  
Xiao F. Ling ◽  
Tee L. Heng ◽  
Ahmad F. Bin Mohamad
Keyword(s):  
Oral Surgery ◽  
Subjective Evaluation ◽  
Randomized Study ◽  
Third Molar ◽  
Surgical Removal ◽  
Safe Procedure ◽  
Early Removal ◽  
Group I ◽  
Mandibular Third Molar ◽  
Facial Swelling

Objective: The purpose of this study was to compare the incidence of complications between surgical removal of third molar and germectomy, objectively and subjectively.Material and Methods: A prospective non randomized study for all patients who were undergoing minor oral surgery of mandibular third molar was carried out in Oral & Maxillofacial Department (OMF) Sultan Abdul Halim Hospital, Malaysia (HSAH). The indication for surgery was for orthodontic reason. The patients were divided into 3 groups according to their radiographic root morphology, namely group I (root not formed), group II (root partially formed), group III (roots fully formed)Results: A total of 44 patients were enrolled into this study, 2 teeth from each patient, henceforth involving 88 teeth. There was statistically difference in age among the 3 groups (p<0.05). Germectomy was the shortest procedure. In the objective evaluation post-operative 1 week, no sign of trismus and facial swelling was observed in these 3 groups. In the subjective evaluation, there were significant differences in ability to tolerate orally (p<0.05) and ability to perform daily activities (p<0.05) among the 3 groups.Conclusion: This study shows low incidence of complications in all 3 groups. Germectomy is a simple and safe procedure, thus, this prompted the author advocate the early removal of mandibular third molar.

scholarly journals Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

2013 ◽  
Vol 13 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Vikrant Dilip Sane ◽  
Kiran Shrikrishna Gadre ◽  
Sanjay Chandan ◽  
Rajshekhar Halli ◽  
Rashmi Saddiwal ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Comparative Study ◽  
Third Molar ◽  
Surgical Removal ◽  
Mandibular Third Molar

The Quantitative Ultrastructure of the Heart Muscle of Japanese Quail by Hypergravitation, Hypodynamy and Combination

1990 ◽  
Vol 48 (3) ◽  
pp. 188-189
Author(s):  
Anton Bózner ◽  
Mikuláš Gažo ◽  
Jozef Dostál
Keyword(s):  
Japanese Quail ◽  
Heart Muscle ◽  
Relative Size ◽  
Combination Group ◽  
Control Group ◽  
Group V ◽  
Group Iii ◽  
Space Flights ◽  
Group I ◽  
Quantitative Ultrastructure

It is anticipated that Japanese quail /Coturnix coturnix japonica/ will provide animal proteins in long term space flights. Consequently this species of birds is of research interest of international space program INTERCOSMOS. In the year 1987 we reported on an experiment /2/ in which the effect of chronic acceleration of 2 G hypergravitation, the hypodynamy and the simultaneous effect of chronic acceleration and the location in the centre of the turntable of the centrifuge on the protein fractions in skeletal muscles was studied. The ultrastructure of the heart muscle was now in this experiments examined as well.Japanese quail cockerels, aged 48 days were exposed to 2 G hypergravitation /group IV/ in a 6,4 m diameter centrifuge, to hypodynamy /group III/ and their combination /group V/, respectively for 6 days / Fig.1/. The hypodynamy in group III was achieved by suspending the birds in jackets without contact the floor. The group II was located in the centre ofthe turntable of the centrifuge. The control group I. was kept under normal conditions. The quantitative ultrastructure of myocard was evaluated by the methods of Weibel/3/ - this enables to determine the number, relative size and volume of mitochondria volume of single mitochondria, defficiency of mitochondrial cristae and volume of myofibrils.

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