scholarly journals A dohányzás hatása a fej-nyak régió daganata miatt sebészi terápiában részesült betegek protetikai rehabilitációt követő életminőség-javulására

2017 ◽  
Vol 158 (5) ◽  
pp. 172-177
Author(s):  
Judit Nagy ◽  
Péter Novák ◽  
Kristóf Buzás ◽  
Katalin Nagy ◽  
Márk Antal

Abstract: Introduction: It is known that the quality of life (QoL) of patients surgically treated for head and neck cancer (HNC) is significantly enhanced by rehabilitation. It is also known that some of these patients will not quit smoking. Aim: To assess if smoking hampers rehabilitation-related QoL enhancement after surgery. Method: Applying the H&N 35 questionnaire of EORTC, we assessed the QoL of 38 smoking and non-smoking patients who underwent surgical therapy for HNC and subsequent rehabilitation. QoL was assessed after surgery (after the healing period) and 6 months after rehabilitation. Results: While the QoL enhancement of nonsmokers was significant in almost all aspects, that of smoking patients did not reach the level of significance on a number of scales. The results suggest that smoking does not hamper rehabilitation directly, rather, it prevents rehabilitation from exerting its beneficial effects through its own effects. Conclusions: Smoking is a factor that measurably acts against the efforts to enhance the QoL of the surgically treated HNC patient. Therefore, it is essential that emphasis is put on smoking cessation right from the cancer diagnosis also for this reason. Orv. Hetil., 2017, 158(5), 172–177.

2018 ◽  
Vol 14 (5) ◽  
pp. e269-e279 ◽  
Author(s):  
Devon Alton ◽  
Lawson Eng ◽  
Lin Lu ◽  
Yuyao Song ◽  
Jie Su ◽  
...  

Purpose: Continued smoking after a cancer diagnosis leads to poorer treatment outcomes, survival, and quality of life. We evaluated the perceptions of the effects of continued smoking on quality of life, survival, and fatigue among patients with cancer after a cancer diagnosis and the effects of these perceptions on smoking cessation. Patients and Methods: Patients with cancer from all disease subsites from Princess Margaret Cancer Centre (Toronto, Ontario) were surveyed between April 2014 and May 2016 for sociodemographic variables, smoking history, and perceptions of continued smoking on quality of life, survival, and fatigue. Multivariable regression models evaluated the association between patients’ perceptions and smoking cessation and the factors influencing patients’ perceptions of smoking. Results: Among 1,121 patients, 277 (23%) were smoking cigarettes up to 1 year before diagnosis, and 54% subsequently quit; 23% had lung cancer, and 27% had head and neck cancers. The majority felt that continued smoking after a cancer diagnosis negatively affected quality of life (83%), survival (86%), and fatigue (82%). Current smokers during the peridiagnosis period were less likely to perceive that continued smoking was harmful when compared with ex-smokers and never-smokers ( P < .01). Among current smokers, perceiving that smoking negatively affected quality of life (adjusted odds ratio [aOR], 2.68 [95% CI, 1.26 to 5.72]; P = .011), survival (aOR, 5.00 [95% CI, 2.19 to 11.43]; P < .001), and fatigue (aOR, 3.57 [95% CI, 1.69 to 7.54]; P < .001) were each strongly associated with smoking cessation. Among all patients, those with a greater smoking history were less likely to believe that smoking was harmful in terms of quality of life (aOR, 0.98 [95% CI, 0.98 to 0.99]; P < .001), survival (aOR, 0.98 [95% CI, 0.98 to 0.99]; P < .001), and fatigue (aOR, 0.99 [95% CI, 0.98 to 0.99]; P < .001). Conclusion: The perceptions of continued smoking after a cancer diagnosis among patients with cancer are strongly associated with smoking cessation. Counseling about the harms of continued smoking in patients with cancer, and in particular among those who have lower risk perceptions, should be considered when developing a smoking cessation program.


2013 ◽  
Vol 23 (1) ◽  
pp. 135-143 ◽  
Author(s):  
Judit Nagy ◽  
Gábor Braunitzer ◽  
Márk Antal ◽  
Csaba Berkovits ◽  
Péter Novák ◽  
...  

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 84s-84s
Author(s):  
M. Cedzyńska ◽  
M. Marta ◽  
P. Koczkodaj ◽  
I. Przepiorka

Background: Despite the fact that smoking has been linked not only to the development of cancer, but also to prognosis upon diagnosis and risk of death during treatment, many cancer patients continue to smoke. Quitting smoking can be beneficial also after cancer diagnosis, regardless of stage and prognosis. Those benefits are: improved survival outcomes, reduced risk of recurrence and second primary formation, increase treatment response to chemo and radiotherapy, reduced treatment-related complications, better self-reported quality of life related to disease and treatment than among smokers and less pain. The evidence is strong enough to incorporate tobacco dependence treatment into routine cancer care, but in majority of countries in central and eastern Europe (CEE) there are no actions taken to help cancer patients to quit smoking. Aim: To identify main barriers in providing smoking cessation to cancer patients in central and eastern Europe. Methods: Data were collected from participants of Workshop on Tobacco Control and Cessation organized by Cancer Center and Institute of Oncology, Poland and the National Cancer Institute, US. Following countries provided detailed data: Armenia, Georgia, Hungary, Kazakhstan, Kirgizstan, Lithuania, Poland, Macedonia, Serbia. The areas that were investigated: guidelines on smoking cessation dedicated to cancer patients, quit smoking programs for cancer patients, existing literature on barriers for delivery smoking cessation advice and personal opinion of tobacco control experts regarding those barriers. Results: I. Guidelines for smoking cessation among cancer patients have been published only in one country (Serbia) out of nine analyzed countries of the region. II. Programs on smoking cessation dedicated to cancer patients were implemented only in two countries: 1: Poland. Pilot program within National Health Program in 2015 (3 months in cancer centers in two cities). 2: Hungary. In 2012 pilot project. In 2017 National Institute for Pulmonology run 3 workshops on smoking cessation for cancer nurses. III. There is no literature on barriers in incorporating smoking cessation into cancer care in the CEE region. IV. Experts opinions are consistent with worldwide literature findings-the main barriers are lack of knowledge, lack of training, overloading with work focused on diagnosis and cancer treatment, difficulties in implementing systemic changes. Conclusion: There is a strong need to take action in central and eastern Europe to engage oncologists and other cancer healthcare providers into smoking cessation. It is crucial to increase the knowledge on benefits of quitting smoking for cancer patients' health and results of cancer treatment. Sustainable change can be achieved by publishing guidelines and implementing training programs that address the attitudes and beliefs. Implementing systemic changes within cancer centers might be required to improve survival and quality of life of cancer patients in central and eastern European region.


1999 ◽  
Vol 17 (1) ◽  
pp. 352-352 ◽  
Author(s):  
Ellen R. Gritz ◽  
Cindy L. Carmack ◽  
Carl de Moor ◽  
Anne Coscarelli ◽  
Christopher W. Schacherer ◽  
...  

PURPOSE: Treatment regimens for head and neck cancer patients profoundly affect several quality-of-life domains. Rehabilitative needs have been identified through cross-sectional analyses; however, few studies have prospectively assessed quality of life, included assessment of psychosocial variables, and identified predictors of long-term follow-up. PARTICIPANTS AND METHODS: The present study addresses these limitations through a prospective assessment of 105 patients with a newly diagnosed first primary squamous cell carcinoma of the oral cavity, pharynx, or larynx. Participants were enrolled onto a larger randomized controlled trial comparing a provider-delivered smoking cessation intervention with a usual-care-advice control condition. Participants completed a battery of self-report measures after diagnosis and before treatment and additional quality-of-life instruments at 1 and 12 months after initial smoking cessation advice. RESULTS: Participants displayed improvements at 12 months in functional status (P = .006) and in the areas of eating, diet, and speech; however, the latter three represent areas of continued dysfunction, and the changes were not statistically significant. Despite these improvements, patients reported a decline in certain quality-of-life domains, including marital (P = .002) and sexual functioning (P = .017), as well as an increase in alcohol use (P < .001). Predictors of quality of life at 12 months included treatment type, the Vigor subscale of the Profile of Mood States instrument, and quality-of-life scores obtained 1 month after initial smoking cessation advice. CONCLUSION: Results reinforce the need for rehabilitation management through the integration of psychologic and behavioral interventions in medical follow-up.


Author(s):  
Anna Rzepakowska ◽  
Bartosz Marcinkiewicz ◽  
Michał Żurek ◽  
Dominika Wiśniewska ◽  
Kazimierz Niemczyk

Abstract Objectives The aim of the study was to determine the influence of oral, oropharyngeal, laryngeal and hypopharyngeal dysplasia and cancer diagnosis on motivation to smoking cessation in patients. Consecutively, we assessed the competence of ENT specialists in counseling anti-smoking therapies. Methods Questionnaire of expected support, Schneider motivation test and Fagerström Test for Nicotine Dependence (FTND) were administered to 50 smoking patients. The online survey was collected from 152 ENT doctors. Results Mean FTND score was 4.58 and Heaviness of Smoking Index (HSI) was 3.1. Patients with oral cavity and oropharyngeal cancer showed the greatest dependence to nicotine 7.67 and 5.25, respectively, and with hypopharyngeal cancer had the lowest 3.5, (p = 0.039). The ranges of HSI were significantly higher for younger patients (p = 0.036). 35 patients were adequately motivated to quit smoking, and their mean age was statistically higher (p = 0.05). Self-reported motivation to smoking cessation was 76%. Of 152 surveyed doctors, only 39% declared knowledge of the diagnostic and therapeutic cessation interventions. 75% showed interest in the training programs.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M Dardouri ◽  
M Limam ◽  
T Ajmi ◽  
A Mtiraoui ◽  
C Zedini ◽  
...  

Abstract Introduction Smoking cessation is the most important step to limit the complications of chronic obstructive pulmonary disease (COPD). Outcomes from studies that assessed the association between health-related quality of life (HRQL) and smoking cessation have been controversial. This study aimed to assess the relationship between HRQL and smoking cessation in patients with COPD in Tunisia. Methods A cross-sectional study was carried out in the two main primary care centers in the center of Tunisia over a period of three months (April-June 2016). Clinic and socio-demographic data were collected from patients' records. HRQL was assessed by the Medical Outcomes Study Short-form 36 (SF-36). This instrument is composed of two dimensions: physical and mental components. The questionnaire outcomes were described as means and standard deviation. T-test was performed to assess the statistical difference between the dependent and categorical variables. Results A total of 249 COPD patients participated in the study with a mean age of 67.77±11.13. Of this sample, 169 (67.9%) ceased smoking. The average period of smoking cessation was 10 years. The mean of total HRQL score in patients who ceased smoking was lower in comparison to patients who did not quit smoking (40.65±24.49, 43.37±24.49; respectively). The T-test reported a significant difference between the physical component of HRQL and smoking status. Patients with current smoking status had a better physical component score in comparison with patients who quit smoking (43.76±22.62, 37,86±18.21, p = 0.04, respectively). No significant differences were found between smoking cessation, mental component, and HRQL total score (p = 0.89, p = 0.39; respectively). Conclusions This study revealed that smoking cessation was associated with the physical component of HRQL. The smoking dependence in patients with COPD could explain this finding. Health care professionals should work harder on effective smoking cessation strategies. Key messages These findings suggested that HRQL was better among patients who did not quit smoking. Patients who did not cease smoking reported better physical status and poorer mental status in comparison with patients who quit smoking.


Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 393
Author(s):  
Oliver Neuhaus ◽  
Wolfgang Köhler ◽  
Florian Then Bergh ◽  
Wolfgang Kristoferitsch ◽  
Jürgen Faiss ◽  
...  

Although fatigue is a common symptom in multiple sclerosis (MS), its pathomechanisms are incompletely understood. Glatiramer acetate (GA), an immunomodulatory agent approved for treatment of relapsing-remitting MS (RRMS), possesses unique mechanisms of action and has been shown to exhibit beneficial effects on MS fatigue. The objective of this study was to correlate clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. In a prospective, open-label, multicenter trial, 30 patients with RRMS and fatigue were treated with GA for 12 months. Inclusion criterion was the presence of fatigue as one of the most frequent and disabling symptoms. Before and during treatment, fatigue was assessed using the Fatigue Severity Scale (FSS), the MS-FSS, and the Modified Fatigue Impact Scale (MFIS). In addition, fatigue and quality of life were assessed using the Visual Analog Scales (VAS). Laboratory assessments included screening of 188 parameters using real-time PCR microarrays followed by further analysis of several cytokines, chemokines, and neurotrophic factors. Fatigue self-assessments were completed in 25 patients. After 12 months of treatment with GA, 13 of these patients improved in all three scales (with the most prominent effects on the MFIS), whereas 5 patients had deteriorated. The remaining 7 patients exhibited inconsistent effects within the three scales. Fatigue and overall quality of life had improved, as assessed via VAS. Laboratory assessments revealed heterogeneous mRNA levels of cytokines, chemokines, and neurotrophic factors. In conclusion, we were not able to correlate clinical and molecular effects of GA in patients with RRMS and fatigue.


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