scholarly journals A parlagfű okozta légzőszervi allergiás megbetegedések előfordulása Magyarországon

2016 ◽  
Vol 157 (50) ◽  
pp. 1989-1993 ◽  
Author(s):  
Zsuzsa Márk ◽  
András Bikov ◽  
Gabriella Gálffy
Keyword(s):  
Patient Care ◽  
Clinical Characteristics ◽  
Medication Use ◽  
Female Gender ◽  
Common Allergen ◽  
Eradication Strategy ◽  
Hungarian Population ◽  
Very High ◽  
Comprehensive Study

Introduction: Although the prevalence of ragweed allergy in Europe is still low, it is increasing according to recent statistics. In contrast, in Hungary ragweed is the most common allergen with very high sensitisation in the general Hungarian population. Aim: We investigated the number and clinical characteristics of ragweed allergy in the Hungarian population, as the first comprehensive study to evaluate ragweed allergy in Hungary. Method: One thousand Hungarian adult subjects were screened with a questionnaire for ragweed allergy. People with ragweed allergy answered further specific questions about their disease history, symptoms and medication use. Results: 305 subjects reported allergy from which 218 patients had symptoms during ragweed pollination suggesting ragweed allergy. 40% of these had symptoms for more than 5 years. Asthma was reported in 18.3%. Around 24% of these patients were undiagnosed; they did not take any medications or visited professionals because of their symptoms. Compared to the non-ragweed allergic patients, subjects with ragweed allergy were older and better educated, but the dominance of female gender was less prominent than in the non-ragweed group (all p<0.05). Conclusions: Around 22% of the Hungarian population suffers from ragweed allergy. Studies should focus on eradication strategy and improvement of patient care. Orv. Hetil., 2016, 157(50), 1989–1993.

scholarly journals Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

2021 ◽  
Author(s):  
Michael Stumpp
Keyword(s):  
Single Agent ◽  
Standard Of Care ◽  
Cooperative Binding ◽  
Wild Type ◽  
Inhibitory Potency ◽  
Alpha Variant ◽  
The Individual ◽  
Very High ◽  
Comprehensive Study

Abstract SARS-CoV-2 has infected millions of people globally and continues to undergo evolution. Emerging variants can be partially resistant to vaccine induced and therapeutic antibodies, emphasizing the urgent need for accessible, broad-spectrum therapeutics. Here, we report a comprehensive study of ensovibep, the first trispecific clinical DARPin candidate, that can simultaneously engage all three units of the spike protein trimer to potently inhibit ACE2 interaction, as revealed by structural analyses. The cooperative binding of the individual modules enables ensovibep to retain inhibitory potency against all frequent SARS-CoV-2 variants, including Omicron, as of December 2021. Moreover, viral passaging experiments show that ensovibep, when used as a single agent, can prevent development of escape mutations comparably to a cocktail of monoclonal antibodies (mAb). Finally, we demonstrate that the very high in vitro antiviral potency also translates into significant therapeutic protection and reduction of pathogenesis in Roborovski dwarf hamsters infected with either the SARS-CoV-2 wild-type or the Alpha variant. In this model, ensovibep prevents fatality and provides substantial protection equivalent to the standard of care mAb cocktail. These results support further clinical evaluation and indicate that ensovibep could be a valuable alternative to mAb cocktails and other treatments for COVID-19.

Abstract TP150: Effects of Pre-existing Psychotropic Medication Use on a Cohort of Patients With Ischemic Stroke Outcome

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Dilip Jayaraman ◽  
Nils Henninger ◽  
Brian Silver ◽  
Majaz Moonis ◽  
Anthony Rothschild ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Psychotropic Medication ◽  
Medication Use ◽  
Female Gender ◽  
Control Group ◽  
Stroke Outcome ◽  
Stroke Registry ◽  
Post Stroke ◽  
Significant Difference

Background: Although SSRI use for ischemic stroke related motor recovery has been studied with mixed results, the effects of the pre-existing psychotropic medication use (PPMU), such as antidepressants, on a long-term ischemic stroke outcome is unknown. Objective: We sought to determine the prevalence of PPMU, and the clinical outcome in a cohort of patients presenting with acute ischemic strokes. Methods: We retrospectively analyzed 323 consecutive patients who presented with an acute ischemic stroke that were included in an institutional stroke registry between January 2015 and December 2017. Baseline characteristics, functional outcome measured by mRS, cardiovascular complications and death within 90 days and 365 days were recorded. The control was defined as a group of ischemic stroke patients that were not on psychotropic medications pre- and/or post-ischemic stroke. Results: The prevalence of PPMU in the studied cohort was 21.4% (69/323). The prevalence of female gender in PPMU was higher compared to the control and post stroke-psychotropic medication use groups (P<0.001), and the patients with PPMU had similar vascular risk factors compared to the control (NS), except for an increased presence of hyperlipidemia (68.1% vs. 57.5%, p<0.05). Among the patients with an available 90-day follow-up (n=175) and 365-day follow-up (n=246), there was no statistically significant difference in outcome events of MI, stroke, death, and dementia. The mRS was higher on PPMU and poststroke-psychotropic medication use groups compared to the control group within the 365-day follow-up (P=0.013). Conclusion: The prevalence of PPMU is common in ischemic stroke, and it is not associated with worsened post-stroke complications within 1 year.

Detected Bruit

2016 ◽  
Author(s):  
Ji Y. Chong ◽  
Michael P. Lerario
Keyword(s):  
Risk Factor ◽  
Carotid Stenosis ◽  
Clinical Characteristics ◽  
Female Gender ◽  
Treatment Decisions ◽  
High Grade ◽  
Asymptomatic Carotid Stenosis ◽  
Asymptomatic Carotid ◽  
Patient Demographic ◽  
Risks And Benefits

Carotid stenosis is a risk factor for stroke. Revascularization of high-grade asymptomatic carotid stenosis in select patients can lower the risk of incident stroke. Endarterectomy and stenting are both associated with periprocedural risk. Risks and benefits need to be evaluated carefully before proceeding with any intervention. Certain patient demographic and clinical characteristics, such as female gender, may reduce the benefits of surgery and influence treatment decisions.

Care of Severely Compromised Patients

1983 ◽  
Vol 4 (S4) ◽  
pp. 325-325
Keyword(s):  
Patient Care ◽  
Risk Of Infection ◽  
High Susceptibility ◽  
Severe Burns ◽  
Isolation Techniques ◽  
Risk Patients ◽  
Total Body ◽  
Skin Conditions ◽  
Very High ◽  
Compromised Patients

Patients with certain diseases (for example, leukemia, cancer, and extensive skin conditions, such as severe burns or dermatitis) and patients who are receiving certain therapeutic regimens (for example, total body irradiation, steroid or antimetabolite therapy) are highly susceptible to infection. These compromised patients are often on special “protective” patient-care regimens intended to reduce the risk of infection. One such regimen, Protective Isolation (as outlined in the previous editions of Isolation Techniques for Use in Hospitals), does not appear to reduce this risk any more than strong emphasis on appropriate handwashing during patient care.Protective isolation, as previously outlined, may fail to reduce the risk of infection because compromised patients are often infected by their own (endogenous) microorganisms or are colonized and infected by microorganisms transmitted by the inadequately washed hands of personnel or by nonsterile items used in routine protective isolation. Such items may include patient-care equipment, food, water, and air. Some studies suggest that vigorous efforts to exclude all microorganisms by using patient-isolator units, eradicating endogenous flora, and sterilizing food, water, and fomites may prevent or delay onset of some infections; thus, these procedures have been recommended by some for use with very-high-risk patients who have a predictable temporary period of high susceptibility. However, these extraordinary and expensive precautions do not appear warranted for most compromised patients.

scholarly journals P2.01-52 Clinical Characteristics and Outcomes in NSCLC Patients Associated with Very High PD-L1 Expression

2019 ◽  
Vol 14 (10) ◽  
pp. S659-S660
Author(s):  
E. Mcloughlin ◽  
L. Hanson ◽  
M. Moore ◽  
B. Horton ◽  
R. Gentzler ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Nsclc Patients ◽  
Very High

Clinical Characteristics and Patterns of Medication Use of Migraneurs in Latin America From 12 Cities in 6 Countries

2005 ◽  
Vol 45 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Luis E. Morillo ◽  
Fernando Alarcon ◽  
Nayesca Aranaga ◽  
Sara Aulet ◽  
Evelina Chapman ◽  
...  
Keyword(s):  
Latin America ◽  
Clinical Characteristics ◽  
Medication Use

scholarly journals Clinical characteristics and treatment outcomes of patients with MDR tuberculosis in Dar Es Salaam region, Tanzania

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
David T Myemba ◽  
George M Bwire ◽  
Godfrey Sambayi ◽  
Betty A Maganda ◽  
Belinda J Njiro ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Medication Use ◽  
Dar Es Salaam ◽  
Hazard Ratio ◽  
Chi Square ◽  
Mdr Tb ◽  
Chi Square Test

Abstract Background In Tanzania more than 28% of all multi-drug resistant tuberculosis (MDR-TB) cases occur in Dar es Salaam. However, information about management and clinical outcomes of patients with MDR-TB in the region is scarce, and hence the need for this study. Methods A 5-year retrospective cohort study was conducted in six centres in Dar es Salaam. Descriptive statistics were used to summarize social demographics and clinical characteristics. Associations between occurrence of adverse events, regimen change and cure were determined using the Chi-square test whereas factors associated with mortality were determined using the Log-ranking test and Cox regression model. Results Three-hundred patient files were found and reviewed. The majority were male 199 (66.3%), aged 25–44 years [176 (58.7%)] and 89 (30.1%) were HIV co-infected. 186 (62%) completed their treatment, 68 (22.0%) were on treatment and 9 (3.3%) were lost to follow-up. The majority, 152 (51.0%) were managed using long MDR-TB regimens. The overall mortality rate was 5.7 per 1000 MDR-TB patients. A higher mortality rate was associated with being ≥45 years [adjusted hazard ratio (AHR): 10.82, 95% CI: 1.14–102.74, P = 0.038), female (AHR: 5.92, 95% CI: 1.75–20.08, P = 0.004), on a short anti-TB regimen (AHR: 4.34, 95% CI: 1.41–13.35, P = 0.010), HIV co-infected [crude hazard ratio (CHR): 2.56, 95% CI: 1.01–6.50, P = 0.048), on concomitant long-term medication use (CHR: 2.99, 95% CI: 1.17–7.64, P = 0.022) and having other co-morbidities (CHR: 3.45, 95% CI: 1.32–9.02, P = 0.011). Conclusions MDR-TB mortality was associated with short anti-TB regimens, sex, age, concomitant long-term medication use and HIV coinfection. In this population, use of long and individualized regimens is recommended.

scholarly journals Psychological profile of COVID-19 pneumonia survivors three month after hospitalization

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E Yaroslavskaya ◽  
O Guskova ◽  
B Prilenskii ◽  
T Petelina
Keyword(s):  
Cardiovascular Diseases ◽  
Clinical Characteristics ◽  
Nyha Class ◽  
Female Gender ◽  
Class I ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Class Iii ◽  
Men And Women ◽  
Symptoms Of Depression

Abstract Background COVID-19 is the highly contagious infectious disease, which affects different organs and systems. Anxiety and depression symptoms, that are common results of severe diseases, used to make recovery more difficult. Purpose To study the prevalence of cardiovascular diseases, signs of anxiety, depression, stress, and their relationship in patients with proven COVID-19 pneumonia 3 months after discharge depending of gender. Methods The study was carried out within “One-year Cardiac Follow-up of COVID-19 Pneumonia”. 103 patients (mean age 46.6±15.8 years) were divided into 2 groups: 52 men (50.9%) and 51 women. Anxiety and depression symptoms were measured by GAD-7 and PHQ-9, respectively. PSS-10 was used to measure stress symptoms. The minimum value of anxiety and depression was a total value of 5 points. Results 48.5% of patients had cardiovascular diseases, out of which arterial hypertension (AH) was the most common (44.7%). Less common was coronary artery disease (CAD) (16.5%), which in 14.6% of patients was accompanied by AH. Chronic heart failure (CHF) NYHA class I-II was found in 19.4% of patients, and severe CHF (NYHA class III–IV) - in 4.9%. Arrhythmia was detected in 11.7% of patients. According to the clinical characteristics, no significant differences were found between the groups of men and women. AH affected 21.4% of men and 23.3% of women, CAD −10.7% and 5.8%, respectively. NYHA class I-II CHF were found in 8.7% of men and 10.7% of women, and severe CHF (NYHA class III–IV) - in 2 men and 3 women. Arrhythmia had a prevalence of less than 6% among both men and women. Anxiety or depression symptoms were reported in 29.1% and 27.2%, respectively. Combination of anxiety and depression symptoms was determined in 18.4%, symptoms of stress in 8.7% of patients. Symptoms of depression were found in women more often (p=0.023). The value of the median scores of the PHQ-9 questionnaire in the group of women was significantly higher than in the group of men (3.00 [1.00; 8.00] and 1.00 [0; 3.75], p=0.006). Depression symptoms were associated with female gender (OR 2.83; CI 95% 1.35–7.08). Despite the absence of gender differences in the prevalence of anxiety (18.4% and 10.7%, p=0.072), when comparing the values of the median scores of the GAD-7 questionnaire in the groups of men and women, the difference was statistically significant (1.00 [0; 4.00] and 3.00 [2.00; 7.00], p=0.001, respectively). Signs of stress among married people were less common in comparison with unmarried (2.9% vs 5.8%, p=0.037). Conclusion Three months after discharge, no significant differences in clinical characteristics between men and women were found. Signs of anxiety or depression were detected in more than a quarter of patients with proven COVID-19-associated pneumonia. Women experienced symptoms of depression 3 times more often than men. Unmarried patients tended to experience stress more often. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals TREATMENT FOR MULTIPLE MYELOMA IN HOSPITAL AT HOME: CLINICAL CHARACTERISTICS AND PATIENT CARE PATHWAYS

Authorea ◽  
2020 ◽  
Author(s):  
Benedicte MITTAINE MARZAC ◽  
Matthieu DE STAMPA ◽  
Odile MARQUESTAUT ◽  
Alexandre GEORGES ◽  
Joel ANKRI ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Patient Care ◽  
Clinical Characteristics ◽  
Care Pathways ◽  
Hospital At Home ◽  
At Home
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