scholarly journals Electroretinographic findings in day-blind dogs

2018 ◽  
Vol 66 (2) ◽  
pp. 204-214
Author(s):  
Magdalena Drążek-Kubiak ◽  
Marcin Lew ◽  
Sylwia Lew
Keyword(s):  
Steady State ◽  
Normal Values ◽  
Labrador Retriever ◽  
Retinal Diseases ◽  
German Shepherd ◽  
Genetic Tests ◽  
Scotopic Vision ◽  
Cone Dysfunction ◽  
The World ◽  
Yorkshire Terrier

Cone degeneration (cd; day blindness) is one of the inherited retinal diseases of dogs. Its diagnosis is based on vision testing, fundoscopy, electroretinography (ERG) and, for some breeds, on genetic tests. Typical signs of the disease are day blindness and cone dysfunction during ERG while fundoscopy does not show any abnormalities. The aim of this study was to compare behavioural findings, fundoscopic lesions and electroretinographic alterations in 12 cd-affected dogs (Alaskan Malamute, Labrador Retriever, German Shepherd, Dachshund, Yorkshire Terrier, Shih Tzu, Siberian Husky and crossbreeds) examined at our clinic. None of the examined dogs had any fundoscopic lesions, and all of them had normal scotopic vision with strongly impaired or absent photopic vision. Light-adapted transient, cone-mediated and steady-state, 31-Hz cone flicker ERGs were much below the 5th percentile limits of normality or even unrecordable, while the rod-driven ERGs were within normal values. Vision test and ERG results corresponded to each other and, combined with the results of fundoscopy, were typical of cd. To date, our research is one of the few studies in the world presenting ERG alterations compared with vision test findings and fundoscopic results in the course of cd.

POVERTY TRAPS AND INFERIOR GOODS IN A DYNAMIC HECKSCHER–OHLIN MODEL

2012 ◽  
Vol 17 (6) ◽  
pp. 1227-1251 ◽  
Author(s):  
Eric W. Bond ◽  
Kazumichi Iwasa ◽  
Kazuo Nishimura
Keyword(s):  
Economic Theory ◽  
Steady State ◽  
World Economy ◽  
Steady States ◽  
The Other ◽  
Poverty Traps ◽  
Poverty Trap ◽  
Multiple Steady States ◽  
The World ◽  
State Capital

We extend the dynamic Heckscher–Ohlin model in Bond et al. [Economic Theory(48, 171–204, 2011)] and show that if the labor-intensive good is inferior, then there may exist multiple steady states in autarky and poverty traps can arise. Poverty traps for the world economy, in the form of Pareto-dominated steady states, are also shown to exist. We show that the opening of trade can have the effect of pulling the initially poorer country out of a poverty trap, with both countries having steady state capital stocks exceeding the autarky level. However, trade can also pull an initially richer country into a poverty trap. These possibilities are a sharp contrast with dynamic Heckscher–Ohlin models with normality in consumption, where the country with the larger (smaller) capital stock than the other will reach a steady state where the level of welfare is higher (lower) than in the autarkic steady state.

On the Regulation of the Respiration in Reptiles

1961 ◽  
Vol 38 (2) ◽  
pp. 301-314 ◽  
Author(s):  
BODIL NIELSEN
Keyword(s):  
Steady State ◽  
Body Temperature ◽  
Metabolic Rate ◽  
Temperature Interval ◽  
Normal Values ◽  
Pulmonary Ventilation ◽  
The Body ◽  
Respiratory Frequency ◽  
Temperature Changes ◽  
Instantaneous Increase

1. In two species of Lacerta (L. viridis and L. sicula) the effects on respiration of body temperature (changes in metabolic rate) and of CO2 added to the inspired air were studied. 2. Pulmonary ventilation increases when body temperature increases. The increase is brought about by an increase in respiratory frequency. No relationship is found between respiratory depth and temperature. 3. The rise in ventilation is provoked by the needs of metabolism and is not established for temperature regulating purposes (in the temperature interval 10°-35°C). 4. The ventilation per litre O2 consumed has a high numerical value (about 75, compared to about 20 in man). It varies with the body temperature and demonstrates that the inspired air is better utilized at the higher temperatures. 5. Pulmonary ventilation increases with increasing CO2 percentages in the inspired air between o and 3%. At further increases in the CO2 percentage (3-13.5%) it decreases again. 6. At each CO2 percentage the pulmonary ventilation reaches a steady state after some time (10-60 min.) and is then unchanged over prolonged periods (1 hr.). 7. The respiratory frequency in the steady state decreases with increasing CO2 percentages. The respiratory depth in the steady state increases with increasing CO2 percentages. This effect of CO2 breathing is not influenced by a change in body temperature from 20° to 30°C. 8. Respiration is periodically inhibited by CO2 percentages above 4%. This inhibition, causing a Cheyne-Stokes-like respiration, ceases after a certain time, proportional to the CO2 percentage (1 hr. at 8-13% CO2), and respiration becomes regular (steady state). Shift to room air breathing causes an instantaneous increase in frequency to well above the normal value followed by a gradual decrease to normal values. 9. The nature of the CO2 effect on respiratory frequency and respiratory depth is discussed, considering both chemoreceptor and humoral mechanisms.

Onto the World Stage

2019 ◽  
pp. 23-40
Author(s):  
Stephen A. Crist
Keyword(s):  
Steady State ◽  
Civil Rights ◽  
State Department ◽  
College Campuses ◽  
Time Out ◽  
The Us ◽  
The World ◽  
Concert Halls ◽  
The Creation ◽  
First Time

This chapter concerns the internationalization of the Dave Brubeck Quartet. After several years of preliminary discussions, in 1958 the group finally traveled abroad for the first time, on a three-month trip, largely under the auspices of the US State Department. By this time, the Quartet’s personnel finally reached a steady state, after a series of different bass players and drummers. The “classic” Quartet was the group of musicians who recorded Time Out the next year. Around the same time, Brubeck became increasingly involved with issues of civil rights. The Quartet also made history in the late 1950s by performing jazz in concert halls and on college campuses. Finally, Dave and Iola Brubeck devoted themselves tirelessly to the creation and promotion of The Real Ambassadors, a musical that they hoped would be produced on Broadway.

Off-label use of bevacizumab in the treatment of retinal disease: ethical implications

2019 ◽  
Vol 45 (10) ◽  
pp. 668-672
Author(s):  
Landon James Rohowetz
Keyword(s):  
Retinal Disease ◽  
World Health ◽  
Societal Implications ◽  
Retinal Diseases ◽  
Off Label Use ◽  
Off Label ◽  
Ethical Implications ◽  
Anti Vegf ◽  
The World ◽  
Label Use

Anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionised the treatment of a variety of ophthalmic conditions and has become the first-line therapy for a range of retinal diseases. Bevacizumab, a VEGF inhibitor first approved for the treatment of colorectal cancer, has been shown to be nearly or virtually as effective and safe as other anti-VEGF therapies in the treatment of certain retinal diseases but is not approved or registered by the Food and Drug Administration or European Medicines Agency. While other anti-VEGF options are approved and registered, they are generally more expensive and less accessible. Accordingly, despite its off-label status, bevacizumab is frequently used for a variety of disabling retinal diseases. Indeed, bevacizumab is included on the World Health Organization’s list of essential medicines. However, its use in some parts of the world remains restricted due to its off-label status. How, then, should healthcare authorities approach this situation? What are the ethical and societal implications of adhering to a standard and generally effective evaluation and approval system while restricting access to a potentially cost-saving therapy? In countries where its use is not restricted, how should providers approach off-label treatment with bevacizumab? By examining the evidence behind bevacizumab’s efficacy and safety and evaluating the individual and societal implications of off-label use and restriction, this paper illustrates the ethical factors providers and policy makers must consider in the off-label use of bevacizumab and ultimately argues for increased access to bevacizumab in the treatment of retinal disease.

scholarly journals P1766 Comparison of left ventricular stroke volume in healthy adults among regions around the world: results from the World Alliance of Societies of Echocardiography (WASE) Normal Values Study

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
T Miyoshi ◽  
K Addetia ◽  
A Blitz ◽  
R Lang ◽  
F Asch
Keyword(s):  
Ejection Fraction ◽  
Stroke Volume ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Normal Values ◽  
Left Ventricular ◽  
Normative Values ◽  
The World ◽  
American Society

Abstract Funding Acknowledgements WASE Normal Values Study is sponsored by American Society Echocardiography Foundation. OnBehalf the WASE Investigators Background The American Society of Echocardiography (ASE) and the European Association of Cardiovascular Imaging (EACVI) chamber quantification guidelines provide normal reference values for a variety of size and function parameters. While used worldwide, these were predominantly obtained from American and European Caucasian populations and may not represent individuals from other regions around the world. Accordingly, ASE in collaboration with its International Alliance Partners conducted the World Alliance of Societies of Echocardiography (WASE) Normal Values Study to establish and compare normal echocardiographic values across races, ethnicities and countries worldwide. While most previous studies focused on left ventricular (LV) size and ejection fraction, LV stroke volume (SV) in healthy normal subjects has not been well defined. In this report, we aim to examine similarities and differences in normal LV SV indexed by body surface area (SVI) among regions around the world. Methods WASE Normal Values Study is a multinational, observational, cross-sectional study. Individuals free from known cardiac, lung and renal disease were prospectively enrolled with even distribution among age groups and gender. Echocardiographic images were acquired following a standardized protocol. LV SV was assessed by Doppler-derived (LVOT diameter and VTI) and two-dimensional (2D) biplane Simpson’s methods. LV SVI was calculated to account for differences in body size. These measurements were analyzed (TOMTEC) in a single core laboratory following ASE/EACVI Guidelines. Results As of May 2019, LV SV has been analyzed in 1164 cases from 13 countries, representing 8 distinct regions worldwide. In this population, age, body surface area and 2D LV ejection fraction were 47 ± 17 years old (range 18-87 years old), 1.76 ± 0.22 m² (range 0.95-2.44 m²) and 63.2 ± 2.9 % (range 52.7-73.7 %), respectively. LV SV and SVI by Doppler were larger than those obtained by 2D method in all regions. LV SV and SVI in both methods had significant differences among regions (p< 0.0001, Kruskal-Wallis test). LV SV and SVI in South Asia (India) were smallest in both methods and were also significantly smaller than other Asian regions (Figure). North America and Europe had largest LV SV and SVI by Doppler method, while Oceania had largest values by 2D. Conclusions The WASE Normal Values Study shows geographical variability in LV SVI across continents and countries. This information should be considered when determining normative values for SV and SVI. Abstract P1766 Figure.

Neuroleptic Malignant Syndrome and Clozapine Monotherapy

1996 ◽  
Vol 30 (5) ◽  
pp. 692-693 ◽  
Author(s):  
Ray Chatterton ◽  
Susette Cardy ◽  
T. Mark Schramm
Keyword(s):  
Steady State ◽  
General Hospital ◽  
Neuroleptic Malignant Syndrome ◽  
Clinical Picture ◽  
Normal Values ◽  
Medical Ward ◽  
Recent History ◽  
Clozapine Treatment ◽  
Laboratory Values ◽  
History Of

Objective: This report identifies neuroleptic malignant syndrome (NMS) occurring on a steady state dosage of clozapine monotherapy. Clinical picture: An outpatient presented with a recent history of stiffness and soreness of his legs, dizziness, polydipsia, polyuria, abdominal and chest pains. After admission to a general hospital, further symptomatology was identified including: pallor, diaphoresis, nausea, confusion, agitation, decrease in normal reflexes, minimally reactive pupils and rigid limbs. Treatment: Intravenous (I/V) diazepam was administered but failed to decrease the agitation and confusion. He was sedated with the administered of IN drop-eradol, intubated and placed on a ventilator with circulatory supports for 4 days. Outcome: On day five he was extubated and transfered to a medical ward. All laboratory values had returned to normal values by this time. The patient was subsequently discharged. Conclusions: Neuroleptic malignant syndrome can occur at any stage of clozapine treatment, and the patient can be rechallenged after such an episode. This person was rechallenged and after 6 months of treatment has suffered no further recurrence of NMS.

scholarly journals Awareness and Practices of Non-Pharmacological Approaches for Management of Hypertension in a Geriatric Population

2014 ◽  
Vol 2 (2) ◽  
pp. 53-55
Author(s):  
Debalina Sahoo ◽  
Harshida Gosai ◽  
Ujjwal Sahoo ◽  
J.M. Harsoda
Keyword(s):  
Public Health ◽  
Blood Pressure ◽  
Salt Intake ◽  
Normal Values ◽  
Geriatric Population ◽  
Hypertensive Patients ◽  
Hypertensive Population ◽  
The World ◽  
Study Population

Background: There is an increase in the prevalence of hypertension all over the world, including India. Hypertension can be initially managed with non-pharmacological measures. This study aims to assess the knowledge of non-pharmacological measures to control hypertension and its application in a geriatric hypertensive population. Methods: The study was conducted at the Department of Physiology, SVU, Vadodara, India. A total 110 hypertensive patients were included in the study and a non-validated survey was conducted to examine knowledge of non-pharmacological measures to control hypertension in this group of patients. Frequencies, percentages, means and standard deviations were calculated and reported. Results: Only 10% of the respondents knew the normal values for blood pressure. Approximately 38% of the subjects did not measure their blood pressure regularly. A total of 24% subjects knew that body weight has a correlation with hypertension. About 27% said that there was no correlation between salt intake and hypertension, and 88% of the study population did not carry out any form of physical activity. Conclusion: Hypertension can be controlled by life style modifications such as exercise, weight management and a healthy diet. Public health and education measures targeting hypertensive population need to be taken to decrease the risk factors for cardiovascular diseases and, therefore, improve people's health and quality of life.

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