scholarly journals The role of PD-1 – a programmed cell death receptor 1 – and its ligands in ovarian cancer immunotherapy

2016 ◽  
Vol 14 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Anna Markowska ◽  
◽  
Stefan Sajdak ◽  
Jolanta Lubin ◽  
Janina Markowska ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cancer Immunotherapy ◽  
Death Receptor ◽  
Cell Death Receptor

scholarly journals HGF/MET and the Immune System: Relevance for Cancer Immunotherapy

2018 ◽  
Vol 19 (11) ◽  
pp. 3595 ◽  
Author(s):  
Federica Papaccio ◽  
Carminia Della Corte ◽  
Giuseppe Viscardi ◽  
Raimondo Di Liello ◽  
Giovanna Esposito ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Cancer Immunotherapy ◽  
Acquired Resistance ◽  
Death Receptor ◽  
Death Receptor Ligand ◽  
Cancer Types ◽  
Mesenchymal Epithelial Transition Factor ◽  
Hepatocyte Growth ◽  
Cell Death Receptor

An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. In general, the pathway seems to play an immunosuppressive role, thus hypothesizing that it could constitute a mechanism of primary and acquired resistance to cancer immunotherapy. Recently, some approaches are being developed, including drug design and cell therapy to combine MET and programmed cell death receptor-1 (PD-1)/programmed cell death receptor-ligand 1 (PD-L1) inhibition. This approach could represent a new weapon in cancer therapy in the future.

Fluoroquinolone Eye Drop–Induced Cytotoxicity: Role of Preservative in P2X7 Cell Death Receptor Activation and Apoptosis

2006 ◽  
Vol 47 (7) ◽  
pp. 2812 ◽  
Author(s):  
Me´lody Dutot ◽  
Franc¸ois Pouzaud ◽  
Isabelle Larosche ◽  
Franc¸oise Brignole-Baudouin ◽  
Jean-Michel Warnet ◽  
...  
Keyword(s):  
Cell Death ◽  
Death Receptor ◽  
Receptor Activation ◽  
Cell Death Receptor

Novel anti-inflammatory mechanism in critically ill: Soluble programmed cell death receptor-1 (sPD-1)

2011 ◽  
Vol 213 (3) ◽  
pp. S54-S55
Author(s):  
Sean F. Monaghan ◽  
Rajan K. Thakkar ◽  
Chun S. Chung ◽  
Yaping Chen ◽  
Daithi S. Heffernan ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Critically Ill ◽  
Death Receptor ◽  
Inflammatory Mechanism ◽  
Anti Inflammatory ◽  
Cell Death Receptor

scholarly journals Sepsis-Induced Potentiation of Peritoneal Macrophage Migration Is Mitigated by Programmed Cell Death Receptor-1 Gene Deficiency

2013 ◽  
Vol 6 (3) ◽  
pp. 325-338 ◽  
Author(s):  
Alfred Ayala ◽  
Gwendolyn F. Elphick ◽  
Ye Sul Kim ◽  
Xin Huang ◽  
Arnaldo Carreira-Rosario ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Peritoneal Macrophage ◽  
Death Receptor ◽  
Macrophage Migration ◽  
Gene Deficiency ◽  
Cell Death Receptor

scholarly journals A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction

2016 ◽  
Vol 22 (1) ◽  
pp. 830-840 ◽  
Author(s):  
Youping Wu ◽  
Chun-Shiang Chung ◽  
Yaping Chen ◽  
Sean Farrell Monaghan ◽  
Sima Patel ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Death Receptor ◽  
Receptor Ligand ◽  
Death Receptor Ligand ◽  
Cell Death Receptor
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