scholarly journals Autoimmune anti-N-methyl-D-aspartate receptor encephalitis – current state of knowledge overview based on the clinical case

2017 ◽  
Vol 17 (1) ◽  
pp. 49-54
Author(s):  
Rafał Wójtowicz ◽  
◽  
Magdalena Krawiec ◽  
Piotr Orlicz ◽  
◽  
...  
Keyword(s):  
Clinical Case ◽  
Current State ◽  
Aspartate Receptor

scholarly journals Vibrio metschnikovii : Current state of knowledge and discussion of recently identified clinical case

2021 ◽  
Author(s):  
Yulian Konechnyi ◽  
Yurii Khorkavyi ◽  
Kateryna Ivanchuk ◽  
Ihor Kobza ◽  
Alicja Sękowska ◽  
...  
Keyword(s):  
Clinical Case ◽  
Current State ◽  
Vibrio Metschnikovii

scholarly journals In Search of Inner Wisdom: Guided Mindfulness Meditation in the Context of Suicide

2004 ◽  
Vol 4 ◽  
pp. 216-227 ◽  
Author(s):  
Liora Birnbaum ◽  
Aiton Birnbaum
Keyword(s):  
Mental Health Professionals ◽  
Health Professionals ◽  
Group Intervention ◽  
Clinical Case ◽  
Mindfulness Meditation ◽  
External Source ◽  
The Self ◽  
Diverse Populations ◽  
Suicide Survivors ◽  
Current State

Spiritual concerns are highly relevant, but often ignored, in psychotherapy in general and in suicide in particular. This article presents Internet data and clinical case material bearing on the topic, and describes an innovative therapeutic intervention administered in a group-workshop format with suicide survivors and mental health professionals. The technique incorporates relaxation and mindfulness meditation, with the addition of guided meditation in search of inner wisdom. Results of the group intervention are described and illustrated. Many participants reported a significant positive experience including connection to knowledge that was highly relevant to them in their current state of life. Whether such insights were experienced as coming from within (a deeper part of the self) or from an external source (a guiding figure or presence), indications are that guided meditation can be a powerful resource for therapists and their clients, suicidal and otherwise. Possible applications in diverse populations and settings, as well as the need for further research, are discussed.

scholarly journals Visceral leishmaniasis: a challenging diagnosis in internal medicine

2020 ◽  
Vol 92 (11) ◽  
pp. 117-121
Author(s):  
M. Iu. Brovko ◽  
L. A. Akulkina ◽  
P. P. Potapov ◽  
V. I. Sholomova ◽  
M. V. Lebedeva ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Visceral Leishmaniasis ◽  
Russian Federation ◽  
Clinical Case ◽  
Diagnostic Approach ◽  
Parasitic Disease ◽  
Visceral Involvement ◽  
Current State ◽  
High Prevalence ◽  
Imported Cases

Leishmaniasis is a vector-born parasitic disease characterized by predominant cutaneous or visceral involvement with fever, hepatosplenomegaly and anemia. Leishmaniasis has relatively high prevalence in tropical and subtropical areas. Several sporadic and mostly imported cases are detected in Russian Federation. Nevertheless, some local incidents are noted in southern areas (Crimea, Dagestan). Lack of epidemiological alertness hampers confirmation of diagnosis and may lead to incorrect treatment. The article summarizes current state of knowledge in epidemiology, diagnostic approach and treatment of leishmaniasis. Particular clinical case is discussed.

Memantine in Patients with Moderate to Severe Alzheimer’s Disease Already Receiving Donepezil

2018 ◽  
Author(s):  
Brandon M. Kitay ◽  
Rajesh R. Tampi
Keyword(s):  
Alzheimer Disease ◽  
Clinical Case ◽  
Cognitive Disorders ◽  
Pharmacological Management ◽  
Aspartate Receptor ◽  
Augmentation Strategy ◽  
Study Intervention ◽  
Receptor Inhibitor ◽  
Landmark Study

This chapter provides a summary of a landmark study on the pharmacological management of cognitive disorders. In patients with moderate to severe Alzheimer disease treated with a cholinesterase inhibitor (donepezil), is the addition of a N-methyl-D-aspartate receptor inhibitor (memantine) a safe and efficacious augmentation strategy? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and controversy within the field, concluding with a discussion of implications, and an exemplary clinical case applying the study evidence.

scholarly journals Clinical trials of new drugs for Alzheimer disease

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Li-Kai Huang ◽  
Shu-Ping Chao ◽  
Chaur-Jong Hu
Keyword(s):  
Clinical Trials ◽  
Alzheimer Disease ◽  
Psychological Symptoms ◽  
Future Trend ◽  
New Drugs ◽  
Amyloid Hypothesis ◽  
Current State ◽  
Aspartate Receptor ◽  
Drug Companies ◽  
Underlying Mechanisms

AbstractAlzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Presently, the drugs available for AD treatment, including cholinesterase inhibitors and an antagonist of the N-methyl-D-aspartate receptor, can only inhibit dementia symptoms for a limited period of time but cannot stop or reverse disease progression. On the basis of the amyloid hypothesis, many global drug companies have conducted many clinical trials on amyloid clearing therapy but without success. Thus, the amyloid hypothesis may not be completely feasible. The number of anti-amyloid trials decreased in 2019, which might be a turning point. An in-depth and comprehensive understanding of the contribution of amyloid beta and other factors of AD is crucial for developing novel pharmacotherapies.In ongoing clinical trials, researchers have developed and are testing several possible interventions aimed at various targets, including anti-amyloid and anti-tau interventions, neurotransmitter modification, anti-neuroinflammation and neuroprotection interventions, and cognitive enhancement, and interventions to relieve behavioral psychological symptoms. In this article, we present the current state of clinical trials for AD at clinicaltrials.gov. We reviewed the underlying mechanisms of these trials, tried to understand the reason why prior clinical trials failed, and analyzed the future trend of AD clinical trials.

scholarly journals CURRENT STATE OF THE PROBLEM OFABNORMAL INVASION OF THE PLACENTA IN OBSTETRICS

2020 ◽  
Vol 73 (12) ◽  
pp. 2688--2693
Author(s):  
Liudmyla A. Vygivska ◽  
Olena A. Yakovenko ◽  
Evgen V. Blagoveschenskiy ◽  
Yevheniia M. Babadzhanian ◽  
Lesia A. Rudenko ◽  
...  
Keyword(s):  
Clinical Case ◽  
Pathological Condition ◽  
Color Doppler ◽  
Perinatal Outcomes ◽  
Clinical Case Study ◽  
Diagnostic Studies ◽  
Current State ◽  
Maternal Morbidity And Mortality ◽  
Placental Invasion

The aim: On the basis of literature data, as well as a clinical case study, to assess the state of the problem of abnormal invasion of the placenta in obstetrics at the present stage. Materials and methods: Based on the materials of the world’s leading citation databases (MEDLINE, EMBASE, Cochrane), a brief review of the literature data over the past 5 years is presented, dedicated to the issues of abnormal placental invasion. The possibilities of a complex of diagnostic studies and clinical management of women with an anomaly of placenta attachment are considered. A clinical case study of abnormal placental invasion is presented. Conclusions: AIP is an extremely serious condition with not fully understood etiological and pathogenic mechanisms. Correct and timely verification of this pathological condition, based on the simultaneous use of a whole complex of diagnostic studies (history taking, 2D, 3D, energy and color Doppler mapping, MRI), contributes to the development of individual tactics for the management and delivery in women with AIP, making it possible to reduce maternal morbidity and mortality and improve perinatal outcomes.

scholarly journals A Rare Combination of a Complex Nevus with Basal Cell Carcinoma of Piloid Differentiation in a Patient with Hyper-Extensible Eyelid Syndrome. Clinical and Morphological Case

Medicina ◽  
2020 ◽  
pp. 11-17
Author(s):  
E. A. Krinitsyna ◽  
◽  
A. A. Fedorov ◽  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Large Volume ◽  
Clinical Case ◽  
Lower Eyelid ◽  
Current State ◽  
Rare Combination ◽  
The Future

A clinical case of a patient with floppy eyelid syndrome who underwent a resection of the lower eyelid for a neoplasm is presented. Despite of the large volume of tissue removed and given his current state, it was possible to close the defect by direct tissue matching. Thus, patients with floppy eyelid syndrome have an advantage in case of removal of large volume neoplasms, which in the future do not require the use of complex plastics.

Parastomal hernia repair: laparoscopic ventral hernia meshplasty with stoma relocation. The current state and a clinical case presentation

Hernia ◽  
2010 ◽  
Vol 15 (1) ◽  
pp. 85-91 ◽  
Author(s):  
L. García-Vallejo ◽  
P. Concheiro ◽  
E. Mena ◽  
J. Baltar ◽  
I. Baamonde ◽  
...  
Keyword(s):  
Hernia Repair ◽  
Ventral Hernia ◽  
Parastomal Hernia ◽  
Clinical Case ◽  
Case Presentation ◽  
Current State ◽  
Parastomal Hernia Repair

Behavioural measures of pain

2013 ◽  
pp. 379-383 ◽  
Author(s):  
Jill MacLaren Chorney ◽  
C. Meghan McMurtry
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Children And Adolescents ◽  
Outcome Measures ◽  
Clinical Case ◽  
Functional Disability ◽  
Procedural Pain ◽  
Future Directions ◽  
Current State

This chapter reviews the current state of evidence on behavioural measures of pain in children and adolescents including a brief discussion of future directions. To demonstrate the utility of behavioural scales, it also includes a clinical case example at the end of this chapter. A few limits of coverage should be noted. First, although some of the measures included in this chapter may have been used for infants, we will not review measures that are only validated for infants as these measures are covered by Lee and Stevens (Chapter 35, this volume)). Second, given that there are no well-established behavioural measures of chronic pain, this chapter will focus on measures that are relevant to acute and procedural pain and will also not cover other pain-related outcome measures (e.g. functional disability, quality of life).

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