scholarly journals Синдроматика та стан метаболічних процесів у корів за мікроелементозів

2017 ◽  
Vol 19 (78) ◽  
pp. 182-186
Author(s):  
L. Slivinska ◽  
S. Demydjuk ◽  
А. Shcherbatyy
Keyword(s):  
Body Temperature ◽  
Blood Serum ◽  
Subcutaneous Fat ◽  
Mucous Membranes ◽  
Intestinal Peristalsis ◽  
Blood Serum Protein ◽  
Elastic Skin ◽  
Loss Of Appetite ◽  
Cu And Zn ◽  
Biogenic Microelements

The article analyzes the results of clinical research and the state of the indicators of the metabolism of high-yielding cows of PP «AGRO-EXPRESS-SERVICE» in the Mlynivskyi district of the Rivne region due to the lack of biogenic microelements (Co, Cu, Zn).During the clinical examination of cows, the characteristic symptoms of microelementosis (Co, Cu, Zn) were found: loss of appetite, taste distortion, pallor of visible mucous membranes (in 65 cows); rude dull hair; low-elastic skin, subcutaneous fat is not sufficiently expressed; intestinal peristalsis weakened, hypotonic prehistoras. In 95 cows, pulse rate, respiration, scarring and body temperature were on the lower limit of physiological oscillations; only 20.8% of cows had tachycardia (85–95 per 1 minute) and tachypnea (35–45 per 1 minute). In addition, in 45.8% of cows fattening below average, the constitution is dense. The productivity of animals was sharply reduced. In 33.3% of cows, the curvaceousness and shrinkage of wool were noted. In 6.8% of animals, alotriophagia was observed. Due to lack of cobalt in 15% of cows revealed symptoms of osteodystrophy: tight course, convexity of the edges, pain of the joints, softening of the tail vertebrae.The violation of the exchange of Cu, Cu, and Zn in cows was characterized by a decrease in blood serum protein content by 14.8% (P < 0.001), albumin by 28.5%; (P < 0.001), carotene by 33.3%, glucose by 21.4% (P < 0.001), reserve alkalinity by 13.7%, increase in the content of globulins by 14.6% (P < 0.001), bilirubin by 24.6%, creatinine by 17.8% (P < 0.001) and cholesterol by 27.8%. 

scholarly journals TOXICOLOGICAL EVALUATION OF INDOMETHACIN AS A RISK FACTOR FOR WORKERS’ HEALTH

2019 ◽  
Vol 98 (5) ◽  
pp. 503-508
Author(s):  
N. A. Martynova ◽  
Larisa G. Gorokhova ◽  
V. A. Shtaiger
Keyword(s):  
Blood Serum ◽  
Guinea Pigs ◽  
Muscle Relaxation ◽  
Lethal Dose ◽  
The Body ◽  
Male Rats ◽  
Hazard Class ◽  
Toxicological Evaluation ◽  
Mucous Membranes ◽  
Ulcerogenic Effect

Introduction. The toxicity of indomethacin was studied for its hygienic regulation. Material and methods. The toxic properties of indomethacin in the experiments on out-bred and linear mice, rats, Guinea pigs and rabbits contained in standard vivarium conditions and quarantined have been studied. In the experiments, various modes (single, repeated, chronic) and ways of exposure (intragastric, inhalation, epicutaneous) were modeled. The average lethal dose (LD50) of Indomethacin and the threshold of a single acute action (Limac) were determined; irritant effect on the skin and mucous membranes, cumulative and allergenic activity were revealed. In subacute and chronic intake to the body, the main target organs were determined on the based of the results of biochemical and hematological studies. Results. DL50 for male rats, females and male mice, when introduced into the stomach, were have been established to be 20, 15 and 25.6 mg/kg respectively. It refers to the substances of hazard class 2. DL50 in the intraperitoneal introduction for the rats accounted for 13.8 mg/kg, for Guinea pigs - 500 mg/kg. The clinical picture of acute poisoning in mice and rats was characterized by low mobility, decreasing breathing, ataxia, muscle relaxation, anorexia, diarrhea, ulceration with the perforation of the intestines, and the death on the 2-4th days after the poisoning. In the experiments on Guinea pigs, the ulcerogenic effect was not detected. Local irritant effect on the skin and mucous membranes of the eyes was not revealed. It has a marked skin-resorptive action causing ulcerogenic effect and the death of the animals after 6 applications. The introduction of verospiron to the rats in a dose of 25 mg/kg simultaneously with the application of indomethacin ointment on the skin prevented the ulcer development in the gastrointestinal tract and the death of the animals. No sensitizing effect was detected. It has an average cumulative ability: the cumulation coefficient amounted to 2.6. In a subacute experiment, there was a decrease in the body temperature and summation-threshold index, an increase in the vertical motor activity and a threshold of pain sensitivity. During the study of blood serum an increase in AcAt activity, a rise of chlorides in the blood serum and their decrease in the urine, and an increase in the number of erythrocytes and hemoglobin in peripheral blood were revealed. In the pathomorphological study, there was an increase in the coefficients of liver mass and ulceration of the stomach and intestines. The threshold of acute inhalation action accounted for 0.52 mg/m3 (by the reduction of the summation-threshold index and the content of sodium and chlorides in the urine). Conclusion. The maximum permissible concentration of indomethacin in the air of the working area was of 0.05 mg/m3 with the mark “special protection of the skin and eyes”, hazard class 1, aerosol.

Tolerance to extreme cold at altitude in a Nepalese pilgrim

1963 ◽  
Vol 18 (6) ◽  
pp. 1234-1238 ◽  
Author(s):  
L. G. C. E. Pugh
Keyword(s):  
Body Temperature ◽  
Skin Temperature ◽  
Rectal Temperature ◽  
Cold Water ◽  
Subcutaneous Fat ◽  
Subcutaneous Fat Thickness ◽  
Fat Thickness ◽  
Extreme Cold

Body temperature and respiratory experiments are reported on a Nepalese pilgrim who survived, uninjured, 4 days of exposure at 15,000–17,500 ft in midwinter, wearing only light clothing and no shoes or gloves. His resistance to cold depended on elevation of metabolism and, unlike tolerance of immersion in cold water, was not related to subcutaneous fat thickness. He slept soundly in spite of the cold and so did not become exhausted. In 3–4-hr experiments at o C (clothed), rectal temperature and skin temperature over the trunk showed only minor changes; hand and foot temperatures did not fall below 10–13 C. Maintenance of body temperature was accounted for by elevation of metabolism. survival in cold Submitted on February 19, 1963

Formation of dipole nanoclusters in blood serum protein solutions containing europium and potassium ions

2011 ◽  
Vol 66 (2) ◽  
pp. 190-195 ◽  
Author(s):  
T. N. Tikhonova ◽  
G. P. Petrova ◽  
Yu. M. Petrusevich ◽  
K. V. Fedorova ◽  
V. V. Kashin
Keyword(s):  
Blood Serum ◽  
Serum Protein ◽  
Protein Solutions ◽  
Potassium Ions ◽  
Blood Serum Protein

Changes in the blood serum protein spectrum of mice after injection of a globulin preparation containing homologous tissue antibodies

1979 ◽  
Vol 88 (2) ◽  
pp. 871-874
Author(s):  
I. S. Zaretskaya ◽  
Z. M. Saraeva ◽  
I. P. Tereshchenko ◽  
T. S. Vtyurina ◽  
N. N. Klemparskaya ◽  
...  
Keyword(s):  
Blood Serum ◽  
Serum Protein ◽  
Protein Spectrum ◽  
Blood Serum Protein ◽  
Homologous Tissue

Blood Serum Protein of the Marine Elasmobranchii

Science ◽  
1954 ◽  
Vol 120 (3125) ◽  
pp. 849-851 ◽  
Author(s):  
H. Irisawa ◽  
A. F. Irisawa
Keyword(s):  
Blood Serum ◽  
Serum Protein ◽  
Blood Serum Protein

scholarly journals Glycomic alterations in the highly-abundant and lesser-abundant blood serum protein fractions for patients diagnosed with hepatocellular carcinoma

2011 ◽  
Vol 305 (2-3) ◽  
pp. 185-198 ◽  
Author(s):  
Pilsoo Kang ◽  
Milan Madera ◽  
William R. Alley ◽  
Radoslav Goldman ◽  
Yehia Mechref ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Blood Serum ◽  
Serum Protein ◽  
Protein Fractions ◽  
Blood Serum Protein

scholarly journals LEVEL OF MARKERS OF NEURODEGENERATION IN PATIENTS WITH OCULAR ISCHEMIC SYNDROME

2014 ◽  
Vol 7 (2) ◽  
Author(s):  
Halidjan Kamilov ◽  
Munirahon Kasimova ◽  
Dilbar Makhkamova
Keyword(s):  
Blood Serum ◽  
Protein S ◽  
Main Group ◽  
Tear Fluid ◽  
Control Group ◽  
Normal Range ◽  
Ocular Ischemic Syndrome ◽  
S 100 ◽  
Blood Serum Protein ◽  
Ischemic Syndrome

The purpose of this study was to investigate the content neurospecific markers protein S-100 and neuroenolaza in blood serum and tear fluid of patients with ocular ischemic syndrome.Material and methods. We observed 43 patients aged 57 to 79 years, mean age 67.3 ± 2.7 years. Control group consisted of 11 volunteers  without ophthalmic symptoms. The main group consisted of 32 patients with OIS. The neurospecific proteins S100 and NSE were investigated in blood serum and tear fluid.Results. The study found that in patients of the control group the content of protein were within the normal range: S- 100 in the tear fluid – 0,0662 ± 0,00335 mkg/l, in the blood serum 0,0508 ± 0,00241 mkg/l. In patients of the main group the indicators of protein in the tear fluid were elevated in all patients - 3,12 ± 0,246 mkg/l ( p<0.005). The normal levels in blood serum of marker S-100 was in 30 patients - 0,0589 ± 0,00303 mkg/l, while, in 2 patients protein S-100 were raised and averaged 0,2175±0,00725 mkg/l. It was found that in patients of the control group content of protein NSE in the tear fluid and blood serum were within normal values - 15,86 ± 0,148 Ng/ml, 15,60 ± 0,202 Ng/ml respectively. In the main group the amount of protein NSE tended to increase in the tear fluid in 23 patients and averaged 33,012 ± 3,2626 Ng/ml (p<0.005), a significant decrease the quantity of protein was observed in 9 patients, which amounted to 5,166 ± 0,8301 Ng/ml. At normal levels in the blood serum protein NSE detected in 30 patients and averaged 14,48 ± 0,263 Ng/ml, whereas, in 2 patients there was a significant increase of content of protein NSE and was 27,47 ± 3,068 Ng/ml.Conclusions. Thus, changes in the concentration of S100 and neuroenolaza in the tear fluid in patients with ocular ischemic syndrome allow to identify as marker of nerve cells damage of the eye, contributing to the definition in conjunction with other signs of stage and etiology of the disease.

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