scholarly journals РЕДОКС-ПОТЕНЦІАЛ ТА СТАН ПЕРЕКИСНОГО ОКИСНЕННЯ ЛІПІДІВ КРОВІ КОРІВ, ЩО УТРИМУЮТЬСЯ У ЕКОЛОГІЧНО НЕСПРИЯТЛИВИХ УМОВАХ

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 197-202
Author(s):  
I.V. Chala ◽  
V.S. Rusak
Keyword(s):  
Redox Potential ◽  
Antioxidant System ◽  
Venous Blood ◽  
Lipid Peroxide ◽  
Ecological Factors ◽  
The Body ◽  
Water Radiolysis ◽  
Peroxide Oxidation ◽  
Emissive Power ◽  
Active Forms Of Oxygen

The paper highlights the investigations into the effects of the complex of unfavorable ecological factors which appear as a result of Chernobyl-derived contamination of farm lands on the intensity of peroxide oxidation of lipids and glutathione chain of the antioxidant system of dairy cows, as well as on the changes in the redox-potential of blood. The territory that suffered from Chernobyl-derived radionuclide contamination is characterized by the unfavorable ecological situation which is connected with the increase in the radioactive load on animals, as well as  with  the decrease in the part of soluble (exchange) form of biogenic mineral elements of soils. The above conditions make it possible to initiate a complex of biochemical changes caused by water radiolysis, by the increase in the active forms of oxygen and by the protection of the body from the products of peroxidation which appear as a result of the effects of radiolysis products. The investigation is aimed at determining the redox-potential of venous blood and separate indices of the peroxide oxidation of lipids and the antioxidant system of blood in cows kept in the zone which was contaminated by the man-caused radio nuclides , as compared with cows kept in the zone with background values of radioactivity and ᶨ- irradiation emissive power. The investigation results make it possible to establish that in the blood of cows kept under ecologically unfavorable conditions one can observe the increase in the concentration of the products of lipid peroxide oxidation: hydroperoxide lipids and malone  dialdehyde. Under the above conditions one can establish the changes in the activity  of the glutathione chain of the antioxidant system: the decrease in the part of renewed glutathione and the authentic increase in the part of oxidized glutathione and the decrease in the activity of glutathione reductase as compared with  cows kept under ecologically favorable conditions. It has been established that under the effects of unfavorable ecological factors one can observe the increase in the positive redox-potential of blood which testifies to the disturbances between oxidized and renewed potentials.

scholarly journals Peroxide oxidation processes and enzyme activity of the antioxidant system in the organism of rabbits of the New Zealand breed

Biologija ◽  
2019 ◽  
Vol 65 (1) ◽  
Author(s):  
Svitlana Tsekhmistrenko ◽  
Nataliia Rol ◽  
Maksym Fedorchenko
Keyword(s):  
New Zealand ◽  
Blood Plasma ◽  
Antioxidant System ◽  
The Body ◽  
Total Lipids ◽  
Peroxide Oxidation ◽  
Back Muscle ◽  
Oxidation Processes ◽  
Peroxidation Processes ◽  
The Brain

The study is devoted to the study of the flow of peroxidation processes in various organs and tissues of the body of rabbits of the New Zealand breed in the age aspect. We used blood plasma and homogenate of the brain, the heart, the liver, and the longest back muscle selected after slaughter, from birth to 90-day-age at intervals of 15 days. The content of total lipids and secondary lipid peroxidation products – TBA-reactive substances and enzymes of the antioxidant system were thoroughly studied in the prototype. The presence of high content of common lipids and TBA- reactive substances in blood plasma and liver tissues of rabbits at one day and 15 days of age was established, which pointed to active process of peroxide oxidation of lipids. An increase in the content of TBA- reactive substances was noted in the heart of rabbits with 2.24 mmol/g tissue in one-day animals to 4.85 mmol/g tissue in 90-day-old animals.

scholarly journals HOW THALICTRUM FOETIDUM EXTRACT INFLUENCES THE LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN RATS SUBJECTED TO CHRONIC IMMOBILISATION STRESS

THE BULLETIN ◽  
2020 ◽  
Vol 3 (385) ◽  
pp. 24-28
Author(s):  
Е. V. Savelyeva ◽  
◽  
I. N. Vladimirova ◽  
L. V. Lukianova ◽  
◽  
...  
Keyword(s):  
Antioxidant System ◽  
Lipid Peroxide ◽  
Peroxide Oxidation ◽  
Immobilisation Stress

Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk
Keyword(s):  
Screening Test ◽  
Venous Blood ◽  
The Body ◽  
Ethylene Diamine ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ethylene Diamine Tetra Acetate ◽  
The Difference ◽  
Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

scholarly journals Metabolic Acidosis in Patients with CKD: Epidemiology, Pathogenesis, and Treatment

2021 ◽  
pp. 1-16
Author(s):  
Marcin Adamczak ◽  
Stanisław Surma
Keyword(s):  
Metabolic Acidosis ◽  
Sodium Bicarbonate ◽  
Current Knowledge ◽  
Venous Blood ◽  
The Body ◽  
Hydrogen Ions ◽  
Ckd Progression ◽  
New Drug ◽  
Treatment And Prevention

<b><i>Background:</i></b> Metabolic acidosis in CKD is diagnosed in patients with plasma or venous blood bicarbonate concentration lower than 22 mmol/L. Metabolic acidosis occurs in about 20% of patients with CKD. Metabolic acidosis may lead to dysfunction of many systems and organs as well as CKD progression. Currently, sodium bicarbonate is mainly used for pharmacological treatment of metabolic acidosis in patients with CKD. Veverimer is a new drug dedicated to treatment of metabolic acidosis in patients with CKD. Orally given veverimer binds hydrogen ions in the intestines and subsequently is excreted from the body with feces. Clinical studies have shown that veverimer is effective in increasing serum bicarbonate concentrations in CKD patients with metabolic acidosis. Here, we present review of the epidemiology, pathogenesis, diagnosis, treatment, and prevention of metabolic acidosis in CKD patients. <b><i>Summary:</i></b> Metabolic acidosis is common in patients with CKD and contributes to CKD progression and many complications, which worsen the prognosis in these patients. Currently, sodium bicarbonate is mainly used in metabolic acidosis treatment. The role of the new drug veverimer in the metabolic acidosis therapy needs further studies. <b><i>Key Message:</i></b> The aim of this review article is to summarize the current knowledge concerning the epidemiology, pathogenesis, diagnosis, treatment, and prevention of metabolic acidosis in CKD patients.

Respiratory measurements of cardiac output: from elegant idea to useful test

2004 ◽  
Vol 96 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Gabriel Laszlo
Keyword(s):  
Cardiac Output ◽  
Human Subjects ◽  
Venous Blood ◽  
The Body ◽  
Mixed Venous Blood ◽  
Indirect Determination ◽  
Arterial Blood ◽  
Pulmonary Capillary ◽  
Pulmonary Arterial ◽  
Mixed Venous

The measurement of cardiac output was first proposed by Fick, who published his equation in 1870. Fick's calculation called for the measurement of the contents of oxygen or CO2 in pulmonary arterial and systemic arterial blood. These values could not be determined directly in human subjects until the acceptance of cardiac catheterization as a clinical procedure in 1940. In the meanwhile, several attempts were made to perfect respiratory methods for the indirect determination of blood-gas contents by respiratory techniques that yielded estimates of the mixed venous and pulmonary capillary gas pressures. The immediate uptake of nonresident gases can be used in a similar way to calculate cardiac output, with the added advantage that they are absent from the mixed venous blood. The fact that these procedures are safe and relatively nonintrusive makes them attractive to physiologists, pharmacologists, and sports scientists as well as to clinicians concerned with the physiopathology of the heart and lung. This paper outlines the development of these techniques, with a discussion of some of the ways in which they stimulated research into the transport of gases in the body through the alveolar membrane.

scholarly journals Observations on the theory of respiration

1837 ◽  
Vol 3 ◽  
pp. 334-335
Keyword(s):  
Carbonic Acid ◽  
Venous Blood ◽  
Hydrogen Gas ◽  
The Body ◽  
Pure Hydrogen ◽  
Atmospheric Air ◽  
Acid Gas ◽  
Arterial Blood ◽  
Dark Colour ◽  
Oxygen Gas

From the fact that no carbonic acid gas is given out by venous blood when that fluid is subjected to the action of the air-pump, former experimentalists had inferred that this blood contains no carbonic acid. The author of the present paper contends that this is an erroneous inference; first, by showing that serum, which had been made to absorb a considerable quantity of this gas, does not yield it upon the removal of the atmospheric pressure; and next, by adducing several experiments in proof of the strong attraction exerted on carbonic acid both by hydrogen and by oxygen gases, which were found to absorb it readily through the medium of moistened membrane. By means of a peculiar apparatus, consisting of a double-necked bottle, to which a set of bent tubes were adapted, he ascertained that venous blood, agitated with pure hydrogen gas, and allowed to remain for an hour in contact with it, imparts to that gas a considerable quantity of carbonic acid. The same result had, indeed, been obtained, in a former experiment, by the simple application of heat to venous blood confined under hydrogen gas; but on account of the possible chemical agency of heat, the inference drawn from that experiment is less conclusive than from experiments in which the air-pump alone is employed. The author found that, in like manner, atmospheric air, by remaining, for a sufficient time, in contact with venous blood, on the application of the air-pump, acquires carbonic acid. The hypothesis that the carbon of the blood attracts the oxygen of the air into the fluid, and there combines with it, and that the carbonic acid thus formed is afterwards exhaled, appears to be inconsistent with the fact that all acids, and carbonic acid more especially, impart to the blood a black colour; whereas the immediate effect of exposing venous blood to atmospheric air, or to oxygen gas, is a change of colour from a dark to a bright scarlet, implying its conversion from the venous to the arterial character: hence the author infers that the acid is not formed during the experiment in question, but already exists in the venous blood, and is extracted from it by the atmospheric air. Similar experiments made with oxygen gas, in place of atmospheric air, were attended with the like results, but in a more striking degree and tend therefore to corroborate the views entertained by the author of the theory of respiration. According to these views, it is neither in the lungs, nor generally in the course of the circulation, but only during its passage through the capillary system of vessels, that the blood undergoes the change from arterial to venous; a change consisting in the formation of carbonic acid, by the addition of particles of carbon derived from the solid textures of the body, and which had combined with the oxygen supplied by the arterial blood: and it is by this combination that heat is evolved, as well as a dark colour imparted to the blood. The author ascribes, however, the bright red colour of arterial blood, not to the action of oxygen, which is of itself completely inert as a colouring agent, but to that of the saline ingredients naturally contained in healthy blood. On arriving at the lungs, the first change induced on the blood is effected by the oxygen of the atmospheric air, and consists in the removal of the carbonic acid, which had been the source of the dark colour of the venous blood; and the second consists in the attraction by the blood of a portion of oxygen, which it absorbs from the air, and which takes the place of the carbonic acid. The peculiar texture of the lungs, and the elevation of temperature in warm-blooded animals, concur in promoting the rapid production of these changes.

Changes in Blood Pressure, Heart Rate and Breathing Rate During Moderate Swimming Activity in Rainbow Trout

1967 ◽  
Vol 46 (2) ◽  
pp. 307-315 ◽  
Author(s):  
E. DON STEVENS ◽  
D. J. RANDALL
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Rainbow Trout ◽  
Venous Blood ◽  
The Body ◽  
Swimming Activity ◽  
Breathing Rate ◽  
Blood Pressures ◽  
Ventral Aorta ◽  
Pressure Changes

1. Changes in blood pressure in the dorsal aorta, ventral aorta and subintestinal vein, as well as changes in heart rate and breathing rate during moderate swimming activity in the rainbow trout are reported. 2. Blood pressures both afferent and efferent to the gills increased during swimming and then returned to normal levels within 30 min. after exercise. 3. Venous blood pressure was characterized by periodic increases during swimming. The pressure changes were not in phase with the body movements. 4. Although total venous return to the heart increased during swimming, a decreased blood flow was recorded in the subintestinal vein. 5. Heart rate and breathing rate increased during swimming and then decreased when swimming ceased. 6. Some possible mechanisms regulating heart and breathing rates are discussed.

Pengaruh Clay Therapy terhadap Kecemasan Anak Usia Prasekolah yang Menjalani Prosedur Invasif di RSUD Al-Ihsan

2019 ◽  
Vol 13 (2) ◽  
pp. 72-86
Author(s):  
Depi Lukitasari
Keyword(s):  
Venous Blood ◽  
Intervention Group ◽  
Invasive Procedure ◽  
T Test ◽  
The Body ◽  
Preschool Age ◽  
Control Group ◽  
P Value ◽  
Invasive Procedures ◽  
Preschool Age Children

Background. During hospitalization large number of invasive procedure recived by patient and preceived as threatening and anxiety experience. One of the invasive procedures that commonly done is the venous blood extraction. The children in preschool age preceived venous blood extraction as something that endanger the integrity of the body and lead to anxiety experience. To reduce the anxiety during the venous blood extraction, a nurse could perform a clay theraphy. The aim of this research is to ascertain the effect of clay therapy toward scoreof anxiety in preschool age children that undergoing venous blood extraction in RSUD Al-Ihsan.Methode. The study was quasi-experiment with nonequivalent control group posttest only. A total of 34 children who recieve venous blood extraction was assigned into 2 group, 17 children in control and 17 children in intevention. The children anxiety level measured using anxiety observation sheet before the procedure complete. Data were analyzed used independent t test for bivariate and logistik regresion for multivariate. Result Findings. The results  show a significat difference in anxiety score between control group and intervention group with p-value 0,001 < α 0.05 which means there is impact of clay therapy to level anxiety in preschool age children undergoing invasive procedure in RSUD Al-Ihsan. Conclusion. This research indicate that clay therapy may be used to reduce anxiety in children that undergoing venous blood extraction.

Skin Perfusion, Arterial and Venous Blood Flow, and Soft Tissue Thickness in Relation to Pressure Ulcers

2013 ◽  
Author(s):  
Abinand Manorama ◽  
Tamara Reid Bush
Keyword(s):  
Blood Flow ◽  
Pressure Ulcers ◽  
Venous Blood ◽  
The Body ◽  
Venous Blood Flow ◽  
Tissue Necrosis ◽  
Tissue Thickness ◽  
Skin Perfusion ◽  
Healthcare Settings ◽  
Soft Tissue Thickness

Pressure ulcers have been a concern in healthcare settings, with more than 50% of bedridden or wheelchair-bound patients being affected [1]. Pressure ulcers typically occur on a region of the body that experiences forces from an external structure (e.g. bed, wheelchair). Researchers believe that such forces cause a decrease in blood flow, which results in tissue necrosis, causing pressure ulcers [2].

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