scholarly journals Гематологічний профіль у щурів при експериментальному диклофенак-індукованому гепатиті

2017 ◽  
Vol 7 (3) ◽  
pp. 78-83 ◽  
Author(s):  
V.А. Gryshchenko
Keyword(s):  
Inflammatory Process ◽  
Toxic Hepatitis ◽  
Diclofenac Sodium ◽  
Blood Rheology ◽  
Red Bone Marrow ◽  
Chronic Inflammatory Process ◽  
Experimental Reproduction ◽  
Inflammatory Drugs ◽  
Experimental Toxic Hepatitis

<p>Sodium diclophenac belongs to a group of nonsteroidal anti-inflammatory drugs, which is indicated for inflammatory, degenerative and traumatic lesions system of the skeleton, muscles and connectives tissues. The features of changes in hematological (above all, morphological) indices in Wistar line rats for experimental reproduction of toxic hepatitis at oral introduction of diclofenac sodium in a dose of 12.5 mg / kg of body weight (once a day, within 14 days) were investigated. This rats demonstrated the development of chronic inflammatory process in liver that was characterized by reactive leukocytosis (an increase in the number of leukocytes by a factor of 3), neutrophil right shift, monocytopenia (a decrease in the number of monocytes by a factor of 2.6) together with compensatory lymphocytosis, high values of ESR (by a factor of 5.5), and thymol test (by a factor of 2.9). However, erythrocytopenia<em> </em>(a decrease in the number of erythrocytes by 44 %) – which is a sign of anemia development – was revealed in animals under the experimental toxic hepatitis. Besides it, the hemoglobin content was in the range of normal values that was an evidence of a compensatory role of red bone marrow in the maintaining homeostasis of the respiratory function of blood. There were no changes in blood rheology that was indicated by definite stability of the hematocrit value in sick animals. We registered the development of chronic inflammatory process and anemia in rats caused by experimental reproduction of toxic liver damage by oral introduction of sodium diclofenac. </p>

Non-steroidal anti-inflammatory drugs for the prevention of post-endoscopic retrograde cholangiography pancreatitis Short title: Post-ERCP pancreatitis prevention

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mirghani HO
Keyword(s):  
Diclofenac Sodium ◽  
Route Of Administration ◽  
The Body ◽  
Endoscopic Retrograde ◽  
Randomized Controlled Studies ◽  
Conflicting Objectives ◽  
The Usa ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a serious disease. The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of PEP is conflicting. Objectives: This review aimed to assess the preventive role of NSAIDs in PEP with special emphasis on the dose and route of administration. Methods: We searched PubMed and Google Scholar for relevant observational studies published in English during the period from January 2010 to January 2020. The terms post-ERCP pancreatitis, diclofenac sodium, indomethacin, NSAIDs, dose, route of administration were used. Results: Of the 179 identified, 19 full texts were screened and included in the review. Ten studies were from Europe, seven from Asia and two were published in the USA, the studies showed that NSAIDs were effective in preventing PEP when used rectally or intramuscularly, higher doses are more efficacious and the combination with stents was not superior, careful patients selection is needed in particular regarding the body mass index. Conclusion: NSAIDs were effective in PEP prevention; however, the evidence is weak due to the observational nature and the different methods used in the included studies. Randomized controlled studies are needed to solve the issue.

scholarly journals Role of genetic structure of Helicobacter Pylori in formation of chronic inflammatory process in gastric mucosa

2021 ◽  
Vol 38 (1) ◽  
pp. 87-99
Author(s):  
O. M. Manyakina ◽  
I. S. Akkuratova-Maksimova ◽  
T. G. Pukhova ◽  
A. S. Shitova
Keyword(s):  
Helicobacter Pylori ◽  
Genetic Structure ◽  
Gastric Mucosa ◽  
Inflammatory Process ◽  
Gastric Glands ◽  
Highly Pathogenic ◽  
Genetic Characteristics ◽  
Chronic Inflammatory Process ◽  
Barr Virus

The literature review highlights the questions of the interaction of Helicobacter pylori and the human body. Modern data on the structure of the pathogenicity island in the Helicobacter pylori genome are presented. There is given a detailed description of both well-known virulence and pathogenicity factors of the infection (genes encoding the formation of urease subunits, in particular urel, cytotoxin associated gene A, vacuolating cytotoxin gen A, blood group associated binding adhesion, induced by contact with epithelium) and less studied ones (sialic acid-binding adhesion, adhesion-associated lipoprotein A and B, adhesin gene of Helicobacter pylori, Hp outer membrane protein). The significance of individual genes and proteins encoded by them in the development of chronic inflammatory process in diseases of the upper digestive tract, as well as in ulcer and carcinogenesis is analyzed. Mechanisms of interaction of bacteria with epithelial cells of the gastric mucosa, adhesive and cytotoxic effects of Helicobacter pylori, factors of biofilm formation are described. The influence of the genetic structure of Infect on cytological composition of the gastric glands in the form of reduction of specialized glandular cells chief and parietal cells of pyloric glands and the increase of endocrine cells in the pool is assessed. It is shown that colonization of the gastric mucosa by highly pathogenic strains of Helicobacter pylori contributes to the development of widespread pronounced and active inflammation in it, the appearance of morphological signs of atrophy. The role of the genetic characteristics of the infection in the failure of anti-helicobacter therapy is emphasized. Separately, the question of the effect of combined infection of the gastric mucosa with highly pathogenic strains of Helicobacter pylori and Epstein-Barr virus is highlighted.

scholarly journals Mite-induced Inflammation: More than Allergy

2012 ◽  
Vol 3 (1) ◽  
pp. ar.2012.3.0025 ◽  
Author(s):  
Mario Sánchez-Borges ◽  
Enrique Fernández-Caldas ◽  
Arnaldo Capriles-Hulett ◽  
Fernan Caballero-Fonseca
Keyword(s):  
Inflammatory Process ◽  
Genetic Factors ◽  
Medical Literature ◽  
Hypersensitivity Reactions ◽  
Atopic Diseases ◽  
Chronic Inflammatory Process ◽  
Clinical Observations ◽  
Cyclooxygenase 1 ◽  
Mite Allergy ◽  
Inflammatory Drugs

Clinical observations have suggested that there is an association of atopic conditions with hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). This relationship has been especially present in patients allergic to mites. This study was designed to review clinical and experimental evidence linking atopy, mite allergy, and hypersensitivity to aspirin and NSAIDs and discuss the possible mechanisms explaining this association. A review of the medical literature concerning the association of atopic diseases, mite hypersensitivity, and intolerance to NSAIDs using PubMed and other relevant articles is presented. NSAID-sensitive patients are frequently atopic and allergic to mites, and patients who develop oral mite anaphylaxis (OMA) show an increased prevalence of NSAID hypersensitivity. The study of atopic, mite-sensitive patients, who experience urticaria and angioedema when exposed to NSAIDs and patients with OMA suggests an interesting interaction between atopic allergy and disorders of leukotriene synthesis or metabolism. Various mechanisms that could be involved in this interaction are presented, including genetic factors, inhibition of cyclooxygenase-1, and other effects (not related to IgE sensitization) of mite constituents on the immune system. The association of mite hypersensitivity with aspirin/NSAIDs intolerance has been confirmed and provides additional clues to various nonallergic pathways that may contribute to the acute and chronic inflammatory process observed in atopic, mite-allergic, individuals. The clinical relevance of these observations is presently under investigation.

Role of viral infection in women with a chronic inflammatory process in the endometrium

2018 ◽  
Vol 18 (2) ◽  
pp. 104 ◽  
Author(s):  
E. G. Atanesyan ◽  
G. A. Penzhoyan ◽  
M. D. Andreeva ◽  
R. V. Morozova ◽  
S. N. Khachak
Keyword(s):  
Viral Infection ◽  
Inflammatory Process ◽  
Chronic Inflammatory Process

scholarly journals Inflammatory process as an etiological and prognostic factor of stroke and the goal of potential treatment strategies

2021 ◽  
Vol 36 (4) ◽  
pp. 297-311
Author(s):  
Agnieszka Kraśniej-Dębkowska ◽  
Maciej Śnieżyński ◽  
Anna Członkowska
Keyword(s):  
Inflammatory Process ◽  
Interleukin 1 ◽  
Treatment Strategies ◽  
Risk Of Infection ◽  
Defence Mechanism ◽  
The Central Nervous System ◽  
Inflammatory Drugs ◽  
The Subject ◽  
Brain Tissue Damage

Objective. Inflammation is the body’s natural defence mechanism against factors that damage its tissues. However, if it lasts chronically, it may adversely affect the body’s homeostasis. Inflammation is not only a long-known risk factor for the development of atherosclerosis and its complications, but also develops brain tissue damage in the course of ischemic stroke or intracerebral haemorrhage, leading to even greater damage. In addition, the immune system functions are impaired, which increases the risk of infection. Literature review. Drugs that can reduce the risk of stroke by inhibiting vascular damage and modifying the inflammatory process in the central nervous system, including counteracting the risk of infection, have become the subject of many experimental and clinical studies on strokes. Such drugs include canakinumab, human recombinant interleukin-1 receptor antagonist, colchicine, fingolimod, siponimod or natalizumab. Conclusions. Considering all available research results, the therapeutic pathway using anti-inflammatory drugs has a high potential; however, the complications associated with evoked immunosuppression in patients should be kept in mind. The paper presents a review of the literature on the role of the inflammatory process in the pathogenesis of stroke as well as related therapeutic options.

scholarly journals Use of infrared thermography in an animal model as a complementary tool for monitoring the inflammatory process: a preliminary study

2021 ◽  
Author(s):  
Agnes Batista Meireles ◽  
Timilly Martins Cruz ◽  
Izabela Cristina Brandão Moreira ◽  
Valéria Gomes de Almeida ◽  
Bethânia Avelar-Freitas ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Diclofenac Sodium ◽  
Chemical Induction ◽  
Temperature Changes ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Preliminary Study ◽  
Blood Leukocyte ◽  
Rat Paw

Abstract PurposeTemperature changes on a surface can be measured by infrared thermographic cameras. Thus, the images obtained by these cameras can be useful for a wide range of biological in vivo studies, including animal models of inflammation. In this preliminary study, the use of thermography in rat paw inflammation was evaluated.MethodsCFA-induced paw edema on rats (n=5) was performed and discrepancies between animals treated or not with anti-inflammatory drugs as triamcinolone acetonide and diclofenac sodium were analyzed. Experimental times were: T0, before chemical induction of inflammatory process (control); and times after injection: T1 (30 min); T2 (24 hours); T3 (48 hours); T4 (72 hours); T5 (96 hours); T6 (7 days); T7 (14 days); T8 (21 days); T9 (28 days). The measured parameters were temperature, the edema (thickness and volume) of each animal paw (left and right), histological analysis, and blood leukocyte count.ResultsThe results demonstrated that the profile of local temperature changes was similar to the volume and thickness of the paws, with an increase at 24 hours. Such increase (the 24 hours peak) is expected for this specific type of inflammation model. From T7 onwards, the temperature values, in all groups, returned to baseline values (T0).ConclusionsThis preliminary study shows a possible use of quantitative high-resolution infrared as a complementary tool for monitoring the inflammatory process.

Pre-emptive Analgesia for Postoperative Pain Relief in Children – Role of Paracetamol

2009 ◽  
pp. 9-16
Author(s):  
Rubina Yasmin ◽  
AKM Akhtaruzzaman ◽  
Paresh Chandra Sarker ◽  
Neaz Ahmed ◽  
Ranadhir Kumar Kundu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Postoperative Pain ◽  
Diclofenac Sodium ◽  
Total Duration ◽  
Pain Scale ◽  
Prospective Clinical Study ◽  
High Dose ◽  
Induction Of Anaesthesia

This prospective clinical study was carried out in the Dept. of Anaesthesia, Analgesia and Intensive Care Medicine, BSMMU, Dhaka, during the period of May 2003 to July 2003. The study was done to emphasize the importance of giving analgesics preemptively instead of waiting for the child to complain of pain and to produce smooth recovery after surgery by decreasing immediate postoperative pain in children by a simple, safe acceptable drug. The children scheduled for tonsillectomy under general anaesthesia were recruited in this study. The analgesic efficiency of rectal paracetamol in two doses, 25 mg/kg bodywt.(Gr-P25) and 50 mg/kg. bodywt. (Gr-P50) were compared with Diclofenac Sodium suppository 1mg/ kg body weight (Gr-D) given half an hour before induction of anaesthesia. Pain scoring was done by TPPPS (Toddler Pre-schooler postoperative pain scale). Heart rate and blood pressure were stable in Gr-P50 and Gr-D. Time of first demand of analgesic was delayed in Gr-P50 and Gr-D. Total paracetamol consumption in 24 hours was less in Gr-P50(181±14.25) and Gr-D (212±25) than Gr-P25(318± 26.39). Total duration of analgesia in Gr- P50 (657±9.94) mins. and in Gr- D(502±10.63) mins. and in Gr-P25(288±23.17) mins. Pre-emptive high dose rectal paracetamol appears to be more effective than diclofenac sodium suppository for postoperative analgesia in children undergoing tonsillectomy. Journal of BSA, Vol. 18, No. 1 & 2, 2005 p.9-16

ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

2018 ◽  
pp. 32-37 ◽  
Author(s):  
Z. A. Shafigullina ◽  
S. Yu. Medvedeva ◽  
I. G. Danilova
Keyword(s):  
Toxic Hepatitis ◽  
Intraperitoneal Administration ◽  
Sharp Decrease ◽  
Cellular Component ◽  
Ki 67 ◽  
Sinusoidal Cells ◽  
Toxic Damage ◽  
Stromal Component ◽  
Regeneration Processes

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

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